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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 509 of 676

Negative / Null Result ReportMedicine

Investigating the necessity of preoperative coronary angiography for infection-related cardiac implantable electronic device explantation.

Caldonazo, Scheler, Fischer et al. · 2026 · American heart journal plus : cardiology research and practice

Device-associated endocarditis is a potentially life-threatening condition that typically requires the removal of the cardiac implantable electronic device (CIED). The role of routine coronary angiography (CAG) as part of preoperative…

View details →DOI: 10.1016/j.ahjo.2026.100762
Negative / Null Result ReportMedicine

The efficacy of acetic acid and citric acid on calcium silicate based cement removal from root canals and their effect on dentine structure - an in vitro study.

Alzraikat, Al-Hiyasat, Jamous et al. · 2026 · Biomaterial investigations in dentistry

This study evaluated the effectiveness of acids on calcium silicate cement surface hardness, perforation, and their impact on root dentine microstructure. Root dentine discs were exposed to hydrochloric, acetic, and citric acids. Fourier…

View details →DOI: 10.2340/biid.v13.45669
Negative / Null Result ReportMedicine

Effects of omega-3 fatty acid supplementation on heart rate variability.

Atef Abdelsattar Ibrahim, Gouda Kamal, Zid et al. · 2026 · World journal of clinical pediatrics

Obesity and overweight are major public health challenges and are associated with autonomic imbalance and decreased heart rate variability (HRV), a non-invasive indicator of cardiovascular risk. Omega-3 polyunsaturated fatty acids have…

View details →DOI: 10.5409/wjcp.v15.i1.116331
Negative / Null Result ReportMedicine

Risk Factors Associated with Mortality in Nosocomial Stenotrophomonas maltophilia Pneumonia: A Single-Center Retrospective Study.

Yıldız, Top, Yıldız et al. · 2026 · Mediterranean journal of hematology and infectious diseases

Stenotrophomonas maltophilia ( S. maltophilia ) is a multidrug-resistant pathogen frequently isolated in hospital-acquired pneumonia and represents a significant clinical challenge. This study aimed to investigate the risk factors…

View details →DOI: 10.4084/mjhid.2026.018
Negative / Null Result ReportMedicine

Inpatient Opioid Use in Head and Neck Microvascular Free Flap Reconstruction.

Timothee, Bliss, Blumenthal et al. · 2026 · Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

The primary objective is to determine whether patients undergoing osseous microvascular free flap reconstruction of head and neck defects have higher inpatient pain requirements than those undergoing nonosseous reconstruction. Secondary…

View details →DOI: 10.1002/ohn.70200
Negative / Null Result ReportMedicine

The effect of horticultural activity program on internet addiction, social skills, and stress levels in children: A randomized controlled trial.

Kacar, Ayaz-Alkaya · 2026 · Journal of pediatric nursing

Internet addiction is a growing problem among children and adolescents. Pathological internet use may lead to psychological and social issues. More effective and innovative interventions are needed to promote the mental health of children.…

View details →DOI: 10.1016/j.pedn.2026.02.035
Negative / Null Result ReportMedicine

Effect of titanium dioxide nanotubes in Ca(OH)2-based intracanal medicaments on odontoblast-like cells.

Lopes, Costa, Nociti Junior et al. · 2026 · Brazilian oral research

This study investigated the effects of incorporating 3wt% titanium dioxide nanotubes (nTiO2) into calcium hydroxide [Ca(OH)2]-based intracanal medicament (ICM) formulations on the proliferation, viability, and mitochondrial metabolic…

View details →DOI: 10.1590/1807-3107bor-2026.vol40.002
Negative / Null Result ReportMedicine

Effect of Tranexamic Acid Administration on the State of Pial Arterial Vessels in Rats with Acute Hemorrahage and Hypothermia.

Melnikova · 2025 · Bulletin of experimental biology and medicine

Using in vivo microscopy, changes in the diameter of pial arterial microvessels were studied in rats with modeled moderate acute blood loss followed by whole-body cooling against the background of a single administration of tranexamic acid…

View details →DOI: 10.1007/s10517-026-06603-2
Negative / Null Result ReportMedicine

The Effect of Anti-TNF Group Drugs on Thyroid Function in Patients with ‎Rheumatoid Arthritis and Ankylosing Spondylitis.

Tuncekin, Toprak · 2026 · Iranian journal of immunology : IJI

Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are chronic autoimmune inflammatory disorders in which TNF-α plays a key role. Anti-TNF agents are widely used in the management of these diseases. Since TNF-α is also…

View details →DOI: 10.22034/iji.2026.107743.3081
Negative / Null Result ReportMedicine

Effect of breathing exercises on depression, sexual function, and exercise capacity in postmenopausal women: a randomized controlled trial.

Elgayar · 2026 · Scientific reports

This trial aimed to explore the effect of supervised breathing exercises (BEs) on depression, sexual function, and exercise capacity in postmenopausal women. Sixty-four depressed postmenopausal women with associated sexual dysfunction were…

View details →DOI: 10.1038/s41598-026-41198-8
Negative / Null Result ReportMedicine

Water-pipe tobacco and cigarette smoking, on preeclampsia: adverse or protective effect: MATCH cohort study.

Rezaeinejad, Sepidarkish, Moini et al. · 2026 · Pregnancy hypertension

While cigarette smoking has been paradoxically associated with a reduced risk of preeclampsia, the effect of waterpipe (WP) smoking, an increasingly prevalent form of tobacco use remains poorly understood. This study aimed to investigate…

View details →DOI: 10.1016/j.preghy.2026.101426
Negative / Null Result ReportMedicine

Questionable indication for postoperative radiotherapy after surgery for metastases of the major long bones: A single-centre cohort study of 552 fractures/526 patients.

Ehne, Kastensson, Wedin et al. · 2026 · Journal of bone oncology

The use of postoperative radiotherapy (PORT) as an adjunct to orthopaedic surgery of the long bones is widely recommended. Evidence of the benefits is however sparse. The primary research question of this study was whether PORT reduces the…

View details →DOI: 10.1016/j.jbo.2026.100746
Negative / Null Result ReportMedicine

Trends and predictors of caesarean section in Thailand before and during the COVID-19 pandemic: a retrospective analysis of national hospitalisation data under the Universal Coverage Scheme.

Karunayawong, Sukmanee, Butchon et al. · 2026 · BMJ open

Since 1985, the international healthcare community has recommended the ideal rate of caesarean section (CS) to be 10%-15% at the national level. The literature has reported that overused CS without necessary medical indications can be…

View details →DOI: 10.1136/bmjopen-2024-096080
Negative / Null Result ReportMedicine

Evaluation of bone repair using sticky bone in preradiotherapy extraction sockets of head and neck cancer patients: a pre- and postradiotherapy follow-up.

Rodrigues, Macedo, de Paulo et al. · 2026 · Oral surgery, oral medicine, oral pathology and oral radiology

To evaluate the effects of sticky bone a biomaterial composed of Solid-PRF (S-PRF), a variant of platelet-rich fibrin (PRF), and deproteinized bovine bone-on bone formation after tooth extraction performed prior to radiotherapy, with…

View details →DOI: 10.1016/j.oooo.2025.12.016
Negative / Null Result ReportMedicine

Conjugation of Functionalized Gold Nanorods and Copper (I)-Based Drug: An Anisotropic Nano Drug Delivery System.

Olivieri, Amatori, Battocchio et al. · 2026 · Nanomaterials (Basel, Switzerland)

Gold nanorods (AuNRs) were synthesized and optimized with the aim of obtaining strongly hydrophilic nanomaterials, suitable as a drug delivery system (DDS) for copper-based drugs. After careful purification, AuNRs were characterized by…

View details →DOI: 10.3390/nano16030217
Negative / Null Result ReportMedicine

Influence of Environmental Factors on the Growth of Colletotrichum godetiae, Causal Agents of Olive Anthracnose in Spain.

Expósito-Díaz, Medina, Moral · 2026 · Environmental microbiology reports

Olive anthracnose, the most critical disease affecting fruit and oil quality, is caused by Colletotrichum species, with C. godetiae dominant in Italian and Spanish orchards. Climate change could exacerbate its impact, particularly through…

View details →DOI: 10.1111/1758-2229.70276
Negative / Null Result ReportMedicine

Preservation of preoperative CPAK is not associated with improved clinical outcomes one-year after functionally aligned robot-assisted TKA.

Pujol, Minguell, Pijoan et al. · 2025 · Journal of orthopaedics

To determine if maintaining the preoperative CPAK class influences on clinical outcomes when performing a functional aligned robotic assisted TKA (RATKA). This prospective cohort study compared patients who maintained their preoperative…

View details →DOI: 10.1016/j.jor.2025.06.030
Negative / Null Result ReportMedicine

Sleep and Haemophilia-A Case-Control Analysis of Associated Factors.

Schmidt, Brühl, Möllers et al. · 2026 · Haemophilia : the official journal of the World Federation of Hemophilia

Sufficient sleep is essential for maintaining both physical and mental health, yet data on sleep health among persons with haemophilia (PwH) remain limited. This study aimed to assess sleep in PwH compared to healthy controls (Con) and…

View details →DOI: 10.1111/hae.70217
Negative / Null Result ReportMedicine

The Impact of Age on Military Trauma Outcomes: A Retrospective Analysis.

Akler, Gelman, Radomislensky et al. · 2026 · The Israel Medical Association journal : IMAJ

Age is a well-established prognostic factor in civilian trauma, where adverse outcomes increase with ages. Whether this pattern holds true in military trauma, where populations, injury mechanisms, and systems of care differ fundamentally,…

Negative / Null Result ReportMedicine

Evaluation of prognostic biomarkers for exacerbation frequency in patients with chronic obstructive pulmonary disease.

Albayrak · 2026 · Revista da Associacao Medica Brasileira (1992)

Systemic inflammation is closely associated with acute exacerbations of chronic obstructive pulmonary disease and may reflect the risk of future exacerbations. Blood-based inflammatory biomarkers represent simple and practical tools for…

View details →DOI: 10.1590/1806-9282.20251626