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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19885 results in Negative / Null Result Report · page 509 of 663

Negative / Null Result ReportMedicine

NELA, P-POSSUM, and Paraspinal Muscle Index in risk stratification of elderly patients undergoing emergency laparotomy.

Ugur MA, Okut G, Buyuktoka RE et al. · 2026 · BMC geriatrics

Background Emergency laparotomy in older adults is associated with substantial morbidity and mortality, necessitating accurate and rapid preoperative risk stratification. Established risk models such as National Emergency Laparotomy Audit…

View details →DOI: 10.1186/s12877-026-07539-y
Negative / Null Result ReportMedicine

The impact of delivery models on psychomotor performance of manual procedures: a pilot study.

Borgehammar J, McClenahan B, Miller E et al. · 2026 · The Journal of manual & manipulative therapy

Objective Developing psychomotor competence in orthopedic manual physical therapy (OMPT) techniques is fundamental to post-professional physical therapy education. Concerns persist about whether online instructional models and the rise of…

View details →DOI: 10.1080/10669817.2026.2680217
Negative / Null Result ReportMedicine

Effect of Concurrent Anti-Seizure Medications on the Efficacy of the Ketogenic Diet in Children with Epilepsy.

Sharma S, Aschner A, Kabir N et al. · 2026 · The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

Rationale The ketogenic diet (KD) is a well-established therapeutic option for children with non-surgical drug-resistant epilepsy (DRE). The purpose of this study was to determine whether specific anti-seizure medications (ASM) are…

View details →DOI: 10.1017/cjn.2026.10620
Negative / Null Result ReportMedicine

Clinical Outcomes in Japanese Patients with Chronic Limb Threatening Ischaemia Undergoing Tibial and Pedal Bypass with a Single Segment Great Saphenous Vein Graft.

Kobayashi T, Takahara M, Kikuchi S et al. · 2026 · European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

Objective A single segment great saphenous vein (GSV) with a diameter ≥ 3.0 mm is widely accepted as the standard conduit for tibial and pedal bypass in chronic limb threatening ischaemia (CLTI) based on studies in European and American…

View details →DOI: 10.1016/j.ejvs.2026.06.037
Negative / Null Result ReportMedicine

Assessing the essential parameters of race, ethnicity and geography in endometrial cancer and the impact on presentation, treatment and outcomes.

Jamieson A, Kwon J, Gao T et al. · 2026 · Gynecologic oncology

Background Race, ethnicity, and geography can impact cancer management, genomics and outcomes. We aimed to determine the ethnic and geographic diversity of endometrial carcinoma (EC) patients in our province and their impact on molecular…

View details →DOI: 10.1016/j.ygyno.2026.05.011
Negative / Null Result ReportMedicine

Identification of chrono-nutrition behavior patterns and their associations with sociodemographic characteristics, diet quality, and obesity.

Murakami K, Shinozaki N, Livingstone MBE et al. · 2026 · The British journal of nutrition

While chrono-nutrition behaviors are inter-related, few studies examined patterns of chrono-nutrition behaviors using a comprehensive set of these behaviors. This study aimed to identify chrono-nutrition behavior patterns and examine their…

View details →DOI: 10.1017/s0007114526107090
Negative / Null Result ReportMedicine

Relationships between rest-activity rhythms, cancer-related fatigue, and quality of life: Results from a time-restricted eating randomized controlled trial.

Kleckner AS, Zhou Y, Diaz-Mercado Y et al. · 2026 · Chronobiology international

Circadian rest-activity rhythms, or a person's consistency in their daily activity and rest patterns, can be quantified using various parametric and non-parametric methods. However, these methods are seldom applied to understand symptoms…

View details →DOI: 10.1080/07420528.2026.2669594
Negative / Null Result ReportMedicine

IL-6 and TNFα are associated with depressive symptoms among men in a community-based cohort, with a tentative trend for IL-17A: Findings from the Shika Study in Japan.

Tsuboi H, Sakakibara H, Minamida-Urata Y et al. · 2026 · Neuro endocrinology letters

Objective Emerging evidence suggests that low-grade systemic inflammation contributes to depressive symptoms; however, population-based longitudinal evidence, particularly from community samples, remains limited. This study examined the…

Negative / Null Result ReportMedicine

Outcomes of extremely preterm infants with neonatal hyperglycemia and hypernatremia: a retrospective cohort study.

Fursule A, Athalye-Jape G, Deepak D et al. · 2026 · Journal of perinatology : official journal of the California Perinatal Association

Objective To assess whether early hypernatremia (HN) and/or hyperglycemia (HG) in the first postnatal week are associated with adverse neurodevelopmental outcomes in extremely preterm (EP; Study design This was a single-center…

View details →DOI: 10.1038/s41372-026-02683-0
Negative / Null Result ReportMedicine

Association between platelet indices and next-day bleeding and clotting in children and adults on extracorporeal membrane oxygenation: A retrospective study.

Chegondi M, Jawahar A, Badheka A et al. · 2026 · Perfusion

IntroductionBleeding and clotting phenotypes are common in patients supported with Extracorporeal Membrane Oxygenation (ECMO) and are associated with increased mortality. However, tools to distinguish bleeding from clotting phenotypes…

View details →DOI: 10.1177/02676591261445354
Negative / Null Result ReportMedicine

Subclinical malaria in sickle cell disease in Northern Uganda: prevalence, predictors, and hematologic impact.

Matejak NJ, Ngolobe H, O'Connell CT et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Objectives Sickle Cell Disease (SCD), characterized by persistently low hemoglobin (Hb) and hematocrit levels, is among the leading causes of under-five mortality in high prevalence countries. Sub-Saharan Africa bears the highest burden of…

View details →DOI: 10.1016/j.ijid.2026.108823
Negative / Null Result ReportMedicine

The relationships between proprioceptive awareness, balance, and spasticity in patients post-stroke with varying levels of trunk impairment.

Ada G, Duray M · 2026 · Physiotherapy theory and practice

Background Cervical and trunk proprioceptive deficits resulting from impaired sensorimotor integration post-stroke may contribute to deficiencies in balance reactions and tone regulation. Purpose: To examine relationships between cervical…

View details →DOI: 10.1080/09593985.2026.2656807
Negative / Null Result ReportMedicine

Associations between attitudes and beliefs about the role of nutrition and diet quality with pain interference and physical function.

Fredhoff B, Bernstetter A, Fotiou H et al. · 2026 · Complementary therapies in clinical practice

Background and purpose Nutrition likely influences pain, but the role of patient beliefs remains understudied in musculoskeletal conditions. This study examined whether beliefs about the role of nutrition in pain, diet quality, and eating…

View details →DOI: 10.1016/j.ctcp.2026.102057
Negative / Null Result ReportOpen accessMedicine

Clinical Predictors of Survival After Palliative Radiotherapy for Glioblastoma in a Real-World Cohort Study.

Bock F, Hildebrandt G, Frerker B et al. · 2026 · Current oncology (Toronto, Ont.)

Background This study sought to evaluate overall survival (OS) following palliative radiotherapy in glioblastoma and to identify clinically applicable predictors supporting patient-centred treatment decisions, with exploration of early…

View details →DOI: 10.3390/curroncol33060305
Negative / Null Result ReportOpen accessMedicine

Glycemic trends following hypoglossal nerve stimulation in patients with obstructive sleep apnea and type 2 diabetes.

Ahmed A, Segal S, Gibber M · 2026 · Sleep & breathing = Schlaf & Atmung

Purpose To describe glycemic trends following hypoglossal nerve stimulation (HNS) therapy in patients with obstructive sleep apnea (OSA) and type 2 diabetes. Methods A retrospective review was conducted of patients with type 2 diabetes who…

View details →DOI: 10.1007/s11325-026-03736-6
Negative / Null Result ReportMedicine

The relationship between pre-incarceration related social determinants and glycaemic control in African Americans with criminal legal involvement and type 2 diabetes.

Akinboboye O, Walker RJ, Campbell JA et al. · 2026 · Diabetic medicine : a journal of the British Diabetic Association

Aims To evaluate the relationship between pre-incarceration social determinants, demographic and clinical factors, and glycaemic control in African Americans with a history of criminal legal involvement and type 2 diabetes mellitus.…

View details →DOI: 10.1111/dme.70342
Negative / Null Result ReportMedicine

Surgical Helmet Systems Were Not Associated With Lower Operative Infection Rates After Total Ankle Arthroplasty: A Retrospective Cohort Study.

McCahon JAS, Thomas GM, Hsu A et al. · 2026 · Foot & ankle international

BackgroundConflicting evidence exists regarding the ability of surgical helmet systems (SHSs) to reduce rates of infection after joint replacement. The purpose of this study was to investigate the use of SHS in total ankle arthroplasty…

View details →DOI: 10.1177/10711007261436417
Negative / Null Result ReportMedicine

Can we predict functional recovery following non-operative treatment of proximal humerus fractures?

Hammond B, Goldstein A, Murugesan D et al. · 2026 · Journal of clinical orthopaedics and trauma

Background Functional recovery following non-operative treatment of proximal humerus fractures (PHFs) varies widely, but the relative impact of patient characteristics and medical comorbidities remain unclear. This study aimed to identify…

View details →DOI: 10.1016/j.jcot.2026.103435
Negative / Null Result ReportMedicine

Discharge destination and one-year mortality in acute limb ischemia survivors after revascularization: A multicenter registry study.

Yoshioka N, Hata Y, Haraguchi T et al. · 2026 · Journal of vascular surgery

Objective Acute limb ischemia may impair functional status and hinder return home after hospitalization, even in patients who survive to discharge. However, the associations among discharge destination, clinical characteristics, and…

View details →DOI: 10.1016/j.jvs.2026.04.027
Negative / Null Result ReportOpen accessMedicine

Associations between fat distribution and obstructive sleep apnea severity among individuals with type 2 diabetes: an MRI-based study.

Ahtola K, Ulander M, Agholme J et al. · 2026 · Scientific reports

Obstructive Sleep Apnea (OSA) affects 1 billion people globally, with a male-to-female ratio of 2:1. While obesity is a major risk factor, sex differences in fat distribution may influence OSA risk. This study examined the relationship…

View details →DOI: 10.1038/s41598-026-58058-0
Negative / Null Result ReportMedicine

Knowledge, attitudes, and practices of occupational health and safety measures among nurses at Bolgatanga Regional Hospital of Ghana.

Ti-Enkawol Nachinab G, Alem JN, Coffie GB · 2026 · BMC health services research

Introduction Occupational health and safety are major concerns for health workers worldwide. Nurses working in resource-constrained areas are at higher risk of occupational hazards. The purpose of the study was to assess the knowledge,…

View details →DOI: 10.1186/s12913-026-14956-7