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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 508 of 676

Negative / Null Result ReportOpen access

Differences in expression of interleukin-6 and tumor necrosis factor-alpha fallopian tubes non-patent and fallopian tubes patent

U. R. Budihastuti, Abdurahman Laqif, Eriana Melinawati et al. · 2024 · Bangladesh Journal of Medical Science

Background: Fallopian tube infertility results from sexually transmitted infections and pelvic inflammatory diseases. The most common causes of infertility in women are infections caused by Chlamydia trachomatis and Neisseria gonorrhoeae.…

View details →DOI: 10.3329/bjms.v23i1.70753
Negative / Null Result ReportOpen accessMedicine

Postprandial changes in cardiometabolic disease risk in young Chinese men following isocaloric high or low protein diets, stratified by either high or low meal frequency - a randomized controlled crossover trial

A. Mok, S. Haldar, J. C. Lee et al. · 2015 · Nutrix Journal

BackgroundCardio-Metabolic Disease (CMD) is the leading cause of death globally and particularly in Asia. Postprandial elevation of glycaemia, insulinaemia, triglyceridaemia are associated with an increased risk of CMD. While studies have…

View details →DOI: 10.1186/s12937-016-0141-5
Negative / Null Result ReportOpen accessMedicine

EFFICACY OF SILODOSIN VS TAMSULOSIN IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA: A DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL

S. T. C. Ariwicaksono, R. B. Prasetyo, Nindra Prasadja et al. · 2019 · International Journal of Applied Pharmaceutics

Objective: Benign prostatic hyperplasia (BPH) is a nonmalignant enlargement of the prostate associated with aging. BPH can cause lower urinary tract syndrome (LUTS). Medical therapy for patients with moderate and severe LUTS symptoms…

View details →DOI: 10.22159/ijap.2019.v11s6.33558
Negative / Null Result Report

СООТНОШЕНИЕ МЕЖДУ ГЕНДЕРНЫМИ ПСИХОЭМОЦИОНАЛЬНЫМИ ХАРАКТЕРИСТИКАМИ И ШКОЛЬНОЙ УСПЕВАЕМОСТЬЮ В РАННЕМ ПОДРОСТКОВОМ ВОЗРАСТЕ

А.И. Боравова · 2024 · Асимметрия

В работе проведен сравнительный анализ психоэмоциональных особенностей учащихся средней школы. Установлены достоверно значимые различия эмоциональных личностных характеристик между мальчиками и девочками подросткового возраста в…

View details →DOI: 10.25692/asy.2024.18.1.003
Negative / Null Result Report

Comparison of Sickle Cell Disease Patient Experiences in Developed and Developing Countries: Insights from UK and India Patient Cohorts

Ashley Lai, Kim Z Summers, Orlando Agrippa et al. · 2024 · Blood

Background Sickle cell disease (SCD) is the most common genetic blood disorder, affecting millions globally with 300,000 new cases annually. ~14,000 people live with SCD in the UK, while the number exceeds 20 million in India. Differences…

View details →DOI: 10.1182/blood-2024-210767
Negative / Null Result ReportOpen access

Correlation of Problem Based Learning Model and Discovery Learning Model with the Development of Creativity and Motivation of Students

Jaka Sayidina Ali, A. Pambudi, Stefanus Prasetyo Yudi Susanto · 2024 · International journal of multidisciplinary research and analysis

This study aims to determine the correlation of Problem-Based Learning Model and Discovery Learning Model with students' creativity and learning motivation. This research uses a quantitative approach of correlation type. . The sample in…

View details →DOI: 10.47191/ijmra/v7-i01-21
Negative / Null Result ReportOpen accessMedicine

Влияние экзогенных сурфактантов на показатели газового состава крови у новорождённых с респираторным дистресс-синдромом

A. A. Перепелица, Array М Голубев, Array В. Мороз · 2007

Objective: to study the effects of the surfactants Surfactant-BL and Curosurf on pulmonary oxygenizing properties in preterm neonatal infants with respiratory distress syndrome (RDS). The studies were performed in 81 preterm neonates with…

View details →DOI: 10.15360/1813-9779-2007-3-59
Negative / Null Result Report

Auto-Induced, Radiofrequency, Downlink Exposure Focused at the Human Ear

Hanne Herssens, Arno Thielens · 2023 · European Microwave Conference

A numerical study is performed to determine the auto-induced downlink exposure due to 5G New Radio (NR) networks at 3.5 GHz. The exposure scenario consists of a subject situated in the far-field of the base station (BS) equipped with…

View details →DOI: 10.23919/eumc58039.2023.10290507
Negative / Null Result ReportMedicine

Concepts of care for people with dementia

N. Rieckmann, C. Schwarzbach, M. Nocon et al. · 2009 · GMS Health Technology Assessment

Introduction Today there are approximately one million people with dementia in Germany. If current demographic trends continue, this number is likely to rise substantially in the coming years. In the older population, dementia is the most…

View details →DOI: 10.3205/hta000063
Negative / Null Result ReportOpen accessMedicine

Ivermectin treatment of demodicosis in 56 hamsters.

K. Tani, T. Iwanaga, K. Sonoda et al. · 2001 · Journal of Veterinary Medical Science

Fifty-six hamsters with demodicosis were treated with daily oral administration of ivermectin (0.3 mg/kg). Thirty-three cases (58.9%) were cured and 6 cases (10.7%) had improved clinically but needed to continue treatment. Of 5 cases…

View details →DOI: 10.1292/jvms.63.1245
Negative / Null Result ReportMedicine

Human papillomavirus types causing recurrent respiratory papillomatosis in Zimbabwe.

N. Matinhira, N. Soko, T. Bandason et al. · 2019 · International Journal of Pediatric Otorhinolaryngology

OBJECTIVE Recurrent respiratory papillomatosis (RRP) caused by human papillomavirus (HPV) is preventable through vaccination. This study was motivated by the recent thrust of the Zimbabwean government to reduce incidence of HPV related…

View details →DOI: 10.1016/j.ijporl.2018.10.036
Negative / Null Result ReportComputer Science

Can Modern NLP Systems Reliably Annotate Chest Radiography Exams? A Pre-Purchase Evaluation and Comparative Study of Solutions from AWS, Google, Azure, John Snow Labs, and Open-Source Models on an Independent Pediatric Dataset

Shruti Hegde, Mabon Ninan, Jonathan R. Dillman et al. · 2025 · arXiv.org

General-purpose clinical natural language processing (NLP) tools are increasingly used for the automatic labeling of clinical reports. However, independent evaluations for specific tasks, such as pediatric chest radiograph (CXR) report…

View details →DOI: 10.48550/arxiv.2505.23030
Negative / Null Result ReportOpen accessMedicine

Dose escalation in radical radio(chemo)therapy for cervical and upper thoracic esophageal cancer with 3DCRT/IMRT (ChC&UES): a multicenter retrospective study

Xiao-han Zhao, Wencheng Zhang, Xin Wang et al. · 2024 · Radiation Oncology

Cervical and upper thoracic esophageal cancer (ESCA) presents treatment challenges due to limited clinical evidence. This multi-center study (ChC&UES) explores radical radio(chemo)therapy efficacy and safety, especially focusing on…

View details →DOI: 10.1186/s13014-024-02521-7
Negative / Null Result ReportOpen accessMedicine

Three-year follow-up of changes of cortical bone thickness after implantation of Endo-Exo-Prosthesis (EEP) for transfemoral amputees

M. Örgel, E. Liodakis, Pratya Jaratjitwilai et al. · 2020 · Journal of Orthopaedic Surgery and Research

Introduction Transcutaneous Osseointegrated Prosthetic Systems (TOPS) offer a good alternative for patients who cannot be satisfactorily rehabilitated by conventional suspension sockets. The Endo-Exo-Prothesis (EEP, ESKA Orthopaedic…

View details →DOI: 10.1186/s13018-020-01675-w
Negative / Null Result ReportOpen access

The Effect of Endoscopic Peritubal Adenoidectomy Vs Myringotomy with Ventilation Tubes Insertion in Management of Otitis Media with Effusion in Children

M. El Begermy, Marwa M El Begermy, H. Kassamy · 2022 · Egyptian Journal of Ear Nose Throat and Allied Sciences

Background: There is a lot of controversy about the role of adenoidectomy and myringotomy with ventilation tubes insertion (MVT) in management of otitis media with effusion (OME). In a previous study we found that endoscopic-assisted…

View details →DOI: 10.21608/ejentas.2021.51633.1290
Negative / Null Result ReportBiology

Optimization of a vacuum-drying protectants for the biocontrol agent Pichia membranifaciens and its influence on viability and efficacy

Hongyan Zhang, Lili Deng, S. Yao et al. · 2020

Abstract In this study, we focused on screening for an optimal protectant formula for vacuum-dried Pichia membranifaciens and compared the biocontrol efficacy of fresh P. membranifaciens and dried one on citrus fruit. We also used several…

View details →DOI: 10.1016/j.biocontrol.2019.104155
Negative / Null Result ReportOpen access

Comparative evaluation of photoactivated disinfection and sonic irrigation as an adjunct to conventional irrigation on Enterococcus faecalis in root canals: An in vitro study

Tushar Kohli, N. Mehta, G. Garima et al. · 2021

Objective: The aim of the in vitro study was to compare the antibacterial efficacy of photoactivated disinfection (PAD), sonic irrigation as an adjunct to conventional irrigation against Enterococcus faecalis in vitro. Materials and…

View details →DOI: 10.4103/endo.endo_12_20
Negative / Null Result ReportMedicine

Interplay Among Reward Processing, Schizotypal Traits, and Psychosocial Stress in a Large Chinese Young Adult Sample: A Cross‐Sectional Network Analysis

Donghao Tuo, Yi-hang Huang, Simon S. Y. Liu et al. · 2026 · PsyCh Journal

ABSTRACT Reward processing comprises reward sensitivity, motivation, and pleasure experience, but how these components jointly relate to schizotypal traits and psychosocial stress in young adult samples remains unclear. Using network…

View details →DOI: 10.1002/pchj.70102
Negative / Null Result ReportMedicine

Glutathione S-transferase expression in benign and malignant eyelid tumors

Efe Saygın, R. Karadag, S. Ozkanlı et al. · 2021 · Biotechnic & Histochemistry

ABSTRACT Eyelid tumors commonly originate from the skin and its appendages. Environmental toxins and oxidants affect eyelid carcinogenesis. Glutathione S-transferases (GST) are antioxidants that participate in pathogenesis. We investigated…

View details →DOI: 10.1080/10520295.2021.1986133
Negative / Null Result ReportOpen accessMedicine

Vaccination counseling with and without excipient skin testing in patients with suspected allergic reactions to mRNA COVID-19 vaccines and patients with atopy

Dilawar Khokhar, K. O’Shea, C. Akin et al. · 2022 · Journal of Allergy and Clinical Immunology: Global

Background Allergic reactions have been reported with mRNA vaccines for COVID-19 prevention. Patients perceived to be at higher risk for a reaction may be referred to an allergist, although evaluation strategies may differ between…

View details →DOI: 10.1016/j.jacig.2022.05.012
Negative / Null Result ReportMedicine

Exploratory safety investigations in normal, freely moving Göttingen minipigs using telemetry: Pharmacological validation.

Julie Jacobsen, Berit Ø. Christoffersen · 2025 · Journal of pharmacological and toxicological methods

INTRODUCTION Adverse cardiovascular (CV) effects is a major cause of drug attrition. Early assessment of CV risk for new drug candidates may be warranted for early de-risking of the further development. Predictive animal models and a…

View details →DOI: 10.1016/j.vascn.2025.108395
Negative / Null Result ReportOpen accessMedicine

Evaluation of Health Literacy and Associated Factors Among Adults Living in Saudi Arabia: A Cross-Sectional Study

Yaser M. Alahmadi · 2023 · Inquiry : a journal of medical care organization, provision and financing

In this westernized culture, maintaining a healthy lifestyle has become a major health concern internationally. Health literacy is an emerging concept and requires effective measures and reform to improve the health status and health of…

View details →DOI: 10.1177/00469580231161428
Negative / Null Result ReportOpen accessMedicine

Natamycin versus natamycin combined with voriconazole in the treatment of fungal keratitis

Jingjing Cai, Chengwen Yang, Qiuhong Wei et al. · 2023 · Pakistan Journal of Medical Sciences

Objective: To observe the therapeutic effect of natamycin combined with voriconazole in the treatment of fungal keratitis (FK). Methods: This is a retrospective study. The subjects of this study were 64 patients with FK who were admitted…

View details →DOI: 10.12669/pjms.39.3.6908
Negative / Null Result ReportMedicine

PP27 Pre-hospital lactate monitoring: a worthy adjunct to systolic blood pressure and shock index in triggering blood product administration in patients with suspected traumatic haemorrhage?

J. Griggs, M. Sherriff, J. Leung et al. · 2019 · Emergency Medicine Journal

Introduction Pre-hospital identification of patients with suspected occult traumatic haemorrhage is problematic. Physiological parameters and clinical gestalt are inadequate surrogates for ongoing haemorrhage. Lactate monitoring may hold…

View details →DOI: 10.1136/emermed-2019-999.27
Negative / Null Result ReportMedicine

AAV2-hCHM Subretinal Delivery to the Macula in Choroideremia: Two Year Interim Results of an Ongoing Phase I/II Gene Therapy Trial.

T. Aleman, Rachel M. Huckfeldt, Leona W. Serrano et al. · 2022 · Ophthalmology (Rochester, Minn.)

PURPOSE To assess the safety of the subretinal delivery of a recombinant adeno-associated virus serotype 2 (AAV2) vector carrying a human CHM-encoding cDNA in choroideremia (CHM). DESIGN Prospective, open-label, non-randomized,…

View details →DOI: 10.1016/j.ophtha.2022.06.006
Negative / Null Result ReportOpen accessMedicine

Potential effects of angiogenesis-related factors on the severity of APAC and surgical outcomes of trabeculectomy

Jing Wang, Ming-shui Fu, Min Zhou et al. · 2020 · BMC Ophthalmology

Background EPO (erythropoietin) and PDGF (platelet derived growth factor) families are thought to be associated with angiogenesis under hypoxic condition. The sharp rise of intraocular pressure in acute primary angle closure (APAC) results…

View details →DOI: 10.1186/s12886-021-02051-w