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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19879 results in Negative / Null Result Report · page 507 of 663

Negative / Null Result ReportOpen accessMedicine

Women With Ovulatory Cycles Have Longer Sleep, but Phases of Their Menstrual Cycles Do Not Differ in Sleep Characteristics.

Wachowicz A, Galbarczyk A, Marcinkowska UM et al. · 2026 · American journal of human biology : the official journal of the Human Biology Council

Objectives Duration and quality of sleep are influenced by many factors, including hormonal changes. The aim of this study was to investigate the differences between the phases of the menstrual cycle in total sleep duration and sleep stage…

View details →DOI: 10.1002/ajhb.70247
Negative / Null Result ReportOpen accessMedicine

The role of household composition in social isolation and anxiety: evidence from adults in South Africa during the COVID-19 pandemic.

Jennings EA, Roberts-Toler C, Harriman NW et al. · 2026 · The journals of gerontology. Series B, Psychological sciences and social sciences

Objectives Social isolation is a concern among aging populations, and household composition may play an important role in its impact on mental health. We use data from an aging cohort in rural South Africa to investigate the moderating…

View details →DOI: 10.1093/geronb/gbag076
Negative / Null Result ReportOpen accessMedicine

Reward-Related Brain Function as an Endophenotype in the Mood-Psychosis Spectrum.

Barendse MEA, Bilder RM, Snijders AL et al. · 2026 · Biological psychiatry global open science

Background Function of the striatal reward system has been implicated in both psychotic and bipolar disorders. We aimed to test whether ventral striatum (VS) activation during reward anticipation meets criteria of an endophenotype of these…

View details →DOI: 10.1016/j.bpsgos.2026.100692
Negative / Null Result Report

Null Results for the Steal-Framing Effect on Out-Group Aggression

Mifune N · 2021 · Preprint

Whether intergroup conflict is a necessary condition for the evolution of human prosociality has been a matter of debate. At the center of the debate is the coevolutionary model of parochial altruism—that human cooperation with in-group…

View details →DOI: 10.21203/rs.3.rs-936427/v1
Negative / Null Result ReportOpen accessMedicine

The Effect of 5G Mobile Phone Electromagnetic Exposure on Corticospinal and Intracortical Excitability in Healthy Adults: A Randomized Controlled Pilot Study.

Torkan A, Zoghi M, Foroughimehr N et al. · 2025 · Brain sciences

Background Research on the impact of 5G mobile phone electromagnetic exposure on corticospinal excitability and intracortical mechanisms is still poorly understood. Objective This randomized controlled pilot study explored the effects of…

View details →DOI: 10.3390/brainsci15111134
Negative / Null Result ReportMedicine

Impact of multi-site clinical trial results on clinical practice: Use of risperidone to treat PTSD nationally in the veterans health administration.

Rosenheck R, Kurtz SG, Anand ST et al. · 2023 · Psychiatry research

Multi-site randomized effectiveness trials evaluate treatments under real-world conditions. Whether results change practice is under-studied. A 6-month 26-site Veterans Health Administration (VHA) cooperative study published in 2011…

View details →DOI: 10.1016/j.psychres.2023.115071
Negative / Null Result ReportMedicine

Statins and Cancer Prevention-Association Does Not Mean Causation.

Das S, Freedland SJ · 2023 · Cancer prevention research (Philadelphia, Pa.)

Statins are widely prescribed medications that inhibit 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG CoA) reductase and therefore reduce cholesterol synthesis. Given the key role of cholesterol in cancer, statins may therefore have…

View details →DOI: 10.1158/1940-6207.capr-22-0420
Negative / Null Result ReportOpen accessMedicine

No associations between blood pressure and brain volumes in a convenience sample of Hispanic/Latino middle-aged and older adults.

Costa CL, Araujo-Menendez CEE, Lawrence A et al. · 2026 · Frontiers in aging neuroscience

Background High blood pressure (BP) is a known risk factor for dementia, but the relationships between BP and gross brain volumes are mixed and are understudied in groups who are at particularly high risk for dementia, such as…

View details →DOI: 10.3389/fnagi.2026.1729134
Negative / Null Result ReportMedicine

Mendelian randomization analysis suggests no associations of herpes simplex virus infections with systemic lupus erythematosus.

Chang MJ, Liu MT, Chen MR et al. · 2023 · Journal of medical virology

Systemic lupus erythematosus (SLE) characterized by immune dysfunction is possibly more vulnerable to herpes simplex virus (HSV) infection. The infection has been intensively considered a common onset and exacerbation of SLE. This study is…

View details →DOI: 10.1002/jmv.28649
Negative / Null Result Report

Is pathogen disgust increased on days of the menstrual cycle when progesterone is high? Evidence from a between-subjects study using estimated progesterone levels

Rafiee Y, Jones BC, Shiramizu V · 2022 · Preprint

Objective: The Compensatory Prophylaxis Hypothesis proposes that women will show increased pathogen disgust at points in the menstrual cycle when progesterone is high, compensating for the immunosuppressive effects of progesterone.…

View details →DOI: 10.21203/rs.3.rs-2096405/v1
Negative / Null Result ReportMedicine

Vitamin D in the prevention or treatment of COVID-19.

Martineau AR · 2023 · The Proceedings of the Nutrition Society

This review summarises evidence relating to a potential role for vitamin D supplementation in the prevention or treatment of coronavirus disease 2019 (COVID-19). Laboratory studies show that the active vitamin D metabolite…

View details →DOI: 10.1017/s0029665122002798
Negative / Null Result ReportOpen accessMedicine

An examination of sleep spindle metrics in the Sleep Heart Health Study: superiority of automated spindle detection over total sigma power in assessing age-related spindle decline.

Palepu K, Sadeghi K, Kleinschmidt DF et al. · 2023 · BMC neurology

Background Sleep spindle activity is commonly estimated by measuring sigma power during stage 2 non-rapid eye movement (NREM2) sleep. However, spindles account for little of the total NREM2 interval and therefore sigma power over the…

View details →DOI: 10.1186/s12883-023-03376-3
Negative / Null Result ReportOpen accessMedicine

Respiratory Cycle Influence on Lumbosacral Muscle Function: A Tensiomyographic Analysis.

Trombetta AB, Hanney WJ, Anderson AW et al. · 2026 · Muscles (Basel, Switzerland)

Background Tensiomyography (TMG) offers a noninvasive means of evaluating skeletal muscle contractile properties, including muscle displacement (Dm), delay time (Td), contraction time (Tc), half-relaxation time (Tr), and sustain time (Ts).…

View details →DOI: 10.3390/muscles5020030
Negative / Null Result ReportOpen accessMedicine

Investigating the replicability of preclinical cancer biology.

Errington TM, Mathur M, Soderberg CK et al. · 2021 · eLife

Replicability is an important feature of scientific research, but aspects of contemporary research culture, such as an emphasis on novelty, can make replicability seem less important than it should be. The Reproducibility Project: Cancer…

View details →DOI: 10.7554/elife.71601
Negative / Null Result ReportMedicine

Year 1 Impact of Offering Non-Emergency Medical Transportation on Care Utilization Among Low-Income and Disabled Beneficiaries in Medicare Advantage.

Ianni KM, Chernew ME, McWilliams JM · 2026 · Health services research

Objective To examine the effects of offering non-emergency medical transportation (NEMT) on care utilization among low-income and disabled beneficiaries in Medicare Advantage (MA). Study setting and design We leveraged the 2019 expansion…

View details →DOI: 10.1111/1475-6773.70086
Negative / Null Result ReportOpen accessMedicine

Who Likes Extraverts? Testing the Interplay Between Perceiver Needs and Target Appearance in Impression Formation.

Jaeger B, Jones AL, Satchell L et al. · 2026 · International review of social psychology

The role of perceiver differences in impression formation remains relatively poorly understood. One line of research has tried to understand these differences by exploring the role of perceivers' needs and motivations, reasoning that…

View details →DOI: 10.5334/irsp.996
Negative / Null Result Report

Is pathogen disgust increased on days of the menstrual cycle when progesterone is high? Evidence from a between-subjects study using estimated progesterone levels

Rafiee Y, Jones BC, Shiramizu VKM · 2022 · Preprint

The Compensatory Prophylaxis Hypothesis proposes that women will show increased pathogen disgust at points in the menstrual cycle when progesterone is high, compensating for the immunosuppressive effects of progesterone. However, evidence…

View details →DOI: 10.31234/osf.io/9fsgq
Negative / Null Result ReportMedicine

Definitive Radiotherapy for Locally Advanced Unresectable Pancreatic Cancer: Historical Review, Current State and Future Directions.

Kumar AR, Sanford NN · 2025 · Seminars in radiation oncology

Based on available Level 1 evidence, standard dose conventional chemoradiation does not improve survival in patients with locally advanced pancreas cancer (LAPC), thus chemotherapy remains the only widely accepted therapy. Yet prognosis…

View details →DOI: 10.1016/j.semradonc.2025.07.002
Negative / Null Result ReportOpen accessMedicine

Drug sequestration and metabolite formation: key pharmacokinetic challenges for levosimendan use during ECMO support in cardiogenic shock.

Tebib N, Liaudet L, Ltaief Z · 2026 · Journal of intensive care

Background In patients with refractory cardiogenic shock, veno-arterial extracorporeal membrane oxygenation (ECMO) provides temporary circulatory support, but optimal strategies to promote myocardial recovery and facilitate ECMO weaning…

View details →DOI: 10.1186/s40560-026-00884-5
Negative / Null Result ReportMedicine

Efficacy and safety of mycophenolate mofetil in patients with high-grade locally advanced or metastatic osteosarcoma (ESMMO): a multicenter, phase II clinical trial.

Koonrungsesomboon N, Teeyakasem P, Dukaew N et al. · 2025 · International journal of clinical oncology

Background Osteosarcoma is a prevalent and aggressive bone malignancy primarily affecting young adults. Despite advances in standard treatment, the 5-year survival rate remains low, highlighting the need for new chemotherapy options.…

View details →DOI: 10.1007/s10147-025-02877-0
Negative / Null Result ReportMedicine

Best Overall Response-Associated Signature to Doxorubicin in Soft Tissue Sarcomas: A Transcriptomic Analysis from ANNOUNCE.

Liu J, Moura DS, Jones RL et al. · 2024 · Clinical cancer research : an official journal of the American Association for Cancer Research

Purpose This exploratory analysis evaluated the tumor samples of the patients treated with doxorubicin (with or without olaratumab) in a negative phase III ANNOUNCE trial to better understand the complexity of advanced soft tissue sarcomas…

View details →DOI: 10.1158/1078-0432.ccr-23-3936
Negative / Null Result ReportMedicine

Recent Advances in Clinical Trials in Multiple System Atrophy.

Bendetowicz D, Fabbri M, Sirna F et al. · 2024 · Current neurology and neuroscience reports

Purpose of review This review summarizes previous and ongoing neuroprotection trials in multiple system atrophy (MSA), a rare and fatal neurodegenerative disease characterized by parkinsonism, cerebellar, and autonomic dysfunction. It also…

View details →DOI: 10.1007/s11910-024-01335-0
Negative / Null Result ReportMedicine

Feasibility of advanced composite endpoint analysis: Post-hoc insights from the vitamin intervention for stroke prevention randomized control trial.

Asaithambi G, Castro-Pearson S, Meyer MK et al. · 2023 · Nutrition, metabolism, and cardiovascular diseases : NMCD

Background and aims Stroke is a major cause of mortality and disability, highlighting the importance of prevention. Clinical trials play an important role in evaluating interventions that can maximize stroke prevention. Traditional…

View details →DOI: 10.1016/j.numecd.2023.07.028