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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19879 results in Negative / Null Result Report · page 506 of 663

Negative / Null Result ReportOpen accessMedicine

Clinical Impact of Flow-Adjusted Transprosthetic Pressure Gradient After Aortic Valve Replacement.

Ohmori T, Hiraoka A, Totsugawa T et al. · 2025 · Annals of thoracic surgery short reports

Background It is still controversial whether prosthesis-patient mismatch (PPM) adversely affects long-term outcomes after aortic valve replacement (AVR). The aim of this study was to examine whether flow-adjusted pressure gradient is a…

View details →DOI: 10.1016/j.atssr.2024.07.008
Negative / Null Result ReportOpen accessMedicine

Corneal biomechanics are not exclusively compromised in high myopia.

Yii F, Strang N, Bernabeu MO et al. · 2024 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

Introduction Research assuming linearity has concluded that corneal biomechanics are compromised in high myopia. We investigated whether this assumption was appropriate and re-examined these associations across different levels of myopia.…

View details →DOI: 10.1111/opo.13313
Negative / Null Result ReportMedicine

The distribution of the Lansing Effect across animal species.

Ivimey-Cook ER, Shorr S, Moorad JA · 2023 · Evolution; international journal of organic evolution

Maternal senescence is the reduction in individual performance associated with increased maternal age at conception. When manifested on adult lifespan, this phenomenon is known as the "Lansing Effect." Single-species studies report both…

View details →DOI: 10.1093/evolut/qpac045
Negative / Null Result ReportOpen accessMedicine

An Exploratory Analysis of Essential Tremor and Associated Phenotypes.

Gharibian D, Medeiros M, Dion PA et al. · 2026 · Tremor and other hyperkinetic movements (New York, N.Y.)

Essential Tremor (ET) is a highly heterogeneous movement disorder with a strong genetic basis. However, the etiology of ET is unclear, largely due to its clinical heterogeneity and frequently observed comorbidities. We conducted a…

View details →DOI: 10.5334/tohm.1168
Negative / Null Result ReportMedicine

New Morbidities During Critical Illness and Associated Risk of ICU Readmission: Virtual Pediatric Systems Cohort, 2017-2020.

Heneghan JA, Akande MY, Ramgopal S et al. · 2024 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Objectives To describe change in Functional Status Scale (FSS) associated with critical illness and assess associated development of new morbidities with PICU readmission. Design Retrospective, cross-sectional cohort study using the…

View details →DOI: 10.1097/pcc.0000000000003542
Negative / Null Result ReportOpen accessMedicine

Viewed touch influences tactile detection by altering decision criterion.

Nair A, Medina J · 2024 · Attention, perception & psychophysics

Our tactile perception is shaped not only by somatosensory input but also by visual information. Prior research on the effect of viewing touch on tactile processing has found higher tactile detection rates when paired with viewed touch…

View details →DOI: 10.3758/s13414-024-02959-7
Negative / Null Result ReportOpen accessMedicine

Optimal time between decompressive craniectomy and cranioplasty to reduce the risk of complications: A retrospective study.

Stretti F, Parvin R, Fariña Nuñez MT et al. · 2026 · Neurosurgical review

Cranioplasty (CP) is performed after decompressive craniectomy (DC), with complication rates of 15-40%. Risk factors and ideal timing for CP are unclear. This study investigates risk factors for complications after CP and the best time to…

View details →DOI: 10.1007/s10143-025-03993-1
Negative / Null Result ReportMedicine

Interacting with supportive adults predicts greater same-day psychosocial functioning among adolescents in a self-driven learning program.

Ratner K, Zhu G, Li Q et al. · 2023 · Journal of adolescence

Introduction Supportive adults are a critical component of effective out-of-school time (OST) youth programs, yet the short-term dynamics that underlie their role are poorly understood. Within GripTape, a US-wide self-driven learning…

View details →DOI: 10.1002/jad.12149
Negative / Null Result ReportOpen accessMedicine

Assessing the Impact of PCSK9 and HMGCR Inhibition on Liver Function: Drug-Target Mendelian Randomization Analyses in Four Ancestries.

Rosoff DB, Bell AS, Wagner J et al. · 2024 · Cellular and molecular gastroenterology and hepatology

Background & aims Observational studies have linked lipid-lowering drug targets pro-protein convertase subtilisin/kexin 9 (PCSK9) and HMG-CoA reductase (HMGCR) with adverse liver outcomes; however, liver disease incidence varies across…

View details →DOI: 10.1016/j.jcmgh.2023.09.001
Negative / Null Result ReportOpen accessMedicine

Establishing validity and measurement invariance of the Claremont Purpose Scale among adolescents from diverse racial-ethnic backgrounds.

Xie H, Ratner K, Estevez M et al. · 2026 · Journal of research on adolescence : the official journal of the Society for Research on Adolescence

The Claremont Purpose Scale (CPS) was designed to assess youth purpose, but the English version has not yet undergone rigorous psychometric evaluation among adolescents. Prior validation efforts have also mostly relied on white-majority…

View details →DOI: 10.1111/jora.70215
Negative / Null Result ReportMedicine

Yield of Sleep Deprivation EEG in Suspected Epilepsy. A Retrospective Study.

Guerrero-Aranda A, Enríquez-Zaragoza A, López-Jiménez K et al. · 2024 · Clinical EEG and neuroscience

Background. Sleep is an activation procedure and is considered the most potent and best-documented modulator of seizures and interictal epileptiform discharges (IEDs) on electroencephalogram (EEG). The precise role of sleep deprivation in…

View details →DOI: 10.1177/15500594221142397
Negative / Null Result ReportOpen accessMedicine

Relationship between serum CA125, prolactin and cortisol levels with disease stage and pain level in endometriosis patients.

Fasha TA, Rajuddin R, Dewi TP et al. · 2026 · Narra J

Endometriosis affects approximately 10% of women of reproductive age and is characterized by the presence of endometrial tissue outside the uterine cavity. Diagnostic delays are common due to nonspecific symptoms and the absence of…

View details →DOI: 10.52225/narra.v6i1.2988
Negative / Null Result ReportOpen accessMedicine

Assessing the causal association between celiac disease and Alzheimer disease and frontotemporal dementia: A bidirectional Mendelian randomization approach.

Liu Y, Zhang H · 2025 · Medicine

This study aimed to investigate the bidirectional causal relationship between celiac disease (CD) and the risk of Alzheimer disease (AD) or frontotemporal dementia (FTD) using Mendelian randomization (MR), in order to clarify prior…

View details →DOI: 10.1097/md.0000000000045059
Negative / Null Result Report

Neural tracking of speech does not unequivocally reflect intelligibility

Kösem A, Dai B, McQueen JM et al. · 2022 · Preprint

During listening, brain activity tracks the rhythmic structures of speech signals. Here, we directly dissociated the contribution of neural tracking in the processing of speech acoustic cues from that related to linguistic processing. We…

View details →DOI: 10.1101/2022.07.25.501422
Negative / Null Result ReportMedicine

Comparisons of extinction, counterconditioning, and novelty-facilitated extinction within ABA vs. ABC renewal designs.

Jozefowiez J, Huff AG, Petruzzo L et al. · 2026 · Journal of experimental psychology. Animal learning and cognition

The expression of an association between a conditioned stimulus (CS) and an aversive unconditioned stimulus (US) can be weakened by presenting the CS by itself (extinction [Ext]), pairing it with an appetitive US (counterconditioning…

View details →DOI: 10.1037/xan0000430
Negative / Null Result Report

Non-enzymatic isothermal strand displacement and amplification (NISDA) does not enable sensitive nucleic acid quantification

Van der Snickt T, Ailliet S, Bassini S et al. · 2025 · Preprint

Enzyme-free isothermal amplification methods offer a promising alternative to enzymatic assays for nucleic acid detection, particularly in low-resource settings. The nonenzymatic isothermal strand displacement and amplification (NISDA)…

View details →DOI: 10.1101/2025.05.19.654176
Negative / Null Result Report

Metascientific replication project with the advanced meta-experimental protocol of the transparent psi project procedures for testing the precognitive effect claimed by Bem

Walleczek J, von Stillfried N, Schmidt S et al. · 2025 · Preprint

This metascientific project studied the replicability of Bem Experiment 1, which had claimed a precognitive effect, i.e., the ability to successfully guess the outcome of future random events (Bem. J Pers Soc Psychol. 2011;100: 407-25).…

View details →DOI: 10.31234/osf.io/53ckh_v1
Negative / Null Result ReportMedicine

Exploring a novel method for inoculation to experimentally induce digital dermatitis in dairy calves.

Petersen Dias A, Orsel K, Gammariello CS et al. · 2025 · Research in veterinary science

Digital dermatitis (DD) is a polymicrobial, multifactorial hoof disorder with an undefined etiology, and existing animal models fail to induce a fast, standardized infection in bovine skin. This study explored bacterial inoculation methods…

View details →DOI: 10.1016/j.rvsc.2025.105794
Negative / Null Result ReportMedicine

Preregistered Direct Replication and Extension of "The Wisdom to Know the Difference: Strategy-Situation Fit in Emotion Regulation in Daily Life Is Associated With Well-Being".

Willroth EC, Young G, Ford BQ et al. · 2025 · Psychological science

Certain emotion-regulation strategies (e.g., reappraisal) are associated with better well-being and are therefore seen as adaptive (health-promoting) strategies. However, it is unlikely that any strategy is adaptive regardless of context.…

View details →DOI: 10.1177/09567976251335567
Negative / Null Result ReportMedicine

A Multidimensional Preclinical Investigation of the Biogenic Amine Depletion and Subchronic Swim Models of Fibromyalgia.

Argenbright CM, Scully IF, Flores D et al. · 2025 · The journal of pain

Pain is a multidimensional phenomenon, encompassing affective-motivational, cognitive-evaluative, and sensory-discriminative domains. Understanding these components is crucial for effective diagnosis and management, particularly in…

View details →DOI: 10.1016/j.jpain.2025.105486
Negative / Null Result ReportMedicine

Multimodal assessments of therapist characteristics are largely unrelated to patient outcomes: A preregistered analysis.

Goldberg SB, Baldwin SA, Flynn AWP et al. · 2026 · Clinical psychological science : a journal of the Association for Psychological Science

While it is known that therapists vary in effectiveness, it is unclear what therapist-level characteristics predict this variation. We conducted a large-scale, preregistered study ( n = 97 therapists from the United States and Canada, n =…

View details →DOI: 10.1177/21677026261424222
Negative / Null Result Report

Re-examining the effect of inoculation messages on anti-vaccine conspiracy attitudes: A conceptual replication of Banas et al (2023)

Adinugroho I, Bentall R, Stafford T · 2025 · Preprint

This is the first study to attempt replication of Banas et al (2023) on inoculation messages. The original experiment demonstrated that inoculation messages could stimulate resistance to anti-vaccine conspiracy theories. However, a gap was…

View details →DOI: 10.31234/osf.io/d3x9p_v1
Negative / Null Result Report

From “Bob/Kirk” to “Błażej/Piotrek” Effect – Replication of Social Bias Effect Towards People Whose Names Match Their Faces

Stawiany K, Kozak K, Sokołowska Z · 2025 · Preprint

The study explores the hypothesis that individuals show greater sympathy towards coherent name-face pairs compared to incoherent pairs, replicating the effect observed by Barton and Halberstadt. A structured questionnaire was designed…

View details →DOI: 10.20944/preprints202501.0057.v1