e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 505 of 676

Negative / Null Result ReportMedicine

Immediate-release/extended-release amantadine (OS320) to treat Parkinson's disease with levodopa-induced dyskinesia: Analysis of the randomized, controlled ALLAY-LID studies.

Rascol O, Tönges L, deVries T et al. · 2022 · Parkinsonism & related disorders

Background Immediate-release (IR) amantadine has been used for treatment of levodopa induced dyskinesia (LID). The immediate-release/extended-release (IR/ER) amantadine formulation OS320 (OSMOLEX ER®) contains an IR outer layer and ER core…

View details →DOI: 10.1016/j.parkreldis.2022.01.022
Negative / Null Result ReportMedicine

Lack of association between corticospinal excitability changes during motor imagery and explicit sequence learning performance.

Takenaka Y, Maeda K, Yamada M et al. · 2026 · Behavioural brain research

Background Motor imagery (MI) improves motor performance, but standardized objective quality evaluation methods are lacking. The relationship between MI quality and actual performance improvements also remains unclear. Purpose We…

View details →DOI: 10.1016/j.bbr.2026.116299
Negative / Null Result ReportMedicine

Lack of association between ADRB2 (Gln27Glu) variant with susceptibility, severity and salbutamol response in South Indian asthmatics.

Bandaru S, Bodduluri S, Swami R et al. · 2026 · Scientific reports

ADRB2 gene polymorphisms have been widely studied for their role in influencing asthma pathophysiology. Of particular note, the Gln27Glu (+ 79 C > G, rs1042714) polymorphism, which alters the extracellular domain at the N-terminus of β 2…

View details →DOI: 10.1038/s41598-026-53042-0
Negative / Null Result ReportMedicine

EXPRESS: Lack of Association Between Inner Ear FLAIR Suppression on MRI and Laterality of Clinical Signs in Feline Idiopathic Vestibular Syndrome.

Putzer M, De Decker S, Gutierrez Quintana R et al. · 2026 · Journal of feline medicine and surgery

ObjectivesThe underlying aetiology of feline idiopathic vestibular syndrome (IVS) remains unclear. In humans, specific magnetic resonance imaging (MRI) sequences are used to demonstrate differences in endolymph composition between…

View details →DOI: 10.1177/1098612x261445137
Negative / Null Result Report

Stable episodic memory and high education do not influence the rate of Alzheimer’s disease pathology as measured by plasma p-tau217

Avelar-Pereira B, Spotorno N, Orduña Dolado A et al. · 2026 · Preprint

Alzheimer’s disease (AD) neuropathological changes can be detected with blood-based biomarkers during the long preclinical phase that precedes clinical diagnosis. Tau phosphorylated at threonine 217 (p-tau217) has been found to closely…

View details →DOI: 10.64898/2026.04.16.718397
Negative / Null Result ReportMedicine

Mobility measures and waking-day movement behaviour composition among older adults: a compositional data analysis of the McMaster Monitoring My Mobility study.

Hakimi S, Kirkwood R, Phillips SM et al. · 2026 · The international journal of behavioral nutrition and physical activity

Background Mobility is a cornerstone of healthy ageing typically assessed using self-report and performance-based measures. Recent research suggests these measures are poor proxies for real-world mobility. Device-derived measures of…

View details →DOI: 10.1186/s12966-026-01939-4
Negative / Null Result ReportMedicine

Lipoprotein(a) levels and common LPA gene variants in patients with chronic coronary syndrome: Genetic determinants and clinical associations.

Gómez-Barrado JJ, Porras-Ramos Y, Romero-Castro MJ et al. · 2026 · Journal of clinical lipidology

Background Despite optimal lipoprotein cholesterol control, patients with chronic coronary syndrome (CCS) exhibit substantial residual cardiovascular risk. Lipoprotein(a) (Lp[a]) is an independent cardiovascular risk factor, primarily…

View details →DOI: 10.1016/j.jacl.2026.05.221
Negative / Null Result ReportMedicine

Semiautomatic analysis of retinal ischemia using widefield OCTA in patients with diabetes mellitus with or without diabetic retinopathy.

Lisa T, Maria CA, Luca BB et al. · 2026 · European journal of ophthalmology

PurposeThis study assessed retinal non-perfusion areas (RNPAs) and vascular density (VD) in the superficial (SCP) and deep (DCP) capillary plexuses of diabetic patients across three stages of diabetic retinopathy (DR): no DR (stage 0),…

View details →DOI: 10.1177/11206721261444772
Negative / Null Result ReportMedicine

The Lack of Association of Infant Gender with Postpartum Depression and Breastfeeding Duration.

Akkurt B, Bülez A · 2025 · Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine

Objective: This study aimed to investigate the association between infant gender and both postpartum depression and breastfeeding duration at multiple time points during the postpartum period. Methods: A prospective longitudinal study was…

View details →DOI: 10.1177/15568253251386877
Negative / Null Result Report

Lack of association between G6PD variants and Parkinson’s disease

Chifamba LV, Parlar SC, Liu L et al. · 2025 · Preprint

Oxidative stress has been implicated in Parkinson’s disease (PD). Genes involved in PD, such as PRKN, PINK1 and PARK7 , contribute to oxidative stress in dopaminergic neurons. The X-linked G6PD gene encodes glucose 6-phosphate…

View details →DOI: 10.1101/2025.04.23.25324774
Negative / Null Result ReportOpen accessMedicine

Optimal duration of neoadjuvant chemotherapy prior to CRS ± HIPEC for colorectal cancer: An assessment of survival and postoperative outcomes.

Bennett FJ, Oppat KM, Zaidi MY et al. · 2026 · Surgical oncology insight

Background Cytoreductive surgery (CRS) with or without heated intraperitoneal chemotherapy (HIPEC) represents a viable therapy for select patients with colorectal cancer (CRC) peritoneal metastases. Given recurrence rates, challenges…

View details →DOI: 10.1016/j.soi.2025.100210
Negative / Null Result ReportOpen accessMedicine

Weight and sleep health in OSA: exploring their link.

Beatty CJ, Landry SA, Mann DL et al. · 2026 · Frontiers in sleep

Objectives Weight loss is often recommended for individuals with obesity and OSA, however, weight loss is particularly hard for this population. This study investigates how weight and weight change are associated with sleep health in…

View details →DOI: 10.3389/frsle.2026.1828583
Negative / Null Result ReportMedicine

Differences in time to treatment and impact on overall survival in adolescents and young adults with Hodgkin lymphoma.

Cruz CA, Rodriguez ER, Thawani M et al. · 2025 · Leukemia & lymphoma

Delays in time to treatment (TTT) have been shown to affect cancer survival, yet this has not been investigated in adolescent and young adult (AYA) Hodgkin lymphoma (HL) patients. This retrospective analysis included 508 patients with TTT…

View details →DOI: 10.1080/10428194.2025.2499607
Negative / Null Result ReportMedicine

Lack of Association of Pediatric Surgical Patient Outcomes With Increased Disposable Operating Room Supply Costs.

Acker SN, Prendergast C, Inge TH et al. · 2024 · Journal of pediatric surgery

Introduction There is wide variation in the cost of disposable operating room supplies between surgeons performing the same operation at the same institution. The general relationship between variation in disposable supply cost and patient…

View details →DOI: 10.1016/j.jpedsurg.2024.03.046
Negative / Null Result ReportOpen accessMedicine

Assessment of the Association Between Whole Blood Viscosity and Coronary Artery Calcium Score.

Duyuler S, Türker Duyuler P, Kalaycı S et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Whole Blood Viscosity (WBV), estimated using the De Simone formula, is a key hemodynamic parameter linked to endothelial dysfunction and atherosclerosis. Its association with significant coronary calcification,…

View details →DOI: 10.3390/medicina62010169
Negative / Null Result ReportMedicine

Unveiling connections: bisphenol A and vitamin D dynamics in breast milk among healthy lactating mothers.

Cinkilli Aktağ E, Yalçin SS, Yіrün A et al. · 2025 · International journal of environmental health research

Bisphenol A (BPA) has negative impact on human health. This study aims to explore the association between the levels of BPA and 25(OH) vitamin D in breastmilk. BPA exposure and vitamin D sources were recorded on the study form. Breastmilk…

View details →DOI: 10.1080/09603123.2024.2412118
Negative / Null Result ReportOpen accessMedicine

Nocturnal gastro-oesophageal reflux and pulmonary abnormalities on chest CT in a general population: the Swedish CArdioPulmonary BioImage Study.

Emilsson ÖI, Malinovschi A, Johnsson Å et al. · 2025 · Thorax

Background Nocturnal gastro-oesophageal reflux (nGER) is common in people with respiratory diseases, but its association with pulmonary abnormalities is not known. Aim Investigate the association between nGER and pulmonary abnormalities on…

View details →DOI: 10.1136/thorax-2024-222570
Negative / Null Result ReportOpen accessMedicine

Association between neutrophil extracellular traps, the Von Willebrand factor axis, and clinical outcome in stable coronary artery disease.

Bratseth V, Kindberg KM, Warlo EMK et al. · 2026 · Frontiers in cardiovascular medicine

Introduction Coronary artery disease (CAD) is the clinical manifestation of atherosclerosis, an inflammatory disorder of the coronary arteries, characterized by endothelial dysfunction, lipid accumulation, immune activation, and formation…

View details →DOI: 10.3389/fcvm.2026.1759117
Negative / Null Result ReportMedicine

Association of Psychotropic and Opioid Medication Use With Physical Function in Hospitalized Older Adults With Dementia.

Kim N, Resnick B, Galik E et al. · 2026 · Journal of gerontological nursing

Purpose To examine whether psychotropic medications (antipsychotics, sedatives, antiseizures, antidepressants, and anxiolytics) and opioids were associated with physical function in hospitalized older adults with dementia. Method A…

View details →DOI: 10.3928/00989134-20251104-01
Negative / Null Result ReportMedicine

Impact of Selective Serotonin Reuptake Inhibitors on Bleeding Rates in HeartMate 3 Left Ventricular Assist Device Patients Not Taking Aspirin.

Ganter M, Bowyer M, Relic E et al. · 2026 · Artificial organs

Background Selective serotonin reuptake inhibitor (SSRI) and serotonin-norepinephrine reuptake inhibitor (SNRI) therapy have been associated with increased bleeding risk in left ventricular assist device (LVAD) patients receiving warfarin…

View details →DOI: 10.1111/aor.70078
Negative / Null Result ReportMedicine

Lack of Association Between Dietary Fiber Intake and Kidney Failure Among Patients With Chronic Kidney Disease: The Chronic Kidney Disease-Japan Cohort Study.

Hattori K, Sakaguchi Y, Isaka Y et al. · 2025 · Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation

Objective It remains unclear whether dietary fiber intake improves kidney outcome. The objective of our study was to examine the association between dietary fiber intake and the risk of kidney failure among patients with proteinuric…

View details →DOI: 10.1053/j.jrn.2025.06.003
Negative / Null Result ReportMedicine

Postoperative Fever Following Pelvic and Acetabular Fixation: Incidence, Risk Factors, and Lack of Association With Surgical Site Infection.

Ayoub M, Curtis E, Vue Y et al. · 2025 · Orthopedics

Background Despite numerous studies showing postoperative fever can be a common and benign occurrence, there is still a significant and costly workup when fevers occur after surgery, including for orthopedic patients with pelvic ring and…

View details →DOI: 10.3928/01477447-20250506-01