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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 504 of 676

Negative / Null Result ReportOpen accessMedicine

Revisiting the relationship between impulsivity, apathy, and action control: Bayesian inference from a stop-signal task study.

Michel E, Garnier-Allain A, Kaliuzhna M et al. · 2026 · PloS one

Apathy and impulsivity are multidimensional constructs that shape goal-directed behavior. Although the motivational dopaminergic spectrum hypothesis frames them as opposing ends of a single continuum, questionnaire-based studies…

View details →DOI: 10.1371/journal.pone.0352351
Negative / Null Result ReportOpen accessMedicine

Exploring the effects of faecal microbiota transplantation on cognitive function: A review of clinical trials.

Alaeddin S, Chatterjee A, Roberts TL et al. · 2025 · Brain, behavior, & immunity - health

Faecal Microbiota Transplantation (FMT) is a widely used microbiota-modulation technique to treat recurrent Clostridioides difficile infections (rCDI). Rodent studies and clinical trials on probiotic interventions indicate that alterations…

View details →DOI: 10.1016/j.bbih.2025.101049
Negative / Null Result ReportOpen accessMedicine

Consensus Report by the Italian Academy of Osseointegration on the Importance of Peri-Implant Soft Tissues.

Bressan E, Zucchelli G, Tommasato G et al. · 2024 · Medicina (Kaunas, Lithuania)

Background and Objectives : The influence of the quantity and quality of peri-implant soft tissue on implant health and long-term maintenance is controversial. This consensus aimed to assess the importance of peri-implant soft tissue by…

View details →DOI: 10.3390/medicina60091393
Negative / Null Result ReportMedicine

Do SGLT2 inhibitors and GLP-1 receptor agonists modulate differently the risk of stroke ? Discordance between randomised controlled trials and observational studies.

Scheen AJ · 2023 · Diabetes & metabolism

Stroke represents a major burden in patients with type 2 diabetes, yet this cerebrovascular complication has been less carefully investigated than the risk of cardiovascular mortality, heart failure and renal disease. Some data suggested…

View details →DOI: 10.1016/j.diabet.2023.101474
Negative / Null Result ReportMedicine

Effects of HIV and Adverse Childhood Experiences on Neurocognition.

Inman EM, Inman EM, Ramsammy CW et al. · 2026 · Journal of acquired immune deficiency syndromes (1999)

Background Both HIV and adverse childhood experiences (ACEs) can affect neurocognitive performance. Among youth with perinatal HIV (PHIV), living with a chronic viral infection and experiencing ACEs simultaneously may result in an…

View details →DOI: 10.1097/qai.0000000000003858
Negative / Null Result ReportOpen accessMedicine

Use of alteplase continuous rate infusion, pentoxifylline, and cyproheptadine in association or not, in acute feline aortic thromboembolism: a study of nine cats.

Ray CC, Wolf J, Guillaumin J · 2025 · Frontiers in veterinary science

Introduction Locomotion improvement without serious complications is the main goal of treatment for feline aortic thromboembolism (FATE). We aimed to describe the survival and functional recovery of cardiogenic FATE treated with tissue…

View details →DOI: 10.3389/fvets.2025.1512649
Negative / Null Result ReportOpen accessMedicine

The effect of intraoperative low-dose ketamine versus dexmedetomidine infusion on postoperative bowel recovery in patients undergoing gastrointestinal malignancy surgeries: Placebo-controlled, randomized trial.

Kumar SK, Misra S, Behera BK et al. · 2025 · Journal of anaesthesiology, clinical pharmacology

Background and aims No studies have compared the effects of ketamine and dexmedetomidine on bowel recovery. We evaluated the effects of intraoperative low-dose ketamine or dexmedetomidine infusion on postoperative bowel recovery in…

View details →DOI: 10.4103/joacp.joacp_322_23
Negative / Null Result ReportMedicine

Extent of Lymphadenectomy for Surgical Management of Right-Sided Colon Cancer: The Randomized Phase III RELARC Trial.

Lu J, Xing J, Zang L et al. · 2024 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Purpose Complete mesocolic excision (CME) is being increasingly used for the treatment of right-sided colon cancer, although there is still no strong evidence that CME provides better long-term oncological outcomes than D2 dissection. The…

View details →DOI: 10.1200/jco.24.00393
Negative / Null Result ReportOpen accessMedicine

The relationship between glaucoma and an electronic frailty index with the cumulative incidence of healthcare encounters for falls and fractures in older adults.

Duy WD, Pajewski NM, Williamson JD et al. · 2025 · The Journal of frailty & aging

Objective To compare the association of glaucoma and glaucoma suspect diagnoses with frailty, quantified via an electronic frailty index (eFI), and to evaluate whether a glaucoma diagnosis moderates the association between frailty and the…

View details →DOI: 10.1016/j.tjfa.2025.100051
Negative / Null Result ReportMedicine

Racial and ethnic disparities in the usage and outcomes of ischemic stroke treatment in the United States.

Metcalf D, Zhang D · 2023 · Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Objectives This study explores racial and ethnic differences in 1) receiving tissue plasminogen activator (tPA) and endovascular thrombectomy (EVT) as treatment for ischemic stroke and 2) outcomes and quality of care after use of tPA or…

View details →DOI: 10.1016/j.jstrokecerebrovasdis.2023.107393
Negative / Null Result ReportOpen accessMedicine

The Effects of Repeated Finger Flexion Movements on Self-Reported Affect and Reward System Activation Are Weak and Inconsistent.

Vander Missen MR, Giovanetti AK, Fisher JS et al. · 2025 · Journal of clinical psychology

Recent research has called into question the robustness and reliability of using body movements to activate motivational systems like approach-reward. The purpose of the current studies was to test the effect of a repeated flexion movement…

View details →DOI: 10.1002/jclp.70017
Negative / Null Result ReportOpen accessMedicine

What is the effect of alarmist media and radiofrequency electromagnetic field (RF-EMF) exposure on salivary cortisol and non-specific symptoms?

Verrender A, Wallace NK, Loughran SP et al. · 2025 · Applied psychology. Health and well-being

While there is consistent evidence that the symptoms reported by people who experience Idiopathic Environmental Intolerance attributed to Electromagnetic Fields (IEI-EMF) are closely associated with a nocebo effect, and that alarmist media…

View details →DOI: 10.1111/aphw.70044
Negative / Null Result ReportOpen accessMedicine

The Effects of CenteringPregnancy: A Quasi-Experimental Evaluation.

Park CH, Driver N, Richards RC Jr et al. · 2025 · Healthcare (Basel, Switzerland)

Background/Objectives : CenteringPregnancy (CP) is a group prenatal care model that empowers pregnant women through risk assessment, education, and social support. CP participants have more contact time with providers compared to those in…

View details →DOI: 10.3390/healthcare13091052
Negative / Null Result ReportOpen accessMedicine

The association of third molars with mandibular incisor crowding in a group of the Yemeni population in Sana'a city: cone-beam computed tomography.

Aldhorae K, Ishaq R, Alhaidary S et al. · 2025 · BMC oral health

Background Multiple factors contribute to mandibular incisor crowding. However, the role of wisdom teeth in these irregularities remains a controversial issue among clinicians. Therefore, this study aimed to determine the potential…

View details →DOI: 10.1186/s12903-025-05733-9
Negative / Null Result ReportOpen accessMedicine

Ground-Level Ozone as Community-Acquired Pneumonia Risk Factor in Different Population Groups in Summer: The Case of Moscow.

Dudorova N, Belan B, Kotel'nikov S · 2026 · Toxics

A correlation between the near-surface ozone concentration in the urban atmosphere and hospitalizations of community-acquired pneumonia patients has been analyzed based on a long-term (five years) series of observations in the warm season…

View details →DOI: 10.3390/toxics14010083
Negative / Null Result ReportOpen accessMedicine

Transcriptional evidence of pluripotency during development of the leaf gall formed by grape phylloxera (Daktulosphaira vitifoliae).

Schultz JC, Body MJA, Edger PP et al. · 2025 · The New phytologist

Galls are structures formed by plants in response to stimuli by parasitic insects. Because galls require altered gene expression to change cell fates, their initiation requires pluripotent or 'reactive' cells. We used RNA sequencing to…

View details →DOI: 10.1111/nph.70241
Negative / Null Result ReportMedicine

In what ways does user experience design improve printed educational materials?

Kealey MR, Urakami J, Henderson K et al. · 2023 · Applied ergonomics

We report on a series of four studies that investigated how user experience design (UXD) can improve printed educational materials (PEMs). We examined the perceived usability of an existing PEM for breast cancer screening and observed the…

View details →DOI: 10.1016/j.apergo.2023.104081
Negative / Null Result ReportMedicine

Association Between Continuous Kidney Replacement Therapy Clearance and Outcome in Pediatric Patients With Hyperammonemia Not Due to Inborn Error of Metabolism.

Starr MC, Cater DT, Wilson AC et al. · 2022 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Objectives To describe a single-center experience of pediatric patients with hyperammonemia not due to inborn errors of metabolism and determine the association between use of continuous kidney replacement therapy (CKRT) treatment and…

View details →DOI: 10.1097/pcc.0000000000002949
Negative / Null Result ReportOpen accessMedicine

Discrete Repetition Effects for Visual Words Compared to Faces and Animals, but No Modulation by Expectation: An Event-Related Potential Study.

Song B, Sommer W, Maurer U · 2025 · The European journal of neuroscience

Repetition suppression (RS) refers to the reduction of neuronal responses to repeated stimuli as compared to nonrepeated stimuli. The predictive coding account of RS proposes that its magnitude is modulated by repetition probability…

View details →DOI: 10.1111/ejn.70047
Negative / Null Result ReportMedicine

Devaluation of NoGo stimuli is both robust and fragile.

Liu H, Holland RW, Blechert J et al. · 2022 · Cognition & emotion

Consistently not responding to stimuli during go/no-go training leads to lower evaluations of these NoGo stimuli. How this NoGo-devaluation-effect can be explained has remained unclear. Here, we ran three experiments to test the hypothesis…

View details →DOI: 10.1080/02699931.2022.2067132