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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19879 results in Negative / Null Result Report · page 503 of 663

Negative / Null Result ReportMedicine

Serum IDO1 and β-catenin levels in patients with multiple sclerosis with and without atherosclerosis: A case-control study.

Abdulridha GAO, Fadhel AS, Al-Kinany SQ et al. · 2026 · Journal of neuroimmunology

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system characterized by leukocyte infiltration, immune activation, demyelination, and axonal injury. This case-control observational study aimed to investigate…

View details →DOI: 10.1016/j.jneuroim.2026.579013
Negative / Null Result ReportMedicine

Acetazolamide-induced metabolic acidosis in pediatric idiopathic intracranial hypertension: associations with bone mineral density, growth, and kidney function.

Baltu D, Taş N, Alıcı N et al. · 2026 · Pediatric nephrology (Berlin, Germany)

Background Although acetazolamide is the main medical treatment for idiopathic intracranial hypertension (IIH), data on acetazolamide-induced metabolic acidosis and its long-term outcomes are limited. This study aimed to investigate the…

View details →DOI: 10.1007/s00467-026-07431-2
Negative / Null Result ReportMedicine

Identification of Gait Patterns Associated with Paretic Propulsion and Velocity in Community-Dwelling Individuals with Stroke: A Multicenter Retrospective Study.

Mano N, Mori K, Kuwabara T et al. · 2026 · Annals of biomedical engineering

Purpose Diverse gait patterns in individuals with stroke require personalized rehabilitation to improve paretic propulsion (Pp), which reflects gait function. However, the gait characteristics associated with Pp have not been fully…

View details →DOI: 10.1007/s10439-026-04203-9
Negative / Null Result ReportOpen accessMedicine

Nature Connectedness and Work Engagement in the Relationship Between Emotional Exhaustion and Life Satisfaction Among Employees.

Jaime-Jorge S, García-Ael C, Azanza G et al. · 2026 · European journal of investigation in health, psychology and education

This paper analyses associations between psychological health at work and life satisfaction among employees. Specifically, it investigates the association between work stress and emotional exhaustion and explores whether connectedness to…

View details →DOI: 10.3390/ejihpe16060079
Negative / Null Result ReportMedicine

Aqueous PFOS exposure decouples gaseous carbon loss from mineral-associated carbon retention in controlled wetland-interface mesocosms.

Lu B, Wang P, Hu J et al. · 2026 · Environmental pollution (Barking, Essex : 1987)

Wetland interfaces regulate greenhouse-gas exchange and carbon retention, yet contaminant exposure may disrupt the relationship between these two processes. Whether aqueous perfluorooctane sulfonate (PFOS), a persistent aquatic…

View details →DOI: 10.1016/j.envpol.2026.128638
Negative / Null Result ReportMedicine

Factors associated with achieving knee flexion around one hundred and twenty five degrees and numerical rating scale around one at one year after posterior cruciate-retaining total knee arthroplasty.

Shioiri H, Takahashi T, Matsumoto T · 2026 · International orthopaedics

Purpose To investigate factors associated with achieving both postoperative knee flexion range of motion (ROM) ≥ 125° and Numerical Rating Scale (NRS) pain score ≤ 1 at one year after posterior cruciate-retaining total knee arthroplasty…

View details →DOI: 10.1007/s00264-026-06884-2
Negative / Null Result ReportMedicine

Climate Change Worry and Flourishing Among Chinese University Students: The Roles of Anxiety-Depressive Symptoms and Physical Activity.

Liu S, Tan Y, Zang L · 2026 · Healthcare (Basel, Switzerland)

Background/Objectives: Climate change worry is an emerging concern in youth mental health, but little is known about how it is associated with positive psychological functioning among university students. This study examined whether…

View details →DOI: 10.3390/healthcare14121624
Negative / Null Result ReportMedicine

Quantitative Systems Toxicology Model Predicts Obeticholic Acid-Associated Liver Injury in Metabolic Dysfunction-Associated Steatotic Liver Disease.

Mayo AK, Beaudoin JJ, Woodhead JL et al. · 2026 · Clinical pharmacology and therapeutics

Obeticholic acid (OCA), a synthetic analog of chenodeoxycholic acid, was approved in 2016 for the treatment of primary biliary cholangitis. Early clinical trials revealed elevated liver biomarkers in healthy subjects receiving…

View details →DOI: 10.1002/cpt.70355
Negative / Null Result ReportOpen accessMedicine

Pulmonary Fibrosis and Pulmonary Function in Patients with Metastatic Testicular Cancer During and after Combination Chemotherapy: The BLEOTOX Study.

Frey L, Grunwald S, Ruckes C et al. · 2026 · European urology open science

Background and objective Metastatic testicular germ cell tumors (mTGCTs) are treated with combination chemotherapy (Cx) containing bleomycin (BEP [bleomycin, etoposide, and cisplatin]). Bleomycin-induced pulmonary toxicity (BPT) is a…

View details →DOI: 10.1016/j.euros.2026.04.004
Negative / Null Result ReportMedicine

Association between extubation timing and functional outcomes in patients with acute ischemic stroke after endovascular treatment.

Liang D, Tong Y, Li F et al. · 2026 · Cerebrovascular diseases (Basel, Switzerland)

Introduction General anesthesia (GA) with endotracheal intubation is standard during endovascular treatment (EVT) for acute ischemic stroke (AIS), but the optimal timing for post-procedural extubation remains unclear. Methods In this…

View details →DOI: 10.1159/000552953
Negative / Null Result ReportMedicine

Preoperative posterior pelvic tilt is associated with residual low back pain and inferior patient-reported outcomes after total hip arthroplasty.

Ito K, Fujii M, Oba Y et al. · 2026 · International orthopaedics

Purpose To determine changes in low back pain (LBP) after total hip arthroplasty (THA), identify preoperative factors associated with residual LBP and LBP improvement, and clarify the association between residual LBP and patient-reported…

View details →DOI: 10.1007/s00264-026-06885-1
Negative / Null Result Report

Association of body composition, daily physical activity and handgrip strength with mortality, cardiovascular events and cancers in Japanese patients with diabetes

Hamasaki H, Taxiarchi V · 2026 · Preprint

Aims Sarcopenia and sarcopenic obesity are associated with increased risks of cardiovascular (CV) disease and mortality. This study examined the associations of body composition and daily physical activity with mortality, CV events and…

View details →DOI: 10.64898/2026.06.09.26355239
Negative / Null Result ReportMedicine

Water intake, switching between bites and sips, and drinking behavior are associated with food intake across meals varying in spiciness: A secondary analysis of two randomized crossover studies.

Cunningham PM, Hayes JE · 2026 · Appetite

Widespread nutrition advice instructs consumers to drink water with meals to increase fullness and reduce energy intake. However, recent data indicates greater water intake is associated with more food intake at a meal, not less. Switching…

View details →DOI: 10.1016/j.appet.2026.108698
Negative / Null Result ReportMedicine

Monotherapy versus combination therapy for treatment of carbapenem-resistant Acinetobacter baumannii complex infections: results from an observational study.

Bertholdi Filho SU, Telles JP, Melo IM et al. · 2026 · Critical care science

Objective To evaluate the efficacy of monotherapy versus combination therapy in the treatment of carbapenem-resistant Acinetobacter baumannii infections. Methods A retrospective observational study was conducted in two tertiary hospitals…

View details →DOI: 10.62675/2965-2774.20260352
Negative / Null Result ReportMedicine

Non-Coding RNAs as Emerging Biomarkers in HPV-Associated Cervical Precancer and Cancer: Molecular Mechanisms and Clinical Perspectives.

Terrinoni M, Caputo V, Palisciano M et al. · 2026 · Genes

Background/Objectives: Cervical cancer is mainly driven by persistent infection with high-risk human papillomaviruses (HPV), particularly HPV16 and HPV18. Despite advances in cytology, HPV-DNA testing and vaccination, challenges remain in…

View details →DOI: 10.3390/genes17060714
Negative / Null Result ReportMedicine

Exosomal MALAT1 expression associated with the cardioprotective effects of carvacrol in acute doxorubicin-induced cardiac injury: Potential involvement of Nrf2/Keap1-related signaling.

Ahmadi T, Ghorbanzadeh V, Hosseinnejad E et al. · 2026 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Doxorubicin remains an indispensable component of many chemotherapy regimens; however, its clinical use is limited by dose-dependent cardiotoxicity that may progress to dilated cardiomyopathy and heart failure. In the present study, we…

View details →DOI: 10.1016/j.biopha.2026.119606
Negative / Null Result ReportMedicine

Thyroid Autoimmunity in Polycystic Ovary Syndrome: Phenotype Distribution, HDL-Cholesterol, and Data-Driven Clusters in a Retrospective Cohort Study.

Mogoș RA, Carauleanu A, Vasilache IA et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Autoimmune thyroiditis (AIT) is often reported patients with PCOS, and may co-occur with altered metabolic risk markers. The aims of this study were to assess baseline differences according to thyroid…

View details →DOI: 10.3390/medicina62061184
Negative / Null Result ReportMedicine

Abdominal massage improves intestinal barrier function via the TLR4/MyD88/NF-κB signaling pathway in obesity-associated T2DM rats.

Han Y, Zhong C, Lu Z et al. · 2026 · Scientific reports

Abdominal massage (AM), a traditional Chinese medicine treatment, is gradually being recognized in clinical practice for its ability to improve the symptoms of obesity and type 2 diabetes mellitus (T2DM) in clinical practice. This study…

View details →DOI: 10.1038/s41598-026-57589-w
Negative / Null Result Report

Inflammation-Driven Epithelial Plasticity in Oral Mucosa Adjacent to Long-Term Restorative Materials: A Retrospective Histopathological and Immunohistochemical Study

Mehedinti R, Earar K, Stefanescu A et al. · 2026 · Preprint

Background: and Objectives: Long-standing contact between oral mucosa and restorative materials may be associated with adaptive epithelial and stromal remodeling. This study evaluated non-dysplastic epithelial plasticity and cumulative…

View details →DOI: 10.20944/preprints202606.1076.v1
Negative / Null Result ReportMedicine

Thoracic radiographs in dogs with gastric dilatation-volvulus rarely affect the decision to proceed with surgery or survival to discharge: a 25-year retrospective study of 176 cases.

Lee J, DeGroot W · 2026 · Journal of the American Veterinary Medical Association

Objective To assess whether thoracic radiographs in dogs with gastric dilatation-volvulus (GDV) are associated with the decision to proceed with surgery and survival to discharge. Methods A retrospective cohort study of dogs with GDV…

View details →DOI: 10.2460/javma.25.12.0871
Negative / Null Result ReportMedicine

When coverage is high: rethinking the role of caregiver perceptions in childhood vaccination uptake in Uganda.

Gunderson AK, Kwon T, Kumarasinghe Y et al. · 2026 · Transactions of the Royal Society of Tropical Medicine and Hygiene

Background Beliefs of a child's primary caregiver are known to influence immunization uptake. As coverage increases, the characteristics of households with undervaccinated children may be shifting. Methods We conducted a cross-sectional…

View details →DOI: 10.1093/trstmh/trag045