Negative / Null Result ReportOpen accessImmunology and Microbiology
on behalf of the Vx-001-201 trial team, Cesare Gridelli, Tudor–Eliade Ciuleanu et al. · 2020 · British Journal of Cancer
BACKGROUND: CD8 + cytotoxic T cells; this immune response is associated with improved overall survival (OS) in patients with advanced/metastatic non-small cell lung cancer (NSCLC). METHODS: A randomised, double blind, phase 2b trial, in HLA-A*201-positive patients with metastatic, TERT-expressing NSCLC, who did not progress after first-line platinum-based chemotherapy were randomised to receive either Vx-001 or placebo. The primary endpoint of the trial was OS. RESULTS: Two hundred and twenty-one patients were randomised and 190 (101 and 89 patients in the placebo and the Vx-001 arm, respectiv
View details →DOI: 10.1038/s41416-020-0785-yCited by 69 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Mukul S. Bansal, Yi-Chieh Wu, Eric J. Alm et al. · 2014 · Bioinformatics
MOTIVATION: The accurate inference of gene trees is a necessary step in many evolutionary studies. Although the problem of accurate gene tree inference has received considerable attention, most existing methods are only applicable to gene families unaffected by horizontal gene transfer. As a result, the accurate inference of gene trees affected by horizontal gene transfer remains a largely unaddressed problem. RESULTS: In this study, we introduce a new and highly effective method for gene tree error correction in the presence of horizontal gene transfer. Our method efficiently models horizonta
View details →DOI: 10.1093/bioinformatics/btu806Cited by 68 Negative / Null Result ReportOpen accessMedicine
Pénélope Paradis‐Deschênes, Denis R. Joanisse, François Billaut · 2017 · Frontiers in Physiology
Prior peripheral hypoxia induced via remote ischemic preconditioning (IPC) can improve physical performance in male athletes through improved O2 delivery and utilization. Since females may have an innate protective mechanism against ischemia-reperfusion injury, and since muscle metabolism during contraction differs between sexes, it is relevant to examine the impact of sex in response to IPC to determine whether it is also ergogenic in females. In a randomized, crossover, single-blind study, we investigated muscle performance, hemodynamic and O2 uptake in strength-trained males (n=9) and femal
View details →DOI: 10.3389/fphys.2016.00674Cited by 68 Negative / Null Result ReportOpen accessNeuroscience
James F. Morley, Abigail Cohen, Laura Silveira‐Moriyama et al. · 2018 · npj Parkinson s Disease
The 40-item University of Pennsylvania Smell Identification Test (UPSIT) is an effective instrument to detect olfactory dusfunction in Parkinson's disease (PD). It is not clear, however, whether tests of this length are necessary to detect such dysfunction. Several studies have suggested that detection of certain odors is selectively compromised in PD, and that a test comprised of these odors could be shorter and more specific for this purpose. Therefore, we attempted to identify a subset of UPSIT odors that distinguish PD from controls with similar or improved test characteristics compared to
View details →DOI: 10.1038/s41531-017-0039-8Cited by 67 Negative / Null Result ReportOpen accessPsychology
Carine Meslot, Aurélie Gauchet, B. Allenet et al. · 2016 · Frontiers in Psychology
Interventions to assist individuals in initiating and maintaining regular participation in physical activity are not always effective. Psychological and behavioural theories advocate the importance of both motivation and volition in interventions to change health behaviour. Interventions adopting self-regulation strategies that foster motivational and volitional components may, therefore, have utility in promoting regular physical activity participation. We tested the efficacy of an intervention adopting motivational (mental simulation) and volitional (implementation intentions) components to
View details →DOI: 10.3389/fpsyg.2016.01789Cited by 67 Negative / Null Result ReportNursing
Abu R. Ayman, Tawfik Khoury, Jonah Cohen et al. · 2016 · Journal of Clinical Gastroenterology
BACKGROUND: Percutaneous endoscopic gastrostomy (PEG) tubes are commonly utilized as a method of enteral feeding in patients unable to obtain adequate oral nutrition. Although some studies have shown improved mortality in select…
View details →DOI: 10.1097/mcg.0000000000000624Cited by 67 Negative / Null Result ReportOpen accessMedicine
Yi‐Hsuan Huang, Meei‐Shyuan Lee, Yu-Sheng Lou et al. · 2019 · PLoS ONE
BACKGROUND: Breast cancer is the most common cancer in women and several perioperative factors may account for tumor recurrence and metastasis. The anesthetic agents employed during cancer surgery might play a crucial role in cancer cell survival and patient outcomes. We conducted a retrospective cohort study to investigate the relationship between the type of anesthesia and overall survival in patients who underwent breast cancer surgery performed by one experienced surgeon. METHODS: All patients who underwent breast cancer surgery by an experienced surgeon between January 2006 and December 2
View details →DOI: 10.1371/journal.pone.0224728Cited by 66 Negative / Null Result Report
Patricia O'Campo, Vicky Stergiopoulos, Pam Nir et al. · 2016 · BMJ Open
Objectives We studied the impact of a Housing First (HF) intervention on housing, contact with the justice system, healthcare usage and health outcomes among At Home/Chez Soi randomised trial participants in Toronto, a city with an…
View details →DOI: 10.1136/bmjopen-2015-010581Cited by 65 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Charles R. Dunlop, Yann Wallez, Timothy Isaac Johnson et al. · 2020 · British Journal of Cancer
BACKGROUND: Personalised medicine strategies may improve outcomes in pancreatic ductal adenocarcinoma (PDAC), but validation of predictive biomarkers is required. Having developed a clinical trial to assess the ATR inhibitor, AZD6738, in combination with gemcitabine (ATRi/gem), we investigated ATM loss as a predictive biomarker of response to ATRi/gem in PDAC. METHODS: Through kinase inhibition, siRNA depletion and CRISPR knockout of ATM, we assessed how ATM targeting affected the sensitivity of PDAC cells to ATRi/gem. Using flow cytometry, immunofluorescence and immunoblotting, we investigate
View details →DOI: 10.1038/s41416-020-1016-2Cited by 63 Negative / Null Result ReportOpen accessEnvironmental Science
Andrés Baselga, Miguel B. Araújo · 2010 · Journal of Biogeography
Abstract Aim The aim of community‐level modelling is to improve the performance of species distributional models by taking patterns of co‐occurrence among species into account. Here, we test this expectation by examining how well three…
View details →DOI: 10.1111/j.1365-2699.2010.02341.xCited by 60 Negative / Null Result ReportOpen accessEnvironmental Science
Hlalefang Khobai, Nwabisa Kolisi, Clement Moyo et al. · 2020 · International Journal of Energy Economics and Policy
The importance of renewable energy consumption has grown to a large extent over the recent years. The benefits of renewable energy consumption ranging from improved environmental quality to higher economic growth are well documented. However, the impact of renewable energy consumption on unemployment has received relatively less attention. This study examines the relationship between renewable energy consumption and unemployment in South Africa over the period 1990-2014. The Autoregressive Distributed Lag (ARDL) model was employed to test the long-run and short-run impacts of renewable energy
View details →DOI: 10.32479/ijeep.6374Cited by 60 Negative / Null Result ReportOpen accessNeuroscience
Mahmoud G. El Baassiri, Zachariah Raouf, Sarah Badin et al. · 2024 · Journal of Neuroinflammation
Traumatic brain injury (TBI) is a chronic and debilitating disease, associated with a high risk of psychiatric and neurodegenerative diseases. Despite significant advancements in improving outcomes, the lack of effective treatments underscore the urgent need for innovative therapeutic strategies. The brain-gut axis has emerged as a crucial bidirectional pathway connecting the brain and the gastrointestinal (GI) system through an intricate network of neuronal, hormonal, and immunological pathways. Four main pathways are primarily implicated in this crosstalk, including the systemic immune syste
View details →DOI: 10.1186/s12974-024-03118-3Cited by 59 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Katarzyna A. Cieslik, George E. Taffet, Jeffrey R. Crawford et al. · 2013 · Journal of Molecular and Cellular Cardiology
We have demonstrated that scar formation after myocardial infarction (MI) is associated with an endogenous pool of CD44(pos)CD45(neg) multipotential mesenchymal stem cells (MSC). MSC differentiate into fibroblasts secreting collagen that forms a scar and mature into myofibroblasts that express alpha smooth muscle actin (α-SMA) that stabilizes the scar. In the aging mouse, cardiac repair after MI is associated with impaired differentiation of MSC; MSC derived from the aged hearts form dysfunctional fibroblasts that deposit less collagen in response to transforming growth factor beta-1 (TGF-β1)
View details →DOI: 10.1016/j.yjmcc.2013.07.005Cited by 58 Negative / Null Result ReportOpen accessMedicine
Josep Tabernero, Paulo M. Hoff, Lin Shen et al. · 2022 · Gastric Cancer
BACKGROUND: Dual-targeted anti-HER2 therapy significantly improves outcomes in HER2-positive breast cancer and could be beneficial in other HER2-positive cancers. JACOB's end-of study analyses aimed to evaluate the long-term efficacy and safety of pertuzumab plus trastuzumab and chemotherapy for previously untreated HER2-positive metastatic gastric or gastroesophageal junction cancer. METHODS: Eligible patients were randomized 1:1 to pertuzumab/placebo plus trastuzumab and chemotherapy every 3 weeks. PRIMARY ENDPOINT: overall survival (OS). Secondary endpoints included progression-free surviva
View details →DOI: 10.1007/s10120-022-01335-4Cited by 57 Negative / Null Result ReportOpen accessMedicine
Christoph Röllig, Hubert Serve, Richard Noppeney et al. · 2021 · Leukemia
Early results of the randomized placebo-controlled SORAML trial showed that, in patients with newly diagnosed acute myeloid leukaemia (AML), sorafenib led to a significant improvement in event-free (EFS) and relapse-free survival (RFS). In order to describe second-line treatments and their implications on overall survival (OS), we performed a study after a median follow-up time of 78 months. Newly diagnosed fit AML patients aged ≤60 years received sorafenib (n = 134) or placebo (n = 133) in addition to standard chemotherapy and as maintenance treatment. The 5-year EFS was 41 versus 27% (HR 0.6
View details →DOI: 10.1038/s41375-021-01148-xCited by 57 Negative / Null Result ReportDentistry
Daniel M. Mazzaferro, Ari M. Wes, Sanjay Naran et al. · 2017 · Plastic & Reconstructive Surgery
BACKGROUND: The effects of orthognathic surgery go beyond objective cephalometric correction of facial and dental disproportion and malocclusion, respectively. The authors hypothesized that there is tangible improvement following surgery…
View details →DOI: 10.1097/prs.0000000000003760Cited by 57 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Brett M. Kroncke, Amanda M. Duran, Jeffrey Mendenhall et al. · 2016 · Biochemistry
There is a compelling and growing need to accurately predict the impact of amino acid mutations on protein stability for problems in personalized medicine and other applications. Here the ability of 10 computational tools to accurately…
View details →DOI: 10.1021/acs.biochem.6b00537Cited by 57 Negative / Null Result ReportOpen accessMedicine
Jolien Schildermans, Greet De Vlieger · 2020 · Frontiers in Medicine
Cytomegalovirus (CMV) is one of the most pathogenic viruses in human. After a primary infection, CMV resides in the host for life as a latent infection. When immunity is reduced, CMV can escape the suppressive effects of the immune system and lead to viremia and antigenemia. This reactivation, first seen in transplant patients, has also been documented in non-immunocompromised CMV-seropositive critically ill patients and is associated with higher morbidity and mortality. In the latter, it is not clear whether CMV reactivation is an innocent bystander or the cause of this observed worse outcome
View details →DOI: 10.3389/fmed.2020.00188Cited by 56 Negative / Null Result ReportOpen accessMedicine
Gil Awada, Laïla Ben Salama, Jennifer Cremer et al. · 2020 · Journal for ImmunoTherapy of Cancer
BACKGROUND: No treatment demonstrated to improve survival in patients with recurrent glioblastoma (rGB) in a randomized trial. Combining axitinib with the programmed cell death ligand 1 blocking monoclonal antibody avelumab may result in…
View details →DOI: 10.1136/jitc-2020-001146Cited by 55 Negative / Null Result ReportOpen accessMedicine
Yoshimasa Miyagawa, Kazuhiro Araki, Ayako Bun et al. · 2018 · Clinical Breast Cancer
INTRODUCTION: Although eribulin and nab-paclitaxel are chemotherapy agents widely used for locally advanced or metastatic breast cancer (MBC), their predictive factors remain unknown. Because the absolute neutrophil-to-lymphocyte ratio…
View details →DOI: 10.1016/j.clbc.2018.03.002Cited by 54 Negative / Null Result ReportOpen accessMedicine
Shoji Kawakami, Yoshio Tahara, Teruo Noguchi et al. · 2016 · Circulation Journal
BACKGROUND: Prehospital ECG improves survival following ST-segment elevation myocardial infarction (STEMI). Although a new International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment…
View details →DOI: 10.1253/circj.cj-15-1322Cited by 54 Negative / Null Result ReportSocial Sciences
Chun‐Yen Tsai · 2014 · International Journal of Science Education
The scientific competencies advocated by the Programme for International Student Assessment (PISA) focus on the abilities needed in students' adult lives. This study investigated how such scientific competencies could be improved by using…
View details →DOI: 10.1080/09500693.2014.987712Cited by 54 Negative / Null Result ReportOpen accessMedicine
Marco Colombo, Stuart J. McGurnaghan, Luke A. K. Blackbourn et al. · 2020 · Diabetologia
Abstract Aims/hypothesis We examined whether candidate biomarkers in serum or urine can improve the prediction of renal disease progression in type 1 diabetes beyond prior eGFR, comparing their performance with urinary albumin/creatinine ratio (ACR). Methods From the population-representative Scottish Diabetes Research Network Type 1 Bioresource (SDRNT1BIO) we sampled 50% and 25% of those with starting eGFR below and above 75 ml min −1 [1.73 m] −2 , respectively ( N = 1629), and with median 5.1 years of follow-up. Multiplexed ELISAs and single molecule array technology were used to measure nin
View details →DOI: 10.1007/s00125-019-05081-8Cited by 53 Negative / Null Result Report
Deborah Gurewich, Michael Shwartz, Erin Beilstein-Wedel et al. · 2021 · Medical Care
Background: The 2014 Veterans Choice Program aimed to improve care access for Veterans through expanded availability of community care (CC). Increased access to CC could particularly benefit rural Veterans, who often face obstacles in…
View details →DOI: 10.1097/mlr.0000000000001490Cited by 52 Negative / Null Result ReportOpen accessPsychology
Jonás Fouz-González · 2018 · ReCALL
Abstract This study investigates the potential of a podcast-based approach aimed at helping foreign language learners improve their pronunciation of features that tend to be fossilised in their interlanguage. Training took place over a…
View details →DOI: 10.1017/s0958344018000174Cited by 51 Negative / Null Result ReportOpen accessMedicine
Pedro Weslley Rosário, Alexandre Lemos Silva, Michelle Aparecida Ribeiro Borges et al. · 2015 · Archives of Endocrinology and Metabolism
The objective of this study was to evaluate whether Doppler ultrasound (DUS) is of additional value to gray-scale ultrasound (GSUS) in predicting the benign or malignant nature of thyroid nodules. A total of 1,502 solid thyroid nodules ≥ 10 mm were evaluated. Suspicious vascularity (predominantly or exclusively central blood flow) was observed in only 5% of the nodules. This finding showed 96% specificity, but only 15% sensitivity. GSUS alone showed sensitivity and specificity of 88.7% and 68.2%, respectively, which did not improve with the addition of DUS (sensitivity of 89.4% and specificity
View details →DOI: 10.1590/2359-3997000000014Cited by 51 Negative / Null Result ReportOpen accessDecision Sciences
Patience Njina Soneka, Jackson Phiri · 2019 · Open Journal of Business and Management
The objective of this study was to assess the factors that influence the level of e-tax systems adoption in Zambia. The study focused on TaxOnline system used by domestic taxes division in Zambia. The study was conducted in rural Zambia. In this study, the researcher used Technology Acceptance Model (TAM). The sample size was purposively selected from various taxpayers who were coming through to Zambia Revenue Authority Solwezi internet bureau. 100 semi structured survey questionnaires were distributed with 100% response. The data collected was analyzed using descriptive statistics. The result
View details →DOI: 10.4236/ojbm.2019.72062Cited by 51 Negative / Null Result ReportOpen accessMedicine
Brian J. Anderson, Carolyn S. Calfee, Kathleen D. Liu et al. · 2019 · Critical Care
BACKGROUND: Enrichment strategies improve therapeutic targeting and trial efficiency, but enrichment factors for sepsis trials are lacking. We determined whether concentrations of soluble tumor necrosis factor receptor-1 (sTNFR1), interleukin-8 (IL8), and angiopoietin-2 (Ang2) could identify sepsis patients at higher mortality risk and serve as prognostic enrichment factors. METHODS: In a multicenter prospective cohort study of 400 critically ill septic patients, we derived and validated thresholds for each marker and expressed prognostic enrichment using risk differences (RD) of 30-day mortal
View details →DOI: 10.1186/s13054-019-2684-2Cited by 50 Negative / Null Result ReportOpen accessPsychology
Sarah Jordan, Laure Brimbal, David B. Wallace et al. · 2019 · Journal of Investigative Psychology and Offender Profiling
Abstract The purpose of the study was to examine the effectiveness of the micro‐expressions training tool (METT) in identifying and using micro‐expressions to improve lie detection. Participants ( n = 90) were randomly assigned to receive…
View details →DOI: 10.1002/jip.1532Cited by 50 Negative / Null Result ReportOpen accessMedicine
Juliano Rodrigues Sangalli, Marcos Roberto Chiaratti, Tiago Henrique Camara De et al. · 2014 · PLoS ONE
Cloning of mammals by somatic cell nuclear transfer (SCNT) is still plagued by low efficiency. The epigenetic modifications established during cellular differentiation are a major factor determining this low efficiency as they act as epigenetic barriers restricting reprogramming of somatic nuclei. In this regard, most factors that promote chromatin decondensation, including histone deacetylase inhibitors (HDACis), have been found to increase nuclear reprogramming efficiency, making their use common to improve SCNT rates. Herein we used valproic acid (VPA) in SCNT to test whether the treatment
View details →DOI: 10.1371/journal.pone.0101022Cited by 50 