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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19879 results in Negative / Null Result Report · page 499 of 663

Negative / Null Result ReportOpen accessMedicine

The relationship between aging out of the special supplemental nutrition program for women, infants, and children assistance and weight status in kindergarten.

Lazic A, Thomsen MR, Brown CC et al. · 2025 · Preventive medicine reports

Objective The Supplemental Nutrition Program for Women, Infants, and Children (WIC) provides access to nutritional resources to low-income children starting at birth through enrollment in kindergarten or turning five years old. The…

View details →DOI: 10.1016/j.pmedr.2025.103125
Negative / Null Result ReportMedicine

Name order effects in measuring adolescent social networks using rosters.

Liu S, Nolin DA, Kitts JA · 2024 · Social networks

Recent studies have found order effects in social network data collection, where later names on a roster receive fewer nominations. Some thus argue for randomizing name orders or sampling peer names for survey rosters. We model order…

View details →DOI: 10.1016/j.socnet.2023.07.002
Negative / Null Result ReportOpen accessMedicine

Biomechanical Factors Associated with Intraindividual Differences in Running Economy Across Advanced Footwear Technology Models in Long-Distance Runners.

Fohrmann D, Schaffarczyk M, Menge C et al. · 2026 · Sports medicine - open

Background Advanced footwear technology (AFT) can enhance long-distance running performance by improving running economy (RE). However, the range of the individual improvements is large. Different intra-individual responses in running…

View details →DOI: 10.1186/s40798-026-01005-0
Negative / Null Result ReportOpen accessMedicine

Exploring the Causal Links Between Toxoplasma gondii Infection and Risk of Brain Tumors: A Bidirectional Mendelian Randomization Analysis.

Shi P, Wei G, Li Z et al. · 2026 · Brain and behavior

Background Toxoplasma gondii (T. gondii) is a ubiquitous protozoan parasite capable of establishing lifelong latent infections in the central nervous system. Previous epidemiological studies have suggested a potential association between…

View details →DOI: 10.1002/brb3.71239
Negative / Null Result ReportOpen accessMedicine

PCSK9 and Breast Cancer Survival: A Mendelian Randomization Study.

Pott J, Mason AM, Salo V et al. · 2026 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) affects lipid metabolism. A recent study identified an association between rs562556 within the PCSK9 gene and breast cancer survival (BCS), suggesting PCSK9 inhibition as an…

View details →DOI: 10.1158/1055-9965.epi-25-1569
Negative / Null Result ReportOpen access

PCSK9 and breast cancer survival: a Mendelian Randomization study

Pott J, Mason A, Salo V et al. · 2025 · Preprint

Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is well known for its causal effects on the lipid metabolism. A recent study identified an association between rs562556 within PCSK9 and breast cancer survival (BCS). It was…

View details →DOI: 10.1101/2025.10.03.25337270
Negative / Null Result ReportOpen accessMedicine

Applying High-Dimensional Propensity Scores in a Study of Inhaled Corticosteroids and COVID-19 Outcomes.

Bokern M, Tazare J, Rentsch CT et al. · 2025 · Pharmacoepidemiology and drug safety

Background In pharmacoepidemiologic studies of COVID-19, there were concerns about bias from residual confounding. We investigated the effects of inhaled corticosteroids (ICS) on COVID-19 outcomes, applying high-dimensional propensity…

View details →DOI: 10.1002/pds.70248
Negative / Null Result ReportOpen accessMedicine

Microstate-based Neurofeedback in Attention Deficit Hyperactivity Disorder Population: A Randomized Controlled Crossover Trial.

Férat V, Deiber MP, Hasler R et al. · 2025 · Brain topography

Neurofeedback (NFB) therapy based on spectral neuromarkers of Attention-Deficit/Hyperactivity Disorder (ADHD) has faced challenges regarding its efficacy and replicability. In this study, we investigate whether a microstate-based EEG…

View details →DOI: 10.1007/s10548-025-01161-8
Negative / Null Result ReportOpen accessMedicine

No Selective Attentional Shift despite Prefrontal Activation during a Working-Memory Task with Unconscious Stimuli.

Pedale T, Karampela O, Eriksson J · 2025 · eNeuro

A key process for successful working memory is to prioritize task-relevant information over distraction, i.e., to control attentional deployment. Here we investigate to what extent attentional control during a delayed match-to-sample task…

View details →DOI: 10.1523/eneuro.0183-25.2025
Negative / Null Result ReportOpen accessMedicine

Vibration-Induced Nystagmus in Patients with Ménière's Disease: Is There a Correlation to Endolymphatic Hydrops?

Lorente-Piera J, Blanco M, Manrique-Huarte R et al. · 2025 · Audiology research

Background/Objectives : Skull vibration-induced nystagmus (SVIN) is a rapid bedside test that reveals vestibular asymmetry. Its clinical utility in Ménière's disease (MD) remains controversial, particularly regarding its association with…

View details →DOI: 10.3390/audiolres15050125
Negative / Null Result ReportOpen accessMedicine

Outcomes and experiences of music workshops for adolescents with depression and anxiety: An exploratory noncontrolled trial in Bogotá.

Gómez-Restrepo C, Roldan MC, Ariza-Salazar K et al. · 2024 · BMC research notes

Objective Adolescents frequently experience mental distress. However, there is little research on community activities that help adolescents recover from depression and anxiety. This study investigated the outcomes and experiences of music…

View details →DOI: 10.1186/s13104-024-07007-z
Negative / Null Result ReportOpen accessMedicine

Alterations of brain network topology and structural-functional connectivity coupling in noise-induced hearing loss based on macroscopic scale.

Wang A, Bao X, Wang C et al. · 2025 · Frontiers in neuroscience

Objective To investigate the changes in the global attributes of structural connectivity (SC) and functional connectivity (FC) graph theory, as well as the coupling topological structure of the whole brain SC-FC in patients with…

View details →DOI: 10.3389/fnins.2025.1661096
Negative / Null Result ReportOpen accessMedicine

Association of cardiovascular risk scores with coronary plaque and its progression among individuals with family history of coronary artery disease.

Soh CH, Nerlekar N, Whitmore K et al. · 2026 · American journal of preventive cardiology

Background Multiple cardiovascular (CV) risk assessment scores can predict CV events. The current trend towards assessing atheroma has led to these scores being used to identify patients who might benefit from coronary plaque imaging.…

View details →DOI: 10.1016/j.ajpc.2026.101423
Negative / Null Result ReportOpen accessMedicine

<i>TNF-α</i> rs1800629 Polymorphism in Vietnamese COPD Patients: Exploratory Evidence for Recessive Protective Association and Clinical Correlates.

Nguyen HM, Le DHH, Ho TTH et al. · 2026 · The application of clinical genetics

Background Chronic obstructive pulmonary disease (COPD) poses a significant health burden in Vietnam. The TNF-α rs1800629 (-308G/A) polymorphism is an influential factor in disease pathogenesis. However, its association is inconsistent…

View details →DOI: 10.2147/tacg.s586977
Negative / Null Result ReportOpen accessMedicine

Kava consumption and the rise of sociopolitical complexity in Oceania.

Hrnčíř V, Sheehan O, Claessens S et al. · 2026 · Proceedings of the National Academy of Sciences of the United States of America

Humans have been using psychoactive substances for millennia, despite their potential negative health and social consequences. According to some scholars, our craving for mind-altering drugs is an evolutionary mistake-a hijacking of our…

View details →DOI: 10.1073/pnas.2521658123
Negative / Null Result ReportOpen accessMedicine

Assessment of β-blocker use and all-cause mortality in patients with myocardial infarction: a real-world analysis of the NHANES 1999-2018 database.

Ling W, Li H, Liu L et al. · 2025 · Open heart

Objective To evaluate the association between β-blocker use and all-cause mortality in a real-world cohort of patients with myocardial infarction (MI). Methods This study included 2308 patients with MI from the National Health and…

View details →DOI: 10.1136/openhrt-2025-003757
Negative / Null Result ReportOpen accessMedicine

Post-Traumatic Headache in Children and Genetic Risk of Migraine: An Observational Cohort Study.

Orr SL, Hershey AD, Kurowski BG et al. · 2026 · Neurology. Genetics

Background and objectives To examine the association between genetic risk of migraine and post-traumatic headache (PTH) in children. Methods This is a secondary analysis of a cohort study that recruited children aged 8-17 years within 48…

View details →DOI: 10.1212/nxg.0000000000200371
Negative / Null Result ReportOpen accessMedicine

Mendelian randomization unveils genetic causal relationships between viral infections and systemic sclerosis.

Cheng T, Zhang HY, Wang TR et al. · 2025 · Scientific reports

This study uses Mendelian randomization (MR) to investigate the potential causal relationships between viral infections, including Epstein-Barr virus (EBV), human immunodeficiency virus (HIV), SARS-CoV-2, cytomegalovirus (CMV), human…

View details →DOI: 10.1038/s41598-025-08361-z
Negative / Null Result ReportOpen accessMedicine

Micronutrient Powders Combined With Malaria Chemoprevention to Improve Anaemia and Cognitive Function in Early Childhood in Mali: A Cluster-Randomised Trial.

Diarra NH, Dicko Y, Roschnik N et al. · 2025 · Maternal & child nutrition

A cluster-randomised controlled trial was conducted in 60 communities in southern Mali to evaluate the impact of micronutrient powders (MNP) combined with seasonal malaria chemoprevention (SMC) on anaemia (primary endpoint), Plasmodium…

View details →DOI: 10.1111/mcn.70033
Negative / Null Result ReportMedicine

Challenges in studying the interplay of genes and environment. A study of childhood financial distress moderating genetic predisposition for peak smoking.

Bierut L, Biroli P, Galama TJ et al. · 2023 · Journal Of Economic Psychology

Smoking is one of the leading causes of preventable disease and death in the U.S., and it is strongly influenced both by genetic predisposition and childhood adversity. Using polygenic indices (PGIs) of predisposition to smoking, we…

View details →DOI: 10.1016/j.joep.2023.102636
Negative / Null Result ReportOpen accessMedicine

Sensory sensitivity and visual discomfort are not associated with altered gamma oscillations: A test of the excitation-inhibition hypothesis.

Sumner P, Powell G, Price A et al. · 2026 · Imaging neuroscience (Cambridge, Mass.)

Many people experience aversive hypersensitivity (discomfort/visual stress) to stimuli such as bright lights, striped patterns, strobing, motion, or complex visual scenes such as supermarkets. Such sensory hypersensitivity is often…

View details →DOI: 10.1162/imag.a.1136
Negative / Null Result ReportMedicine

Weight cycling and cancer risk in the Sister Study.

Stevens VL, Priest J, Wilkerson J et al. · 2026 · American journal of epidemiology

Weight cycling, when weight is repeatedly lost intentionally and then regained, may perturb biological processes that could influence cancer development. However, results from epidemiologic studies of weight cycling are mixed and provide…

View details →DOI: 10.1093/aje/kwaf191
Negative / Null Result ReportMedicine

Association of Intensive Care Unit Patient-to-Clinician Ratios with Mortality across Two U.S. Health Systems.

Gershengorn HB, Anesi GL, Liu VX et al. · 2025 · Annals of the American Thoracic Society

Rationale: The association of interprofessional team member workload with intensive care unit (ICU) outcomes is understudied. Objectives: To evaluate the association of patient-to-intensivist ratio (PIR), patient-to-respiratory therapist…

View details →DOI: 10.1513/annalsats.202501-045oc