A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19879 results in Negative / Null Result Report · page 498 of 663
Ayazi H, Kalani N, Rabiee M et al. · 2026 · Musculoskeletal care
Background and purpose Lumbopelvic rhythm describes the relationship between the lumbar spine and hip motion during trunk bending tasks, while the lumbar lordosis angle represents the normal sagittal curvature of the lumbar spine. This…
Bhavya ML, Bayati M, Poojary MM et al. · 2026 · Food chemistry
Ultrasound (US) processing is a promising food technology to improve protein solubility, reduce particle size, and modify functional properties. However, concerns exist regarding US-induced protein oxidation due to reactive oxygen species…
Wolinsky D, Blaine S, Strickland JC et al. · 2026 · Journal of cannabis research
Background This Phase I randomized controlled trial aimed to assess the safety and tolerability of cannabidiol (CBD) and alcohol co-administration among moderate alcohol consumers in acute laboratory and chronic outpatient settings.…
Celik C, Celik MS · 2026 · Cutaneous and ocular toxicology
Background and objective Acne vulgaris is a chronic inflammatory skin disease frequently treated with systemic agents such as isotretinoin and doxycycline. Although these treatments are known to modulate inflammatory pathways, their…
Qasim MSA, Kang P, Evans B et al. · 2026 · Contact lens & anterior eye : the journal of the British Contact Lens Association
Purpose To investigate the utility of in vivo confocal microscopy (IVCM) combined with standardized image grading for identifying early morphological changes in the central corneal and superior limbal basal epithelial cells during…
Dobariya A, Patel R, Patel M · 2026 · European journal of hospital pharmacy : science and practice
Objective The study aimed to analyse the physicochemical stability and compatibility of ceftriaxone sodium (CEF) (2mg/mL) with pantoprazole sodium (PAN) (0.08mg/mL) and ondansetron hydrochloride (OND) (0.008mg/mL) in different infusion…
Amiri D, Hellmann PH, Thyssen JP et al. · 2026 · JAMA dermatology
Importance Increased intraocular pressure (IOP) is a known adverse effect of corticosteroid use and may lead to corticosteroid-induced glaucoma. However, clinical evidence on the impact of topical corticosteroids (TCS) on IOP is limited.…
Nechemya Y, Shames J · 2026 · Harefuah
Introduction Background: Chronic pain syndrome is a common disease with major economic costs. The aim of this study is to examine the effect of outpatient multidisciplinary pain rehabilitation on the utilization of medical services in…
Nemes A, Ambrus N, Szili-Török T et al. · 2026 · Journal of clinical medicine
Introduction : The left ventricular (LV) function can be characterized by the spatial displacement of the aortic valve annulus (AVA), represented by the AVA plane systolic excursion (AAPSE). AAPSE, measured using 3DSTE, has been shown to…
Ozden H · 2026 · Open life sciences
Perfluorooctanoic acid (PFOA) is widely utilized perfluoroalkyl substance (PFAS) in various industrial and household applications, known for its persistence in the environment. Due to the limited toxicity data for PFOA in edible vegetable…
Kathpalia A, Vlachos I, Hlinka J et al. · 2026 · Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Objective Finding indicators of early response to antidepressant treatment in EEG signals recorded from patients suffering from major depressive disorder. Methods Functional brain connectivity networks based on weighted imaginary coherence…
Putos J, Atkinson HF, Walton DM · 2026 · Osteoarthritis and cartilage open
Objectives The acute response of lumbar intervertebral discs (IVD) to spinal rotation mobilization (SRM) is poorly understood. We evaluated sustained morphological changes in lumbar IVDs following a rotation mobilization commonly used to…
Ajiki H, Tanaka M · 2026 · Journal of imaging
Even when an object's color is accurately reproduced in a colorimetrically reproduced image (CRI), the perceived material appearance does not necessarily match that of the original object. This mismatch remains a challenge for faithfully…
Uysal A, Soslu R, Soslu R · 2026 · Journal of strength and conditioning research
Abstract Uysal, A and Soslu, R. Acute and long-term effects of spinning-based high-intensity interval training on inducible nitric oxide synthase: a randomized controlled trial. J Strength Cond Res XX(X): 000-000, 2026-This study…
Kathpalia A, Vlachos I, Hlinka J et al. · 2026 · Preprint
ABSTRACT Objective Finding: indicators of early response to antidepressant treatment in EEG signals recorded from patients suffering from major depressive disorder. Methods Functional brain connectivity networks based on weighted imaginary…
Ravenda S, Gerra MC, Barbetti M et al. · 2026 · Psychoneuroendocrinology
MicroRNAs (miRNAs) have attracted great interest as potential biomarkers in several research domains, including acute and chronic stress conditions. While most of these studies focused on circulating blood miRNA levels, the investigation…
Guo C, Geng A, Wang Q et al. · 2026 · Journal of integrative neuroscience
Background The cortex and cerebellum have a closely connected closed-loop circuit. Intermittent theta burst stimulation (iTBS) targeting the cerebellum has shown promise in improving balance function and inducing neuroplasticity. This…
Salimi Y, Namdarzadeh B, Aarani FD et al. · 2026 · Behavioural brain research
The gut-brain axis plays a key role in the bidirectional communication between the gastrointestinal system and the brain, with gut microbiota significantly influencing cognitive function. While synbiotic and probiotic interventions have…
Sudhakar S, Mishra VK, Harikrishna S et al. · 2026 · Physical chemistry chemical physics : PCCP
Human PrimPol (hPrimPol) is the primase and polymerase enzyme involved in reinitiating DNA replication at stalled replication forks. The hPrimPol mutants are linked to multiple ophthalmoplegic conditions and mitochondriopathies. The WFYY…
Sanmartino F, Rashid-López R, López-Sosa F et al. · 2026 · International journal of neural systems
Resting-state eye conditions modulate cortical oscillations, but their impact on subthalamic nucleus (STN) and cortico-STN dynamics in Parkinson's disease (PD) remains poorly understood. Here, we characterized electrophysiological changes…
Mabkhot BA, Taha SEE, Kamel MH et al. · 2026 · BMC oral health
BACKGROUND: Subgingival crown margins have been linked to chronic gingival inflammation in pediatric patients. This clinical trial evaluated periodontal outcomes in first permanent molars that had undergone root canal therapy and were…
Koper M, Jaworska K, Kopacz W et al. · 2026 · Kidney & blood pressure research
Hypertension contributes to renal dysfunction, partly through dysregulation of the renin-angiotensin system (RAS). Betaine, an osmolyte that helps maintain medullary osmotic gradients, has demonstrated renoprotective effects in models of…
Wiel É, Menu H, Roger F et al. · 2026 · Anaesthesia, critical care & pain medicine
Background Endotracheal Intubation (ETI) inserts an endotracheal tube (ETT) inside the human trachea to allow a proper mechanical ventilation of the lungs. Practitioners insert the ETT through the human vocal cords following a…
Yuan Y, Gao Y, Moen H et al. · 2026 · NPJ digital medicine
Digital phenotyping leverages continuous data from smartphones and wearable devices for real-time mental health monitoring, offering opportunities for early detection and personalized care in mood disorders by enabling clinicians to…
Montasser ZM, Montasser MA · 2026 · BMC oral health
Objective To review the available evidence on temporomandibular joint morphological changes after orthodontic treatment with clear aligners, as assessed using CBCT scans. Materials and methods This review sought randomized clinical trials,…
Singh Y, Lei Q, Dixit M et al. · 2026 · Medical care research and review : MCRR
Corporate employment of primary care physicians by hospitals and private equity-backed organizations has increased in recent years, raising concerns that the financial incentives of corporate employment will incentivize provision of…
Karacaer C, Kaya G, Ergenc H et al. · 2026 · Pakistan journal of medical sciences
Objectives This study aimed to evaluate the prognostic significance of Cluster of Differentiation 4 (CD4+) and Cluster of Differentiation 8 (CD8+) T cell dynamics and cytokine profiles during the early stage of Coronavirus Disease 2019…
Chowdhury M, Bustamante AV · 2026 · Health affairs (Project Hope)
Lawfully present noncitizen immigrants face persistent coverage gaps due to federal restrictions on Medicaid eligibility, including the five-year bar under the 1996 Personal Responsibility and Work Opportunity Reconciliation Act, and…
Yakasai AM, Maharaj SS, Danazumi MS · 2026 · American journal of physical medicine & rehabilitation
Objective This study evaluated the efficacy of endurance exercise on balance impairment and gait disturbance among individuals living with Human Immunodeficiency Virus (HIV)-related distal symmetrical polyneuropathy (DSPN). Design This was…
Peng J, Zou M, Ng ML et al. · 2025 · Preprint
Abstract Objective To investigate the therapeutic efficacy and application of different straw phonation exercise regimens as interventions for vocal fatigue. Methods One hundred and fourteen healthy adults aged 20–40 years with no organic…