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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19879 results in Negative / Null Result Report · page 496 of 663

Negative / Null Result ReportOpen accessSocial Sciences

Antioxidant and Antistaphylococcal Activity of Topical Fucoidan Gel from Sargassum oligocystum Montagne

Richie Bayuran · 2019 · JPAIR

Brown seaweed is one of the algal species that has been used as food, a source of nutritional supplements, and formulated for therapeutic and cosmetic purposes. This study evaluated the antioxidant and antistaphylococcal activities of topical fucoidan gel (TFG) from the Sargassum oligocystum. A completely randomized design was used, and the experimental protocol includes extraction, lyophilization, and characterization, quality testing, and biological assay. Physicochemical tests suggested that the lyophilized fucoidan is comparable with the properties of pharmaceutical-grade fucoidan. FTIR ch

View details →DOI: 10.7719/jpair.v38i1.731
Negative / Null Result ReportOpen accessTherapeutics. Pharmacology

Evaluation of Bile Salts on the Survival and Modulation of Virulence of Aliarcobacter butzleri

Cristiana Mateus, Cláudio J. Maia, Fernanda Domingues et al. · 2023 · Antibiotics

Aliarcobacter butzleri is a Gram-negative bacterium associated with infections of the gastrointestinal tract and widely distributed in various environments. For successful infection, A. butzleri should be able to tolerate various stresses during gastrointestinal passage, such as bile. Bile represents an antimicrobial host barrier that acts against external noxious agents and consists of a variety of bile salts. The intestinal bile salts act as detergents involved in the antimicrobial host defense; although, on the bacterial side, they could also serve as a signal to activate virulence mechanis

View details →DOI: 10.3390/antibiotics12091387
Negative / Null Result Report

P5264There is no significant effect of ischemic time and elapse time since cardiac allograft transplant on myocardial T1 relaxation time

J Vietheer, C Unbehaun, K Classen et al. · 2019 · European Heart Journal

Abstract Background Graft failure caused by allograft rejection and vasculopathy is the most common cause of mortality after heart transplantation. To detect an early allograft rejection, endomyocardial biopsy is still needed. Tissue…

View details →DOI: 10.1093/eurheartj/ehz746.0235
Negative / Null Result Report

The Pandemic Effect: Secondary Impact on the Diagnosis of Clinically Significant Congenital Heart Disease and Role of Deprivation Index

Cassandra Campbell, Kristin Wyckoff, Ronak Naik et al. · 2025 · Pediatric Cardiology

Abstract We sought to determine the impact of the COVID-19 on prenatal diagnosis (PND) of clinically significant congenital heart disease (CHD) and the role of socioeconomic status (SES), complexity of diagnosis, and proximity to advance…

View details →DOI: 10.1007/s00246-025-03844-2
Negative / Null Result Report

Non-significant Effect of El Niño on the Nest Occupancy and Breeding Success of Markham’s Storm Petrel <i>Hydrobates markhami</i>

Fernando Medrano, Benjamín Gallardo, Pablo Gutiérrez et al. · 2024 · Marine Ornithology

The impact of the El Niño varies across seabirds, usually altering the distribution and causing population declines. Understanding El Niño’s effects is thus critical for conservation. We monitored 296 nests of the little-known Hydrobates…

View details →DOI: 10.5038/2074-1235.52.2.1603
Negative / Null Result ReportOpen access

Correlation of c-erbb2 Expression in Undifferentiated Nasopharyngeal Carcinoma and Tumor Size (T-Stage) (Dyah Fauziah et al.) 290 CORRELATION OF C-ERBB2 EXPRESSION IN UNDIFFERENTIATED NASOPHARYNGEAL CARCINOMA AND TUMOR SIZE (T-STAGE), REGIONAL LYMPHNODES

Willy Sandhika, Faroek Hoesin, Dyah Fauziah · 2020

No significant correlation was found between c-erbB2 expression and tumor size (T-stage). c-erbB2 expression in various N-stages were as follows: N0 (80%), N1 (33,3%), N2 (50%), N3 (42,9%). No significant correlation was found between…

Negative / Null Result ReportOpen access

有酸素運動 (Aerobics) を中心にした一般教養体育実技の有効性と限界について-第一報:血液組成と体組成におよぼす影響-

田原, 靖昭, 西澤, 昭, 管原, 正志 et al. · 1991

Aerobic exercise class was opened and blood and physical composition were examined. Results indicated that no significant improvement on measured items was observed. Frequency of participation is suggested to be increased or class goal…

Negative / Null Result ReportOpen access

Performance of Perforated Heat Exchanger Surfaces

J. R. Mondt, D. C. Siegla · 1974

Heat transfer and flow friction behavior have been measured for plain and perforated plate-fin and 10-deg herringbone surfaces. For the range of geometries and Reynolds numbers studied, the perforations produced no significant improvement…

View details →DOI: 10.1115/1.3445766
Negative / Null Result ReportOpen access

The SOS Pilot Study: a RCT of routine oxygen supplementation early after acute stroke—effect on recovery of neurological function at one week

Khalid Mustafa Ali (4461853), Christine Roffe (220471), Anushka Warusevitane (220475) et al. · 2011

Mild hypoxia is common after stroke and associated with poor long-term outcome. Oxygen supplementation could prevent hypoxia and improve recovery. A previous study of routine oxygen supplementation showed no significant benefit at 7 and 12…

Negative / Null Result ReportOpen access

Effects of α-MSH treatment on Caspase 3 activity.

Andrew W. Taylor (451751) · 2013

The macrophages lysates were assayed for protein concentration and Caspase 3 activity. There was no significant change of Caspase 3 activity in cells treated with α-MSH compared to SFM cells. The graft is the mean ± SD of Caspase 3…

View details →DOI: 10.1371/journal.pone.0074488.g004
Negative / Null Result ReportOpen access

Supplementary Table S1 from Radiation-induced Adaptive Response: New Potential for Cancer Treatment

Sandra Demaria (15026216), Shannon Martello (11246282), Molykutty J. Aryankalayil (5544962) et al. · 2020

Metabolic data from PC3 cells 6h, 24h, and 48h after SD or MF radiation. Samples were sent to Metabolon for processing. Results indicate decrease in glycolysis intermediates in SD sample at 6h. No significant changes to TCA cycle…

View details →DOI: 10.1158/1078-0432.22477403.v1
Negative / Null Result ReportOpen access

Conflict duration on the flanker task (i.e., reaction time for each incongruent trial–reaction time for each congruent trial) pre- (white bar) and post-treatment (black bar) with OT or placebo.

Yuko Yoshimura (283970), Hirotoshi Hiraishi (283977), Mitsuru Kikuchi (140272) et al. · 2015

Two-way ANOVA (treatment × drug) failed to demonstrate any drug or treatment effects, and no significant interaction between these two factors was detected. Therefore, we failed to demonstrate any OT-related effect on…

View details →DOI: 10.1371/journal.pone.0116918.g004
Negative / Null Result ReportOpen access

Cutaneous sterile pyogranuloma/granuloma syndrome in a dog

SPATERNA, Andrea, MECHELLI A., SANTORO D. et al. · 2008

A case of canine cutaneous sterile pyogranuloma/granuloma syndrome (SPGS) with generalized asymmetrical alopecia and plaques is described. Results from histopathologic examination were suggestive of SPGS and failed to demonstrate any…

Negative / Null Result ReportOpen access

Visual impairment, aging and driving ability

Wood, Joanne M. · 2002

It has been suggested that over 90% of the sensory information for driving is visual. Despite this belief, traditional studies have failed to demonstrate that increased crash rates arise from impaired vision. However, more recent studies…

Negative / Null Result ReportOpen access

Sodium lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain-injured patients.

Grimaud, Dominique, Berthier, Fréderic, Ichai, Carole et al. · 2009

International audienceOBJECTIVES: Traumatic brain injury (TBI) is still a major cause of mortality and morbidity. Recent trials have failed to demonstrate a beneficial outcome from therapeutic treatments such as corticosteroids,…

View details →DOI: 10.1007/s00134-008-1283-5
Negative / Null Result ReportOpen access

The MINERVA study design and rationale: A controlled randomized trial to assess the clinical benefit of minimizing ventricular pacing in pacemaker patients with atrial tachyarrhythmias

Manolis AS, Padeletti L., Mont L et al. · 2008

Dual-chamber (DDD) pacing has generally been regarded as "physiologic pacing" and therefore expected to be superior to ventricular pacing. Major randomized trials have so far failed to demonstrate significant reductions in the incidences…

View details →DOI: 10.1016/j.ahj.2008.05.004
Negative / Null Result ReportOpen access

Transient Crossed Aphasia: A Case Study with SPECT

José M. Ferro, Guilhermina Cantinho, Élia Baeta · 1991

A 45-year-old right-handed man developed “crossed” anomie aphasia, neglect and inaccurate reaching of his left arm in both hemispaces due to a right parietal haemorrhage. Aphasia cleared in a few days. SPECT failed to demonstrate crossed…

View details →DOI: 10.3233/ben-1991-4203
Negative / Null Result ReportOpen access

Subscriptions: Information about subscribing to Stroke is online at at UNIV OF EDINBURGH on Comments, Opinions, and Reviews Good Laboratory Practice Preventing Introduction of Bias at the Bench

Marc Fisher, Ulrich Dirnagl, Geoffrey A Donnan et al. · 2020

Background and Purpose-As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Summary of Review-Accumulating…

Negative / Null Result ReportOpen access

Feasibility of progesterone treatment for ischaemic stroke

Claire L. Gibson (6162488), Philip M. Bath (3111867) · 2015

Two multi-centre phase III clinical trials examining the protective potential of progesterone following traumatic brain injury have recently failed to demonstrate any improvement in outcome. Thus, it is timely to consider how this impacts…