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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19879 results in Negative / Null Result Report · page 493 of 663

Negative / Null Result ReportMedicine

Acute effects of the FIFA 11 + kids warm-up program compared with a judo-specific warm-up on explosive and functional performance in youth judo athletes: a randomized crossover study.

Mor H, Şar H, Arslan T et al. · 2026 · BMC sports science, medicine & rehabilitation

Background The FIFA 11 + Kids (FIFA 11+) warm-up program is effective for injury prevention and to enhance sports performance, including vertical jump (VJ), sprint, balance, and agility. However, no previous study has examined the acute…

View details →DOI: 10.1186/s13102-026-01751-4
Negative / Null Result Report

Validation of a novel indirect Swept-source optical coherence tomography method for assessing internal fit and marginal adaptation: An in vitro study

Zeng C, Tabata T, Takahashi R et al. · 2026 · Preprint

Abstract Background Adaptation of indirect restorations is critical for clinical success. Although the conventional silicone replica method is destructive, direct in-situ Swept-source optical coherence tomography (SS-OCT) can be used to…

View details →DOI: 10.21203/rs.3.rs-9841824/v1
Negative / Null Result ReportOpen accessMedicine

Clinicopsychological stratification of recovery outcomes in cerebral aneurysm patients following cluster analysis.

Reder SR, Hardt J, Brockmann MA et al. · 2026 · PNAS nexus

The aim of this present study was to investigate the multifactorial determinants of recovery outcomes in cerebral aneurysm patients by identifying subgroups based on clinical and psychological factors. A cross-sectional approach was used (…

View details →DOI: 10.1093/pnasnexus/pgag157
Negative / Null Result ReportOpen accessMedicine

Delayed orocecal transit in pediatric gut-brain interaction disorders: A comparative study using the lactulose breath test.

Devanarayana NM, Rajindrajith S, de Silva DGH et al. · 2025 · World journal of gastrointestinal pathophysiology

Background Functional abdominal pain disorders (FAPDs) are common gut-brain interaction disorders with unclear pathophysiology. While impaired gastrointestinal motility is thought to play a key role, small intestinal dysmotility remains…

View details →DOI: 10.4291/wjgp.v16.i4.110421
Negative / Null Result Report

A population genetic study of Fusarium graminearum , the causal agent of Fusarium Head Blight, provides insights into patterns of inoculum dispersal in wheat fields at a regional scale

Nguyen TBH, Le Floch G, Henri-Sanvoisin A et al. · 2025 · Preprint

ABSTRACT Fusarium graminearum is the primary pathogen responsible for Fusarium Head Blight (FHB) in cereals, causing yield losses and mycotoxin contamination. The present study investigated the genetic diversity and population structure of…

View details →DOI: 10.1101/2025.07.11.664332
Negative / Null Result ReportMedicine

Immunotherapy Strategies After Immune Checkpoint Inhibitor Exposure in Renal Cell Carcinoma: A Review.

Giudice GC, Beckermann KE, Siqueira Do Amaral P et al. · 2025 · JAMA oncology

Importance Immune checkpoint inhibitors have transformed the treatment landscape for metastatic renal cell carcinoma; however, the failure of first-line therapeutic strategies remains a considerable challenge. Currently, clinicians face…

View details →DOI: 10.1001/jamaoncol.2025.0017
Negative / Null Result ReportOpen accessMedicine

Non-tobacco nicotine dependence is associated with increased complications following clavicle open reduction internal fixation.

Adio AA, Goyal RK, Skiena A et al. · 2026 · Archives of orthopaedic and trauma surgery

Background Tobacco dependence is well established to impair bone healing and increase postoperative complications. However, the independent effects of nicotine, separate from combustion-related factors, remain unclear. This study aimed to…

View details →DOI: 10.1007/s00402-026-06377-2
Negative / Null Result ReportOpen accessMedicine

Changes in the Mechanical Properties of Nickel-Titanium Orthodontic Archwires After Clinical Use with Conventional and Self-Ligating Brackets.

Ruiz G, Moyano J, Alcaraz I et al. · 2026 · Dentistry journal

Background/Objectives : Changes in the mechanical behavior of orthodontic archwires during clinical use are not fully understood, particularly when different bracket systems are employed. Self-ligating (SL) brackets have gained…

View details →DOI: 10.3390/dj14060351
Negative / Null Result ReportOpen accessMedicine

Effectiveness of Dry Needling Versus Percutaneous Electrolysis in Achilles Tendinopathy: A Randomized Clinical Trial.

Delgado Álvarez S, Méndez Sánchez R, Polo Ferrero L et al. · 2026 · Cureus

Introduction Achilles tendinopathy (AT) is characterized by pain, inflammation, and functional limitations. It is also the most common cause of pain located at the back of the calcaneus. The Achilles tendon is among the most vulnerable…

View details →DOI: 10.7759/cureus.104384
Negative / Null Result Report

Exploration of shift work among nursing professionals related to interconnected determinants of health in a hospital: a cross-sectional study

Rubiño-Díaz JÁ, Ferrández-Sempere S, Canellas F et al. · 2026 · Preprint

Abstract Aim To assess sleep quality and its relationship with interconnected health variables among nursing professionals working shifts. Methods A cross-sectional descriptive observational study. A total of 247 nursing professionals…

View details →DOI: 10.21203/rs.3.rs-9731930/v1
Negative / Null Result ReportOpen accessMedicine

Gut microbiota dysbiosis in intensive care unit patients with acute kidney injury: insights from 16S sequencing and mediation analysis.

Li J, Shi Y, Meng H et al. · 2026 · BMC nephrology

Background The gut-kidney axis is critical in acute kidney injury (AKI) pathophysiology, but its specific characteristics in intensive care unit (ICU) patients remain unclear. This study aimed to investigate compositional and functional…

View details →DOI: 10.1186/s12882-026-05134-2
Negative / Null Result ReportOpen accessMedicine

Effects of Defatted Black Soldier Fly (<i>Hermetia illucens</i>) Meal on the Performance, Digestibility and Blood Parameters of Weaned Piglets.

Parreiras M, Pinheiro V, Moreira O et al. · 2026 · Animals : an open access journal from MDPI

This study investigated the effects of different inclusion levels of defatted black soldier fly ( Hermetia illucens : BSF) larval meal on growth performance, haematological and biochemical blood parameters, and nutrient digestibility in…

View details →DOI: 10.3390/ani16111571
Negative / Null Result ReportMedicine

Relationships between morphological score changes during embryonic development and pregnancy outcomes.

Gan Q, Ma W, Liu L et al. · 2026 · Clinical and experimental reproductive medicine

Objective This study investigated whether changes in embryonic morphological scores can predict pregnancy outcomes to support optimal blastocyst selection. Methods This retrospective dual-center study analyzed 1,492 single blastocyst…

View details →DOI: 10.5653/cerm.2025.08179
Negative / Null Result ReportOpen accessMedicine

Deficit irrigation and grafting effects on soil attributes, vegetative growth, yield components, and quality of 'Crimson Seedless' grapevines under a semiarid region.

Salama AM, Al-Obeed RS, Helmy A et al. · 2026 · Frontiers in plant science

This study evaluated the combined effects of grafting and deficit irrigation (DI) on soil attributes, vegetative growth, yield components, fruit quality, and water productivity of 'Crimson Seedless' grapevines under semiarid conditions. It…

View details →DOI: 10.3389/fpls.2026.1785340
Negative / Null Result ReportOpen accessMedicine

Fiber-to-stone distance and fragment size with holmium laser lithotripsy.

Glienke L, Hall TL, Ghani KR et al. · 2026 · Urolithiasis

Control of fragment size during laser lithotripsy has taken on increasing importance with adoption of ureteroscopic aspiration technologies. The objective of this study was to characterize the relationship between laser-fiber-to-stone…

View details →DOI: 10.1007/s00240-026-01970-x
Negative / Null Result ReportMedicine

Effect of ulnar positive variance on outcomes after arthroscopic transosseous repair of palmer 1B TFCC foveal tears.

Won JH, Shin JW, Kwon J et al. · 2026 · Journal of orthopaedic surgery and research

Purpose To determine whether ulnar positive variance (UPV) and relative ulnar positive variance (RUPV) affect clinical outcomes following arthroscopic transosseous repair of triangular fibrocartilage complex (TFCC) foveal tears. Methods…

View details →DOI: 10.1186/s13018-026-07010-z
Negative / Null Result ReportMedicine

Influence of surface treatment and cement type on the bond strength of additively manufactured permanent resin materials.

Diken Türksayar AA, Öztemel N, Yeşil Kurt İB et al. · 2026 · Odontology

This study evaluated the shear bond strength (SBS) of two dual-cure resin cements to a stereolithography-fabricated 3D-printed permanent crown material after various surface pretreatment protocols. Disc-shaped specimens were fabricated…

View details →DOI: 10.1007/s10266-026-01464-7
Negative / Null Result ReportMedicine

Comparison of the efficacy of posterior lumbar interbody fusion and transforaminal lumbar interbody fusion in the treatment of double-level lumbar spondylolisthesis combined with spinal stenosis: a retrospective comparative study.

Ma Z, Luan H, Abulimiti K et al. · 2026 · BMC surgery

Objective To compare the clinical and radiographic outcomes of posterior lumbar interbody fusion (PLIF) and transforaminal lumbar interbody fusion (TLIF) in the treatment of double-level lumbar spondylolisthesis combined with spinal…

View details →DOI: 10.1186/s12893-026-03917-w
Negative / Null Result ReportMedicine

Correlation between swallowing and diaphragmatic functions in stroke patients with hemiplegia: a cross-sectional observational study.

Liu X, Zhao J, Wu Y et al. · 2026 · Scientific reports

Swallowing and diaphragmatic functions share neural regulatory pathways and require synchronous assessment. Patients who have had a stroke are susceptible to many complications, of which dysphagia and diaphragmatic dysfunction are…

View details →DOI: 10.1038/s41598-026-50341-4
Negative / Null Result ReportMedicine

The Effect of Preoperative Tranexamic Acid on Blood Transfusions in Geriatric Hip Fracture Surgery: A Randomized Controlled Trial.

Sullivan M, Perea LL, Bradburn E et al. · 2026 · Journal of orthopaedic trauma

Objectives To evaluate whether preoperative intravenous tranexamic acid (TXA) reduces postoperative blood transfusion rates in geriatric patients undergoing operative treatment for hip fracture. Methods Design Prospective, double-blinded,…

View details →DOI: 10.1097/bot.0000000000003172
Negative / Null Result ReportOpen accessMedicine

A comparative study of clinical efficacy, electrophysiological outcomes, and perioperative parameters between endoscopic carpal tunnel release and open carpal tunnel release for carpal tunnel syndrome.

Zhang Z, Liu Y, Yang H et al. · 2026 · Frontiers in cellular neuroscience

Purpose To compare the clinical efficacy of endoscopic (ECTR) and open (OCTR) carpal tunnel release for carpal tunnel syndrome (CTS) and provide evidence-based surgical guidance. Methods A retrospective cohort study was conducted including…

View details →DOI: 10.3389/fncel.2026.1845917
Negative / Null Result ReportOpen accessMedicine

Comparison of the Bond Strength of Silane-Treated Glass Fiber Posts at Different Solvent Evaporation Times: An In Vitro Study.

Ramos-Ramos V, Dextre-Herrera S, Ramírez-Vargas G et al. · 2026 · Journal of clinical and experimental dentistry

Background Silane is used as a coupling agent on glass fiber posts to enhance chemical interaction at the post-resin cement interface. This in vitro study evaluated the bond strength of silane-treated glass fiber posts at different solvent…

View details →DOI: 10.4317/jced.63939
Negative / Null Result ReportOpen accessMedicine

Association of central α-klotho with dopaminergic and melanocortin receptors on feed intake regulation in chicken.

Hassania Y, Hassanpour S, Zendehdel M et al. · 2026 · Poultry science

This study aimed to detemine association of central α-klotho with dopaminergic and melanocortin receptors on feed intake regulation in chicken. 264 meat-type chicken were included 6 experiments, each containing 4 groups. In experiment 1,…

View details →DOI: 10.1016/j.psj.2026.107042
Negative / Null Result ReportOpen accessMedicine

Association Between Early Childhood Caries and Systemic Inflammatory Profiles: A Retrospective Analysis of Children Undergoing Dental Treatment Under General Anesthesia.

Tez Yaşar BÇ, Çakmak AB, Eberliköse H et al. · 2026 · Children (Basel, Switzerland)

Background/objectives Early childhood caries (ECC) is a chronic inflammatory condition that may impose a systemic burden in pediatric patients. This study aimed to evaluate the association between dental caries severity, classified by dmft…

View details →DOI: 10.3390/children13050691
Negative / Null Result ReportMedicine

Impact of primary tumor SUVmax on PET accuracy in mediastinal lymph node staging of non-small cell lung cancer (NSCLC).

Kużdżał A, Gambuś K, Moszczyński K et al. · 2026 · Advances in clinical and experimental medicine : official organ Wroclaw Medical University

Background Positron emission tomography (PET) using 18-fluorodeoxyglucose (18-FDG) is the primary imaging modality for mediastinal staging of lung cancer. Higher standardized uptake value (SUVmax) reportedly correlates with more aggressive…

View details →DOI: 10.17219/acem/210368
Negative / Null Result ReportMedicine

Innovative competency-based education approach to radiology residency: integrating modular training in clinical practice and research.

Wan S, Ye L, Yang X et al. · 2026 · Insights into imaging

Objectives This study aimed to design and evaluate a competency-based education (CBE)-oriented modular training model for radiology residents, emphasizing interdisciplinary integration and disease-focused instruction to enhance clinical…

View details →DOI: 10.1186/s13244-026-02335-z
Negative / Null Result ReportMedicine

The Effect of Sleep Environment on Sleep Quality and Behavior in Firefighters: A Cross-Sectional Study.

Zera JN, Esper E, Simonson AP et al. · 2026 · International journal of environmental research and public health

Firefighters face high-stress occupational demands and irregular shift work that negatively impact sleep quality, which is intrinsically linked to long-term physical and psychological health. This cross-sectional study examines how the…

View details →DOI: 10.3390/ijerph23060692
Negative / Null Result ReportOpen accessMedicine

Tinnitus, temporomandibular disorders and muscle activity: what's the connection?

Çoban E, Altay B, Ulucan MÇ et al. · 2026 · Brazilian oral research

This study was aimed at comparatively evaluating the relationship between temporomandibular disorder (TMD) and subjective tinnitus, as well as the effects of TMD treatment on masticatory muscle activity, tinnitus symptoms, and patient…

View details →DOI: 10.1590/1807-3107bor-2026.vol40.037
Negative / Null Result Report

The Impact of Pregnant Women’s Dietary Behavior on the Physiological Adaptation Paradox and Maternal-Fetal Resource Conflict in Conflict Settings: A Predictive Analytical Study

Al-Wesabi MM, Eskander NA · 2026 · Preprint

This scientific study aims to assess the level of awareness, nutritional knowledge, and actual behavioral practices among pregnant women in the Capital District of Sana’a, Republic of Yemen, and to determine their impact on the health and…

View details →DOI: 10.64898/2026.06.17.26355845