Negative / Null Result ReportOpen accessPlant culture
Gy. Horváth, A. Farkas, Gy. L. Szabó · 2004 · International Journal of Horticultural Science
The presence of phloretin-glycosides in the hypanthium and pistil of apple and pear flowers can be verified. Thin layer chromatography is a reliable method for detecting phloretin, gained by acidic hydrolysis. The dominance of phloretin was equally characteristic for flowers in apple (`Sampion', 'Freedom') and pear (Tem-re Bosc', 'Conference') cultivars treated with various bioregulators (Biomit, Bion 50WG, Regalis), no significant difference could be found visually as compared to control samples. Chlorogenic acid and caffeic acid was detected in all apple and pear samples, rutin was present o
View details →DOI: 10.31421/ijhs/10/2/459 Negative / Null Result ReportOpen accessScience
Sang-Suk Choi, Jin Jung, Sung-Ho Her et al. · 2023 · Life
(1) Background: Moderate-intensity statin therapy, when compared to high-intensity statin therapy in Asian populations, has shown no significant difference in cardiovascular prognosis in small studies. The aim of this study was to compare the prognosis of patients based on statin intensity following rotational atherectomy (RA) during high-complexity percutaneous coronary intervention (PCI). (2) Methods: The ROCK registry, a multicenter retrospective study, included patients who had undergone rotational atherectomy (RA) during percutaneous coronary intervention (PCI) at nine tertiary medical ce
View details →DOI: 10.3390/life13112232 Negative / Null Result ReportOpen accessMedicine
LU Yongping, PAN Tingfang · 2025 · Jichu yixue yu linchuang
In order to cultivate interdisciplinary innovative medical talents who can adapt to the development of the needs of national medical care and of global file of medical education, Peking Union Medical College has initiated the project of the “4+4” model, which covers a series of education remodeling like candidate trainees’ enrollment, curriculum integration application of new teaching methods, assessment and evaluation, etc., and has made a great progress. The existing evaluation data show that there is no significant difference between the academic performance of students in the “4+4” trainin
View details →DOI: 10.16352/j.issn.1001-6325.2025.04.0551 Negative / Null Result ReportOpen accessMedicine
Seyed Mohammadreza Fatemi Khorasgani, Neda Ramezani, Negar Ebrahimi Varnousfaderani · 2020 · Journal of Research in Medical Sciences
Background: Previous studies report an association between joint hypermobility (JH), as a hallmark of connective tissue disorder, and autonomic dysfunction, digestive problems, and irritable bowel syndrome. However, its association with functional constipation (FC) has not been evaluated. This study is run and implemented to justify this theme/topic. Materials and Methods: In this case–control study among 200 subjects, 100 were of FC according to the ROME III Criteria (case group) and each child was matched for age and gender with a healthy control that did not meet criteria for FC (control gr
View details →DOI: 10.4103/jrms.jrms_881_19 Negative / Null Result ReportMedicine
Diamantino GML, Beeler-Marfisi J, Foster RA et al. · 2026 · Veterinary pathology
The objective of this study was to evaluate the effect of different fixatives and demineralizers on immunohistochemical (IHC) detection of antigens in bone marrow (BM). Sternal BM samples were collected within 24 hours of death from dogs…
View details →DOI: 10.1177/03009858261426547 Negative / Null Result ReportMedicine
Xu P, Li Y, Chen Y et al. · 2026 · Children (Basel, Switzerland)
Background Moderate-to-severe preterm brain injury (PBI), including intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL), remains an important cause of adverse neurodevelopmental outcomes in preterm infants. Early risk…
View details →DOI: 10.3390/children13060796 Negative / Null Result ReportMedicine
Pratt AS, Ramos MN, Peña ED et al. · 2026 · Journal of speech, language, and hearing research : JSLHR
Purpose This study attempts to discriminate developmental language disorder (DLD) in bilinguals using only the child's second language (L2), English. We grouped bilinguals by their current weekly language experience (high English…
View details →DOI: 10.1044/2025_jslhr-24-00606 Negative / Null Result ReportMedicine
Wade ML, Litvak MK · 2026 · Zebrafish
Cryopreservation enables the long-term storage of viable biological material at ultra-low temperatures and forms the foundation for germplasm cryobanks that maintain valuable genetic lines of model organisms such as zebrafish ( Danio rerio…
View details →DOI: 10.1177/15458547261441744 Negative / Null Result ReportMedicine
Xu J, Ashebir YA, Shao Y · 2026 · Genes
Background: The dual agonism of glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) becomes a groundbreaking treatment for type 2 diabetes (T2D) that achieves robust glycemic control…
View details →DOI: 10.3390/genes17060602 Negative / Null Result Report
Nguyen Van H, Vu Dang L, Nguyen The A et al. · 2026 · Preprint
Objectives: Histologic grade is an important prognostic factor in hepatocellular carcinoma (HCC). Gd-EOB-DTPA-enhanced MRI may provide noninvasive im-aging markers related to tumour differentiation. This study aimed to evaluate the…
View details →DOI: 10.20944/preprints202605.0460.v1 Negative / Null Result ReportMedicine
Shi Y, Li S, He L et al. · 2026 · Annals of clinical microbiology and antimicrobials
Background In this study, we aimed to evaluate the performance of different tigecycline susceptibility testing methods for CRKP and CRAB using the broth microdilution (BMD) method as the gold standard, under different breakpoint criteria.…
View details →DOI: 10.1186/s12941-026-00869-0 Methods Dead-End
Hossain D, Abir FA, Zhang S et al. · 2026 · Preprint
ABSTRACT Despite major advances in computational antibody engineering, no systematic comparison of modern open-source LLM backbone families for antibody sequence generation exists, nor is it known whether architectural differences matter…
View details →DOI: 10.64898/2026.04.18.716776 Negative / Null Result ReportMedicine
Ramos MN, Bedore LM, Peña ED · 2026 · American journal of speech-language pathology
Purpose This study examines the diagnostic accuracy of four measures derived from English narrative language samples for identifying developmental language disorder (DLD) in 5- and 6-year-old Spanish-English bilinguals. Method Ninety-two…
View details →DOI: 10.1044/2025_ajslp-25-00182 Failed Experiment ReportMedicine
Dowling EW, Sloman KN, McGarry KM et al. · 2026 · Journal of applied behavior analysis
Previous research on the relation between heart rate patterns and severe behavior has yielded mixed findings. Specifically, some studies have identified distinct heart rate patterns surrounding challenging behavior, whereas others have…
View details →DOI: 10.1002/jaba.70072 Abandoned HypothesisMedicine
Calabrese EJ · 2026 · Chemico-biological interactions
This paper evaluates the final major research effort of Hermann J. Muller, Nobel Laureate, to assess whether radiation displays a dose-rate process for radiation-induced germ cell mutation. Muller tried to extend the dose-rate findings of…
View details →DOI: 10.1016/j.cbi.2026.112074 Negative / Null Result ReportMedicine
Blanco-Moreno C, Bippus AC, Tomescu AMF · 2026 · Annals of botany
Background and aims The bryophyte fossil record is less abundant and diverse than predicted by the age of the group and as compared to the fossil record of younger plant groups. Taphonomic biases explain only partially its scarcity. Here,…
View details →DOI: 10.1093/aob/mcaf070 Abandoned HypothesisOpen accessMedicine
Ghosh AK, Bhattacharjee A, Jayashankar U et al. · 2026 · Organic & biomolecular chemistry
We have investigated diastereoselective Ugi-multicomponent reactions (Ugi-MCR) relevant to bis-amide scaffolds related to SARS-CoV-2 main protease (Mpro) inhibitors. The studies were mainly focussed on development of diastereoselective…
View details →DOI: 10.1039/d5ob01897h Abandoned Hypothesis
khoiriyah z, Pandin MGR · 2026 · Preprint
Abstract Indonesia faces a persistent labor market paradox wherein rapid expansions in formal educational attainment have not yielded a proportional decline in educated unemployment. This mini literature review synthesizes five…
View details →DOI: 10.21203/rs.3.rs-9997028/v1 Methods Dead-End
Upreti A, Shonkwiler K, Riddick SN et al. · 2026 · Preprint
Methane (CH4) is a major component of natural gas and a potent greenhouse gas. Increasing atmospheric methane concentrations are attributed to emissive anthropogenic activities by an average of 13 ppb per yr since 2020 and are linked to a…
View details →DOI: 10.20944/preprints202603.0217.v1 Negative / Null Result ReportMedicine
Ashouri R, Reynolds PS, Rajavel S et al. · 2026 · Urology
Objective To guide biopsy decision making via a predictive model for clinically significant prostate cancer (csPCa) in men with positive imaging (PI-RADS 3-5). We aim to elucidate the influence of zone on the predictive accuracy of PI-RADS…
View details →DOI: 10.1016/j.urology.2026.01.028 Negative / Null Result ReportOpen accessMedicine
Christianson G, Howard ZM, Kenney S et al. · 2026 · mAbs
The use of animal models that can reliably predict drug performance in human patients is critical to antibody therapeutic development. Along with assessing toxicity and efficacy, determining the pharmacokinetic (PK) properties of…
View details →DOI: 10.1080/19420862.2026.2649990 Negative / Null Result ReportMedicine
Lutfi W, Desai ND, Pan Z et al. · 2026 · The Annals of thoracic surgery
Background The choice between bioprosthetic or mechanical surgical aortic valve replacement (SAVR) for dialysis patients is debated. Rapid adoption of transcatheter aortic valve replacement (TAVR) complicates decision-making further. This…
View details →DOI: 10.1016/j.athoracsur.2026.03.007 Negative / Null Result Report
Keskinel I, Eryilmaz M, Diktas Tahtasakal S · 2026 · Preprint
Objectives: Streptococcus pneumoniae is a major respiratory pathogen. Reports during the COVID-19 era suggest decreased pneumococcal activity. This study aimed to assess the frequency of S. pneumoniae in adult sputum cultures and its…
View details →DOI: 10.20944/preprints202606.0633.v1 Negative / Null Result ReportMedicine
Akmansoy ŞC, Kahramanoğlu E · 2026 · Journal of oral science
Purpose This study compares the marginal and internal gaps for four restorative materials produced by two fabrication methods in both minimally invasive occlusal veneer and conventional onlay cavities. Methods Eighty mandibular molars…
View details →DOI: 10.2334/josnusd.25-0348 Negative / Null Result ReportMedicine
Xie J, Song Z, Fang W et al. · 2026 · Naunyn-Schmiedeberg's archives of pharmacology
This study aimed to elucidate the potential molecular mechanisms by which artificial sweeteners contribute to the initiation and progression of atherosclerosis, with the goal of providing a theoretical basis for the safety evaluation of…
View details →DOI: 10.1007/s00210-026-05241-9 Negative / Null Result ReportMedicine
Robinson E, Chapman C, Orchard F et al. · 2026 · Journal of child and adolescent mental health
Background: Exposure of children and young people to potentially traumatic events is common. There is a need for increased access to early interventions following a potentially traumatic event. Objective: This review aimed to identify…
View details →DOI: 10.2989/17280583.2025.2581754 Failed Experiment Report
Leinbach D, Burcham DC, Kane B · 2026 · Preprint
Trees are routinely pruned to mitigate the risk of wind damage, but there are few studies examining changes in wind loads after pruning, especially for large conifers. In this study, ten Colorado spruces ( Picea pungens ) were monitored…
View details →DOI: 10.64898/2026.06.11.731663 Negative / Null Result Report
Ross SR, Suzuki H, Urabe J et al. · 2026 · Preprint
1 Ecosystem functioning can be maintained in species-rich communities even under fairly severe perturbations. This is because communities with high richness include variation both in species’ functional roles ( functional diversity ) and…
View details →DOI: 10.64898/2026.06.19.733370 Abandoned HypothesisMedicine
AlTahan FA, AlHadlag A · 2026 · Ocular immunology and inflammation
Purpose To report the first documented case of postoperative endophthalmitis progressing to panophthalmitis in a silicone oil-filled eye (SO) following pars plana vitrectomy (PPV), and to review the relevant literature. Methods A single…
View details →DOI: 10.1080/09273948.2026.2681735 Abandoned HypothesisMedicine
Fan J, Zeng J, Li H · 2026 · Research in developmental disabilities
Background/aims Children with autism spectrum disorder (ASD) often experience conversational difficulties that hinder social interactions and peer relationships. This study examined whether a conversational AI-enhanced peer-mediated…
View details →DOI: 10.1016/j.ridd.2026.105249 