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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 491 of 676

Negative / Null Result Report

P–212 Mitochondrial DNA content shows a significant association with timing of human embryo development and fertility diagnosis in euploid embryos

C Hur, V Nanavaty, A Chehab et al. · 2021 · Human Reproduction

Abstract Study question Does mitochondrial DNA content (mtDNA) correlate with clinical parameters and embryo morphokinetics using advanced time-lapse technology? Summary answer mtDNA correlated with embryo morphokinetics and the growth…

View details →DOI: 10.1093/humrep/deab130.211
Negative / Null Result Report

No significant association between term premature rupture of membranes and neonatal APGAR score: A cross-sectional study

Shelvy Era Chintia, Henidekasari, Veronica Ela Rimawati et al. · 2025 · Jurnal Ilmiah Kesehatan Sandi Husada

Introduction: Premature rupture of membranes (PROM) is defined as the rupture of the amniotic sac before the onset of labor, potentially increasing the risk of infection, hypoxia, and a low APGAR score in newborns. The APGAR score assesses…

View details →DOI: 10.35816/jiksh.v14i2.269
Negative / Null Result Report

No significant association between term premature rupture of membranes and neonatal APGAR score: A cross-sectional study

Shelvy Era Chintia, Henidekasari Henidekasari, Veronica Ela Rimawati et al. · 2025 · Jurnal Ilmiah Kesehatan Sandi Husada

Introduction: Premature rupture of membranes (PROM) is defined as the rupture of the amniotic sac before the onset of labor, potentially increasing the risk of infection, hypoxia, and a low APGAR score in newborns. The APGAR score assesses…

View details →DOI: 10.35816/jiskh.v14i2.1293
Negative / Null Result Report

Lack of Association between Cholelithiasis and Significant Coronary Artery Disease: An Autopsy Study from Greece

Christos Soutis, Chara Spiliopoulou, Nikolaos Goutas et al. · 2022 · Journal of Advances in Medicine and Medical Research

Aims: Cholelithiasis or Gallstone disease and coronary artery disease have been reported to share several common risk factors. The aim of this study was to examine if there is an association between coronary artery disease (CAD) and…

View details →DOI: 10.9734/jammr/2022/v34i2031472
Negative / Null Result Report

Significant association of specific DRB1 & DQB1 sequence feature variant types with systemic sclerosis autoantibodies types and racial groups (159.20)

Richard Scheuermann, Nishanth Marthandan, Paula Guidry et al. · 2012 · The Journal of Immunology

Abstract The sequence feature variant type (SFVT) approach to genetic association analysis has previously identified parts of HLA proteins that are associated with development of a variety of autoimmune diseases. Using the SFVT approach,…

View details →DOI: 10.4049/jimmunol.188.supp.159.20
Negative / Null Result Report

A200 HIGH-DEFINITION CHROMOENDOSCOPY RESULTS IN MORE SIGNIFICANT DYSPLASIA DETECTION THAN WHITE LIGHT ENDOSCOPY WITH RANDOM BIOPSIES IN ULCERATIVE COLITIS PATIENTS

T T Hoang, Y Leung, G Rosenfeld et al. · 2023 · Journal of the Canadian Association of Gastroenterology

Abstract Background Ulcerative colitis (UC) is an inflammatory bowel disease that results in inflammation of the colonic mucosa, leading to abdominal pain, rectal bleeding, weight loss, and diarrhea. This chronic inflammation results in a…

View details →DOI: 10.1093/jcag/gwac036.200
Negative / Null Result Report

Significant Factors Affecting the Outcome in Emergency Open Surgery for Perforated Peptic Ulcer

Md Shahidul Islam, Md Sohel Aktar, Md Nur Islam Dewan et al. · 2026 · TAJ: Journal of Teachers Association

Background: Perforated peptic ulcer remains a life-threatening surgical emergency, with outcomes strongly influenced by patient-related, disease-related, and perioperative factors despite advances in medical therapy. Objective: To identify…

View details →DOI: 10.70818/taj.v39i01.0578
Negative / Null Result Report

Role of Carotid Intima-Media Thickness and Carotid Plaque in Predicting Significant Coronary Artery Stenosis in Thai Patients with Chronic Coronary Syndrome: A Cross-Sectional Study

· 2022 · Journal of the Medical Association of Thailand

Objective: To evaluate the diagnostic role of carotid artery intima-media thickness and plaque for significant coronary artery disease (CAD) in Thai patients with chronic coronary syndrome (CCS) when coronary angiography (CAG) was…

View details →DOI: 10.35755/jmedassocthai.2022.11.13693
Negative / Null Result Report

Heparinized venous blood gas syringes are associated with a significant decrease in measured packed cell volume in dogs due to hemodilution

Coyne M. Hopey, Dana Caldwell, Erin Binagia et al. · 2025 · Journal of the American Veterinary Medical Association

Abstract OBJECTIVE To assess the effect of hemodilution on PCV when commercial preheparinized venous blood gas (PH-VBG) syringes are used compared to directly filled Hct tubes, and to evaluate the impact of delayed centrifugation on PCV.…

View details →DOI: 10.2460/javma.24.11.0718
Negative / Null Result Report

Allergies, asthma treatment, and eviction diet have a significant impact on the respiratory effort during sleep and the apnea-hypopnea index in children with obstructive sleep apnea-obesity/asthma association: A STROBE-compliant study

Kalomoira Kefala, Philippe Guerin · 2026 · Medicine

The pathophysiological mechanisms implicated in obstructive sleep apnea (OSA) associated with asthma/allergies remain unclear. Apnea-hypopnea index (AHI) alone is insufficient to accurately guide adequate treatment without identifying the…

View details →DOI: 10.1097/md.0000000000041730
Negative / Null Result Report

Traduttore, traditore: can machines outperform humans in translation accuracy?

Felipe Von Hausen, Cristóbal Muñoz, Carlos Contreras · 2024 · Lengua y Sociedad

Este estudo examina a eficácia e precisão da Tradução Automática (TA) em comparação com a Tradução Humana (TH), empregando a métrica de Avaliação Bilíngue Sob Estudo (BLEU) para avaliação. O campo rapidamente evolutivo da tradução de…

View details →DOI: 10.15381/lengsoc.v23i2.26968
Negative / Null Result Report

Cyber defence automation: Can AI outperform hackers?

Vitalii Yasenenko · 2025 · Technologies and Engineering

Growing cyber threats in the context of digital transformation require improved methods of automating cyber defence, in particular, through the use of artificial intelligence to detect and respond to attacks. The purpose of the study was…

View details →DOI: 10.30857/2786-5371.2025.3.7
Negative / Null Result Report

Can Artificial Intelligence Outperform Humans in ETF Management?

Sahana Ganesan · 2024 · Journal of Student Research

‘Exchange Traded Funds’ (ETFs) are basket/bundle funds consisting of a portfolio of stock assets from multiple companies and organizations, traded similar to normal stocks. ETFs help with diversification of the investment, risk management…

View details →DOI: 10.47611/jsrhs.v13i3.6946
Negative / Null Result Report

Human therapists outperform AI therapists in delivering CBT

Valerie A. Canady · 2025 · Mental Health Weekly

An AI therapist cannot replicate the nuanced empathy and therapeutic alliance of human therapists when delivering cognitive behavioral therapy (CBT), concluded researchers of a new study presented during the American Psychiatric…

View details →DOI: 10.1002/mhw.34464
Negative / Null Result Report

(Un)Sustainable Development: Do Democracies Outperform Autocracies?

Leonel Prieto, Arman Canatay, Muhammad R. Amin · 2025 · Sustainable Development

ABSTRACT Political regimes significantly determine the ability of nations to develop in one way or another. The current crisis of democracy has prompted the following question: to what degree does democracy deliver? To answer this…

View details →DOI: 10.1002/sd.70228
Negative / Null Result Report

A Baldrige Portfolio: Does Quality Outperform The Market?

John A. Helmuth, Hei-Wai Lee · 2011 · International Business & Economics Research Journal (IBER)

This paper investigates the claim, by the Department of Commerce, that a portfolio of Baldrige National Quality Award winners outperforms the market. They find that there is a 92 percent return for Baldrige winners as compared to a 33…

View details →DOI: 10.19030/iber.v1i4.3909
Negative / Null Result ReportMedicine

The effect of different deproteinization agents and thermal cycling on the shear bond strength of fissure sealants: an in vitro study.

Tatar, Coşgun · 2026 · BMC oral health

BACKGROUND: Enamel pretreatment with a deproteinization agent enhances fissure sealant bonding. This in vitro study investigates the effect of surface preparation methods and thermal cycling on the shear bond strength of fissure sealants…

View details →DOI: 10.1186/s12903-026-08167-z
Negative / Null Result Report

Later-generation epigenetic aging clocks outperform first-generation models in predicting survival in TCGA breast cancer

Xianglong Tan, Matteo Pellegrini, Su Yon Jung · 2026 · Clinical Epigenetics

Abstract Background Epigenetic aging bridges the gap between biological and chronological age by exploiting DNA methylation (DNAm) patterns. Over the past decade, successive DNAm-based clocks have been introduced, beginning with the…

View details →DOI: 10.1186/s13148-026-02102-3
Negative / Null Result ReportMedicine

Macrophage-enriched GPR91 aggravates acute liver injury by inhibiting efferocytosis via the AC/cAMP/PPARγ pathway.

Qiu, Hu, Guo et al. · 2026 · Metabolism: clinical and experimental

Acute liver injury is a common precipitating factor in the progression of various liver diseases including liver failure, underscoring the urgent need to identify novel therapeutic targets. G-protein coupled receptors (GPCRs) are widely…

View details →DOI: 10.1016/j.metabol.2026.156684