e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 488 of 676

Negative / Null Result ReportOpen accessMedicine

Effect of diode laser biostimulation on implant stability, post-surgical inflammation, and bone healing in immediate implant in the maxillary premolars. A randomized double-blind trial.

Kassem BA, Osman SM, El-Mahallawy Y · 2026 · Clinical oral investigations

INTRODUCTION: The stimulatory effects of laser Biostimulation on immediate implant clinical wound healing and radiographic bone quality analysis is with insufficient evidence. AIM: To evaluate the effect of low-level diode laser as a…

View details →DOI: 10.1007/s00784-026-06847-2
Negative / Null Result ReportOpen accessMedicine

Clinical characteristics and prognostic differences between elderly-onset and adult-onset ulcerative colitis: a two-center retrospective cohort study.

Li H, Ding S, Li J et al. · 2026 · Frontiers in medicine

Background The incidence of elderly-onset ulcerative colitis (EO-UC) has been gradually increasing. The unique characteristics of clinical manifestations, therapeutic strategies, and prognosis in EO-UC patients compared with adult-onset…

View details →DOI: 10.3389/fmed.2026.1847513
Negative / Null Result ReportMedicine

[Mechanism of vitamin K2 in modulating matrix Gla protein to inhibit tumor growth in inflammation-associated colorectal cancer model mice].

Zhang HM, Wu MX, Wang HY et al. · 2026 · Zhonghua yi xue za zhi

Objective: To explore the mechanism of vitamin K2 (VitK2) regulating matrix Gla protein (MGP) in inhibiting tumor growth in inflammation-associated colorectal cancer (CAC) model mice. Methods: Twenty-six C57BL/6 male mice, 6-8 weeks old…

View details →DOI: 10.3760/cma.j.cn112137-20250708-01661
Negative / Null Result ReportOpen accessMedicine

Effectiveness of prophylactic single-dose IV antibiotic versus postoperative multi-dose oral antibiotic regimen for preventing surgical site infections: A prospective comparative study.

Pusdekar VP, Dare G, Bhojwani P et al. · 2026 · Turkish journal of surgery

Objective Surgical site infections (SSIs) are among the most common postoperative complications, contributing to morbidity, prolonged hospital stays, and healthcare costs. Prophylactic antibiotics are widely used, but the optimal regimen…

View details →DOI: 10.47717/turkjsurg.2026.2025-9-30
Negative / Null Result ReportMedicine

The effects of repetitive transcranial magnetic stimulation over the lateral parietal region on episodic future thinking and episodic memory.

Toufexis C, Grant JB, van Boxtel JJA et al. · 2026 · Consciousness and cognition

The left angular gyrus (AG) has been implicated in the level of detail elicited during both episodic memory (EM) and episodic future thinking (EFT). This study aimed to investigate whether repetitive transcranial magnetic stimulation…

View details →DOI: 10.1016/j.concog.2026.104070
Negative / Null Result ReportOpen accessMedicine

Radiation Countermeasure Gamma-Tocotrienol Inhibits Accumulation of Lipid Peroxidation Products in the Serum of Nonhuman Primates Exposed to Partial- or Total-Body Radiation-A Hallmark of Inhibition of Irradiation-Induced Ferroptosis?

Brzóska K, Carpenter AD, Petrus SA et al. · 2026 · International journal of molecular sciences

Gamma-tocotrienol (GT3) is one of the constituents of vitamin E that demonstrated significant radioprotective efficacy in murine and nonhuman primate (NHP) models. Considering the antioxidant activity of GT3 and its role in terminating…

View details →DOI: 10.3390/ijms27083387
Negative / Null Result ReportMedicine

Treatment Outcomes in Frail Patients with Advanced Pancreatic Ductal Adenocarcinoma: A Real-World Comparison of Gemcitabine, S-1, and Stereotactic Ablative Radiotherapy.

Kim CH, Kim EJ, Lee TS et al. · 2026 · Oncology

Background Elderly patients or those with poor performance status are underrepresented in clinical trials of pancreatic ductal adenocarcinoma (PDAC), and optimal treatment strategies for this frail population remain unclear. In real-world…

View details →DOI: 10.1159/000552276
Negative / Null Result ReportMedicine

The outcome of pulp revascularization of necrotic mature permanent teeth with periapical lesions using platelet-rich fibrin versus induced bleeding: a prospective preliminary randomized clinical trial.

Awawdeh L, Almesleh B, Hammouri H et al. · 2026 · Clinical oral investigations

Objectives The present study evaluated clinically and radiographically the effectiveness of Regenerative endodontic procedures (REPs) using platelet-rich fibrin (PRF) versus induced bleeding (IB) in treating mature necrotic teeth.…

View details →DOI: 10.1007/s00784-026-06877-w
Negative / Null Result ReportOpen accessMedicine

Effects of acute high-intensity exercise on heart rate variability following rapid weight loss in elite wrestlers.

Yıldırım Y, Arabacı R, Rodoplu C et al. · 2026 · Scientific reports

Investigating how the autonomic functions of the heart are affected during rapid weight loss practices is extremely important for athletes’ health. This study aimed to investigate how rapid weight loss (3–5%) affects heart rate variability…

View details →DOI: 10.1038/s41598-026-38394-x
Negative / Null Result ReportOpen accessMedicine

Clinical Microbial Contamination of Multidose Brimonidine: A Prospective Comparison of Benzalkonium Chloride and Purite® Preservatives.

Karaca S, Yilmaz OF, Sarmis A et al. · 2026 · Journal of ophthalmology

Objective To compare microbial contamination between multidose brimonidine eye drops preserved with benzalkonium chloride (BAK-MDB) and multidose brimonidine eye drops preserved with Purite® (PUR-MDB) using a comparative approach on the…

View details →DOI: 10.1155/joph/2867565
Negative / Null Result ReportOpen accessMedicine

Effect of Universal Adhesives on Resin Cement-Fiber Post-Core Materials.

Irie M, Okada M, Maruo Y et al. · 2026 · Polymers

This study evaluated eleven resin cements used as core build-up materials by examining the following properties: (a) push-out force between root dentin and the fiber post; (b) pull-out force between the fiber post and the core build-up…

View details →DOI: 10.3390/polym18070810
Negative / Null Result ReportMedicine

Ultrasound-Guided Transperineal Versus Transrectal Prostate Aspiration Biopsy in Diagnosing Prostate Cancer: An Observational Comparison Study.

Cao Y, Zhu H, Wu J · 2026 · Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

Background Ultrasound-guided prostate biopsy is the standard method for the diagnosis of prostate cancer. However, the effect of the optimal puncture approach on diagnostic yield and patient outcomes remains controversial. Objective To…

View details →DOI: 10.1002/jum.70255
Negative / Null Result ReportMedicine

Nirmatrelvir-Ritonavir Versus Short-Course Remdesivir for Mild COVID-19 in High-Risk Hospitalized Patients: A Propensity Score-Matched Study.

Steuber TD, Belk M, Thayer B et al. · 2026 · The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians

Background: As coronavirus disease 2019 (COVID-19) has evolved, patients increasingly present with milder disease, raising questions about optimal management of those hospitalized for other conditions, but found to have COVID-19 with high…

View details →DOI: 10.1177/87551225261436716
Negative / Null Result ReportOpen accessMedicine

First- Versus Second- or Subsequent-Line Use of Cyclin-Dependent Kinase 4/6 Inhibitors for Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Metastatic or Recurrent Breast Cancer: A Multicenter, Retrospective Cohort Study.

Yao S, Imoto S, Tsuchiya A et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy are recommended as first- or second-line treatment for hormone receptor (HR)-positive, human epidermal growth factor receptor 2…

View details →DOI: 10.3390/medicina62040661
Negative / Null Result ReportMedicine

Similar Strength and Hypertrophic Adaptations in Less Time? Myo-Reps vs. Traditional Straight-Sets in Resistance-Trained Men.

Bradshaw JT, Sanzo K, Barakat C et al. · 2026 · Journal of strength and conditioning research

Abstract Bradshaw, JT, Sanzo, K, Barakat, C, Barshun, A, Inglima, S, Gotla, T, Thompson, BK, De Souza, EO, and Walters, JA. Similar strength and hypertrophic adaptations in less time? Myo-reps vs. traditional straight-sets in…

View details →DOI: 10.1519/jsc.0000000000005388
Negative / Null Result ReportOpen accessMedicine

Effect of output intensity of light curing unit on coronal tooth discoloration induced by silicate calcium-based materials: an ex vivo study.

Farshad F, Shokouhinejad N, Pedram P et al. · 2026 · Biomaterial investigations in dentistry

Objective Clinicians have various curing options due to new light-cure devices with different intensities. The present study aimed to evaluate the effect of two light-curing intensities (1,200 mW/cm² vs. 3,000 mW/cm²) on coronal…

View details →DOI: 10.2340/biid.v13.45896
Negative / Null Result ReportOpen accessMedicine

Association Between DOAC Exposure and Lower-Extremity Arterial Calcification: A Propensity-Matched Exploratory CT Study.

Pomozi E, Zatyko DZ, Suhai FI et al. · 2026 · Journal of clinical medicine

Background : Lower limb arterial calcification (LLAC) is a robust imaging biomarker of peripheral artery disease (PAD) severity. Vitamin K antagonists are presumed to accelerate cardiovascular calcification. Direct oral anticoagulants…

View details →DOI: 10.3390/jcm15093399
Negative / Null Result ReportOpen accessMedicine

Impact of Neoadjuvant Chemotherapy on Prognosis of Patients with Mucinous Gastric Adenocarcinoma: A Propensity Score Matching Study.

Lu Y, Zhu D, Shen K et al. · 2026 · Annals of surgical oncology

Background Mucinous gastric adenocarcinoma (MGC) is a rare, aggressive malignancy. This study aimed to explore whether MGC is associated with poorer survival compared with nonmucinous gastric adenocarcinoma (NMGC) and to further…

View details →DOI: 10.1245/s10434-025-19069-9
Negative / Null Result ReportMedicine

Effect of Pharmacological Neuroprotection During Surgical Clipping of Anterior Circulation Intracranial Aneurysm on Neurological Outcome-A Randomized Controlled Study.

Gopalakrishna KN, Chakrabarti D, Bharadwaj S et al. · 2026 · Neurology India

Objective Patients with intracranial aneurysms while undergoing neurosurgical clipping frequently require the use of temporary clip, and this involves the risk of cerebral ischemia. The usual approaches for prevention of such an adverse…

View details →DOI: 10.4103/neurol-india.neurol-india-d-25-00595
Negative / Null Result ReportMedicine

Long-term clinical outcomes of minimally invasive transforaminal lumbar interbody fusion (Mis-TLIF) compared with open TLIF(O-TLIF): A retrospective cohort study for at least 5 years.

Zhu F, Ning Y, Leng X et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

OBJECTIVE: The short-term outcomes of minimally invasive transforaminal lumbar interbody fusion (Mis-TLIF) and Open TLIF (O-TLIF) have been reported in previous studies. However, the long-term clinical outcomes of both procedures have been…

View details →DOI: 10.1007/s00586-026-09824-1
Negative / Null Result ReportOpen accessMedicine

Preoperative Lugol's solution and surgical outcomes in Graves' disease: a single-center retrospective study.

Ünlü MT, Caliskan O, Çetinoğlu I et al. · 2026 · Frontiers in surgery

Introduction Basedow Graves disease (BG) is the most common cause of hyperthyroidism. Lugol's solution (LS) is used preoperatively to inhibit thyroid hormone production, decrease thyroid gland vascularity and ensure a safer surgical field.…

View details →DOI: 10.3389/fsurg.2026.1755477
Negative / Null Result ReportOpen accessMedicine

Does Inguinal TAPP Repair Increase the Rate of Midline Supraumbilical Trocar Site Hernia?-A Single-Center Retrospective Study.

Augustin G, Jeričević K, Bogdanić B · 2026 · Journal of clinical medicine

Background/Objectives : This study aimed to determine the inguinal hernia recurrence rate after transabdominal preperitoneal (TAPP) repair, particularly considering the effect of simultaneous umbilical hernia repair. The secondary aim was…

View details →DOI: 10.3390/jcm15083083
Negative / Null Result ReportMedicine

Clinical characteristics and kidney outcomes in children with posterior urethral valve: a single-center experience.

Inceoğlu S, Uçkardeş D, Göknar N et al. · 2026 · International urology and nephrology

Introduction and aim Posterior urethral valve (PUV) represent a congenital obstructive uropathy, and despite advances in prenatal diagnosis and postnatal management, chronic kidney disease (CKD) develops in nearly 20% of affected patients.…

View details →DOI: 10.1007/s11255-026-05149-6
Negative / Null Result ReportOpen accessMedicine

Evaluating poultry by-product meal, tomato pomace, and azolla with or without Natuzyme supplementation as sustainable alternatives to fish meal for Nile tilapia (Oreochromis niloticus).

Kamel AM, Mahmoud MM, Ibrahim MT et al. · 2026 · Tropical animal health and production

Several studies have predicted that developing countries will be unable to afford fish meal as a primary aquafeed protein source in the future. This experiment evaluated the effect of replacing fish meal (FM) with poultry by-product meal…

View details →DOI: 10.1007/s11250-026-05001-0
Negative / Null Result Report

Body Mass Index and Outcomes in HR+/HER2−Metastatic Breast Cancer Treated with Palbociclib: Insights from a National Real-World Study

Badau LM, Epure P, Margan M et al. · 2026 · Preprint

Background: /Objectives: The prognostic and predictive role of BMI in patients with HR+/HER2– MBC remains controversial, particularly in the era of CDK4/6 inhibitors. This study aimed to evaluate the association between baseline BMI and…

View details →DOI: 10.20944/preprints202604.1156.v1
Negative / Null Result ReportOpen accessMedicine

Monitoring the Adverse Implications of Coronavirus 2019-induced Pulmonary Complications on Patients' Respiratory Capacity and Physical Abilities with Moderate and Severe Signs during Interval Follow-up.

Aali F, Habibi Z, Aali F et al. · 2026 · Journal of medical signals and sensors

Background The respiratory system of individuals with coronavirus 2019 (COVID-19) experiences significant strain due to the body's immunological response and inflammation, leading to organ failure. Over time, patients have improvement in…

View details →DOI: 10.4103/jmss.jmss_15_25