A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19879 results in Negative / Null Result Report · page 486 of 663
Webers C, Been M, van Tubergen A · 2023 · Current opinion in rheumatology
Purpose of review For almost a decade, treat-to-target (T2T) has been advocated as a management strategy for axial spondyloarthritis (axSpA), despite a lack of trial evidence. Recently, the first and only published T2T trial in axSpA did…
Gatto L, Di Nunno V, Tosoni A et al. · 2023 · Cancers
The lack of significant improvement in the prognosis of patients with GB over the last decades highlights the need for innovative treatments aimed at fighting this malignancy and increasing survival outcomes. The results of the phase III…
Sciscione AC, Booker WA, Clifton RG et al. · 2026 · Obstetrics and gynecology
Objective Activity restriction is commonly recommended in pregnancy despite lacking evidence of benefit. We sought to evaluate the amount of physical activity in patients at high risk for preterm birth and pregnancy latency and preterm…
Aparajita, Barmon D, Baruah U et al. · 2025 · World journal of surgical oncology
Background Recent studies have found the presence of post- hysterectomy atypical glandular cells in upper vagina in ~ 30% patients of Endometrial Cancer (EC) with implications of causing isolated vaginal recurrence. The primary objective…
Cai LY, Hoseinyazdi M, Lakhani DA et al. · 2025 · Stroke (Hoboken, N.J.)
Background Recent trials of endovascular thrombectomy (EVT) for acute distal medium vessel occlusions (DMVOs) were negative but also used inconsistent imaging-based inclusion criteria, whereas many successful large vessel occlusion (LVO)…
Mol F, Scheltinga M, Roumen R et al. · 2023 · Neuromodulation : journal of the International Neuromodulation Society
Objectives Approximately 10% of patients who undergo inguinal hernia repair or Pfannenstiel incision develop chronic (> three months) postsurgical inguinal pain (PSIP). If medication or peripheral nerve blocks fail, a neurectomy is the…
Nathan SD, Lacasse V, Bell H et al. · 2024 · Pulmonary circulation
The PERFECT study, a randomized, controlled, double-blind study of inhaled treprostinil in patients with COPD and associated pulmonary hypertension (PH-COPD) was a negative trial that was terminated early. The reason(s) for the negative…
Ghimouz A, Dureau S, Carton M et al. · 2026 · Scientific reports
The value of music (MUS) and virtual reality (VR) in reducing pain or anxiety during central venous port implantation (CVPI) is controversial. We conducted a randomised multicenter controlled trial in 127 patients who received either MUS…
Janeway KA, Chou AJ, Buxton A et al. · 2026 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose Mouse models demonstrate a role for RANK and its ligand, RANKL, in osteosarcoma. The primary objective of this single-arm, open-label phase 2 trial was to determine whether denosumab, a RANKL mAb, improved disease control in…
Savsani PK, Khan SH, Perkins AJ et al. · 2025 · Critical care medicine
Objectives To describe the performance of the Healthy Aging Brain Care Monitor Self Report (HABC-M SR) in assessment of post-intensive care syndrome (PICS) among Acute Respiratory Failure ICU survivors. Design Secondary data analysis of a…
Chaudhari A, Almajali M, Khan N et al. · 2026 · Stroke (Hoboken, N.J.)
Background Endovascular thrombectomy (EVT) has transformed the management of acute ischemic stroke, but remains inaccessible to many patients due to anatomic, clinical, or logistical limitations. Treatment strategies for patients with…
Andersson Y, Løvstakken E, Herud TM et al. · 2025 · Annals of surgical oncology
Background Hyperthermic intraperitoneal chemotherapy (HIPEC) following cytoreductive surgery is a potentially curative treatment for patients with peritoneal metastases. Currently, there is no standardized protocol for performing HIPEC and…
Dubbelman MA, Vromen EM, Tijms BM et al. · 2024 · Alzheimer's & dementia (New York, N. Y.)
With the advent of the first generation of disease-modifying treatments for Alzheimer's disease, it is clearer now more than ever that the field needs to move toward personalized medicine. Pooling data from past trials may help identify…
Scahill L, Shillingsburg MA, Ousley O et al. · 2022 · Journal of the American Academy of Child and Adolescent Psychiatry
Objective To compare Direct Instruction Language for Learning (DI) plus treatment as usual (TAU) with TAU alone in children with autism spectrum disorder and moderate language delay. Method In this study, 83 children (age range, 4 years to…
Bremhorst A, Mills DS, Würbel H et al. · 2022 · Animal cognition
Facial expressions potentially serve as indicators of animal emotions if they are consistently present across situations that (likely) elicit the same emotional state. In a previous study, we used the Dog Facial Action Coding System…
Desai R, Tan F, Wu M et al. · 2026 · Arthritis care & research
Objective Ultrasound (US) has been proposed as a potential tool for assessing skin fibrosis in systemic sclerosis (SSc). However, a large-scale comparison of US-based assessment with histologic markers of skin fibrosis has not been…
Bedlack R, Barkhaus P, Carter G et al. · 2022 · Amyotrophic lateral sclerosis & frontotemporal degeneration
Vitamin C is one of the most common supplements taken by people with ALS. As an antioxidant, it has a plausible mechanism for slowing disease progression and there are some flawed pre-clinical studies and case reports suggesting benefit.…
Aouad K, El-Zorkany B · 2022 · Mediterranean journal of rheumatology
The Treat-to-target (T2T) strategy in axial spondyloarthritis (axSpA) stipulates that treatment should reach a predefined target and if not reached, intensification of therapy is implemented aiming at best future outcomes. Clinical…
Turvill J, Haritakis M, Pygall S et al. · 2026 · Endoscopy international open
Background and study aims During the COVID-19 pandemic the National Health Service introduced colon capsule endoscopy (CCE) as an alternative to colonoscopy in patients awaiting 3-year post-polypectomy surveillance. We determined the…
Pepine CJ, Handberg E, Cooper-DeHoff R et al. · 2026 · Open heart
Importance Women with angina due to suspected ischaemia referred for coronary angiography often have no obstructive coronary artery disease (ANOCA/INOCA). Objective To determine if intensive medical treatment (IMT) reduces major ischaemic…
Chalak LF, Kang S, Kota S et al. · 2023 · Early human development
Background There is a critical need for development of physiological biomarkers in infants with birth asphyxia to identify the physiologic response to therapies in real time. This is an ancillary single site study of the High-Dose…
Mudugal D, Monteith TS · 2021 · Expert review of neurotherapeutics
Introduction : Cluster headache [CH] is a severely disabling trigeminal autonomic cephalalgia [TAC]. Approximately 1 in 1,000 adults are affected by CH. Calcitonin gene-related peptide [CGRP] is an important mediator in the pathophysiology…
Figueroa-Parra G, Putman MS, Crowson CS et al. · 2024 · Lupus science & medicine
Objective We aimed to evaluate the robustness of phase III randomised controlled trials (RCTs) for SLE and lupus nephritis (LN) using the fragility index (FI), the reverse FI (RFI) and the fragility quotient (FQ). Methods We searched for…
Li S, Mahr C, Kataria R et al. · 2026 · JACC. Advances
Background Landmark randomized controlled trials like DanGer Shock, IABP-SHOCK II, and ECLS-SHOCK guide infarct-related cardiogenic shock (CS) management with temporary mechanical circulatory support (tMCS), but strict enrollment criteria…
Albers GW, Bernstein R, Brachmann J et al. · 2021 · Stroke
Occult atrial fibrillation (AF) is a leading cause of stroke of unclear cause. The optimal approach to secondary stroke prevention for these patients remains elusive. The term embolic stroke of undetermined source (ESUS) was coined to…
Ishizuka K, Ono S · 2025 · Journal of clinical pharmacology
Despite the tremendous effort in the oncology community, the success rate of anticancer development remained low at 30% to 40% from the Phase 3 study to the regulatory approval. The factors associated with the regulatory approval for…
Chen H, Colasurdo M, Matsukawa H et al. · 2026 · European stroke journal
Introduction Endovascular thrombectomy (EVT) is an effective treatment for basilar artery occlusion (BAO) stroke in select patients. While there is a growing body of literature suggesting that advanced imaging modalities such as computed…
Cerbone L, Orecchia S, Bertino P et al. · 2023 · Cancers
Mesothelioma comprises a group of rare cancers arising from the mesothelium of the pleura, peritoneum, tunica vaginalis testis and pericardium. Mesothelioma is generally associated with asbestos exposure and has a dismal prognosis, with…
Pellesi L, Onan D, Martelletti P · 2024 · Toxins
Post-traumatic headache (PTH) is a common and debilitating consequence of traumatic brain injury (TBI), often resembling migraine and tension-type headaches. Despite its prevalence, the optimal treatment for PTH remains unclear, with…
Zhou Q, Gao B, Hu J et al. · 2026 · BMJ oncology
Background Many patients with non-small cell lung cancer (NSCLC) have tumours that are either refractory or develop resistance following an initial response to anti-programmed cell death protein (ligand)-1 (PD-(L)1)-based treatment,…