Negative / Null Result ReportMedicine
Flämig L, Felix Zhu W, Hoffmann K et al. · 2026 · Organic & biomolecular chemistry
Agonists of the κ-opioid receptor are useful drugs for the treatment of severe pain, itching skin diseases and inflammatory and immunological diseases. Herein, novel κ agonists with the κ-pharmacophoric ethylenediamine system embedded in a…
View details →DOI: 10.1039/d6ob00422a Negative / Null Result ReportMedicine
Chiang YW, Chang JY, Yeh KL et al. · 2026 · Investigative ophthalmology & visual science
Purpose To investigate whether exposure to artificial lighting with different correlated color temperatures (CCTs) affects ocular structure and myopia-related molecular signaling pathways before axial elongation in a murine model. Methods…
View details →DOI: 10.1167/iovs.67.6.46 Negative / Null Result ReportMedicine
Yamakawa R, Sakaue Y, Okada S et al. · 2026 · Gait & posture
Background Hip osteoarthritis (HOA) often leads to compensatory movements such as trunk lateral bending during gait due to pain and restricted range of motion. Because multiple joints coordinate to control the center of mass (CoM) during…
View details →DOI: 10.1016/j.gaitpost.2026.110228 Negative / Null Result Report
van der Velde M, de Boer J, Arslan B et al. · 2026 · Preprint
Background. Multiplication is a key skill in primary education, but traditional teaching methods vary in effectiveness and may not suit individual needs. Adaptive learning systems personalise practice and promote the use of effective study…
View details →DOI: 10.31234/osf.io/gjqun_v1 Negative / Null Result ReportMedicine
Lines JB, Cungi PJ, Da Silva C et al. · 2026 · BMJ military health
Introduction Non-surgical management of non-neurological thoracic or lumbar spine (TL) fractures seems to provide good results in the civilian population, leading to return to work in most cases. However, data on the military population…
View details →DOI: 10.1136/military-2024-002916 Negative / Null Result ReportMedicine
García-García A, Goyoaga M, Nuño F et al. · 2026 · Carbohydrate Polymers.
Despite the increasing interest on self-healing hydrogels in the fabrication of customized scaffolds for tissue engineering applications, their optimal printability is still a challenge due to the weak mechanical stability of dynamic…
Negative / Null Result ReportMedicine
Shimoyama M, Nakada-Tsukui K, Nozaki T · 2026 · Journal of cell science
Rho guanine nucleotide-exchange factors (RhoGEFs) activate Rho and Rac small GTPases, orchestrating cellular processes, such as actin remodeling, endocytosis and migration. In the protozoan parasite Entamoeba histolytica, the causative…
View details →DOI: 10.1242/jcs.264490 Negative / Null Result ReportMedicine
Vera-Escalona I, Peralta-Prato J, Jorquera E et al. · 2026 · Gene
Over the decades, the Cytochrome Oxidase I (COI) gene has been widely used as a low-cost standardized identification method for phylogenetic and phylogeographic studies. However, the literature of the COI gene amplification, cloning, and…
View details →DOI: 10.1016/j.gene.2026.150224 Negative / Null Result ReportMedicine
Pu Y, Gampa A, Simon C et al. · 2026 · Journal of investigative medicine : the official publication of the American Federation for Clinical Research
Atrial arrhythmias (AA), including atrial fibrillation (AF) and atrial flutter, are a significant clinical problem in oncological patients. The effect of AA on clinical outcome of patients with non-small cell lung cancer (NSCLC) is not…
View details →DOI: 10.1177/10815589261455329 Negative / Null Result ReportOpen accessMedicine
Kahveci ME, Yigit AA, Kabakci R · 2026 · Reproduction in domestic animals = Zuchthygiene
Linuron, chloridazon and metribuzin are herbicides thought to have potential endocrine disruption (ED) effects. This study investigated the effects of linuron, chloridazon and metribuzin on bovine granulosa cell viability and oestrogen…
View details →DOI: 10.1111/rda.70204 Negative / Null Result ReportMedicine
Kashiri M, Berk B, Yemenicioğlu A · 2026 · International journal of biological macromolecules
This study aimed at utilizing soy protein-based emulsion gel as a fat substitute in spirulina enriched plant-based spreadable cheese (PBC). For this purpose, spirulina enriched vegetable oil-in-water emulsions prepared using soy protein as…
View details →DOI: 10.1016/j.ijbiomac.2026.152131 Negative / Null Result Report
Skarstad H, Skrede S, Haganes K et al. · 2026 · Preprint
Objectives To examine the acute effects of a single bout of high-intensity interval training (HIIT) on fetal blood flow distribution during the third trimester of pregnancy. Methods Thirty-four healthy pregnant participants (mean age 31.6…
View details →DOI: 10.64898/2026.05.27.26354197 Negative / Null Result ReportMedicine
Jaafar LS, Sous NS, Shehadi HH et al. · 2026 · The Journal of nutrition
Background Emerging evidence suggests that each Branched-chain amino acids (BCAA; leucine, valine, and isoleucine) exert distinct physiological effects. Moreover, leucine and valine, but not isoleucine, are structural components of…
View details →DOI: 10.1016/j.tjnut.2026.101687 Negative / Null Result ReportMedicine
Rebeis LM, Baruselli PS, Harden H et al. · 2026 · Journal of dairy science
The aim of this study was to evaluate the effects of administering 325 mg of recombinant bovine somatotropin (rbST) at the initiation of the synchronization protocol (SYNCd) and/or on the day of embryo transfer (ETd) using a 2 × 2…
View details →DOI: 10.3168/jds.2026-28503 Negative / Null Result ReportMedicine
Roubalová R, Luthar J, Procházková P et al. · 2026 · NPJ biofilms and microbiomes
Anorexia nervosa (AN) is a severe eating disorder that profoundly affects quality of life. Despite increasing understanding of the neurobiological basis of the disease, many patients develop a chronic course of illness accompanied by a…
View details →DOI: 10.1038/s41522-026-01055-y Negative / Null Result ReportMedicine
Schade AC, Vilella KD, Neves ETB et al. · 2026 · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry
Objective To assess the impact of parental psychosocial profile on the effectiveness of educational interventions aiming to improve oral hygiene among preschool children living in a rural area. Methods A controlled randomised trial…
View details →DOI: 10.1007/s40368-026-01229-4 Negative / Null Result ReportOpen accessMedicine
Persons AL, Napier TC · 2026 · Drug and alcohol dependence reports
Background The addiction profile of opioids reflects imbalances in downstream transmitters, including dopamine and serotonin (5-HT). The atypical antidepressant mirtazapine has multiple sites of action, including antagonism at 5-HT 2A…
View details →DOI: 10.1016/j.dadr.2026.100441 Negative / Null Result Report
Gallagher CA, Chandler DJ, Manvich DF · 2025 · Preprint
ABSTRACT Background The persistent threat of the opioid epidemic warrants investigation into risk factors that predispose individuals to opioid use disorder (OUD). Adolescent stress has been linked to enhanced risk for OUD in humans,…
View details →DOI: 10.1101/2025.09.10.675431 Negative / Null Result ReportMedicine
Lu S, Paengkoum S, Chen S et al. · 2025 · Animal Nutrition
This experiment aimed to investigate the potential impact of supplementing different levels of black soldier fly (BSF) on growth performance, serum antioxidants, and ruminal microbiota of goats. Twenty-four native Anglo-Thai male goats…
Negative / Null Result ReportMedicine
Schommer S, Drost L, Finke J et al. · 2026 · Biological psychology
Human learning and memory are considered 'embodied', but it is unclear which body signals affect which memory facet. We investigated whether ascending cardiac signals affect memory encoding and consolidation. Due to its relevance for…
View details →DOI: 10.1016/j.biopsycho.2026.109283 Negative / Null Result ReportMedicine
Padoin Y, de Pellegrin SF, Castillo DC et al. · 2026 · European journal of oral sciences
This study evaluated the effect of the number of simulated endodontic treatment visits and the type of irrigant on the surface roughness, microhardness, topography, and fracture resistance of root dentin. Bovine roots were distributed into…
View details →DOI: 10.1111/eos.70103 Negative / Null Result ReportOpen accessMedicine
Zimmermann V, Fourré N, Senn L et al. · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Purpose Duration of treatment for uncomplicated enterococcal bacteremia is unknown. This study aims to evaluate the clinical outcomes of patients treated with short courses (4-10 days) compared to those receiving longer regimens (11-18…
View details →DOI: 10.1007/s10096-025-05348-6 Negative / Null Result ReportOpen accessMedicine
Crook G, Lamberth E, Lockhart SP et al. · 2026 · Open forum infectious diseases
This phase 3 trial compared immunogenicity and safety of 2-dose versus 3-dose PF-06425090 Clostridioides difficile vaccine regimens in ≥50-year-olds (N = 1994) at increased C difficile infection risk. Because C difficile toxin-A but not C…
View details →DOI: 10.1093/ofid/ofag219 Negative / Null Result ReportMedicine
Kim SJ, Park K, Daher R et al. · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]
Objective This study aimed to evaluate the impact of storage temperature and duration on the dimensional stability and mechanical properties of 3D-printed surgical guides. Materials and methods Sixty surgical guides were designed using two…
View details →DOI: 10.1111/jerd.70198 Negative / Null Result Report
Toczylowski K, Lewandowski D, Martonik D et al. · 2026 · Preprint
Abstract Multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease (KD) are pediatric hyperinflammatory conditions with overlapping features, but their molecular basis remains poorly defined. Matrix metalloproteinases…
View details →DOI: 10.21203/rs.3.rs-7754190/v1 Negative / Null Result Report
Stédile EdSN, Galon L, Korchagin J et al. · 2026 · Preprint
In southern Brazil, a large proportion of farmers maintain their fields under fallow conditions during the transition period between summer and winter crops. During this interval, mechanical practices such as chiseling or the introduction…
View details →DOI: 10.20944/preprints202604.1370.v1 Negative / Null Result ReportMedicine
Lazado CC, Brenne H, Olaisen D et al. · 2026 · Scientific reports
The diplomonad parasite Spironucleus salmonicida causes spironucleosis, a systemic infection characterised by internal haemorrhaging, splenomegaly, and granulomatous lesions in multiple organs. Prevention is the primary control strategy,…
View details →DOI: 10.1038/s41598-026-51626-4 Negative / Null Result ReportMedicine
Zhang S, Zheng T, Zhou M et al. · 2026 · Journal of phycology
This study investigates the chemical and morphological responses of two domoic acid (DA)-producing diatoms, Pseudo-nitzschia multiseries and P. fukuyoi, to conspecific chemical cues released from mechanically damaged cells. Cell homogenate…
View details →DOI: 10.1111/jpy.70179 Negative / Null Result ReportMedicine
Setiawan AS, Caesarini M, Musnamirwan IA et al. · 2026 · BMC public health
Background Stunting, a form of chronic malnutrition, is associated with impaired growth and potential changes in salivary function that may increase susceptibility to early childhood caries (ECC). These oral conditions may further…
View details →DOI: 10.1186/s12889-026-27304-5 Negative / Null Result ReportMedicine
Yang H, Dai T, Wolf RM · 2026 · NPJ digital medicine
Artificial intelligence (AI) is increasingly used for diagnostic screening. In diabetic retinopathy screening, autonomous AI systems can identify disease without a specialist. However, patient trust in AI remains a challenge, and it…
View details →DOI: 10.1038/s41746-026-02635-0 