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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 484 of 676

Negative / Null Result Report

Developing and Validating a Machine Learning Model to Predict Brain Injury in Preterm Infants Using Multisource Data from the Early Postnatal Period

Xu P, Li Y, Chen Y et al. · 2026 · Preprint

Background: Moderate-to-severe preterm brain injury (PBI), including intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL), remains an important cause of adverse neurodevelopmental outcomes in preterm infants. Early risk…

View details →DOI: 10.20944/preprints202606.0340.v1
Negative / Null Result ReportMedicine

Implicit Global-Local Learning in Young People With and Without Autism.

Ziva A, Ziori E, Pothos EM · 2026 · Quarterly journal of experimental psychology (2006)

Implicit (unconscious) learning ostensibly affects cognitive and social skills in both typical and atypical populations, such as those on the autism spectrum. Research into implicit learning in autism has yielded conflicting results,…

View details →DOI: 10.1177/17470218261446884
Negative / Null Result ReportOpen accessMedicine

Boundary Vector Cells Encode a Future-Biased Spectrum of Positions in the Rat.

Newman EL, Mashanova-Galikova I, Tiganj Z et al. · 2026 · Hippocampus

Spatial tuning is a hallmark property of neural firing in the hippocampal formation. Yet, that tuning is often less well correlated with the instantaneous current position of an animal than it is with an integrated version of the past or…

View details →DOI: 10.1002/hipo.70110
Negative / Null Result ReportMedicine

End-to-end multimodal attention fusion for drug-target interaction prediction with cold-scaffold validation on the Davis kinase benchmark.

Agboola OE, Agboola SS, Shaleye AB et al. · 2026 · Journal of molecular graphics & modelling

Predicting drug-target interactions computationally is a practical strategy for prioritizing candidate compounds in early drug discovery, but the reliability of published models is often limited by small resampled datasets, warm-only…

View details →DOI: 10.1016/j.jmgm.2026.109461
Negative / Null Result ReportMedicine

Statistical Learning in Dynamic Assessment to Identify Developmental Language Disorder in Spanish-English-Speaking Preschoolers: A Feasibility Study.

Neiling SL, Alt M, Kapa LL · 2026 · Language, speech, and hearing services in schools

Background The current project was a prospective feasibility study using a dynamic assessment of statistical learning of a novel morpheme for the identification of developmental language disorder (DLD) in Spanish-English-speaking…

View details →DOI: 10.1044/2026_lshss-25-00141
Negative / Null Result ReportMedicine

A cumulative-morbidity plasma proteomic architecture of critical-illness susceptibility: a UK biobank proteome-wide study of critical-care exposure, in-hospital death, and sex-specific signals.

Ren X, Dai Q, Jin C · 2026 · Journal of intensive care

Background Existing biomarker studies profile plasma during acute illness, leaving pre-illness proteomic susceptibility to critical care largely uncharacterised. We mapped the baseline proteomic architecture of critical-care outcomes in UK…

View details →DOI: 10.1186/s40560-026-00887-2
Negative / Null Result ReportMedicine

Effects of fixation and demineralization on immunohistochemical assessment of canine bone marrow.

Diamantino GML, Beeler-Marfisi J, Foster RA et al. · 2026 · Veterinary pathology

The objective of this study was to evaluate the effect of different fixatives and demineralizers on immunohistochemical (IHC) detection of antigens in bone marrow (BM). Sternal BM samples were collected within 24 hours of death from dogs…

View details →DOI: 10.1177/03009858261426547
Negative / Null Result ReportMedicine

Developing and Validating a Machine Learning Model to Predict Brain Injury in Preterm Infants Using Multisource Data from the Early Postnatal Period.

Xu P, Li Y, Chen Y et al. · 2026 · Children (Basel, Switzerland)

Background Moderate-to-severe preterm brain injury (PBI), including intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL), remains an important cause of adverse neurodevelopmental outcomes in preterm infants. Early risk…

View details →DOI: 10.3390/children13060796
Negative / Null Result ReportMedicine

Tailoring Grammatical Test Items in English According to Language Experience for the Classification of Developmental Language Disorder in Bilinguals.

Pratt AS, Ramos MN, Peña ED et al. · 2026 · Journal of speech, language, and hearing research : JSLHR

Purpose This study attempts to discriminate developmental language disorder (DLD) in bilinguals using only the child's second language (L2), English. We grouped bilinguals by their current weekly language experience (high English…

View details →DOI: 10.1044/2025_jslhr-24-00606
Negative / Null Result ReportMedicine

Molecular Basis of Synergistic Causal Effect of Dual GLP-1R and GIPR Agonists for Risk Reduction in Diabetic Retinopathy, Alzheimer Disease, and Coronary Artery Disease in Diabetic Patients.

Xu J, Ashebir YA, Shao Y · 2026 · Genes

Background: The dual agonism of glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) becomes a groundbreaking treatment for type 2 diabetes (T2D) that achieves robust glycemic control…

View details →DOI: 10.3390/genes17060602
Negative / Null Result Report

Gd-EOB-DTPA-Enhanced MRI Combined with ALBI Score and AFP for Predicting Histologic Grade in Hepatocellular Carcinoma: A Multicenter Study from Vietnam

Nguyen Van H, Vu Dang L, Nguyen The A et al. · 2026 · Preprint

Objectives: Histologic grade is an important prognostic factor in hepatocellular carcinoma (HCC). Gd-EOB-DTPA-enhanced MRI may provide noninvasive im-aging markers related to tumour differentiation. This study aimed to evaluate the…

View details →DOI: 10.20944/preprints202605.0460.v1
Negative / Null Result ReportMedicine

Comparative evaluation of tigecycline susceptibility testing methods for carbapenem-resistant Klebsiella pneumoniae and Acinetobacter baumannii.

Shi Y, Li S, He L et al. · 2026 · Annals of clinical microbiology and antimicrobials

Background In this study, we aimed to evaluate the performance of different tigecycline susceptibility testing methods for CRKP and CRAB using the broth microdilution (BMD) method as the gold standard, under different breakpoint criteria.…

View details →DOI: 10.1186/s12941-026-00869-0
Negative / Null Result ReportMedicine

The Diagnostic Value of English Language Sample Measures for Identifying Developmental Language Disorder in Bilingual Children.

Ramos MN, Bedore LM, Peña ED · 2026 · American journal of speech-language pathology

Purpose This study examines the diagnostic accuracy of four measures derived from English narrative language samples for identifying developmental language disorder (DLD) in 5- and 6-year-old Spanish-English bilinguals. Method Ninety-two…

View details →DOI: 10.1044/2025_ajslp-25-00182
Negative / Null Result ReportMedicine

Development of a Prognostic Prediction Model for Clinically Significant Prostate Cancer Based on Lesion Zone and Apparent Diffusion Coefficient Value Quantification.

Ashouri R, Reynolds PS, Rajavel S et al. · 2026 · Urology

Objective To guide biopsy decision making via a predictive model for clinically significant prostate cancer (csPCa) in men with positive imaging (PI-RADS 3-5). We aim to elucidate the influence of zone on the predictive accuracy of PI-RADS…

View details →DOI: 10.1016/j.urology.2026.01.028
Negative / Null Result ReportMedicine

Aortic Valve Prosthesis Choice in Dialysis Patients: A Review of Medicare Data.

Lutfi W, Desai ND, Pan Z et al. · 2026 · The Annals of thoracic surgery

Background The choice between bioprosthetic or mechanical surgical aortic valve replacement (SAVR) for dialysis patients is debated. Rapid adoption of transcatheter aortic valve replacement (TAVR) complicates decision-making further. This…

View details →DOI: 10.1016/j.athoracsur.2026.03.007
Negative / Null Result ReportMedicine

Long-term artificial sweetener exposure increases the risk of atherosclerosis.

Xie J, Song Z, Fang W et al. · 2026 · Naunyn-Schmiedeberg's archives of pharmacology

This study aimed to elucidate the potential molecular mechanisms by which artificial sweeteners contribute to the initiation and progression of atherosclerosis, with the goal of providing a theoretical basis for the safety evaluation of…

View details →DOI: 10.1007/s00210-026-05241-9
Negative / Null Result ReportMedicine

Early psychotherapeutic interventions for posttraumatic stress responses in children and adolescents: A scoping review.

Robinson E, Chapman C, Orchard F et al. · 2026 · Journal of child and adolescent mental health

Background: Exposure of children and young people to potentially traumatic events is common. There is a need for increased access to early interventions following a potentially traumatic event. Objective: This review aimed to identify…

View details →DOI: 10.2989/17280583.2025.2581754
Negative / Null Result ReportMedicine

Reassessing the Incidence and Risk Factors of Radiation Pneumonitis in Treatment-Naive EGFR-Mutant NSCLC With Concurrent Third-Generation EGFR-TKI and Thoracic Radiotherapy.

Zheng, Jia, Jing et al. · 2026 · International journal of cancer

This single-center retrospective study evaluated radiation pneumonitis (RP) in 209 treatment-naive EGFR-mutant non-small cell lung cancer (NSCLC) patients receiving first-line third-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs)…

View details →DOI: 10.1002/ijc.70630
Negative / Null Result ReportMedicine

Estimating differences in life satisfaction as a function of health-related behaviours: cross-sectional evidence from the Health Survey for England.

Ng Fat, West, E Jackson · 2026 · BMJ public health

Stopping tobacco smoking, reducing alcohol consumption from high-risk levels, increasing physical activity and improving diet can improve mental well-being. To gain a preliminary estimate of the potential benefits of healthy lifestyle…

View details →DOI: 10.1136/bmjph-2025-004301
Negative / Null Result ReportMedicine

Mortality among adolescent and young adults in specialized substance use treatment: a Swedish register study.

Karlsson, Ekendahl, Lindner · 2026 · Child and adolescent psychiatry and mental health

Individuals with substance use problems have higher mortality risks than the general population. This study aimed to assess all-cause and specific-cause mortality among adolescents and young adults in specialized substance use treatment in…

View details →DOI: 10.1186/s13034-026-01125-1
Negative / Null Result ReportMedicine

Brain kappa opioid receptor availability across stress and social buffering conditions: A positron emission tomography study in coppery titi monkeys.

Manca, Paulus, Almeida et al. · 2026 · Neuroscience

Social connectedness strongly influences health and longevity, and adult pair bonds provide psychological benefits distinct from other social relationships. Oxytocin (OT), corticotropin-releasing hormone (CRH), and opioids play an…

View details →DOI: 10.1016/j.neuroscience.2026.06.028