A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19878 results in Negative / Null Result Report · page 480 of 663
Shen C, Zhu Z, Zhang X et al. · 2024 · Preprint
Purpose: Numerous epidemiological studies have explored the association between the components of metabolic syndrome (MetS) and risk of prostate cancer (PCa). However, to date, the findings have yielded inconclusive results. This study…
Mildner FO, Sykora MM, Hackl H et al. · 2024 · Lung cancer (Amsterdam, Netherlands)
Background Cancer immune evasion is critical in non-small cell lung cancer (NSCLC) and has been targeted by immunotherapy. High soluble (s)PD-L1 is associated with reduced survival and treatment failure in advanced stages. Here we…
Johnson MS, Adams VM, Byrne J · 2024 · Preprint
Abstract Effective adaptation to climate risks requires identifying and realizing community beliefs about which locations require management attention. Environmental planners and asset managers, especially those in rural and regional…
Le NT, Nguyen TG, Huynh NYN et al. · 2025 · Scientific reports
Dietary calcium's role in human health and disease prevention is inconclusive. We examined the associations between dietary calcium intake and the risk of overall and specific causes of mortality. A prospective cohort study was performed…
Manni G, Pambianco M, Sicuro C et al. · 2025 · International journal of molecular sciences
Hepatic actinomycosis (HA) and IgG4-related inflammatory pseudotumors are rare and often overlooked causes of liver mass, which can easily be misdiagnosed as primary liver cancer or metastasis. Diagnosis is arduous due to unspecified…
Borz-Baba L, Aydin A, Parvin R · 2026 · Cureus
Metabolic-associated steatotic liver disease (MASLD) is a common medical condition that can progress to metabolic-associated steatohepatitis (MASH) and advanced fibrosis, leading to severe outcomes. Liver biopsy continues to be the…
Sakuma K, Yoshimura K · 2026 · Journal of environmental radioactivity
Tritium ( 3 H) is the principal radionuclide remaining in ALPS-treated water discharged from the Fukushima Dai-ichi Nuclear Power Plant (FDNPP), and its potential environmental impact has drawn considerable attention. To evaluate possible…
Larson ME, Pan Y, Reidy L et al. · 2026 · PloS one
People with HIV (PWH) experience elevated cardiovascular disease risk compared to people without HIV. Stimulant use may further increase subclinical myocardial injury among PWH, but data on cardiovascular biomarkers, including serum…
Geamănu A, Pîrvulescu RA, Tricorache D et al. · 2026 · Diagnostics (Basel, Switzerland)
Background: Hydroxychloroquine (HCQ) is widely used in systemic lupus erythematosus (SLE), yet cumulative exposure may result in progressive retinal toxicity. Structural biomarkers capable of identifying subclinical damage remain…
Sung K · 2026 · Environmental management
Trail penetration within strictly designated protected areas is often treated as a conservation concern, yet its consequences for vegetation trends at national scales remain empirically unresolved. This study evaluated whether trail…
Simonis L, Marcour Y, Embacher J et al. · 2026 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Background & aims Assessment of hepatic steatosis is key for diagnosis and monitoring of steatotic liver disease. Controlled attenuation parameter is widely used, but concerns regarding its measurement variability exist. We evaluated the…
Ünlü C, Aksoy H · 2026 · BMC pregnancy and childbirth
Background Anti-D immunoglobulin administered in the early third trimester to Rhesus D negative women with Rhesus D incompatibility is widely assumed to provide protection against silent fetomaternal haemorrhage until delivery. However,…
Corn E, Becht K, Adefres B et al. · 2026 · Gynecologic oncology reports
Purpose Cervical cancer is the number one cause of cancer-related mortality for women in Botswana, where care is complicated by the country's severe shortage of gynecologic oncologists. Recent data suggests that "low-risk" stage I cervical…
Martinos N, Kroupis C, Gypari M et al. · 2026 · Current issues in molecular biology
Background/objectives Histologic mucosal healing is an increasingly recognized therapeutic target in inflammatory bowel disease (IBD), yet reliable non-invasive correlates remain limited. This study aimed to evaluate circulating cytokine…
Walmsley SL, Nabipoor M, Qi F et al. · 2026 · Clinical & translational immunology
Objectives To assess neutralizing antibody responses to emerging SARS-CoV-2 variants. Methods We explored SARS-CoV-2 neutralizing antibodies in140 adults participating in a longitudinal study of antibody responses to COVID vaccines.…
Oehring D · 2026 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)
Purpose Non-invasive tear film metrics from automated topographers are used increasingly, yet device-specific analytical performance remains incompletely characterised. This study quantified the analytical performance of the Oculus…
Torkan A, Zoghi M, Foroughimehr N et al. · 2026 · Sensors (Basel, Switzerland)
The rapid global expansion of 5G technology has increased concerns regarding its potential health effects. Postural balance, a complex sensorimotor function reflecting central nervous system integrity, may be susceptible to electromagnetic…
Sapkota S, Brewer AN, Underhill A et al. · 2026 · Preprint
Abstract While dominant qualitative disease resistance loci are well known for being easily introgressed in breeding programs and easily overcome by pathogens, the additivity and durability of dominant minor and moderate quantitative loci…
Aguiar Pavesi RO, Boening A, Meyrelles SDS et al. · 2026 · Physiotherapy research international : the journal for researchers and clinicians in physical therapy
Background The 6-minuteute step test is an alternative for estimating cardiorespiratory fitness after stroke. Objective To investigate its measurement properties and minimal detectable change early after stroke. Methods Cross-sectional,…
Bell KS, Chen R, Weitzner AS et al. · 2026 · Journal of biological rhythms
The circadian system coordinates daily physiology across nearly all tissues to temporally organize metabolism and maintain homeostasis. In the brain, circadian timing regulates neural activity, cellular function, and neuroimmune signaling,…
Scilipoti P, Callenmark M, Garmo H et al. · 2026 · European urology open science
Background and objective There are several methods for estimating prostate-specific antigen (PSA) doubling time (DT), and many men exhibit long periods of undetectable PSA below 0.1 ng/ml after radical prostatectomy (RP). We quantified…
Banerjee S · 2026 · Preprint
The Fermi Paradox (“Where is everybody?”) refers to the apparent contradiction between the visualisable abundance of extraterrestrial civilizations and the continued absence of confirmed detections. This work explores whether finite…
Sánchez-Valle J, Zambrana C, Navarro-Martínez A et al. · 2026 · Preprint
Multimorbidity is the dominant clinical reality of primary care, yet the temporal dynamics governing when and how persistent comorbidity associations emerge remain poorly characterised. Most large-scale comorbidity studies adopt a single…
van Caelenberg E, Belpaire A, Dewaele D et al. · 2026 · Clinical and experimental dermatology
Background The Severity of Alopecia Tool (SALT) score is widely used. However, its inter- and intrarater reliability and smallest detectable difference (SDD) have not been rigorously evaluated. Objectives To determine the interrater and…
Keshavarzi F, Arazpour M, Behzadipour S · 2026 · JMIR biomedical engineering
Background The application of spinal orthoses and local vibration in the treatment of hyperkyphosis is a developing concept. Further research is needed to determine the impact of leaf springs and local vibration techniques on the…
McCaughan KJ, Danyluk MD, Kniel KE · 2026 · Applied and environmental microbiology
Tilling under is a method growers employ in an effort to remediate instances of widespread contamination in fields of crops, but its effectiveness with respect to specific pathogens remains poorly understood. This study had two overarching…
Zhang S, Zhang H, Dong X et al. · 2026 · Frontiers in immunology
Background Radical cystectomy remains a standard curative treatment for muscle-invasive bladder cancer (MIBC). Bladder preservation after systemic therapy without immediate surgery remains investigational and requires careful patient…
Swaine T, Bhagani S · 2026 · Current opinion in HIV and AIDS
Purpose of review Two-drug regimens (2DR) for antiretroviral therapy are increasingly being recommended for people living with HIV to reduce pill burden and reduce short and long-term toxicity. The exclusion of tenofovir and lamivudine or…
Nicklas A, Rudari M, Reidow N et al. · 2026 · Plastic and reconstructive surgery. Global open
Background Postoperative wound healing remains a critical challenge, particularly in complex reconstructions such as free flap surgeries. Despite technical improvements, perfusion-related complications may cause partial flap loss.…
Chen A, Daniels W, Huang Z et al. · 2026 · Preprint
Abstract The U.S. federal government undertook a flurry of new actions to monitor and regulate methane emissions beginning in years 2021 and 2022, including the Inflation Reduction Act (IRA). The IRA and Waste Emissions Charge (WEC)…