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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20253 results in Negative / Null Result Report · page 473 of 676

Negative / Null Result Report

EP37 TECHNICAL PRECAUTIONS TO REDUCE THE PACEMAKER RATE AFTER SUTURELESS AORTIC VALVE REPLACEMENT: DID WE FIND THE KEY?

G. Santarpino, M. Moscarelli, A. Nicoletti et al. · 2018 · Journal of Cardiovascular Medicine

Background and Aim: The aim of this study is to evaluate the patients who have required a pacemaker implantation after a sutureless aortic valve implant, evaluating their clinical history and preoperative risk factors, the peri- and…

View details →DOI: 10.2459/01.jcm.0000550003.29669.37
Negative / Null Result ReportMedicine

Return to duty after non-surgical treatment of a non-neurological thoracic or lumbar spine fracture in French military patients: a retrospective analysis of 54 patients.

Lines JB, Cungi PJ, Da Silva C et al. · 2026 · BMJ military health

Introduction Non-surgical management of non-neurological thoracic or lumbar spine (TL) fractures seems to provide good results in the civilian population, leading to return to work in most cases. However, data on the military population…

View details →DOI: 10.1136/military-2024-002916
Negative / Null Result ReportMedicine

Dynamic chitosan-hyaluronic acid hydrogels for extrusion printing: Combined effects of polymer molecular weight and carbon nanofillers

García-García A, Goyoaga M, Nuño F et al. · 2026 · Carbohydrate Polymers.

Despite the increasing interest on self-healing hydrogels in the fabrication of customized scaffolds for tissue engineering applications, their optimal printability is still a challenge due to the weak mechanical stability of dynamic…

Negative / Null Result ReportMedicine

A RhoGEF activates RacM to selectively promote motility without affecting macropinocytosis in Entamoeba histolytica.

Shimoyama M, Nakada-Tsukui K, Nozaki T · 2026 · Journal of cell science

Rho guanine nucleotide-exchange factors (RhoGEFs) activate Rho and Rac small GTPases, orchestrating cellular processes, such as actin remodeling, endocytosis and migration. In the protozoan parasite Entamoeba histolytica, the causative…

View details →DOI: 10.1242/jcs.264490
Negative / Null Result ReportMedicine

Impact of atrial arrhythmias on long-term survival in non-small cell lung cancer patients.

Pu Y, Gampa A, Simon C et al. · 2026 · Journal of investigative medicine : the official publication of the American Federation for Clinical Research

Atrial arrhythmias (AA), including atrial fibrillation (AF) and atrial flutter, are a significant clinical problem in oncological patients. The effect of AA on clinical outcome of patients with non-small cell lung cancer (NSCLC) is not…

View details →DOI: 10.1177/10815589261455329
Negative / Null Result ReportOpen accessMedicine

Endocrine Disruptive Effects of the Herbicides Linuron, Chloridazon and Metribuzin on Bovine Granulosa Cells.

Kahveci ME, Yigit AA, Kabakci R · 2026 · Reproduction in domestic animals = Zuchthygiene

Linuron, chloridazon and metribuzin are herbicides thought to have potential endocrine disruption (ED) effects. This study investigated the effects of linuron, chloridazon and metribuzin on bovine granulosa cell viability and oestrogen…

View details →DOI: 10.1111/rda.70204
Negative / Null Result ReportMedicine

Development of spirulina-enriched vegan cheese by utilizing soy protein-based emulsion gel as a fat substitute: Effects of spirulina and emulsion gel on texture/rheology, antioxidant and sensory properties.

Kashiri M, Berk B, Yemenicioğlu A · 2026 · International journal of biological macromolecules

This study aimed at utilizing soy protein-based emulsion gel as a fat substitute in spirulina enriched plant-based spreadable cheese (PBC). For this purpose, spirulina enriched vegetable oil-in-water emulsions prepared using soy protein as…

View details →DOI: 10.1016/j.ijbiomac.2026.152131
Negative / Null Result ReportMedicine

Individual Branched-Chain Amino Acid Restriction Alters Body Composition Without Affecting Hemoglobin in Rats Fed a Low Protein Diet.

Jaafar LS, Sous NS, Shehadi HH et al. · 2026 · The Journal of nutrition

Background Emerging evidence suggests that each Branched-chain amino acids (BCAA; leucine, valine, and isoleucine) exert distinct physiological effects. Moreover, leucine and valine, but not isoleucine, are structural components of…

View details →DOI: 10.1016/j.tjnut.2026.101687
Negative / Null Result ReportMedicine

Recombinant bovine somatotropin at synchronization initiation, but not at embryo transfer, enhances fertility in embryo-recipient heifers: Associations with follicular, luteal, and embryonic outcomes.

Rebeis LM, Baruselli PS, Harden H et al. · 2026 · Journal of dairy science

The aim of this study was to evaluate the effects of administering 325 mg of recombinant bovine somatotropin (rbST) at the initiation of the synchronization protocol (SYNCd) and/or on the day of embryo transfer (ETd) using a 2 × 2…

View details →DOI: 10.3168/jds.2026-28503
Negative / Null Result ReportMedicine

Effects of multistrain probiotics on metabolic biomarkers, inflammation, and antioxidant system in patients with type 2 diabetes mellitus: a prospective controlled trial in Türkiye.

Kilavuz A, Zorbozan O, Yildirim Simsir I et al. · 2026 · BMC nutrition

Background Recent evidence suggests that the gut microbiota plays a crucial role in the development and progression type 2 diabetes mellitus (T2DM). This study aimed to investigate the effects of multi-strain probiotic supplementation on…

View details →DOI: 10.1186/s40795-026-01354-9
Negative / Null Result ReportMedicine

Periprocedural Outcomes of Carotid Artery Stenting According to Embolic Protection Strategy: A 20-Year Single-Center Experience.

Tajima Y, Kubota M, Yoshida Y et al. · 2026 · World neurosurgery

Objective This study aimed to evaluate the impact of embolic protection strategies on outcomes in asymptomatic patients undergoing carotid artery stenting (CAS). Methods We retrospectively analyzed 312 consecutive asymptomatic patients…

View details →DOI: 10.1016/j.wneu.2026.124997
Negative / Null Result ReportMedicine

The weekend effect in internal medicine admissions: A limited impact at a large tertiary-care center.

Feigin L, Feigin E, Bronstein Y · 2026 · The American journal of medicine

Background This study was conducted to examine whether a "weekend effect" exists in internal medicine departments of a large tertiary medical center in Israel. Methods We conducted a retrospective cohort study of patients > 18 admitted to…

View details →DOI: 10.1016/j.amjmed.2026.03.005
Negative / Null Result ReportMedicine

NEUTROPHIL-TO-LYMPHOCYTE RATIO AS A POTENTIAL PREDICTOR OF IN-HOSPITAL MORTALITY AMONG ISCHEMIC STROKE PATIENTS: A PROSPECTIVE COHORT STUDY.

Urasheva Z, Khamidulla A, Yermagambetova A et al. · 2026 · Georgian medical news

Background Ischemic stroke is a major cause of death and disability worldwide. Recent evidence highlights the role of systemic inflammation in stroke pathophysiology and prognosis. The neutrophil-to-lymphocyte ratio (NLR), an accessible…

Negative / Null Result ReportMedicine

The Immediate Impact of Hemodialysis on Gait Metrics.

Cernes R, Hershkovich O, Tsehovsky T et al. · 2026 · The Israel Medical Association journal : IMAJ

Background Gait disturbances are common in patients undergoing hemodialysis and are associated with increased fall risk, mobility decline, and adverse health outcomes. Prior research suggests that hemodialysis may impact gait parameters…

Negative / Null Result ReportMedicine

Right Ventricular Functional Changes in Patients Undergoing Bone Marrow Transplantation: An Advanced Echocardiographic Analysis.

Ugurluoglu G, Ulutas Z, Yigit Y et al. · 2026 · Echocardiography (Mount Kisco, N.Y.)

Objective This study aimed to evaluate right ventricular (RV) function pre and post bone marrow transplantation (BMT) using transthoracic echocardiography (TTE), in order to detect subclinical or clinical RV dysfunction that may occur in…

View details →DOI: 10.1111/echo.70437
Negative / Null Result ReportMedicine

Relaxing Environment Lowers Anxiety During Chemodenervation: a Randomized Trial.

Franks E, Rigdon J, Kennelly M et al. · 2026 · Urogynecology (Philadelphia, Pa.)

Importance Intradetrusor chemodenervation with onabotulinumtoxinA (BOTOX) injections, a common office-based procedure for overactive bladder (OAB), is associated with patient anxiety and discomfort. Aromatherapy and music have been shown…

View details →DOI: 10.1097/spv.0000000000001809
Negative / Null Result ReportOpen accessMedicine

Periodontal Status of Patients with Celiac Disease and Non-Celiac Gluten Sensitivity: A Literature Review.

Angelopoulou T, Bobetsis YA · 2026 · Journal of clinical medicine

Background/Objectives : Celiac disease (CD) is a chronic, immune-mediated enteropathy induced by dietary gluten exposure in genetically predisposed individuals. Along with non-celiac gluten sensitivity (NCGS), these disorders present with…

View details →DOI: 10.3390/jcm15082828
Negative / Null Result ReportMedicine

Endoscopic-Assisted Osteotomy with Absorbable Plate as Internal Attachment Point for External Spring Distraction Osteogenesis in the Treatment of Sagittal Synostosis in Infants.

Shen W, Cui J, Ji Y et al. · 2026 · World neurosurgery

Background Sagittal synostosis (SS) is the premature closure of sagittal sutures. To investigate the use of absorbable plates as internal attachment points for external spring (ES) traction in the treatment of sagittal craniosynostosis in…

View details →DOI: 10.1016/j.wneu.2026.124977
Negative / Null Result ReportOpen accessMedicine

Postoperative Outcomes After Rectal Cancer Surgery With or Without Primary Anastomosis: A Propensity Score-Weighted Study.

Sanda NA, Filip PV, Bobirca FT et al. · 2026 · Diagnostics (Basel, Switzerland)

Background: The role of primary anastomosis in rectal cancer surgery remains debated, particularly due to concerns regarding postoperative morbidity. Evidence from randomized trials is limited, and observational studies are frequently…

View details →DOI: 10.3390/diagnostics16101533
Negative / Null Result ReportOpen accessMedicine

T4bN0 colon cancer shows worse survival than T1-2N1 disease: a multicenter real-world study in China.

Li X, Liang L, Yang ZY et al. · 2026 · Translational cancer research

Background Growing evidence suggests that deeply invasive node-negative colon cancer, particularly T4bN0 disease, may have a worse prognosis than early node-positive tumors, challenging the current American Joint Committee on Cancer (AJCC)…

View details →DOI: 10.21037/tcr-2026-0545
Negative / Null Result ReportMedicine

Night shift work and epigenetic modifications: cardiovascular-related miRNA expression within a European cohort of night shift workers.

Harding BN, Jiang Z, Pineda D et al. · 2026 · Environmental health : a global access science source

Background The major pathways contributing to cardiovascular disease among night shift workers remain poorly understood. MicroRNAs (miRNAs) have been identified as novel regulators of cardiovascular risk factors. Our objective was to…

View details →DOI: 10.1186/s12940-026-01308-5
Negative / Null Result ReportMedicine

Development of a therapeutic education program for patients with chronic rhinosinusitis with nasal polyps.

Perrignon C, Baudouin R, Perrignon M et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

Introduction Chronic rhinosinusitis with nasal polyps (CRSwNP) is a long-lasting inflammatory disease that affects 1-4% of the population and markedly impairs quality of life, daily functioning, and socio-professional activities. As no…

View details →DOI: 10.1007/s00405-026-10190-3
Negative / Null Result ReportMedicine

Clinical and imaging differences between pancreatic carcinoma in situ and T1a/T1b pancreatic ductal adenocarcinoma.

Satoh T, Kawaguchi S, Nakatani E et al. · 2026 · Abdominal radiology (New York)

Background/objectives Accurate differentiation between pancreatic carcinoma in situ (CIS) and small invasive pancreatic ductal adenocarcinoma (PDAC) is critical for optimizing patient management. This study aimed to assess the diagnostic…

View details →DOI: 10.1007/s00261-026-05453-w
Negative / Null Result ReportMedicine

Intraoperative optic nerve sheath diameter changes in vNOTES versus total laparoscopic hysterectomy: a prospective randomized study.

Acil F, Dedeoğlu A, Tosun Söner H et al. · 2026 · Surgical endoscopy

Background Pneumoperitoneum and steep Trendelenburg positioning during laparoscopic hysterectomy may increase intracranial pressure. Optic nerve sheath diameter (ONSD), measured by transorbital ultrasonography, is a validated noninvasive…

View details →DOI: 10.1007/s00464-026-12731-7
Negative / Null Result ReportMedicine

Robot-Assisted TKA for Varus Knees: Post Hoc Exploratory Analysis of Alignment Strategy and Deformity Severity.

Lychagin AV, Gritsyuk AA, Elizarov MP et al. · 2026 · Journal of clinical medicine

Background: Robot-assisted total knee arthroplasty (raTKA) improves the precision of component positioning and coronal alignment restoration, but it remains uncertain whether that technical accuracy modifies the clinical effect of…

View details →DOI: 10.3390/jcm15124515