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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20253 results in Negative / Null Result Report · page 471 of 676

Negative / Null Result ReportOpen accessMedicine

Epstein-Barr virus and human papillomavirus infections and genotype distribution in head and neck cancers.

Zeyi Deng, Takayuki Uehara, Hiroyuki Maeda et al. · 2014 · PLoS ONE

To investigate the prevalence, genotypes, and prognostic values of Epstein-Barr virus (EBV) and human papillomavirus (HPV) infections in Japanese patients with different types of head and neck cancer (HNC).HPV and EBV DNA, EBV genotypes and LMP-1 variants, and HPV mRNA expression were detected by PCR from fresh-frozen HNC samples. HPV genotypes were determined by direct sequencing, and EBV encoded RNA (EBER) was examined by in situ hybridization.Of the 209 HNC patients, 63 (30.1%) had HPV infection, and HPV-16 was the most common subtype (86.9%). HPV E6/E7 mRNA expression was found in 23 of 60

View details →DOI: 10.1371/journal.pone.0113702
Negative / Null Result ReportOpen accessAgriculture

The probiotic effects of dietary inactive yeast Saccharomyces cerevisiae var. ellipsoideus on growth factors, survival, body composition and intestinal microbiota of Beluga juvenile (Huso huso)

S.H. Hoseinifar email ; A.R. Mirvaghefi; B. Mojazi Amiri; H.A. Khoshbavar Rostami; M. Poor Amini; K. Darvish Bastami · 2011 · ‬‭Majallah-i ̒Ilmī-i Shīlāt-i Īrān

The probiotic effects of inactive yeast, Saccharomyces cerevisiae var. ellipsoideus was studied on growth performance, survival and intestinal microbiota of beluga juveniles (Huso huso). The study was done in complete randomize design that included feeding of beluga juveniles with diets supplemented with 0 (control), 1, 2 and 5% yeast (4 treatments with 3 replicates). Beluga juveniles (11.40±0.56g) were randomly allocated in 12 oval tanks at a density of 35 fish per tank and triplicate group were fed with experimental diets. At the end of the trial, growth factors (final weight, weight gain,

Negative / Null Result ReportOpen accessMedicine (General)

Effect of Needle Tip Position on Contrast Media Dispersion Pattern in Transforaminal Epidural Injection Using Kambin’s Triangle Approach

Lee J, Jo D, Song S et al. · 2020 · Journal of Pain Research

Jongseok Lee,1 Daehyun Jo,2 Shinmi Song,1 Dahee Park,1 Dohyeong Kim,1 Jinyoung Oh1 1Department of Anesthesiology and Pain Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea; 2Pain Center, Pohang Wooridul Hospital, Pohang-si, Gyeongsangbuk-do, Republic of KoreaCorrespondence: Jinyoung OhDepartment of Anesthesiology and Pain Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonju-Ro, Gangnan-Gu, Seoul, Republic of KoreaTel +82-2-2019-3600Fax +82-2-2019-4833Email sgcms3@gmail.comPurpose: Dispersion of contrast media

Negative / Null Result ReportOpen accessMedicine

Depression in Parkinson's disease: A case-control study.

Yu-Hsuan Wu, Yi-Huei Chen, Ming-Hong Chang et al. · 2018 · PLoS ONE

To evaluate the association between Parkinson's disease (PD) prognosis and the patient's onset of depression.A total of 353 patients with newly-diagnosed PD and a history of depression were enrolled. On the basis of the onset of depression before or after PD diagnosis, we divided participants into PD patients with pre- or post-diagnostic depression. Cox's regression analysis was used to detect risks between the onset of depression and outcomes (including death, accidental injury, dementia, and aspiration pneumonia). The association between the onset of depression and levodopa equivalent dosage

View details →DOI: 10.1371/journal.pone.0192050
Negative / Null Result ReportOpen accessMedicine

Clinical characteristics of gout patients with shoulder joints involved from 24 cases

WANG Yibo, HAN Yingdong, XIE Tiange, WU Juan, DI Hong, ZHANG Yun, ZENG Xuejun · 2025 · Jichu yixue yu linchuang

Objective To characterize the clinical features of the group of gout patients to facilitate earlier identification, and optimize the diagnosis and treatment of the condition. Methods The retrospective study analyzed 24 gout patients with shoulder joint(s) involved and consulted by physicians of Peking Union Medical College Hospital from March 2021 to April 2025, while 70 outpatient gout patients matched by clinical course duration and sex were enrolled as control group. Clinical data including medical history, laboratory tests, therapeutic interventions. Prognosis was systematically collected

View details →DOI: 10.16352/j.issn.1001-6325.2025.11.1485
Negative / Null Result ReportOpen accessSurgery

A new proposal for laparoscopic left colectomy in a rat model

Leonardo de Castro Durães, Eliana Ferreira Ribeiro Durães, Pedro Felipe Silva de Freitas et al. · 2013 · Acta Cirúrgica Brasileira

PURPOSE: To evaluate the feasibility and safety of a new technique for laparoscopic segmental colectomy and primary anastomosis in the left colon of rats. METHODS: Thirty rats were randomly assigned to three groups of ten animals each. All animals underwent segmental resection of the left colon and end-to-end anastomosis. In Group I, the animals underwent laparoscopic surgery with carbon dioxide pneumoperitoneum at a pressure of 5 mmHg. In Group II, the animals underwent pneumoperitoneum with carbon dioxide at a pressure of 12 mmHg. In Group III, the control group, the animals underwent open s

Negative / Null Result ReportOpen accessInternal medicine

Correlation of Moxifloxacin Concentration, C-Reactive Protein, and Inflammatory Cytokines on QTc Interval in Rifampicin-Resistant Tuberculosis Patients Treated with Shorter Regimens

Tutik Kusmiati, Ni Made Mertaniasih, Johanes Nugroho Eko Putranto et al. · 2022 · Acta Medica Indonesiana

Background: Drug-resistant tuberculosis (DR-TB) is a global health concern. QTc prolongation is a serious adverse effect in DR-TB patients receiving a shorter regimen. This study aimed to evaluate the correlation of moxifloxacin concentration, CRP, and inflammatory cytokines with QTc interval in DR-TB patients treated with a shorter regimen. Methods: This study was performed in 2 groups of rifampicin-resistant (RR-TB) patients receiving shorter regimens. Correlation for all variables was analyzed. Results: CRP, IL-1β, and QTc baseline showed significant differences between 45 RR-TB patients on

Negative / Null Result ReportOpen accessAnimal culture

Is the establishment rate and fecundity of Haemonchus contortus related to body or abomasal measurements in sheep?

A. Idris, E. Moors, C. Budnick et al. · 2011 · Animal

The relationship among parasitological parameters, abomasal size and body size measurements was investigated in lambs following an experimental infection with Haemonchus contortus. In total, 100 lambs from five different genotypes (German Merino (GM), Texel × GM, Suffolk × GM, German Blackhead Mutton × GM and Ile de France × GM) were experimentally infected with 5000 infective third stage larvae of H. contortus at the time of weaning at 12 weeks of age. Four and six weeks after infection, individual faecal samples were collected for estimation of faecal egg counts (FECs). Furthermore, wither h

View details →DOI: 10.1017/s1751731111000292
Negative / Null Result ReportOpen accessMedicine (General)

The Distribution of Apolipoprotein E Gene Polymorphism and Apolipoprotein E Levels among Coronary Artery Patients Compared to Controls

Omer Atis, Semsettin Sahin, Koksal Ceyhan et al. · 2019 · Eurasian Journal of Medicine

Abstract Objective: Coronary artery disease (CAD) is a multifactorial disease that is caused by various genetics and environmental factors. Genetically, predisposition is an important component for CAD. The candidate apolipoprotein E (apoE) gene is the most studied one. ApoE is composed of e2, e3, e4 alleles and E2/2, E2/3, E2/4, E3/3, E3/4, E4/4 genotypes. In this study, the relationship between CAD and apoE polymorphism and apoE level has been studied in Tokat region. Materials and Methods: The study population is composed of 100 CAD patients diagnosed by coronary angiography and 100 control

View details →DOI: 10.5152/eurasianjmed.2015.25
Negative / Null Result ReportOpen accessDentistry

Evaluation of Shear Bond Strength and Adhesive Remnant Index of New-Generation Adhesive-Coated Bracket Systems In Comparison With Traditional Systems

Gökay Üstdal, Ayça Üstdal Güney, Eyüp Burak Küçük · 2024 · Current Research in Dental Sciences

Objective: To evaluate the shear bond strength (SBS) and the adhesive remnant index (ARI) of different traditional orthodontic adhesive systems and newly developed pre-coated adhesive systems.Methods: A total of 50 human maxillary premolars were bonded with Clarity advanced ceramic brackets using APC™ Flash-Free, APC™ PLUS, Transbond™ XT Light Cure, Opal® Bond™MV and, Blugloo™ adhesives. All samples underwent thermo-cycling. The SBS was determined using a testometric machine. A stereomicroscope was used to evaluate the adhesive remnant on debonded enamel surface. Differences among the adhesive

View details →DOI: 10.17567/currresdentsci.1555935
Negative / Null Result ReportOpen accessSpecial aspects of education

Reading Online in Foreign Languages: A Study of Strategy Use

Richard Tsan-Jui Cheng · 2016 · International Review of Research in Open and Distributed Learning

Scores of studies have established that when learning online, students must be equipped with different sets of strategies and skills than in a physical classroom setting (Anderson, 2003; Broadbent & Poon, 2015; Coiro, 2007; Leu et al., 2007; Michinov, Brunot, Le Bohec, Juhel, & Delaval, 2011; Salmon, 2013). The present study, by virtue of exploring foreign language learners’ online reading experience, aimed to identify the reading strategies that learners would use when engaged in online reading activities in the target foreign languages. Thirty-two foreign language learners whose native langu

View details →DOI: 10.19173/irrodl.v17i6.2567
Negative / Null Result ReportOpen accessMedicine

Evaluation of the Association Among Cerebrospinal Fluid Protein, Inflammatory Markers, and Electromyography in Pediatric Guillain-Barre Syndrome

Dilek Agircan, Ozlem Ethemoglu, Mustafa Calik et al. · 2024 · Haseki Tıp Bülteni

Aim: Previous studies have shown that the cerebrospinal fluid (CSF) protein level correlates with the number of demyelination criteria in electromyography in adult patients with Guillain-Barré syndrome (GBS), which is a potentially life-threatening postinfectious disease. We aimed to assess the association between CSF protein level, inflammatory markers, and electrophysiological values in the diagnosis of pediatric patients to act quickly in treating GBS. Methods: In this cross-sectional study, thirty-nine children with GBS were retrospectively analyzed from the medical records of patients who

View details →DOI: 10.4274/haseki.galenos.2024.9521
Negative / Null Result ReportOpen accessMedicine

Sensitivity of influenza virus to ultraviolet irradiation

Hessling, Martin, Gierke, Anna-Maria, Sicks, Ben et al. · 2022 · GMS Hygiene and Infection Control

Background: The measures implemented against the coronavirus pandemic also led to a sharp decline in influenza infections in the 2020/2021 flu season. In the meantime, however, the number of influenza infections has risen again; it is known from history that influenza viruses can also trigger severe pandemics. Therefore, we investigated the efficacy of ultraviolet radiation in the spectral range of 200–40 for inactivating influenza viruses.Materials and methods: The scientific literature was searched for published ultraviolet (UV) irradiation experiments with influenza viruses and the results

View details →DOI: 10.3205/dgkh000423
Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens

Influence of Pre‐Vaccination HPV Status on Vaccine Effectiveness Among Chinese Women: A Multicenter Cross‐Sectional Study

Lucia Li, Haiyue Wu, Yibo Chen et al. · 2025 · Cancer Reports

ABSTRACT Background and Aims Human papillomavirus (HPV) vaccines have been available in China for only 8 years, and routine HPV testing is not recommended prior to vaccination. Therefore, evaluation of HPV vaccine effectiveness and the impact of pre‐vaccination HPV infection status on vaccine protective effect in Chinese women is warranted. Methods From June 2022 to June 2023, women aged 18 to 50 years without a history of cervical or uterine excision were recruited from three medical institutions. Baseline characteristics were compared between vaccinated and unvaccinated participants, with in

View details →DOI: 10.1002/cnr2.70294
Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system

The impact of robotic assistance for lumbar fusion surgery on 90-day surgical outcomes and 1-year revisions

Jeremy C Heard, Yunsoo A Lee, Nicholas D D'Antonio et al. · 2024 · Journal of Craniovertebral Junction and Spine

Objectives: To evaluate the (1) 90-day surgical outcomes and (2) 1-year revision rate of robotic versus nonrobotic lumbar fusion surgery. Methods: Patients >18 years of age who underwent primary lumbar fusion surgery at our institution were identified and propensity-matched in a 1:1 fashion based on robotic assistance during surgery. Patient demographics, surgical characteristics, and surgical outcomes, including 90-day surgical complications and 1-year revisions, were collected. Multivariable regression analysis was performed. Significance was set to P < 0.05. Results: Four hundred and fiftee

View details →DOI: 10.4103/jcvjs.jcvjs_145_23
Negative / Null Result ReportOpen accessMedicine

Partos pélvicos.

J Neves, P J Santos, I Azevedo et al. · 1999 · Acta Médica Portuguesa

Labour is very important in breech presentation and it is associated to significant morbidity and mortality enhancement in recent years. The authors made a retrospective study of breech presentation and labour with this kind of fetal presentation, in Santa Maria Hospital in 1993 and analysed the following data: maternal age, parity, gestational age, the mode of delivery, the fetal weight, the maternal and fetal morbidity and mortality. The authors also reviewed the Literature on the incidence, the most frequent complications and the management in labour to compare with the results of the study

View details →DOI: 10.20344/amp.2145
Negative / Null Result ReportOpen accessMedicine

Technological infrastructure, sleep, and rest-activity patterns in a Kaqchikel Maya community.

Leela McKinnon, David R Samson, Charles L Nunn et al. · 2022 · PLoS ONE

Sleep duration, quality, and rest-activity pattern-a measure for inferring circadian rhythm-are influenced by multiple factors including access to electricity. Recent findings suggest that the safety and comfort afforded by technology may improve sleep but negatively impact rest-activity stability. According to the circadian entrainment hypothesis, increased access to electric lighting should lead to weaker and less uniform circadian rhythms, measured by stability of rest-activity patterns. Here, we investigate sleep in a Maya community in Guatemala who are in a transitional stage of industria

View details →DOI: 10.1371/journal.pone.0277416
Negative / Null Result ReportOpen accessMicrobiology

The change of SPAD value and the establishment of correlation model of lettuce in intercropping mode

Wang Linlin, Song Tingting, Du Yuejiao et al. · 2024 · BIO Web of Conferences

In order to find out the change rule of SPAD value in lettuce leaves and the rapid, non-destructive and more accurate detection method of chlorophyll content in lettuce leaves under intercropping mode, the effect of intercropping on SPAD value in lettuce leaves was studied and the correlation model between chlorophyll content and SPAD value was established. The results show that the SPAD value of lettuce leaves increases at first and then decreases slowly with the development of the days of aerosol culture, and intercropping has obvious advantage in the middle and late stages of aerosol cultur

View details →DOI: 10.1051/bioconf/202411103003
Negative / Null Result ReportOpen accessMedicine

Software-based noise reduction in cranial magnetic resonance imaging: Influence on image quality.

Philipp Fuelkell, Soenke Langner, Nele Friedrich et al. · 2018 · PLoS ONE

OBJECTIVES:To investigate acoustic noise reduction, image quality and white matter lesion detection rates of cranial magnetic resonance imaging (MRI) scans acquired with and without sequence-based acoustic noise reduction software. MATERIAL AND METHODS:Thirty-one patients, including 18 men and 13 women, with a mean age of 58.3±14.5 years underwent cranial MRI. A fluid-attenuated inversion recovery (FLAIR) sequence was acquired with and without acoustic noise reduction using the Quiet Suite (QS) software (Siemens Healthcare). During data acquisition, peak sound pressure levels were measured wit

View details →DOI: 10.1371/journal.pone.0206196
Negative / Null Result ReportOpen accessMedicine

Questioning the lasting effect of galvanic vestibular stimulation on postural control.

Mujda Nooristani, Maxime Maheu, Marie-Soleil Houde et al. · 2019 · PLoS ONE

Noisy galvanic vestibular stimulation (nGVS) has been shown to enhance postural stability during stimulation, and the enhancing effect has been observed to persist for several hours post-stimulation. However, these effects were observed without proper control (sham condition) and the possibility of experimental bias has not been ruled out. The lasting effect of nGVS on postural stability therefore remains in doubt. We investigated the lasting effect of nGVS on postural stability using a control (sham) condition to confirm or infirm the possibility of experimental bias. 28 participants received

View details →DOI: 10.1371/journal.pone.0224619
Negative / Null Result ReportOpen accessSports medicine

Effects of stimulation conditions and subcutaneous tissue properties on acupressure-induced changes in blood circulation of human tendons

Ayaka Yasuda, Shuhei Sasajima, Takehiro Kosaka et al. · 2023 · Journal of Physical Fitness and Sports Medicine

The purpose of this study was to investigate the effects of stimulation conditions (pressing force and frequency) and subcutaneous tissue properties (thickness and hardness) on the changes in tendon blood circulation caused by acupressure. Before and after acupressure, blood circulation of the Achilles tendon was measured using red laser lights. Acupressure was applied to the Achilles tendon for 3-min under three conditions. The following four conditions (including no stimulation condition) with different combinations of pressing forces and frequencies were established: 1) 50N and 1.5Hz, 2) 25

View details →DOI: 10.7600/jpfsm.12.147
Negative / Null Result ReportOpen accessMedicine

Efficacy of a tight-control and treat-to-target strategy in axial spondyloarthritis: results of the open-label, pragmatic, cluster-randomised TICOSPA trial.

Molto A, López-Medina C, Van den Bosch FE et al. · 2021 · Annals of the rheumatic diseases

Objectives To compare the benefits of a tight-control/treat-to-target strategy (TC/T2T) in axial spondyloarthritis (axSpA) with those of usual care (UC). Methods Pragmatic, prospective, cluster-randomised, controlled, open, 1-year trial…

View details →DOI: 10.1136/annrheumdis-2020-219585
Negative / Null Result ReportOpen accessMedicine

The effect of intermittent pneumatic compression on deep-vein thrombosis and ventilation-free days in critically ill patients with heart failure

Hasan M. Al-Dorzi, Abdulaziz Al-Dawood, Fahad M. Al-Hameed et al. · 2022 · Scientific Reports

Abstract There are contradictory data regarding the effect of intermittent pneumatic compression (IPC) on the incidence of deep-vein thrombosis (DVT) and heart failure (HF) decompensation in critically ill patients. This study evaluated the effect of adjunctive use of IPC on the rate of incident DVT and ventilation-free days among critically ill patients with HF. In this pre-specified secondary analysis of the PREVENT trial (N = 2003), we compared the effect of adjunctive IPC added to pharmacologic thromboprophylaxis (IPC group), with pharmacologic thromboprophylaxis alone (control group) in c

View details →DOI: 10.1038/s41598-022-12336-9
Negative / Null Result Report

304 To Raise Awareness About the NHS Cervical Screening Programme and to Reduce the Number of Did-Not-Attend (DNAs) Cervical Screening Appointments Among Women Aged 25–35 Years Through a Collaborative Reward System with Local Businesses

S. Singh · 2022 · British Journal of Surgery

Abstract Introduction Cervical screening is offered free under NHS Cervical Screening Programme since 1988. However, compliance is dwindling in the last decade, especially among women aged 25–35 years who had the least awareness. NHS…

View details →DOI: 10.1093/bjs/znac039.200
Negative / Null Result Report

The Asian crisis: what did we learn and when did we learn it?

Stephen Grenville · 2017 · Asian-Pacific Economic Literature

This paper steps back from the detail of the Asian crisis, to ask whether the 1997 crisis advanced our broad understanding of the age‐old problem of economic crises. Some immediate lessons were learned from the failures of the…

View details →DOI: 10.1111/apel.12194
Negative / Null Result ReportOpen access

Influence of Syphilis Infection on Abortions in Iraq

A. Alwan · 2022 · JOURNAL OF COMMUNICABLE DISEASES

Introduction: Syphilis is a sexually transmitted disease, that may be transferred from mothers to infants during pregnancy if it is left untreated. Method: This study was conducted among 65 women who suffered from recurrent abortions in…

View details →DOI: 10.24321/0019.5138.2022101
Negative / Null Result Report

Exploratory outcomes of the DHA WIN randomized controlled trial: Supplementing women with docosahexaenoic acid did not reduce the impact of neoadjuvant breast cancer chemotherapy on quality of life or exercise behaviour

Claire M. Douglas, Marnie Newell, Susan Goruk et al. · 2025 · PLOS One

Supplementation of omega-3 (n-3) polyunsaturated fatty acids has been associated with reduced side effects and improved quality of life (QoL) in breast cancer patients receiving chemotherapy. The current study reports secondary outcomes…

View details →DOI: 10.1371/journal.pone.0322178
Negative / Null Result Report

Domestic Violence against Women in Turkey, What Did Women Say?

· 2016 · Journal of Nursing &amp; Healthcare

The present study presents the findings about domestic violence women experienced by their husbands in 2015 in Turkey. A total of 50 women between the ages of 18 and 50 participated in the study. They answered the questions about physical,…

View details →DOI: 10.33140/jnh.01.01.10
Negative / Null Result Report

Analysis of the Significant Difference in Fishing Gear Used According to Income Levels of Fisherfolks

JHEMIMA M. GANAPIN, EULIE GAY N. ESPINOCILLA, DECEMA B. WALLACE et al. · 2025 · International Journal of Science and Research Archive

Fishing serves as one of the vital livelihood for communities in Diadi, Nueva Vizcaya, providing both income and food security. This study examined the significant difference in fishing gear used according to income levels of fisherfolks.…

View details →DOI: 10.30574/ijsra.2025.17.2.3006