A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19786 results in Negative / Null Result Report · page 46 of 660
Jared W. Magnani, Carlee Moser, Joanne M. Murabito et al. · 2014 · Circulation Arrhythmia and Electrophysiology
BACKGROUND: Endogenous sex hormones have been related to cardiovascular outcomes and mortality. We hypothesized that sex hormones are related to atrial fibrillation (AF) in a community-based cohort of middle-aged to older men. METHODS AND…
Joel B. Nelson, Karim Fizazi, Kurt Miller et al. · 2012 · Cancer
BACKGROUND: Endothelin-1 and the endothelin A (ET(A) ) receptor have been implicated in prostate cancer progression in bone. This study aimed to determine whether the specific ET(A) receptor antagonist, zibotentan, prolonged overall…
Monique Maas, Patty J. Nelemans, Vincenzo Valentini et al. · 2014 · International Journal of Cancer
Recent literature suggests that the benefit of adjuvant chemotherapy (aCT) for rectal cancer patients might depend on the response to neoadjuvant chemoradiation (CRT). Aim was to evaluate whether the effect of aCT in rectal cancer is…
Ling Ji, Todd Chaba, Lin-Fu Zhu et al. · 2011 · Hepatology
UNLABELLED: A major predictor of failed liver resection and transplantation is nonalcoholic fatty liver disease (NAFLD). NAFLD is linked to a wide spectrum of diseases including obesity and diabetes that are increasingly prevalent in…
David R. Friedland, Christina L. Runge, Humera F. Baig et al. · 2010 · Archives of Otolaryngology - Head and Neck Surgery
OBJECTIVE: To characterize speech perception performance in elderly cochlear implant users compared with younger adult users. DESIGN: Case-control retrospective analysis from January 1, 1999, to January 28, 2008. SETTING: Tertiary care,…
Anqi Zhu, Avi Srivastava, Joseph G Ibrahim et al. · 2019 · Nucleic Acids Research
Abstract A primary challenge in the analysis of RNA-seq data is to identify differentially expressed genes or transcripts while controlling for technical biases. Ideally, a statistical testing procedure should incorporate the inherent…
Hans J. Grabe, Christian Schwahn, Katja Appel et al. · 2010 · American Journal of Medical Genetics Part B Neuropsychiatric Genetics
Dysregulations of the hypothalamic-pituitary-adrenal (HPA) axis have been implicated in the pathogenesis of depressive disorders and the corticotropin-releasing hormone (CRH) was found to modulate emotional memory consolidation. Recently,…
Casey W. Dunn, Felipe Zapata, Catriona Munro et al. · 2018 · Proceedings of the National Academy of Sciences
There is considerable interest in comparing functional genomic data across species. One goal of such work is to provide an integrated understanding of genome and phenotype evolution. Most comparative functional genomic studies have relied…
Eko Wahjudi · 2019 · Journal of Management Development
Purpose The purpose of this paper is to analyze the variables that significantly affect dividend policy. Design/methodology/approach This research uses a type of comparative causal research (causal-comparative research), where the fact or…
Coren L. Apicella, David Cesarini, Magnus Johannesson et al. · 2010 · PLoS ONE
BACKGROUND: Oxytocin (OXT) has been implicated in a suite of complex social behaviors including observed choices in economic laboratory experiments. However, actual studies of associations between oxytocin receptor (OXTR) gene variants and experimentally elicited social preferences are rare. METHODOLOGY/PRINCIPAL FINDINGS: We test hypotheses of associations between social preferences, as measured by behavior in two economic games, and 9 single nucleotide polymorphisms (SNPs) of the OXTR gene in a sample of Swedish twins (n = 684). Two standard economic games, the dictator game and the trust ga
Robert L. Ferris, Nabil F. Saba, Barbara J. Gitlitz et al. · 2018 · JAMA Oncology
Importance: Immunotherapy for recurrent and/or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN) is promising. The toll-like receptor 8 (TLR8) agonist motolimod may stimulate innate and adaptive immunity. Objective: To…
Javier Palma‐Guerrero, Xin Ma, Stefano F. F. Torriani et al. · 2017 · Molecular Plant-Microbe Interactions
Zymoseptoria tritici is an ascomycete fungus that causes Septoria tritici blotch, a globally distributed foliar disease on wheat. Z. tritici populations are highly polymorphic and exhibit significant quantitative variation for virulence.…
Amy Roberts, Jennifer LoCasale‐Crouch, Bridget K. Hamre et al. · 2016 · Early Education and Development
Research Findings: This study explored the role Head Start teachers’ (n = 355) depressive symptoms play in their interactions with children and in children’s (n = 2,203) social-emotional development, specifically changes in children’s…
Bo Abrahamsen, Henrik L. Jørgensen, Anne Sofie Laulund et al. · 2014 · Journal of Bone and Mineral Research
The relationship between thyrotoxicosis and osteoporotic fractures remains controversial, particularly in men. Register-based cohort study including all patients with a serum thyrotropin (TSH) measurement in the region of Funen 1996-2010.…
Yoshio N. Hall, Brett Larive, Patricia Painter et al. · 2012 · Clinical Journal of the American Society of Nephrology
BACKGROUND AND OBJECTIVES: Relatively little is known about the effects of hemodialysis frequency on the disability of patients with ESRD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This study examined changes in physical performance…
Leigh S. Wilton, Ariana N. Bell, Mariam Vahradyan et al. · 2020 · Personality and Social Psychology Bulletin
Organizations aim to convey that they are diverse and inclusive, in part, to recruit racial minorities. We investigate a previously unexamined downside of this recruitment strategy: diversity dishonesty, that is, belief that an…
Hanisom Abdullah, Kun Mediaswanti, Hongwei Wu · 2010 · Energy & Fuels
This study shows the significant differences in the fuel quality and ash properties of biochars produced from the slow pyrolysis of various biomass components (leaf, wood, and bark). The objective is to identify which component is likely…
Carlos Oliveira Cruz, Rui Cunha Marques · 2013 · Journal of Construction Engineering and Management
Renegotiations are frequently perceived as the Achilles’ heel of concessions. After two decades of concessions development, empirical evidence suggests a recurrent need to renegotiate contracts. What drives renegotiation? Why does it…
Marius M. Hoeper, Juergen Behr, Matthias Held et al. · 2015 · PLoS ONE
BACKGROUND: Pulmonary hypertension (PH) is a common finding in patients with chronic fibrosing idiopathic interstitial pneumonias (IIP). Little is known about the response to pulmonary vasodilator therapy in this patient population. COMPERA is an international registry that prospectively captures data from patients with various forms of PH receiving pulmonary vasodilator therapies. METHODS: We retrieved data from COMPERA to compare patient characteristics, treatment patterns, response to therapy and survival in newly diagnosed patients with idiopathic pulmonary arterial hypertension (IPAH) and
Marian L. Kohut, David S. Senchina · 2026 · PubMed
Decreases in immune responsiveness with age are thought to contribute to the increased incidence and severity of infectious disease among the elderly. Several interventions, including exercise, have been proposed to restore immune function…
Michael S. Northrop, Robert F. Sidonio, Sharon Phillips et al. · 2014 · Pediatric Critical Care Medicine
OBJECTIVES: To determine if a comprehensive extracorporeal membrane oxygenation anticoagulation monitoring protocol results in fewer hemorrhagic complications, reduced blood product usage, and increased circuit life. DESIGN: In September…
Payton J. Jones, Benjamin W. Bellet, Richard J. McNally · 2020 · Clinical Psychological Science
Trigger warnings alert trauma survivors about potentially disturbing forthcoming content. However, empirical studies on trigger warnings suggest that they are functionally inert or cause small adverse side effects. We conducted a…
Alice Tseng, Leah Szadkowski, Sharon Walmsley et al. · 2013 · Annals of Pharmacotherapy
BACKGROUND: Interactions between antiretroviral (ARV) therapy and medications to treat age-related comorbidities are a growing concern in the aging HIV population. OBJECTIVE: To investigate the association of age with potential drug-drug…
C. Avendaño, António Ramos, Elena Múñez et al. · 2021 · Journal of Clinical Investigation
BACKGROUNDPassive immunotherapy with convalescent plasma (CP) is a potential treatment for COVID-19. Evidence from controlled clinical trials is inconclusive.METHODSWe conducted a randomized, open-label, controlled clinical trial at 27…
J. Randolph Hecht, Sara Lonardi, Johanna C. Bendell et al. · 2021 · Journal of Clinical Oncology
PURPOSE SEQUOIA compared efficacy and safety of adding pegilodecakin (PEG), a pegylated recombinant human interleukin (IL)-10, with folinic acid, fluorouracil, and oxaliplatin (FOLFOX) in patients following progression on first-line…
Christian von Bodman, Kazuhito Matsushita, Caroline Savage et al. · 2012 · The Journal of Urology
PURPOSE: We determined whether pelvic soft tissue and bony dimensions on endorectal magnetic resonance imaging influence the recovery of continence after radical prostatectomy, and whether adding significant magnetic resonance imaging…
Yoshinobu Onuma, Patrick W. Serruys, J.A. Fernández Gómez et al. · 2011 · Catheterization and Cardiovascular Interventions
OBJECTIVES: The ABSORB cohort A trial using the bioresorbable everolimus-eluting scaffold (BVS revision 1.0, Abbott Vascular) demonstrated a slightly higher acute recoil with BVS than with metallic stents. To reinforce the mechanical…
Charles de Mestral · 2011 · Canadian Journal of Surgery
BACKGROUND: A multidisciplinary tracheostomy team was created in 2005 to follow critically ill patients who had undergone a tracheostomy until their discharge from hospital. Composed of a surgeon, surgical resident, respiratory therapist,…
Michael R. Sperling, Bassel Abou‐Khalil, Jay Harvey et al. · 2014 · Epilepsia
OBJECTIVE: To evaluate the efficacy and safety of adjunctive eslicarbazepine acetate (ESL) in patients with refractory partial-onset seizures. METHODS: This randomized, placebo-controlled, double-blind, parallel-group, phase III study was…
Christiane Al‐Haddad, Georges M. El Mollayess, Carol Cherfan et al. · 2011 · British Journal of Ophthalmology
BACKGROUND/AIMS: To study peripapillary retinal nerve fibre layer (RNFL) and macular thickness in amblyopia using high-definition spectral-domain optical coherence tomography (SD-OCT) and to compare the results with available literature…