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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20253 results in Negative / Null Result Report · page 452 of 676

Negative / Null Result ReportMedicine

Inhibitory Control and Creativity in Children With Mild Intellectual Disabilities.

Japundža-Milisavljević M, Buha N, Milanović-Dobrota B · 2026 · Journal of applied research in intellectual disabilities : JARID

Background The study is based on the Dual Pathway to Creativity Model and explores the relationship between inhibitory control and creativity in children with mild intellectual disabilities. Method The sample consisted of 58 children with…

View details →DOI: 10.1111/jar.70213
Negative / Null Result ReportMedicine

Evaluation of corneal aberrations and meibomian gland function after botulinum toxin A in blepharospasm/hemifacial spasm.

Doganay D, Ismayilov AS, Sevınc D et al. · 2026 · Cutaneous and ocular toxicology

Purpose To evaluate the changes in aberrometry values on corneal topography and the function of the meibomian glands following therapeutic Botulinum toxin type A injections in patients with blepharospasm and hemifacial spasm. Materials and…

View details →DOI: 10.1080/15569527.2026.2673150
Negative / Null Result ReportMedicine

Modulation of oxidative stress mediates kaempferol induced enhancement of bovine oocyte In Vitro maturation developmental efficiency.

Wang H, Wang W, Li Y et al. · 2026 · Animal reproduction science

This study aimed to examine the protective effects of kaempferol on the in vitro maturation (IVM) of bovine oocytes and their subsequent embryonic development, and to investigate the underlying mechanisms. Bovine oocytes were cultured with…

View details →DOI: 10.1016/j.anireprosci.2026.108252
Negative / Null Result ReportMedicine

Tasting beer based on the tactile thickness of the glass lip

Ariga A, Kubo N, Koizumi T et al. · 2026 · Food Quality and Preference.

Multisensory research has demonstrated that the perceptual characteristics of a receptacle can influence how beverages are experienced, a phenomenon known as sensation transference. Previous studies have shown that the lip thickness of a…

Negative / Null Result Report

Do drugs with biliary toxicity cause cholangiocarcinoma?

Zong C, Lim K, Walker SA et al. · 2026 · Preprint

A bstract Many commonly used therapeutic drugs cause biliary toxicity, but it is unclear if they are directly responsible for the increasing incidence of cholangiocarcinoma (CCA). We tested experimentally and analyzed through a cohort…

View details →DOI: 10.64898/2026.03.31.715688
Negative / Null Result ReportMedicine

Incidence and associated factors of metachronous contralateral cryptorchidism after unilateral cryptorchidism: a retrospective cohort study.

Grande-Moreillo C, Pérez-López C, Vicente-Sánchez N et al. · 2026 · European journal of pediatrics

Acquired cryptorchidism is an increasingly recognized condition and may present bilaterally with a metachronous pattern. The objective of this study was to evaluate the incidence of acquired contralateral metachronous cryptorchidism and to…

View details →DOI: 10.1007/s00431-026-07154-4
Negative / Null Result ReportMedicine

Frequent Ambulatory Care Visits Predict Harmful Diagnostic Errors in High-Risk Hospitalized Patients: a Retrospective Cohort Study.

Goyal A, Konieczny K, Plombon S et al. · 2026 · Journal of general internal medicine

Background Diagnostic errors (DEs) are a major threat to hospital patient safety. Identifying admission-based predictors associated with harmful DEs may help improve diagnostic safety in high-risk populations. Objective To assess the…

View details →DOI: 10.1007/s11606-026-10527-y
Negative / Null Result ReportOpen accessMedicine

Effectiveness of Hyaluronic Acid Gel in Preventing Postoperative Intrauterine Adhesion Formation Following Operative Hysteroscopy.

Ciftci B, Karadag B · 2026 · International journal of women's health

Objective To evaluate the effectiveness of intrauterine hyaluronic acid (HA) gel application in preventing postoperative intrauterine adhesion formation following operative hysteroscopy. Methods This retrospective comparative study was…

View details →DOI: 10.2147/ijwh.s609095
Negative / Null Result ReportOpen accessMedicine

Trend and clinical outcomes of transcatheter aortic valve replacement in connective tissue disease from the national inpatient sample database (2016-2022).

Yasmin F, Rab AU, Asghar MS et al. · 2026 · Journal of cardiothoracic surgery

Purpose Given the systemic nature of connective tissue diseases (CTD), open surgical intervention for aortic stenosis is often considered high risk, making transcatheter aortic valve replacement (TAVR) a potentially preferable alternative.…

View details →DOI: 10.1186/s13019-026-04170-1
Negative / Null Result ReportMedicine

Factors Affecting the Quantitative Value of the Pivot Shift Test Using a Navigation System in Anterior Cruciate Ligament Injured Knees.

Nakamae A, Nekomoto A, Nakata K et al. · 2026 · The journal of knee surgery

Abstract This study aimed to identify factors associated with greater quantitative pivot shift in anterior cruciate ligament (ACL)-injured knees by quantitatively assessing the pivot shift under anesthesia using a navigation system prior…

View details →DOI: 10.1055/a-2865-3249
Negative / Null Result ReportMedicine

Evaluation of the Effect of Different Drilling Systems on Trabecular Bone Microarchitecture During Implant Cavity Preparation Using CBCT: Ex Vivo Study.

Cakir M, Buyuk C, Kan B · 2026 · The International journal of oral & maxillofacial implants

Purpose Achieving optimal primary stability is critical for dental implant success, particularly in low-density bone regions such as the posterior maxilla. Conventional high-speed drilling with irrigation may remove vital bone fragments…

View details →DOI: 10.11607/jomi.11740
Negative / Null Result ReportOpen accessMedicine

Dosimetric Impact of Artificial Intelligence (AI)-Based Autocontouring Software, OncoStudio, in High-Risk Prostate Cancer Treatment Planning: A Three-Group Comparative Study on the Slice Ranges of Seminal Vesicles.

Kawaguchi M, Hoshina M, Sugahara S et al. · 2026 · Cureus

Objective This pilot study investigated the dosimetric impact of artificial intelligence (AI)-generated seminal vesicle (SV) autocontouring (AC) compared with manual contouring (MC) in high-risk prostate cancer volumetric-modulated arc…

View details →DOI: 10.7759/cureus.103403
Negative / Null Result ReportMedicine

Real-World Outcomes of Total Neoadjuvant Therapy Versus Standard Neoadjuvant Chemoradiotherapy in Stage II-III Locally Advanced Rectal Cancer: A Comparative Cohort Study.

Erken AA, Dincer ST · 2026 · Asia-Pacific journal of clinical oncology

Aim Total neoadjuvant therapy has been adopted to improve systemic disease control in locally advanced rectal cancer, yet long-term real-world outcomes, particularly in non-Western populations, remain incompletely defined. We compared…

View details →DOI: 10.1111/ajco.70118
Negative / Null Result ReportMedicine

Inflammatory Biomarkers and Their Associations with Arrhythmic Burden Following SGLT2-I Treatment in Chronic Heart Failure-A Subanalysis of the ERASe Trial.

Benedikt M, Herrmann M, Aziz F et al. · 2026 · Journal of clinical medicine

Background : Sodium glucose-linked transport 2 inhibitors (SGLT2-Is) are well known to exert beneficial effects in chronic heart failure (CHF) independent of left ventricular ejection fraction (LVEF). As inflammation plays a key role in…

View details →DOI: 10.3390/jcm15124681
Negative / Null Result ReportOpen accessMedicine

Two versus three cannulated screws in pediatric Delbet type II femoral neck fractures: a retrospective comparative study.

Erdoğan F, Cengiz T, Şimşek ŞA et al. · 2026 · Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES

Background Pediatric femoral neck fractures are rare but carry a high risk of complications such as avascular necrosis (AVN), premature physeal closure, and coxa vara. Although stable internal fixation is essential, the optimal number of…

View details →DOI: 10.14744/tjtes.2026.97273
Negative / Null Result ReportMedicine

Outcome of preterm newborns admitted with respiratory distress in relation to time of initiation of CPAP.

Pandey K, Choubey B, Gupta N et al. · 2026 · Journal of neonatal-perinatal medicine

BackgroundRespiratory distress is a frequent complication in preterm infants, often requiring respiratory support. Respiratory distress syndrome (RDS), caused by surfactant deficiency in the immature lung, is the predominant etiology in…

View details →DOI: 10.1177/19345798261443957
Negative / Null Result ReportMedicine

[Influenza virus infection affects the efficacy of the treatment of dyslipidemia in mice with a polyisoprenoid-based drug].

Makiev EA, Kozhevnikova TN, Pronin AV et al. · 2026 · Voprosy virusologii

Objective To evaluate how influenza infection affects the hypolipidemic effect of a novel combined drug - Prenophytol based on polyisoprenoids (sodium polyprenyl phosphate and beta-sitosterol) in mice with experimental dyslipidemia.…

View details →DOI: 10.36233/0507-4088-343
Negative / Null Result ReportMedicine

Short-term vaginal prasterone therapy induces steroid receptor modulation and extracellular matrix remodeling in human vaginal mucosa.

Tomczyk K, Yang-Jensen KC, Lorentzen LG et al. · 2026 · Scientific reports

Prasterone (dehydroepiandrosterone, DHEA) is increasingly used in the treatment of genitourinary syndrome of menopause (GSM), although its molecular effects on vaginal tissue remain insufficiently characterized. This prospective study…

View details →DOI: 10.1038/s41598-026-50491-5
Negative / Null Result ReportMedicine

Analysis of patients with hydrogen sulfide poisoning reported to the Taiwan Poison Control Center between 1986 and 2021.

Wen YC, Chu FY, Wang TH et al. · 2026 · Clinical toxicology (Philadelphia, Pa.)

Introduction Hydrogen sulfide exposure is a major cause of occupational poisoning and is frequently associated with life-threatening effects. This study aimed to investigate the patterns, poisoning severity, and predictors of severity in…

View details →DOI: 10.1080/15563650.2026.2675040
Negative / Null Result ReportMedicine

Age at menopause and risk of sarcopenia in postmenopausal women: evidence from the China health and retirement longitudinal study.

Li Y, Qin L, Wang Y et al. · 2026 · Reproductive health

Background Menopausal age is closely associated with women's health, but research on its association with sarcopenia risk remains insufficient. Our study aimed to explore how menopausal age affects the risk of sarcopenia in postmenopausal…

View details →DOI: 10.1186/s12978-026-02358-1
Negative / Null Result ReportMedicine

Nailfold capillaroscopy findings after anthracycline-based chemotherapy and their association with subclinical changes in left ventricular ejection fraction.

Kiracı M, Soytürk G, Köş FT et al. · 2026 · BMC cancer

Background Anthracyclines can induce endothelial and microvascular injury that precedes measurable myocardial dysfunction. However, reliable early markers of such injury are lacking. Nailfold capillaroscopy (NFC) is a noninvasive imaging…

View details →DOI: 10.1186/s12885-026-16187-9
Negative / Null Result ReportMedicine

Changes in female sexual function during the retirement transition.

Virkkunen V, Kero K, Stenholm S et al. · 2026 · Menopause (New York, N.Y.)

Objectives For many women, retirement represents a significant transition in late adulthood, which may result in many alterations in lifestyle habits and behavioral patterns. Several factors known to improve during the retirement…

View details →DOI: 10.1097/gme.0000000000002778
Negative / Null Result ReportOpen accessMedicine

Factors Influencing Interest in Urology Among Osteopathic and Allopathic Medical Students: A Single-Institution Cross-Sectional Survey.

Woodworth E, Sheppard C, Wong R et al. · 2026 · Cureus

Background Following the transition to a single-accreditation residency system, Doctor of Osteopathic Medicine (DO) and Doctor of Allopathic Medicine (MD) students now apply for the same urology residency positions. Despite this…

View details →DOI: 10.7759/cureus.107827
Negative / Null Result ReportMedicine

Differential Factor-Level MADRS Response Associated With Seizure Duration in Electroconvulsive Therapy: Exploratory Findings.

Swierkosz-Lenart K, Ranjbar S, Compagne C et al. · 2026 · The journal of ECT

Background Electroconvulsive therapy (ECT) is a widely used treatment for severe and treatment-resistant depression, with high efficacy but considerable interindividual variability of response. The neurophysiological mechanisms underlying…

View details →DOI: 10.1097/yct.0000000000001264
Negative / Null Result ReportMedicine

Cross-sectional and prospective relations between dysfunctional cognitive beliefs and obsessive-compulsive symptoms during late childhood and early adolescence: a test of two aetiological models.

Barcaccia B, Cervin M, Borrelli DF et al. · 2026 · Journal of child psychology and psychiatry, and allied disciplines

Background Obsessive-compulsive symptoms (OCS) often emerge during childhood and adolescence, and two aetiological models have been proposed. According to the first model, maladaptive cognitive beliefs facilitate the transformation of…

View details →DOI: 10.1111/jcpp.70077
Negative / Null Result ReportOpen accessMedicine

Dyadic Dynamic in Generalized Political Attitudes: Homophily, Relationship Satisfaction, and Convergence.

Miculka A, Imhoff R · 2026 · International review of social psychology

Despite the social nature of generalized political attitudes such as conspiracy mentality, right-wing authoritarianism (RWA), and social dominance orientation (SDO), dyadic phenomena concerning these attitudes have not been comprehensively…

View details →DOI: 10.5334/irsp.1102