A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20253 results in Negative / Null Result Report · page 451 of 676
Bermingham MD, Meredith RT, Mills H et al. · 2026 · Frontiers in allergy
Quantifying food allergens in complex matrices is hindered by thermal processing, particularly in baked products used for oral food challenges (OFCs), where limited data exists on effects on clinically relevant allergens. To address this,…
Kennedy J, Cooley SA, Roman Fox J et al. · 2026 · The Journal of infectious diseases
Background As persons with human immunodeficiency virus (PWH) live longer, interactions between human immunodeficiency virus (HIV), aging, and structural brain integrity become increasingly vital for understanding cognitive disorders. This…
Kuo MC, Younan SA, Williams PJ et al. · 2026 · Techniques in coloproctology
Background Robotic approach is increasingly being used for surgery in Crohn's disease. Robotic ileocolic resection (ICR) for Crohn's disease (CD) is comparable to laparoscopic ICR for short term outcomes; however, no studies have compared…
Flora RJ, Bullo J, Talaban J et al. · 2026 · Preprint
Abstract Organochlorine pesticides (OCPs) are persistent organic pollutants known for their environmental stability, hydrophobicity, and strong potential for bioaccumulation. Although many OCPs have been banned or restricted under…
Jankovič P, Chodzyński KJ, Vanrossomme AE et al. · 2026 · Neurology international
Background The risk stratification of unruptured intracranial aneurysms (UIAs) relies largely on static clinical and morphological parameters, which may not fully capture aneurysm-specific wall behavior. ECG-gated four-dimensional computed…
Kanack AJ, Mauch EE, Kohlhagen MC et al. · 2026 · Preprint
ABSTRACT Background Monoclonal gammopathy of thrombotic significance (MGTS) is a recently described chronic prothrombotic condition characterized by monoclonal anti-PF4 antibodies that are detected above the polyclonal antibody background…
Mirza S, Fine L, McClure JA et al. · 2026 · Antibiotics (Basel, Switzerland)
Background Staphylococcus aureus acquires methicillin resistance genes through the SCC mec element. Although spontaneous SCC mec excision has been observed, its frequency, type-specific variation, and responsiveness to environmental…
Shahri ZJ, Noda A, Hayashi T et al. · 2026 · Preprint
Abstract Whether developmentally competent pancreatic progenitors can restore pancreatic structure and metabolic function in a defective host environment remains unclear. Here, we used intraplacental transplantation to compare the fate of…
Buttke DE, Kaplan BS, Jones LC et al. · 2026 · Journal of wildlife diseases
Mycoplasma bovis is a growing threat to American bison (Bison bison) health and restoration efforts, causing significant mortality and disease in affected bison herds. Despite this, little is known about the epidemiology or clinical course…
Oehring D · 2026 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)
Purpose Non-invasive tear film metrics from automated topographers are used increasingly, yet device-specific analytical performance remains incompletely characterised. This study quantified the analytical performance of the Oculus…
Torkan A, Zoghi M, Foroughimehr N et al. · 2026 · Sensors (Basel, Switzerland)
The rapid global expansion of 5G technology has increased concerns regarding its potential health effects. Postural balance, a complex sensorimotor function reflecting central nervous system integrity, may be susceptible to electromagnetic…
Sapkota S, Brewer AN, Underhill A et al. · 2026 · Preprint
Abstract While dominant qualitative disease resistance loci are well known for being easily introgressed in breeding programs and easily overcome by pathogens, the additivity and durability of dominant minor and moderate quantitative loci…
Aguiar Pavesi RO, Boening A, Meyrelles SDS et al. · 2026 · Physiotherapy research international : the journal for researchers and clinicians in physical therapy
Background The 6-minuteute step test is an alternative for estimating cardiorespiratory fitness after stroke. Objective To investigate its measurement properties and minimal detectable change early after stroke. Methods Cross-sectional,…
Bell KS, Chen R, Weitzner AS et al. · 2026 · Journal of biological rhythms
The circadian system coordinates daily physiology across nearly all tissues to temporally organize metabolism and maintain homeostasis. In the brain, circadian timing regulates neural activity, cellular function, and neuroimmune signaling,…
Scilipoti P, Callenmark M, Garmo H et al. · 2026 · European urology open science
Background and objective There are several methods for estimating prostate-specific antigen (PSA) doubling time (DT), and many men exhibit long periods of undetectable PSA below 0.1 ng/ml after radical prostatectomy (RP). We quantified…
Banerjee S · 2026 · Preprint
The Fermi Paradox (“Where is everybody?”) refers to the apparent contradiction between the visualisable abundance of extraterrestrial civilizations and the continued absence of confirmed detections. This work explores whether finite…
Sánchez-Valle J, Zambrana C, Navarro-Martínez A et al. · 2026 · Preprint
Multimorbidity is the dominant clinical reality of primary care, yet the temporal dynamics governing when and how persistent comorbidity associations emerge remain poorly characterised. Most large-scale comorbidity studies adopt a single…
van Caelenberg E, Belpaire A, Dewaele D et al. · 2026 · Clinical and experimental dermatology
Background The Severity of Alopecia Tool (SALT) score is widely used. However, its inter- and intrarater reliability and smallest detectable difference (SDD) have not been rigorously evaluated. Objectives To determine the interrater and…
Keshavarzi F, Arazpour M, Behzadipour S · 2026 · JMIR biomedical engineering
Background The application of spinal orthoses and local vibration in the treatment of hyperkyphosis is a developing concept. Further research is needed to determine the impact of leaf springs and local vibration techniques on the…
McCaughan KJ, Danyluk MD, Kniel KE · 2026 · Applied and environmental microbiology
Tilling under is a method growers employ in an effort to remediate instances of widespread contamination in fields of crops, but its effectiveness with respect to specific pathogens remains poorly understood. This study had two overarching…
Zhang S, Zhang H, Dong X et al. · 2026 · Frontiers in immunology
Background Radical cystectomy remains a standard curative treatment for muscle-invasive bladder cancer (MIBC). Bladder preservation after systemic therapy without immediate surgery remains investigational and requires careful patient…
Swaine T, Bhagani S · 2026 · Current opinion in HIV and AIDS
Purpose of review Two-drug regimens (2DR) for antiretroviral therapy are increasingly being recommended for people living with HIV to reduce pill burden and reduce short and long-term toxicity. The exclusion of tenofovir and lamivudine or…
Nicklas A, Rudari M, Reidow N et al. · 2026 · Plastic and reconstructive surgery. Global open
Background Postoperative wound healing remains a critical challenge, particularly in complex reconstructions such as free flap surgeries. Despite technical improvements, perfusion-related complications may cause partial flap loss.…
Chen A, Daniels W, Huang Z et al. · 2026 · Preprint
Abstract The U.S. federal government undertook a flurry of new actions to monitor and regulate methane emissions beginning in years 2021 and 2022, including the Inflation Reduction Act (IRA). The IRA and Waste Emissions Charge (WEC)…
Antaky CC, Leinbach IL, Plissner JH et al. · 2026 · PloS one
The use of rodenticides is a primary method for eradicating rodents from islands for conservation purposes. Rodenticide residue monitoring is often incorporated into rodent eradication project planning to understand the potential effects…
Aderibigbe AS · 2026 · Poultry science
Despite increasing attention to broiler welfare, there is still limited information comparing physiological stress responses between fast-growing (FG) and slow-growing (SG) genotypes under evolving production conditions. Investigating this…
Popiolek I, Hydzik P, Ciszowski K et al. · 2026 · Journal of clinical medicine
Background/Objectives: Alcohol-related liver disease (ALD) lacks widely adopted biomarkers that reflect disease activity and severity. High-mobility group box 1 (HMGB1), a damage-associated molecular pattern, has been implicated in ALD…
Awadallah M, Singh A, Hale GL et al. · 2026 · Case reports in transplantation
Hepatitis E virus (HEV) infection is an increasingly recognized cause of acute and chronic hepatitis in immunosuppressed individuals, including solid organ transplant recipients. Although typically self-limited in immunocompetent hosts,…
Yoon HJ, Kim GC, Nam SH · 2026 · Pathogens (Basel, Switzerland)
Background Oral candidiasis is an opportunistic infection caused by Candida albicans (C. albicans) , highlighting the need to evaluate candidate substances that ensure both antifungal efficacy and mucosal safety. This study aimed to assess…
Carretero D, Giménez E, Pérez A et al. · 2026 · Enfermedades infecciosas y microbiologia clinica (English ed.)
Introduction Studies assessing SARS-CoV-2 antibodies and functional T-cell responses in hematological patients following receipt of a three-dose mRNA vaccine schedule have yielded conflicting results. Methods We conducted a retrospective…