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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20253 results in Negative / Null Result Report · page 447 of 676

Negative / Null Result Report

A Case Report of Korean Medicine Treatment, including Jakyakgamcho-tang, in a Patient with Unilateral Vocal Cord Paralysis That Did Not Improve After Injection Laryngoplasty

Ye-seul Park, Ja-eun Kwak, Ho-ryong Yoo et al. · 2024 · The Journal of Internal Korean Medicine

Background: Unilateral vocal cord paralysis can occur due to various causes. Among them, unilateral vocal cord paralysis that takes place after endotracheal intubation is often caused by damage to the left recurrent nerve branch during…

View details →DOI: 10.22246/jikm.2024.45.6.1309
Negative / Null Result Report

Do Polluters Outperform Non-Polluters?

Yigit Atilgan, K. Ozgur Demirtas, A. Doruk Gunaydin · 2024 · SSRN Electronic Journal

This paper investigates whether industrial companies with higher toxic emissions outperform those with lower toxic emissions. First, the highest polluters do not consistently outperform the lowest polluters in an almost stochastic…

View details →DOI: 10.2139/ssrn.4828452
Negative / Null Result ReportOpen accessPhysics

How to generate a significant effective temperature for cold dark matter, from first principles

Patrick McDonald · 2009 · arXiv

I show how to reintroduce velocity dispersion into perturbation theory (PT) calculations of structure in the Universe, i.e., how to go beyond the pressureless fluid approximation, starting from first principles. This addresses a possible deficiency in uses of PT to compute clustering on the weakly non-linear scales that will be critical for probing dark energy. Specifically, I show how to derive a non-negligible value for the (initially tiny) velocity dispersion of dark matter particles, , where δv is the deviation of particle velocities from the local bulk flow. The calculation is essen

Negative / Null Result ReportMedicine

Comparative Evaluation of ChatGPT-5.4 Mini and Gemini 3 Flash in Scar Patient Education: Quality, Reliability, and Readability Analysis.

Zang, Yan, Dong et al. · 2026 · The Journal of craniofacial surgery

Scar is an inevitable pathological product of tissue injury repair, and pathological scars often occur in exposed areas, bringing severe psychological burden and economic losses to patients. With the popularization of digital healthcare,…

View details →DOI: 10.1097/scs.0000000000013099
Negative / Null Result ReportMedicine

Beyond peak wavelength: spectral bandwidth of blue and red-blue laser diodes modulates photosynthesis, canopy architecture, chlorophyll maintenance, and whole-plant growth.

Li, Sugita, Togawa et al. · 2026 · Frontiers in plant science

High planting densities in indoor horticulture often accelerate lower-leaf chlorophyll degradation, increasing trimming frequency, reducing effective photosynthetic area, and raising labor costs. While spectral composition has been widely…

View details →DOI: 10.3389/fpls.2026.1817114
Negative / Null Result ReportMedicine

Investigating the effect of casein phosphopeptide-amorphous calcium phosphate, fluoride varnish, and diode laser on enamel microhardness.

Hali, Mahmoudi, Namdar et al. · 2026 · Dental research journal

Laser therapy with fluoride-containing material, such as casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), is a new technique for caries prevention. The purpose of this study is to investigate the effect of CPP-ACP, fluoride…

View details →DOI: 10.4103/drj.drj_556_24
Negative / Null Result ReportMedicine

Deep and repetitive transcranial magnetic stimulation improves motor dysfunction after basal ganglia infarction: preliminary findings on efficacy and electrophysiological mechanisms.

Yang, Zhu, Chen et al. · 2026 · Frontiers in neuroscience

To observe the therapeutic effects of deep transcranial magnetic stimulation (dTMS) and repetitive transcranial magnetic stimulation (rTMS) on upper and lower limb motor dysfunction in patients with basal ganglia infarction, and to…

View details →DOI: 10.3389/fnins.2026.1870537
Negative / Null Result ReportMedicine

Connective tissue graft with injectable platelet rich fibrin for treatment of RT1 gingival recession by tunnel technique: a randomized clinical and immunohistochemical study.

Mahmoud, Elrefaei, Shata et al. · 2026 · Frontiers in oral health

The literature regarding the use of injectable platelet- rich fibrin (i-PRF) for root coverage is scarce. Therefore, this RCT aimed to evaluate and compare the effect of using connective tissue graft (CTG) with and without i-PRF using the…

View details →DOI: 10.3389/froh.2026.1801423
Negative / Null Result ReportMedicine

Association of achieved LDL-C levels with global coagulability and clinical outcomes in patients with acute coronary syndrome receiving PCSK9 inhibitors: a prospective cohort study.

Fu, Yao, Zhang et al. · 2026 · Frontiers in cardiovascular medicine

The safety of achieving ultra-low low-density lipoprotein cholesterol (LDL-C) levels in acute coronary syndrome (ACS) patients on dual antiplatelet therapy (DAPT), particularly regarding global coagulability, specific platelet reactivity,…

View details →DOI: 10.3389/fcvm.2026.1804585
Negative / Null Result ReportMedicine

Pain-Related Impairment and Talar Tilt as Predictors of Surgical Decision Making in Advanced Varus Ankle Osteoarthritis.

Kurokawa, Taniguchi, Nakaniwa et al. · 2026 · Foot & ankle orthopaedics

Varus-type ankle osteoarthritis (OA) is often managed conservatively; however, surgical intervention is required in some patients. Identifying factors associated with transition to surgery may help optimize treatment timing. This…

View details →DOI: 10.1177/24730114261454964
Negative / Null Result ReportMedicine

Low-Intensity Pulsed Ultrasound Enhances Intramembranous Bone Healing in a Critical-Size Bone Defect of the Rat Calvaria.

Volarić, Žauhar, Chen et al. · 2026 · Journal of clinical medicine

Objectives : Low-intensity pulsed ultrasound (LIPUS) has been widely utilized as a biophysical modality accelerating fracture healing, particularly in bones undergoing endochondral ossification. However, its efficacy in facilitating…

View details →DOI: 10.3390/jcm15124595
Negative / Null Result ReportMedicine

Comparison of Early Postoperative Recovery and Radiologic Outcomes Between Microscopic and Unilateral Biportal Endoscopic Posterior Cervical Foraminotomy for Cervical Radiculopathy.

Han, Lee, Jang et al. · 2026 · Journal of clinical medicine

Objective : This study aimed to compare the clinical and radiological outcomes between microscopic and unilateral biportal endoscopic (UBE) posterior cervical foraminotomy (PCF). Methods : This study included 73 patients who underwent…

View details →DOI: 10.3390/jcm15124589
Negative / Null Result ReportMedicine

Effect of Failed Debridement, Antibiotics, and Implant Retention on Subsequent Two-Stage Reimplantation for Periprosthetic Joint Infection Following Total Knee Arthroplasty: A Retrospective Cohort Study.

Kim, Lee, Ko et al. · 2026 · Journal of clinical medicine

Background : Periprosthetic joint infection (PJI) following total knee arthroplasty (TKA) is a serious complication associated with substantial morbidity and healthcare costs. Although two-stage revision arthroplasty is widely accepted as…

View details →DOI: 10.3390/jcm15124563
Negative / Null Result ReportMedicine

Erectile Function Before and After Elective Inguinal Hernia Repair: A Paired IIEF-5 Study Comparing Laparoscopic and Open Techniques.

Sayur, Avcı, Güler et al. · 2026 · Journal of clinical medicine

Objective: This study aimed to evaluate changes in erectile function, assessed using the International Index of Erectile Function-5 (IIEF-5), in male patients undergoing elective inguinal hernia repair and to compare outcomes according to…

View details →DOI: 10.3390/jcm15124433
Negative / Null Result ReportMedicine

Effect of a Prior Two-Hour Postural Test on Seated Saline Suppression Test Results in Patients Predominantly Evaluated for Adrenal Incidentalomas.

Lewandowski, Wojciechowska-Durczyńska, Krawczyk-Rusiecka et al. · 2026 · Journal of clinical medicine

Background/Objectives : The Seated Saline Suppression Test (SSST) is widely used for investigation of primary hyperaldosteronism (PA); however, the impact of a one-hour sitting period prior to SSST (as recommended by the Endocrine Society,…

View details →DOI: 10.3390/jcm15124410
Negative / Null Result ReportMedicine

Quality of Life and Associated Factors in Primary Caregivers of Children with Refractory Epilepsy on Long-Term Ketogenic Diet: A Cross-Sectional Study.

Li, Wang, Yi et al. · 2026 · Healthcare (Basel, Switzerland)

Background/Objectives: In ketogenic therapy for children with refractory epilepsy-a special patient group-the quality of life of primary caregivers is often overlooked. This study aimed to explore the current state of primary caregivers'…

View details →DOI: 10.3390/healthcare14121761
Negative / Null Result ReportMedicine

Association of Ascending Aortic Aneurysm with NOX4 and miRNA 146a.

Çalışkan, Karpuzoğlu, Karpuzoğlu et al. · 2026 · Genes

Objective: To evaluate the efficacy of NADPH oxidase 4 and miR-146a-5p in current treatment planning for ascending aortic aneurysms, independent of aortic diameter, and to develop protocols that will ensure the treatment of ascending…

View details →DOI: 10.3390/genes17060709
Negative / Null Result ReportMedicine

Multi-Omics Analysis Reveals the Gut-Mediated Mechanism Underlying the Seasonal Non-Laying Phenotype in Zhedong White Geese ( Anser cygnoides domesticus ).

Shi, Zhou, Li et al. · 2026 · Animals : an open access journal from MDPI

As a precious indigenous goose resource in China, the Zhedong white goose occupies an essential position in the domestic goose industry. However, this breed spontaneously enters a prolonged non-laying period of over two months per year,…

View details →DOI: 10.3390/ani16121899
Negative / Null Result ReportMedicine

Antimicrobial effect of 1064 nm Nd:YAG laser with flat-top homogeneous beam profile on oral fungal and bacterial biofilms: an in vitro study.

Grzech-Leśniak, Pyrkosz, Szwajkowski et al. · 2026 · Lasers in medical science

This in vitro study aimed to evaluate the antimicrobial effects of a 1064 nm Nd:YAG laser delivered through a novel handpiece designed to provide a flat-top, homogeneous energy distribution profile (MarcoM handpiece) against key oral…

View details →DOI: 10.1007/s10103-026-04921-5
Negative / Null Result ReportMedicine

Alveolar socket preservation with human umbilical cord mesenchymal stem cell-seeded hydroxyapatite-chitosan scaffolds: An in vivo assessment of osteoprotegerin and receptor activator of nuclear factor-κB expression.

Alshaibani, Kamadjaja, Sitalaksmi et al. · 2026 · Journal of molecular histology

Tooth extraction is a common procedure often followed by alveolar bone resorption, which may compromise future implant placement, prosthetic rehabilitation, esthetics, and periodontal support. Hydroxyapatite-chitosan (HA-Chi) scaffolds…

View details →DOI: 10.1007/s10735-026-10874-4
Negative / Null Result ReportMedicine

Metformin and renal dosimetry in patients undergoing [ 177 Lu]Lu-PSMA therapy: reduced kidney absorbed dose without impact on tumor dosimetry.

Siegmund, Delker, Widjaja et al. · 2026 · European journal of nuclear medicine and molecular imaging

Prostate-specific membrane antigen (PSMA)-targeted radiopharmaceutical therapy (RPT) is an established treatment for advanced prostate cancer, but renal radiation exposure remains a major safety concern, as no clinically established…

View details →DOI: 10.1007/s00259-026-08030-x
Negative / Null Result ReportMedicine

Deep Learning Reconstruction Specialized for Inner Ear: Improving Image Quality and Anatomical Structure Visualization as Compared with Conventional Hybrid-Type Iterative Reconstruction on High-Definition CT.

Nomura, Kimata, Ito et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives: To directly compare the capabilities of hybrid-type iterative reconstruction (IR) with the newly developed deep learning reconstruction (DLR) for the inner ear on high-definition CT (HDCT) obtained using the…

View details →DOI: 10.3390/diagnostics16121756
Negative / Null Result ReportMedicine

Rural medical disparities in multimodal glioblastoma treatment.

Momii, Hata, Fudaba et al. · 2026 · Scientific reports

Glioblastoma continues to have a poor prognosis, although recent advancements in multimodal treatments have gradually improved outcomes. However, treatment options have become increasingly complex and highly specialized. In rural areas,…

View details →DOI: 10.1038/s41598-026-48867-8