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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21720 results · page 445 of 724

Negative / Null Result ReportOpen accessMedicine

The Role of <i>REL</i> and <i>IL2</i> and Their Polymorphisms in the Pathogenesis of Vitiligo-Exploratory Genetic Association Study.

Kądziela M, Migdalska-Sęk M, Domańska-Senderowska D et al. · 2026 · International journal of molecular sciences

Vitiligo is a chronic autoimmune skin disorder characterized by progressive melanocyte loss and depigmented skin lesions, whose pathogenesis has been attributed to genetic and immunological factors. The aim of this exploratory study was to…

View details →DOI: 10.3390/ijms27115084
Negative / Null Result ReportMedicine

Relationship between gestational diabetes and term infant hearing outcomes: a cross-sectional data linkage study.

Anderson N, Kimlin K, O'Rourke JL et al. · 2026 · Pediatric research

Background Congenital hearing loss can significantly affect childhood development, yet more than half of affected infants present without identifiable risk factors. A possible association between maternal diabetes and congenital hearing…

View details →DOI: 10.1038/s41390-026-04846-3
Negative / Null Result ReportMedicine

Associations between atherogenic index of plasma and chronic kidney disease in individuals with hypertension, diabetes mellitus, and hyperuricemia.

Li Y, Zhu YX, Qiu Y et al. · 2026 · Clinical nephrology

Objective The association between the atherogenic index of plasma (AIP) and chronic kidney disease (CKD) among individuals with different metabolic syndromes remains inadequately characterized. The aim of this study is to assess the…

View details →DOI: 10.5414/cn111841
Negative / Null Result ReportMedicine

Surgical Site Infections in Spine Surgery: A Retrospective Study of 1,578 Procedures with Identification of Tattooed Skin as a Novel Risk Factor Associated with Surgical Site Infection.

Mostofi K, Caragliano G · 2026 · The Journal of hospital infection

Background Surgical site infections (SSIs) are a major complication of spinal surgery. The influence of tattoos overlying the operative incision has not been previously evaluated as a risk factor in this context. Methods Retrospective…

View details →DOI: 10.1016/j.jhin.2026.06.006
Negative / Null Result ReportOpen accessMedicine

Association of biofilm formation with multidrug resistance in burn wound patients isolates of <i>Pseudomonas aeruginosa</i> in Sana'a City, Yemen.

Maher AA, Maad AH, Al-Jaufy AY et al. · 2026 · Frontiers in medicine

Background Burn wound infections (BWIs) represent a major cause of morbidity and mortality among hospitalized burn patients. Pseudomonas aeruginosa is recognized for its ability to acquire multidrug resistance (MDR) and form biofilms that…

View details →DOI: 10.3389/fmed.2026.1762684
Negative / Null Result Report

Anthropometric Correlates of Systolic and Diastolic Blood Pressure Among Children and Adolescents in Ibadan, Southwest, Nigeria

Alayande AA, Williams JE, Olawuni DA et al. · 2026 · Preprint

Abstract Introduction: Abnormal anthropometric indices in children and adolescents, can potentially increase the risk of developing elevated blood pressure at a younger age. Children and adolescents with abnormal blood pressure at an early…

View details →DOI: 10.21203/rs.3.rs-8625118/v1
Negative / Null Result ReportOpen accessMedicine

Preliminary Psychometric Evaluation of the Romanian Version of the Hospital Anxiety and Depression Scale in Relapsing-Remitting Multiple Sclerosis.

Böckels L, Lisnic V, Alexa D et al. · 2026 · Journal of clinical medicine

Background/Objectives: Relapsing-remitting multiple sclerosis (RRMS) is frequently associated with anxiety and depressive symptoms, which significantly impact quality of life and clinical outcomes. The Hospital Anxiety and Depression Scale…

View details →DOI: 10.3390/jcm15114165
Negative / Null Result ReportOpen accessMedicine

Association between alpha 1-antitrypsin levels and intracranial aneurysms: a case-control study.

Rosi Júnior J, Telles JPM, Santana LS et al. · 2026 · Arquivos de neuro-psiquiatria

Background Alpha 1-antitrypsin (A1AT) helps maintain vascular-wall integrity, but its role in the formation and rupture of intracranial aneurysms is unclear. Objective To compare A1AT levels between patients with ruptured and unruptured…

View details →DOI: 10.1055/s-0046-1820525
Negative / Null Result ReportMedicine

Familial hypercholesterolaemia in children: diagnostic profile and factors influencing diagnosis in a tertiary referral centre.

Kavrul Kayaalp G, Balcı MC, Kürkçü Güneş D et al. · 2026 · Cardiology in the young

Background Early identification of familial hypercholesterolaemia is critical to prevent long-term cardiovascular complications. This study assessed diagnostic features and age at diagnosis in children with familial hypercholesterolaemia…

View details →DOI: 10.1017/s104795112611302x
Negative / Null Result ReportMedicine

Epidemiology of rehabilitation practices for inpatients with nephrotic syndrome: a retrospective cohort study using an administrative database.

Shinkawa K, Yoshida S, Nakao YM et al. · 2026 · Clinical and experimental nephrology

Introduction The clinical characteristics of patients with nephrotic syndrome undergoing in-hospital rehabilitation are not well-understood, and the effects of exercise on acute kidney injury (AKI) or venous thromboembolism (VTE) in this…

View details →DOI: 10.1007/s10157-026-02832-x
Negative / Null Result Report

Changes in anthropometric nutritional status and physical activity levels and five-year survival in women with endometrioid endometrial cancer: a prospective cohort study

Conteville LV, Fernandes JPA, Frajacomo FT et al. · 2026 · Preprint

Abstract OBJECTIVES To examine the association between longitudinal trajectories of anthropometric nutritional status, physical activity, and overall survival among women with endometrial cancer. METHODS In a prospective cohort study, we…

View details →DOI: 10.21203/rs.3.rs-9438420/v1
Negative / Null Result ReportOpen accessMedicine

Genetic Association Study of Brain-Derived Neurotrophic Factor (BDNF) and Serotonin-Related Gene Variants in Suicide Attempters with Major Depressive Disorder and Control Persons.

Kim T, Oh SB, Choi HJ et al. · 2025 · Genes

Objective Suicide attempts have become one of the most serious problems worldwide in recent years. Suicide attempts are known to be genetically highly associated with serotonin and BDNF in international studies. Methods In this study, we…

View details →DOI: 10.3390/genes16111304
Negative / Null Result Report

Independent and Joint Associations of Social Participation and Depressive Symptoms with Incident Stroke Risk in Older Adults: A Prospective Cohort Study Based on CHARLS and ELSA

Ma L, Ma Y, Huang Z et al. · 2026 · Preprint

Abstract Background: Stroke remains a leading cause of death and disability among older adults. Depressive symptoms and low social participation may increase stroke risk via behavioural and biological pathways. This study examined the…

View details →DOI: 10.21203/rs.3.rs-8765182/v1
Negative / Null Result ReportOpen accessMedicine

Surgeon-Patient Sex Concordance and Postoperative Outcomes in Cataract Surgeries: A 16-Year Retrospective Cohort Study.

Majmudar IP, Aggarwal S, Hamzeh N et al. · 2026 · Clinical ophthalmology (Auckland, N.Z.)

Purpose To determine if there is an association between surgeon-patient sex concordance and post-surgical complications for cataract surgeries. Patients and methods In this 16-year retrospective cohort study, data was collected from the…

View details →DOI: 10.2147/opth.s612384
Negative / Null Result ReportMedicine

Impact of socioeconomic deprivation on the rate of residual or recurrent cholesteatoma following primary mastoidectomy.

Foo JF, Haddow K, Jones S et al. · 2026 · The Journal of laryngology and otology

Objectives To investigate whether socioeconomic deprivation is associated with residual or recurrent cholesteatoma following primary mastoidectomy. Methods A retrospective cohort study included all patients undergoing primary mastoidectomy…

View details →DOI: 10.1017/s002221512610499x
Negative / Null Result ReportMedicine

Association between rivaroxaban use and acute kidney injury in patients over 65 years: A large-scale analysis of spontaneous reporting system data.

Peng P, Guo Y, Zhu Y · 2026 · Advances in clinical and experimental medicine : official organ Wroclaw Medical University

Background Given that long-term anticoagulant therapy is required in many clinical scenarios, continuous safety monitoring of direct factor Xa inhibitors is of great importance. To date, the renal safety of these agents remains a subject…

View details →DOI: 10.17219/acem/210295
Negative / Null Result ReportOpen accessMedicine

Genetic influence of PPAR-γ rs1801282 and MTRR rs162036 variants on non-small cell lung cancer risk in Egyptians.

Metwally YF, Zahran RF, El Sadda RR et al. · 2026 · Discover oncology

Background Lung cancer remains the leading cause of cancer-related deaths worldwide. Despite advances in diagnostics and treatment, most patients are diagnosed at advanced stages. Genetic variants such as single nucleotide polymorphisms…

View details →DOI: 10.1007/s12672-026-04972-8
Negative / Null Result ReportMedicine

Analysis of Homocysteine Level in Patient with Acute Kidney Injury.

Aryal SB, Raj Joshi D · 2026 · Journal of Nepal Health Research Council

Background Homocysteine (Hcy) contributes to oxidative stress and renal injury by generating reactive oxygen species and reducing heme oxygenase-1 levels. Elevated Hcy (Hhcy) may worsen outcomes after acute renal failure(ARF), promoting…

View details →DOI: 10.33314/jnhrc.v23i03.4635
Negative / Null Result ReportMedicine

Bias in the Composite Outcomes of Kidney-Cardio Protective Trials in Chronic Kidney Disease: A Meta-Epidemiological Study.

Bellos I, Marinaki S, Benetou V · 2026 · Journal of clinical medicine

Background/Objectives : Composite endpoints are commonly used in chronic kidney disease (CKD) trials to enhance statistical efficiency but may not reflect clinically meaningful outcomes. We assessed agreement between composite endpoints…

View details →DOI: 10.3390/jcm15124840
Negative / Null Result ReportMedicine

Seroprevalence of hepatitis B, hepatitis C and HIV among male injecting drug users in Afghanistan.

Hakim MS, Hashimi MH, Saeed KM et al. · 2026 · Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit

Background Viral hepatitis and HIV infections are common public health concerns among injecting drug users, however, there is limited evidence on their seroprevalence in Afghanistan. Aim To determine the seroprevalence of hepatitis B,…

View details →DOI: 10.26719/2026.32.2.61
Negative / Null Result ReportMedicine

County-Level Environmental Quality and Risk of Hypospadias in Arkansas.

Famuyide L, Patel J, Nembhard WN · 2026 · Birth defects research

Background Hypospadias is one of the most common genital defects in boys, affecting about 1 in 125 live-born boys. Several studies have examined the association between a single environmental exposure and risk of hypospadias, but few have…

View details →DOI: 10.1002/bdr2.70022