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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19875 results in Negative / Null Result Report · page 444 of 663

Negative / Null Result ReportMedicine

Effect of different vaccination schedules and administration of a nonsteroidal anti-inflammatory drug around dry-off on inflammation, immunity, and performance of dairy cows.

Gao J, Savegnago CG, Marins TN et al. · 2026 · Journal of dairy science

This study evaluated the effects of different vaccination schedule and oral administrating a nonsteroidal anti-inflammatory drug (NSAID) around dry-off on systemic inflammation, immune responses, behaviors during the early dry period, and…

View details →DOI: 10.3168/jds.2026-28261
Negative / Null Result ReportMedicine

A Performance Evaluation of Bayesian Forecasting for Serum Linezolid Concentrations: Impact of Clinical Factors on Prediction Accuracy.

Hashimoto N, Wakimoto Y, Kusama T et al. · 2026 · Therapeutic drug monitoring

Background Pycsim, a dosing software for linezolid (LZD) based on Bayesian estimation, predicts dosing in the therapeutic drug monitoring (TDM) of LZD. However, its predictive performance, examined using an independent data set with a…

View details →DOI: 10.1097/ftd.0000000000001468
Negative / Null Result ReportMedicine

Copper regulates the synthesis of steroid hormones through CCS and ATOX1 dependent MEK1-ERK1/2 pathway in follicular granulosa cells of yak (Bos grunniens).

Lou Y, Yang T, Xia C et al. · 2026 · Molecular and cellular endocrinology

Steroid hormone synthesis in granulosa cells (GCs) is crucial for normal follicular development and ovulation. Emerging evidence suggests that copper (Cu), a trace element, influences hormone secretion in yak granulosa cells (YGCs);…

View details →DOI: 10.1016/j.mce.2026.112812
Negative / Null Result ReportMedicine

Effects of emamectin benzoate spiked sediment on adult, larval and post-larval stages of the American lobster (Homarus americanus).

Asnicar D, Jonah L, Kingsbury M et al. · 2026 · The Science of the total environment

Salmon farming represents a significant economic sector on both Canada's Atlantic and Pacific coasts. To manage sea lice outbreaks, medicated feeds containing emamectin benzoate (EMB) are commonly applied. Because EMB is poorly soluble and…

View details →DOI: 10.1016/j.scitotenv.2026.181799
Negative / Null Result ReportMedicine

Primary and steroid-induced antibody deficiency in severe asthma: a real-life analysis of a well-defined biologic-treated cohort.

Yegin Katran Z, Argın Ö, Bulut İ · 2026 · The Journal of asthma : official journal of the Association for the Care of Asthma

Background Severe asthma is frequently associated with recurrent exacerbations and prolonged systemic corticosteroid use, which may lead to secondary immunodeficiency (SID). In addition, unrecognized primary immunodeficiencies (PIDs) may…

View details →DOI: 10.1080/02770903.2026.2644881
Negative / Null Result ReportMedicine

The effects of imidacloprid exposure on the mouse ovary in vivo.

Mourikes VE, Lee C, Oladosu JI et al. · 2025 · Reproductive toxicology (Elmsford, N.Y.)

Imidacloprid (IMI) is an insect-selective synthetic nicotine derivative used in commercial agricultural systems, home gardening, and veterinary pharmaceuticals. People are exposed to IMI through consumption of contaminated food and water…

View details →DOI: 10.1016/j.reprotox.2025.109045
Negative / Null Result ReportMedicine

Co-administration of digoxin and trans-2-decenoic acid ethyl ester improves motor learning performance in mice.

Fujita E, Hadano J, Hashimoto J et al. · 2026 · Behavioural brain research

Neural circuit formation through synaptogenesis plays a crucial role in learning, memory, and the recovery of neural function following brain dysfunction. We previously reported that administering the low-dose cardiac glycoside digoxin,…

View details →DOI: 10.1016/j.bbr.2026.116225
Negative / Null Result ReportMedicine

Post-COVID-19 diabetes outcomes.

Lin CJ, Bosco AA, Alves LI et al. · 2026 · Scientific reports

Long-COVID-19 presentation has not been evaluated with proper depth in patients with diabetes (DM). This retrospective study evaluated 870 patients (320 DM, 550 non-DM) followed for up to 7.1 months post-hospitalization. Acute myocardial…

View details →DOI: 10.1038/s41598-026-42284-7
Negative / Null Result ReportMedicine

Physicochemical, rheological, textural, tribological, and sensory insights into the role of citrus fiber in quark cheese spreads with varying fat content.

Vincová A, Šantová K, Jaššo M et al. · 2026 · Journal of dairy science

The objective of this study was to evaluate the effect of citrus fiber (1% wt/wt) on the physicochemical, rheological, textural, tribological, and sensory properties of quark cheese spreads with different fat content (10%, 15%, and 20%…

View details →DOI: 10.3168/jds.2025-27829
Negative / Null Result ReportMedicine

Dual Role of Microglial TREM2 in Neuronal Degeneration and Regeneration after Axotomy.

Pottorf TS, Lane EL, Haley-Johnson Z et al. · 2026 · The Journal of neuroscience : the official journal of the Society for Neuroscience

Spinal cord ventral horn microglia proliferate after nerve injuries and migrate toward cell bodies of injured motoneurons (MNs) enwrapping them. The significance of this microglia reaction has remained unclear. Moreover, some injured MNs…

View details →DOI: 10.1523/jneurosci.0112-26.2026
Negative / Null Result ReportMedicine

Persistence of Campylobacter fetus subsp. venerealis in the reproductive tract of vaccinated heifers after experimental infection: Insights into vaginal mucosal immunity in heifers.

Scioli MV, Sosa E, Barale J et al. · 2026 · Veterinary immunology and immunopathology

Bovine genital campylobacteriosis (BGC) remains a major cause of reproductive failure in beef cattle systems. This study evaluated the persistence of Campylobacter fetus subsp. venerealis (Cfv) and associated lesions in the reproductive…

View details →DOI: 10.1016/j.vetimm.2026.111131
Negative / Null Result ReportMedicine

Mechanisms for enhancement of μ-opioid receptor-mediated antinociception in the central nervous system through gallein-dependent modulation of downstream G protein βγ subunit signaling.

Ormes JA, Smrcka AV, Jutkiewicz EM · 2026 · Molecular pharmacology

The clinical utility of μ-opioid receptor (MOR) agonists is limited by side effects and tolerance. G protein βγ subunits (Gβγ) are critical mediators of MOR signaling that not only drive anticonception but also regulate phospholipase C and…

View details →DOI: 10.1016/j.molpha.2026.100123
Negative / Null Result ReportMedicine

Using Telehealth in End-of-Life Palliative Care: A Multimethod Randomized Controlled Trial.

Sigaard JVA, Spindler H, Joensen EDR et al. · 2026 · Journal of palliative medicine

Background An estimated 4.4 million people in Europe require palliative care annually, a number expected to rise with population aging. Telepalliative care (TPC) has been practiced in various settings over the past two decades. The Telepal…

View details →DOI: 10.1177/10966218261444643
Negative / Null Result ReportMedicine

Anemia Following One Anastomosis Gastric Bypass: A Comparative Study of Diabetic and Non-Diabetic Patients.

AhmadQaderi F, Pazouki A, Pishgahroudsari M et al. · 2026 · Obesity surgery

BACKGROUND: Metabolic-bariatric surgery (MBS) is recognized as the most effective long-term intervention for obesity and its associated conditions, including type 2 diabetes mellitus (T2DM) One-anastomosis gastric bypass (OAGB), the third…

View details →DOI: 10.1007/s11695-026-08632-2
Negative / Null Result ReportMedicine

Relaxation of Guinea Pig Aorta Induced by 5-HT<sub>2B</sub> Receptor. Exploration of Potential Mechanisms.

Del-Ángel-Monroy S, Rodríguez-Márquez A, Orozco-Suárez S et al. · 2026 · Basic & clinical pharmacology & toxicology

Vascular relaxation induced by 5-HT 2B receptor is thought to be mediated by stimulation of endothelial nitric oxide synthase (eNOS), but this assumption still requires investigation. To investigate potential mechanisms, BW723C86 (5-HT 2B…

View details →DOI: 10.1111/bcpt.70236
Negative / Null Result ReportMedicine

Synergism of TNF and IFNγ promotes cell death, but TNF drives innate immune-mediated colitis independent of IFNγ.

Torres-Huerta A, Ruley-Haase K, Boger-May A et al. · 2026 · Journal of immunology (Baltimore, Md. : 1950)

The cause of inflammatory bowel disease (IBD) is not known, but both innate and adaptive immunity contribute to IBD pathogenesis. To better understand the contributions of innate immunity to IBD, we have generated a mouse model of IBD that…

View details →DOI: 10.1093/jimmun/vkag111
Negative / Null Result ReportOpen accessMedicine

Suffocating neck hematoma in thyroidectomy: use of drains and perioperative risk factors in 1,334 surgeries.

Aragone L, Burbano P, Cameron A et al. · 2026 · Annals of surgical treatment and research

Purpose A Suffocating Neck Hematoma (Snh) Is A Rare But Potentially Fatal Surgical Complication Of Thyroidectomy. In An Effort To Reduce Its Incidence, Many Surgeons Opt For The Selective Use Of Drains. However, There Are No Studies…

View details →DOI: 10.4174/astr.2026.110.3.144
Negative / Null Result ReportMedicine

Deep brain stimulation or best medical treatment for Parkinson's disease patients: 36-month longitudinal neuropsychological and motor assessment - a prospective case-control study.

Szlufik S, Duszyńska-Wąs K, Koźmińska A et al. · 2026 · Neurologia i neurochirurgia polska

Introduction Bilateral subthalamic nucleus deep brain stimulation (DBS STN) is a very effective surgical method of treating motor symptoms in Parkinson's disease (PD) patients. The long-term cognitive outcome after the surgery is still…

View details →DOI: 10.5603/pjnns.107017
Negative / Null Result ReportMedicine

SUPERROOT1 is not the only C-S lyase capable to contribute to glucosinolate biosynthesis in Arabidopsis thaliana.

Piślewska-Bednarek M, Czerniawski P, Kuczewska S et al. · 2026 · Phytochemistry

Glucosinolates (GLs) are sulfur-containing specialized metabolites from plants representing the Brassicales order. They can be derived from several amino acids through a complex biosynthetic pathway. The majority of steps on this pathway…

View details →DOI: 10.1016/j.phytochem.2026.114872
Negative / Null Result ReportMedicine

Impact of oral nutritional supplements on nutritional outcomes and survival in post-gastrectomy patients receiving chemotherapy.

Wang X, Xi Q, Zhuang Q et al. · 2026 · Clinical nutrition ESPEN

Background & aims Malnutrition complicates recovery in gastrectomy patients, worsened by adjuvant chemotherapy and linked to poorer outcomes. However, evidence regarding the influence of Oral Nutritional Supplements (ONS) on skeletal…

View details →DOI: 10.1016/j.clnesp.2026.103263
Negative / Null Result ReportMedicine

Exogenous Carbohydrate Oxidation Is Higher When Consuming Glucose + Fructose Compared with Glucose Alone during Endurance Exercise Regardless of Energy Status.

Barney DE Jr, Panik KN, Michalak J et al. · 2026 · The Journal of nutrition

Background When glucose (GLU) is consumed during endurance exercise in an energy deficit state (DEF), exogenous carbohydrate oxidation is lower than in energy balance (BAL). Whether consuming multiple transportable carbohydrates, such as…

View details →DOI: 10.1016/j.tjnut.2026.101593
Negative / Null Result ReportMedicine

Concomitant prophylactic trochanteric epiphysiodesis may not be an effective procedure for Perthes varus surgery.

Agarwal A, Iqbal MZ, Bhalla S · 2026 · Journal of clinical orthopaedics and trauma

Background Prophylactic trochanteric epiphyseodesis is commonly performed with proximal femoral varus osteotomy in Perthes disease to reduce relative trochanteric overgrowth. However, its effectiveness, particularly in children at the…

View details →DOI: 10.1016/j.jcot.2026.103379
Negative / Null Result ReportMedicine

Maternal SARS-CoV-2 Antibodies in Mink Kits: Dynamics of Passive Immunity and Implications for Silent Farm-Wide Transmission Following Virus Re-Incursion.

Thomou Z, Dovas CI, Poutahidis T et al. · 2026 · Viral immunology

Maternal antibodies protect mink kits early in life, but their duration and impact on subsequent SARS-CoV-2 exposure remain unclear. We longitudinally characterized passive immunity in kits born to mothers previously infected with lineage…

View details →DOI: 10.1177/08828245261444539
Negative / Null Result ReportMedicine

Influence of Barrier Membrane and Peri-Implantitis-Like Bone Defect Configurations on Graft Stability.

Suárez F, Couso-Queiruga E, Osorio J et al. · 2026 · Clinical implant dentistry and related research

Objectives The objective of this ex vivo investigation was to study the significance of barrier membrane application on graft stability across different peri-implantitis-related bone defect configurations. Materials and methods Fresh pig…

View details →DOI: 10.1111/cid.70140