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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20253 results in Negative / Null Result Report · page 439 of 676

Negative / Null Result ReportMedicine

The Association of Ramadan Fasting on Relative Leukocyte Telomere Length in Type 2 Diabetes Mellitus.

Hardika, Kurniawan, Laksmi et al. · 2026 · Journal of the ASEAN Federation of Endocrine Societies

Leukocyte telomere length (LTL) is considered a biomarker of cellular senescence. Previous studies have reported the associations between shortened telomere length and type 2 diabetes mellitus (T2DM). However, the role of underlying…

View details →DOI: 10.15605/jafes.041.01.5071
Negative / Null Result ReportMedicine

Comparison of wear behavior of 3D printed permanent resin, milled zirconia, and primary tooth enamel on antagonist primary canines: in vitro study.

Akdogan, Aydin · 2026 · BMC oral health

Data comparing the wear of 3D printed permanent resin (PR) and milled zirconia (Z) to that of primary tooth enamel are limited. This study aimed to investigate the wear behavior of two materials and their effect on antagonist primary…

View details →DOI: 10.1186/s12903-026-08916-0
Negative / Null Result ReportMedicine

Effects of Topical Lidocaine and Benzocaine on Pain Level and Injection Satisfaction in Arteriovenous Fistula Catheter Applications.

Güler, Kaplan, Şahan et al. · 2026 · Pain management nursing : official journal of the American Society of Pain Management Nurses

Pain during arteriovenous fistula (AVF) catheterization is a common discomfort faced by hemodialysis patients and can negatively affect treatment adherence, satisfaction, and overall quality of life. Effective pain management strategies…

View details →DOI: 10.1016/j.pmn.2026.05.016
Negative / Null Result ReportMedicine

Comparison between the fast and the traditional nitroglycerin head-up tilt test in paediatric population.

Russo, Comune, Di Nardo et al. · 2026 · International journal of cardiology

The shortened protocol of Nitroglycerin (NTG)-potentiated head-up tilt testing (HUTT), the so-called "fast Italian protocol," has been shown to significantly reduce test duration while maintaining diagnostic yield and safety in adults with…

View details →DOI: 10.1016/j.ijcard.2026.134623
Negative / Null Result ReportMedicine

Adjunctive GLP1 Receptor Agonists in Patients with Inflammatory Bowel Diseases and Obesity and/or Diabetes: A Target Trial Emulation.

Yeh, Ahuja, Patel et al. · 2026 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

We conducted a target trial emulation study to examine the effect of two glucagon-like peptide-1 receptor agonists (GLP1RAs) (semaglutide and tirzepatide) on clinical outcomes in patients with inflammatory bowel diseases (IBD) with obesity…

View details →DOI: 10.1016/j.cgh.2026.06.008
Negative / Null Result ReportMedicine

Pulmonary venoocclusive disease/pulmonary capillary hemangiomatosis: Inadequacy of clinico-radiologic features in diagnosis.

Hurst, White, Ryu et al. · 2026 · Human pathology

Pulmonary venoocclusive disease (PVOD)/pulmonary capillary hemangiomatosis (PCH) belongs to the WHO group 1 pulmonary hypertension (PH), labeled as pulmonary arterial hypertension (PAH), though it mainly involves pulmonary veins, venules…

View details →DOI: 10.1016/j.humpath.2026.106203
Negative / Null Result ReportMedicine

Decoding marginal adaptation and microleakage: A field emission scanning electron microscopy and stereomicroscopic evaluation of cavity liners under class II composite restorations.

Mann, Sharma, Jhamb et al. · 2026 · Journal of conservative dentistry and endodontics

Esthetics are in high demand in modern dentistry; conservative dentistry offers tooth-colored restorative materials; however, drawbacks such as polymerization shrinkage can lead to microleakage. To minimize this problem, cavity liners are…

View details →DOI: 10.4103/jcde.jcde_180_26
Negative / Null Result ReportMedicine

Periodontal status, oral inflammatory biomarker, and relative expression of red complex bacteria in periodontitis-rheumatoid arthritis: a cross-sectional preliminary study.

Mahardika, Rakhmawati, Sulijaya et al. · 2026 · Frontiers in cellular and infection microbiology

To determine the differences in periodontal status-Probing Depth (PD), Clinical Attachment Loss (CAL), Bleeding on Probing (BOP); oral inflammatory biomarkers-Tumor Necrosis Factor Alpha (TNF-α), Interleukin 1 Beta (IL-1β),…

View details →DOI: 10.3389/fcimb.2026.1824946
Negative / Null Result ReportMedicine

Association Between Advanced Age and Perioperative Complications Among Women Operated for Pelvic Organ Prolapse in Urogynecology Camps in Uganda.

Kato, Ngonzi, Byamukama et al. · 2026 · Cureus

The burden of pelvic organ prolapse (POP) is the highest among elderly women compared to their young and middle-aged counterparts. These women are also faced with various medical comorbidities. Surgery in these women presents a…

View details →DOI: 10.7759/cureus.108822
Negative / Null Result ReportMedicine

Artificial Intelligence for Molecular Subtyping in Unresectable Gallbladder Cancer: A Proof-of-Concept Study for CT-based HER2 Status Prediction.

Gupta, Madan, Dutta et al. · 2026 · Journal of clinical and experimental hepatology

Human epidermal growth factor receptor 2 (HER2) overexpression is a critical therapeutic target in gallbladder cancer (GBC), but detection requires invasive sampling. We developed a fully automated computed tomography (CT)-based framework…

View details →DOI: 10.1016/j.jceh.2026.103563
Negative / Null Result ReportMedicine

Impact of language concordant care on comprehension and adherence to infection prevention protocols among hospitalized patients: A multicentre survey.

Reason, Rizvi, Chawla et al. · 2026 · Canada communicable disease report = Releve des maladies transmissibles au Canada

Language concordant care can influence patient outcomes. The level of language concordant care and its impact on adherence to infection prevention protocols has not been well described. To assess whether patients' preferred language…

View details →DOI: 10.14745/ccdr.v52i04a05
Negative / Null Result ReportMedicine

Screening criteria for drainage-free patients after retroperitoneal laparoscopic adrenal tumor resection and their prospective validation study value.

Zhao, He, Li et al. · 2026 · Experimental and therapeutic medicine

Retroperitoneal laparoscopic resection is the preferred minimally invasive surgery for adrenal tumors. Patients vary greatly in postoperative drain output, but no clear criteria exist to select candidates for a drainage-free strategy. The…

View details →DOI: 10.3892/etm.2026.13200
Negative / Null Result ReportMedicine

Relationship Between Position, Shape, and Deformation of Papillary Muscles and Mitral Regurgitation After Transcatheter Aortic Valve Replacement.

Li, Chen, Zhou et al. · 2026 · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

Moderate/severe mitral regurgitation (MR) can affect the prognosis of patients with transcatheter aortic valve replacement (TAVR). However, few studies have focused on the role played by papillary muscles (PMs). We intend to explore the…

View details →DOI: 10.1002/ccd.70703
Negative / Null Result ReportMedicine

The effect of different access cavity designs and different irrigaton solutions on the removal of calcium hydroxi̇de from root canals: in vitro study.

Bodur, Küçükekenci̇ · 2026 · BMC oral health

This study investigated how different access cavity designs and irrigation solutions influence the removal of calcium hydroxide from root canals. Eighty-four mandibular molars were divided into three groups according to their access…

View details →DOI: 10.1186/s12903-026-08868-5
Negative / Null Result ReportMedicine

Clinical Application of Surgical Methods Based on Different Lung Segments and Pathological Subtypes in the Treatment of T1b Lung Adenocarcinoma.

Zhai, Zhu, Lan et al. · 2026 · Annali italiani di chirurgia

This study aimed to explore the clinical application of surgical methods based on different lung segments and pathological subtypes in the treatment of T1b lung adenocarcinoma. A total of 207 patients with T1b lung adenocarcinoma admitted…

View details →DOI: 10.62713/aic.4485
Negative / Null Result ReportMedicine

Evaluation of Critical Risk Factors and Development of a Predictive Model for Surgical Site Infection in Type 2 Diabetic Patients Undergoing Oral and Maxillofacial Surgery.

Sun, Gong, Zhu et al. · 2026 · Annali italiani di chirurgia

This study aims to explore the critical risk factors associated with surgical site infection (SSI) in patients with type 2 diabetes mellitus (T2DM) undergoing oral and maxillofacial surgery, and to develop a predictive model to support…

View details →DOI: 10.62713/aic.4470
Negative / Null Result ReportMedicine

Impact of Evidence-Based Nursing and Health Empowerment on Self-Efficacy and Cognitive Function in Lung Cancer Patients Undergoing Thoracoscopic Surgery.

Shu, Jin, Peng · 2026 · Annali italiani di chirurgia

Given the high incidence of postoperative cognitive decline and reduced self-efficacy in lung cancer patients undergoing radical thoracoscopic surgery, this study aimed to investigate the effect of evidence-based nursing combined with…

View details →DOI: 10.62713/aic.4456
Negative / Null Result ReportMedicine

Preperitoneal analgesia under direct visualization: laparoscopic-guided deep rectus sheath block improves postoperative pain control after laparoscopic cholecystectomy: a randomized controlled trial.

Kavakli, Bozkurt, Diri et al. · 2026 · Surgical endoscopy

Conventional abdominal wall blocks primarily target somatic afferent nerves and may therefore provide limited relief for the peritoneal component of postoperative pain. This study aimed to investigate whether a laparoscopic-guided deep…

View details →DOI: 10.1007/s00464-026-12973-5
Negative / Null Result ReportMedicine

Diagnostic Value of Quantitative Lung Perfusion Single-photon Emission CT/CT for Chronic Lung Allograft Dysfunction in Patients After Bilateral Lung Transplantation.

Nakashima, Iguchi, Sugimoto et al. · 2026 · Clinical nuclear medicine

Chronic lung allograft dysfunction (CLAD) is a major cause of late morbidity after lung transplantation, and spirometry lacks the ability to detect regional lung changes. Thus, in this study, we investigated whether quantitative perfusion…

View details →DOI: 10.1097/rlu.0000000000006557
Negative / Null Result ReportMedicine

Digital nudge emails to increase early registration for an occupational health support program: a stratified randomized controlled trial.

Muto, Ohtake · 2026 · Journal of occupational and environmental medicine

To evaluate whether nudge emails increased early registration for an occupational health support program among employees advised to act after annual health checkups. In this stratified randomized controlled trial, 871 employees with no…

View details →DOI: 10.1097/jom.0000000000003791
Negative / Null Result ReportMedicine

Post COVID REspiratory mechanisms and the efficacy of a breathing exercise intervention for DYsregulated breathing (Remedy): A feasibility RCT study.

Tc, S, J et al. · 2026 · Chronic respiratory disease

BackgroundDysregulated breathing is a major cause of persisting breathlessness for many people following acute COVID-19 illness. There is little evidence to support the use of breathing interventions within this population.MethodsA…

View details →DOI: 10.1177/14799731261454679