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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20253 results in Negative / Null Result Report · page 436 of 676

Negative / Null Result ReportMedicine

Comparative Evaluation of Serum Hepcidin and Fecal Calprotectin for Disease Activity Assessment in Inflammatory Bowel Disease.

Akıncıoğlu P, Dağlı Ü, Koca E · 2026 · The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

Background/aims Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a chronic inflammatory disorder commonly associated with iron deficiency anemia and anemia of chronic disease. Hepcidin is a key…

View details →DOI: 10.5152/tjg.2026.25774
Negative / Null Result ReportMedicine

The Effect of EMG biofeedback in female patients with stress urinary incontinence: a randomized sham controlled blinded clinical study.

Cigdem-Karacay B, Bayramoglu-Demirdogen E, Konar NM et al. · 2026 · Irish journal of medical science

AIM: The effectiveness of EMG-BF in SUI has not yet been proven. This study aimed to the effectiveness of EMG-BF on pelvic floor muscle activity, pad test, severity of complaints, and quality of life in female patients with Stress Urinary…

View details →DOI: 10.1007/s11845-026-04374-3
Negative / Null Result ReportMedicine

Compression Garments and Adaptations to Plyometric Training in Soccer Players: A Randomized-Controlled Study.

Gosset M, Coquart A, Delaval B et al. · 2026 · Journal of strength and conditioning research

Abstract Gosset, M, Coquart, A, Delaval, B, Catalano, J, Huou, G, Boufflers, M, Bozok, D, Bellanger, L, Douchet, T, Viroux, P, Jaffré, C, and Abaïdia, A-E. Compression garments and adaptations to plyometric training in soccer players: A…

View details →DOI: 10.1519/jsc.0000000000005489
Negative / Null Result ReportMedicine

Impact of peptide receptor radionuclide therapy (PRRT) on the quality of life in patients with neuroendocrine tumours.

Fernando H, Vito I, Santillan N et al. · 2026 · Journal of neuroendocrinology

As peptide receptor radionuclide therapy (PRRT) maintains a key role in the treatment of neuroendocrine tumours (NETs), there is growing recognition of the importance of evaluating patient-reported health related quality of life (HRQoL).…

View details →DOI: 10.1111/jne.70201
Negative / Null Result ReportMedicine

Efficacy of Testosterone Replacement Therapy Combined With Exercise on Body Composition in Hypogonadal Men.

Shigehara K, Shinzawa R, Sakatoku N et al. · 2026 · International journal of urology : official journal of the Japanese Urological Association

Objectives We assessed the efficacy of testosterone replacement therapy (TRT) combined with exercise on body composition in hypogonadal men. Methods Two hundred-fourteen patients were enrolled. All patients were divided into four groups:…

View details →DOI: 10.1111/iju.70524
Negative / Null Result ReportMedicine

Real-World Integrative Oncology in Patients With Cancer and Diabetes: Engagement Patterns, Outcomes.

Kassem S, Gressel O, Samuels N et al. · 2026 · Journal of pain and symptom management

Context and objective Integrative oncology (IO) programs address quality of life (QoL)-related concerns within palliative and supportive cancer care. This study examined adherence to and outcomes of an IO program among patients with both…

View details →DOI: 10.1016/j.jpainsymman.2026.05.013
Negative / Null Result ReportMedicine

Safety and efficacy of Esculin and Digitalis glycosides eye drops in individuals with presbyopia.

Zhang Y, Wang J, Hao M et al. · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

PURPOSE: This proof-of-concept study aimed to detect preliminary signals of efficacy and assess the short-term safety of Esculin and Digitalis glycoside eye drops for the management of presbyopia. METHODS: This study was a 30-day,…

View details →DOI: 10.1007/s00417-026-07184-6
Negative / Null Result ReportMedicine

A person-centred and data-driven approach to phenotyping anorexia nervosa.

Bovenberg C, Keeler JL, Cardi V et al. · 2026 · Journal of eating disorders

Background Anorexia nervosa (AN) is a severe psychiatric disorder (ED) with high mortality, marked functional impairment, and substantial phenotypical heterogeneity. Despite extensive research, treatment outcomes remain poor, and it is…

View details →DOI: 10.1186/s40337-026-01632-8
Negative / Null Result ReportMedicine

Comparison of sesame oil wafers and lozenges as saliva substitutes for dry mouth in head and neck cancer patients: A crossover randomized control trial.

Abbas Amanat M, Srichana T, Takahashi Yupanqui C et al. · 2026 · Pakistan journal of pharmaceutical sciences

Background Dry mouth is a condition associated with significant morbidity. It not only causes discomfort but also increases risk of many health and oral health problems. Objectives This study compared the efficacy and patient satisfaction…

View details →DOI: 10.36721/pjps.2026.39.5.reg.15179.1
Negative / Null Result ReportMedicine

Feasibility and advantages of delivering radiofrequency ablation treatment for haemorrhoids under local anaesthesia in the outpatient setting in the UK: our initial experience.

Rajendiran A, Maharjan A, Gerrard AD et al. · 2026 · Techniques in coloproctology

Introduction Radiofrequency ablation (RFA) for haemorrhoids has emerged as a minimally invasive treatment for grade II-III haemorrhoids, offering reduced postoperative pain and faster recovery compared with conventional surgery. However,…

View details →DOI: 10.1007/s10151-026-03353-1
Negative / Null Result ReportMedicine

Real-Time Perfusion Assessment with Hyperspectral Imaging After Revascularization in Peripheral Artery Disease.

Kluckner M, Hitzl W, Enzmann FK et al. · 2026 · Journal of clinical medicine

Background/Objectives : Hyperspectral imaging (HSI) facilitates noninvasive assessment of tissue perfusion in patients with peripheral arterial disease. However, available studies are either based on small cohorts and provide no comparison…

View details →DOI: 10.3390/jcm15041667
Negative / Null Result ReportOpen accessMedicine

Anatomy changes, signalling pathways, and clinical treatment after ankle sprain.

Wang J, Chen J, Zhao Y et al. · 2026 · Bone & joint research

Aims Ankle sprain (AS), a prevalent sports injury, often progresses to chronic ankle instability (CAI) and post-traumatic arthritis if inadequately treated. Despite known clinical manifestations, the molecular mechanisms driving poor…

View details →DOI: 10.1302/2046-3758.154.bjr-2025-0168.r1
Negative / Null Result ReportOpen accessMedicine

Patterns of recovery after arthroscopic repair of the rotator cuff over a 2-year follow-up period: are they similar regardless of the tear size?

Seok HG, Park SG · 2026 · Archives of orthopaedic and trauma surgery

INTRODUCTION: The recovery patterns following arthroscopic rotator cuff repairs are influenced by several factors, including the size of the tear and the degree of patient compliance. This study aimed to ascertain whether a correlation…

View details →DOI: 10.1007/s00402-026-06218-2
Negative / Null Result ReportMedicine

Eustachian Tube Balloon Dilation in Children: Prospective Clinical Outcomes of a Low-Cost Endovascular Balloon.

Hassan AM, Elgarem HF, Sheta E et al. · 2026 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

Objective Balloon dilation of the Eustachian tube (BDET) is increasingly used to treat pediatric obstructive Eustachian tube dysfunction (OETD); however, its broader adoption is limited by the cost of commercially available devices.…

View details →DOI: 10.1097/mao.0000000000004903
Negative / Null Result ReportMedicine

Challenges of heart failure treatment in patients with chronic kidney disease: A call to action.

Metry M, Bernard S · 2026 · JAAPA : official journal of the American Academy of Physician Assistants

Abstract Heart failure (HF) is one of the most common and consequential conditions encountered in clinical practice. It frequently coexists with chronic kidney disease (CKD), a highly prevalent and economically burdensome condition. The…

View details →DOI: 10.1097/01.jaa.0000000000000375
Negative / Null Result ReportOpen accessMedicine

Postbiotics in Dermatology: A Literature Review of Emerging Topical Therapies for Acne, Rosacea, and Eczema.

Flores Rodríguez JC, Morán Ortega MJ, Jimenez Ordoñez AC et al. · 2026 · Cureus

Postbiotics, defined as non-viable microbial cells and their metabolites, have emerged as topical therapies for inflammatory dermatoses and provide more clinical benefits than live postbiotics by eliminating infection risk and stability.…

View details →DOI: 10.7759/cureus.105440
Negative / Null Result ReportOpen accessMedicine

Constipation with bloating: a clinical approach to evaluation and management.

Cangemi DJ, Laitman AP, Faiman O et al. · 2026 · Annals of medicine

Introduction Constipation and bloating are common bothersome gastrointestinal (GI) symptoms that frequently occur concurrently. It is important to recognize the underlying condition(s) and tailor therapeutic interventions appropriately.…

View details →DOI: 10.1080/07853890.2026.2684172
Negative / Null Result ReportMedicine

Intravaginal Aloe barbadensis and cervical HPV clearance: A retrospective observational study.

Gozde Ozdemir B, Avci F, Huseynli L et al. · 2026 · Pakistan journal of pharmaceutical sciences

Background Persistent infection with human papillomavirus (HPV) is a key factor in cervical carcinogenesis. Immune-mediated mechanisms play a central role in viral clearance, leading to interest in immunomodulatory supportive therapies.…

View details →DOI: 10.36721/pjps.2026.39.7.reg.190.1
Negative / Null Result ReportMedicine

Maltodextrin as sucrose replacer: Effect of dextrose equivalence and sucrose/maltodextrin ratio on physical and sensory properties of non-fat whipped cream analogue

Yang J, Han Y · 2026 · Food Hydrocolloids.

The development of non-fat whipped cream analogue (NFWCA) addresses the demand for low-fat and reduced-sucrose foods. This study systematically evaluated how the dextrose equivalent (DE) value of maltodextrin (MD) and the sucrose/MD ratio…

Negative / Null Result ReportMedicine

Efficacy of multimodal therapy for sudden sensorineural hearing loss: a propensity score-matched analysis of 1632 patients.

Li G, Wang C, Gao Y et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

OBJECTIVE: This study evaluated the efficacy and safety of multimodal outpatient therapy compared with conventional inpatient therapy during the initial treatment of sudden sensorineural hearing loss (SSNHL). The goal was to provide…

View details →DOI: 10.1007/s00405-026-10175-2
Negative / Null Result ReportMedicine

Outcomes of secondary interventions in treatment of post-traumatic stiff shoulder in conservatively managed proximal humeral fractures: a scoping review.

Zhang Y, Sadeh N, Mitchell O et al. · 2026 · Irish journal of medical science

Aims There is no current gold standard in treating post-traumatic stiff (PTS) shoulder complicating conservatively managed proximal humeral fractures (PHFs). This scoping review seeks to present available outcome evidence in this cohort of…

View details →DOI: 10.1007/s11845-026-04474-0
Negative / Null Result ReportMedicine

Postoperative syphilitic scleritis following strabismus surgery.

Parunakian E, Yehezkeli V, Khitri M et al. · 2026 · Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

Syphilis can present with a wide range of ocular manifestations; however, scleritis is exceedingly rare. Although various infectious and noninfectious causes of scleritis following strabismus surgery have been documented, syphilitic…

View details →DOI: 10.1016/j.jaapos.2026.104883
Negative / Null Result ReportMedicine

Olfactory outcomes after primary endoscopic sinus surgery and dupilumab for post-operative recurrence in eosinophilic chronic rhinosinusitis.

Saito T, Hirose T, Haruna T et al. · 2026 · The Journal of laryngology and otology

Objective. To compare subjective and psychophysical olfactory outcomes in patients with eosinophilic chronic rhinosinusitis controlled after primary functional endoscopic sinus surgery (FESS) alone versus those treated with dupilumab for…

View details →DOI: 10.1017/s0022215126104976
Negative / Null Result ReportOpen accessMedicine

The association between cognitive function trajectories and all-cause mortality in middle-aged and older Chinese adults with cardiovascular disease: A longitudinal study from CHARLS.

Song X, Wang Y, Chen H · 2026 · International journal of cardiology. Cardiovascular risk and prevention

Objective To identify distinct multi-year cognitive function trajectories in middle-aged and older Chinese adults with established cardiovascular disease (CVD) and evaluate their independent associations with all-cause mortality. Methods…

View details →DOI: 10.1016/j.ijcrp.2026.200583
Negative / Null Result ReportOpen accessMedicine

Dupilumab-Induced Psoriasiform Eruption in an 83-Year-Old Patient.

Pham VX, Gilbertson E · 2026 · Cureus

This case report describes an 83-year-old female who developed severe psoriasiform lesions suspected to be induced by dupilumab. The patient initially presented with eczematous papules affecting her back, arms, torso, and scalp, and a…

View details →DOI: 10.7759/cureus.109041