A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20253 results in Negative / Null Result Report · page 426 of 676
Groothof D, Bakker SJ · 2025 · Preprint
Tolvaptan is the only approved therapy for slowing disease progression in autosomal dominant polycystic kidney disease (ADPKD). Its use necessitates a careful balance between its kidney-protective effects and the burdensome aquaretic…
Cai J, Li W, Xu S · 2025 · BMC medical education
Introduction To explore the impact of teaching by clinical educators and faculty educators on the academic performance of vocational medical students, this study analyzed the final exam scores of four classes in the General Surgery course…
Shankar DA, Bosch NA, Jafarzadeh SR et al. · 2025 · CHEST pulmonary
Background Corticosteroids are a mainstay of treatment for acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF), but dosing practices vary. We leveraged between-hospital variation in propensity to administer pulse dose…
Saithna A · 2025 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Evaluations of practice patterns after rotator cuff repair reveal that both simple slings and abduction braces are commonly used, with the latter most frequently preferred in the United States. A preference for a shoulder abduction brace…
Stróżyk A, Horvath A, Kozłowska-Jalowska A et al. · 2026 · Frontiers in pediatrics
Objective Evidence supporting the effectiveness of a low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (low-FODMAP) diet in treating functional abdominal pain disorders remains limited. We aimed to assess the…
Tabaru A, Yigit O, Akyel S et al. · 2025 · Ear, nose, & throat journal
Objective The use of mastoid pressure dressings (MPDs) after otologic surgery has been a standard practice for decades, believed to minimize complications such as hematoma and wound infection. However, the efficacy of MPDs in improving…
Tsubakimoto Y, Takahara M, Soga Y et al. · 2025 · Cardiovascular intervention and therapeutics
Drug-coated balloon (DCB) angioplasty is an effective endovascular therapy for femoropopliteal artery (FPA) disease in patients with peripheral artery disease (PAD). However, the long-term impact of statin and anticoagulant therapy on…
Feliberti J, Alam A, Maulion C · 2025 · Current opinion in cardiology
Purpose of review Hypertension is one of the most common comorbidities affecting patients after solid organ transplantation. Here we review the mechanisms leading to hypertension, along with common practices in terms of medical management.…
Jamal F, Sahvan O, Junior PLSU et al. · 2025 · The oncologist
Background The increasing reliance on accelerated approvals and surrogate endpoints for Food and Drug Administration (FDA) approvals of gastrointestinal (GI) cancer therapies raises concerns about their clinical benefit and long-term…
Cristarella E, Ambrosini M, Di Maio M et al. · 2025 · European journal of cancer (Oxford, England : 1990)
Background In the ARMANI trial, switch maintenance with paclitaxel plus ramucirumab improved progression-free survival and overall survival versus continuation of oxaliplatin-based chemotherapy in patients with HER2-negative advanced…
Vang K, Panich J, Folz C et al. · 2025 · Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
IntroductionImmune checkpoint inhibitors (CPIs) work by engaging the patient's immune system against tumor cells and have demonstrated a significant benefit in the treatment of cancers. Activation of the patient's immune system can lead to…
Schonhaut EB, Scherpereel KL, Young AJ · 2026 · IEEE transactions on bio-medical engineering
Objective Accurate, non-invasive methods for estimating joint and muscle physiological states have the potential to greatly enhance control of wearable devices during real-world ambulation. Traditional modeling approaches and current…
Lusilla Lopez A, Fält UA, Buchwald P et al. · 2026 · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
Aim Treatment of complex anal fistulae remains a significant challenge for physicians and patients. A sphincter-preserving technique with bioactive platelet-rich fibrin matrix is one option. This three-year study aimed to evaluate the…
Marsh A, Quelch D, Mackonochie M et al. · 2026 · The international journal of neuropsychopharmacology
The incidence of cognitive disorders is rising, and medications to address cognitive impairments are limited. Phytochemical compounds have had some success in improving cognitive outcomes in preclinical studies. However, the evidence…
Godoy MR, Brochado-Neto FC, Martins Cury MV et al. · 2025 · Journal of vascular surgery
Objective This study aimed to assess whether duplex ultrasound (DUS) surveillance yielded a better outcome compared with ankle-brachial index (ABI) surveillance after femoropopliteal endovascular therapy (EVT) in a cohort of patients…
Aggarwal A, Adie S, Harris IA et al. · 2025 · The Cochrane database of systematic reviews
Background Total knee replacement (TKR) is a common intervention for people with end-stage symptomatic knee osteoarthritis, resulting in significant improvements in pain, function and quality of life within three to six months. It is,…
Bi Z, Ren T, Wang Y · 2025 · Chinese journal of cancer research = Chung-kuo yen cheng yen chiu
The latest data from the NATALEE trial showed the absolute 3-year invasive disease-free survival benefit was 4.9% between the experimental and control groups. That is to say, in the intermediate-risk hormone receptor positive/human…
Wee YC, Hewage U, Horwood C et al. · 2026 · Journal of clinical medicine
Background : Statins have anti-inflammatory properties beyond their lipid-lowering effects, but their impact on skin and soft tissue infections (SSTIs) remains unclear. This study evaluated whether statins improve clinical outcomes in…
Robertson NP · 2025 · Journal of neurology
The first of several phase 3 trials examining efficacy in relapsing MS has not been able to demonstrate a significant benefit and has also raised important safety concerns. More results are on their way and it will be important to…
Tabibian K, Vadlakonda A, Coaston T et al. · 2025 · The American journal of cardiology
Despite advancements in cardiogenic shock (CS) management, mortality remains high. While hospital volume has been linked to reduced mortality across myriad complex procedures, the cross-volume effects of mechanical circulatory support…
Ghotboddin Mohammadi S, Shafie D, Feizi A et al. · 2026 · Scientific reports
Chronic inflammation and dyslipidemia are common pathophysiological features of heart failure (HF). Astaxanthin, a potent marine-derived antioxidant, has shown anti-inflammatory and lipid-lowering properties. This study conducted to…
Cardoso A, Naghibi M, Climent E et al. · 2026 · Allergy
Background Allergic rhinitis (AR) is an increasingly common chronic inflammatory condition of the nasal mucosa. While conventional anti-allergy treatments are widely used, they can come with side effects and are not always effective. As a…
Wang AI, Duong MP, Frohlich JR et al. · 2026 · Journal of the American Association for Laboratory Animal Science : JAALAS
Systemic analgesics, such as opioids and nonsteroidal anti-inflammatory drugs, may be contraindicated in certain studies due to their mechanisms of action and risk for systemic effects. Local anesthetics (LAs) are therefore crucial in…
Shruthi P P, Chandran M O, Chandrasekaran B et al. · 2026 · Preprint
Background: Prolonged uninterrupted sitting impairs central vascular hemodynamics, which may compromise cerebral perfusion and cognitive performance. Activity micro-breaks have been proposed to mitigate these effects, yet the association…
Na K, Qiu M, Zhang T et al. · 2026 · Preprint
Abstract Background Patients with acute coronary syndrome (ACS) who have concurrent high ischemic and high bleeding risk represent a common but understudied group after percutaneous coronary intervention. Evidence guiding P2Y₁₂ inhibitor…
Mongia N, Mohammed AI, McCullough M et al. · 2026 · Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Background Hemidesmosomal subunits have gained attention for their potential role in the progression of oral squamous cell carcinoma (OSCC). However, formal analysis of quantitative expression patterns correlating with OSCC disease…
Guo P, Yang Y, Chen X et al. · 2026 · PLoS neglected tropical diseases
Objectives This study seeks to investigate the characteristics, dynamics, and association with disease progression of monocyte inflammation in patients with AIDS/Talaromycosis Marneffei (TSM). The findings are expected to contribute to a…
de Marcos Carpio I, de Vicente F, Vallefuoco R · 2026 · Veterinary and comparative orthopaedics and traumatology : V.C.O.T
Objectives (1) To describe and compare the morphometric changes of the tibia following four virtual proximal tibial osteotomies for treatment of canine cranial cruciate ligament deficiency and (2) to determine how these changes are…
Tan-Ho G, Choo PY, Ma SHXY et al. · 2026 · Psychological trauma : theory, research, practice and policy
Objective Caring for a loved one with dementia imposes significant physical strain, emotional burden, and psychological trauma on family caregivers. Singaporean caregivers face added pressures under cultural norms that emphasize familial…
Ortíz Aguirre MJ, Barrientos Chinchilla AC, León-Velásquez M et al. · 2026 · Journal of gynecology obstetrics and human reproduction
Objective To assess the efficacy of topical lidocaine versus placebo in reducing pain during manual vacuum aspiration (MVA) for endometrial sampling in patients with endometrial thickening, as measured by the visual analog scale (VAS).…