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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19871 results in Negative / Null Result Report · page 421 of 663

Negative / Null Result ReportMedicine

Investigation of circulating natural autoantibodies against ANXA1 and MYC as potential biomarkers in hepatocellular carcinoma.

Wang J, Liu S, Zhang X · 2025 · Advances in medical sciences

Purpose In this study, we examined novel autoantibodies targeting tumor-associated antigens (TAAs) as biomarkers for clinical assessment of hepatocellular carcinoma (HCC) in a Chinese population. Methods and methods A total of 119 patients…

View details →DOI: 10.1016/j.advms.2025.01.004
Negative / Null Result ReportOpen accessMedicine

Effectiveness of dilution ventilation in mitigating occupational exposure to volatile organic compounds (VOCs) at the breathing zone of nail technicians: a simulation study.

Salari S, Fazeli-Tabar S, Karimi A et al. · 2026 · Scientific reports

Volatile Organic Compounds (VOCs) from nail products pose potential health risks to technicians and clients. The present study investigates the exposure of nail technicians to VOC and assesses the effectiveness of dilution ventilation in…

View details →DOI: 10.1038/s41598-025-33777-y
Negative / Null Result ReportOpen accessMedicine

Medication count, including statin or metformin use, is not associated with influenza vaccine responses in older adults.

Li V, McClure H, Patel R et al. · 2025 · Vaccine

Background Vaccination helps prevent infections and associated sequelae, especially in older adults. Since the degree to which vaccine responses are influenced by medications is not well described, we examined the association of medication…

View details →DOI: 10.1016/j.vaccine.2025.127913
Negative / Null Result ReportOpen accessMedicine

Motives of Children for Digital Gaming and Physical Activity and Their Parents' Perceptions: Cross-Sectional Matched-Pair Study.

Wachholz F, Gamper N, Kruse S et al. · 2026 · JMIR pediatrics and parenting

Background Physical activity (PA) is essential for the healthy development of children. However, the pervasive presence of digital technologies has made digital gaming (DG) a prominent part of children's everyday lives. As children grow up…

View details →DOI: 10.2196/80129
Negative / Null Result Report

Altered coagulation profile of patients with high-grade glioma: clinical study with control group.

Quispe-Pastor NJ, Gorritti-Rubio AP, Fernández-Rodríguez LJ · 2024 · Preprint

Background: Disregulation of coagulation is a common phenomenon in patients with high-grade glioma, a primary malignant brain tumor. Objective Identify if there is an alteration in the coagulation profile in patients with high-grade glioma…

View details →DOI: 10.12688/f1000research.154700.2
Negative / Null Result ReportOpen accessMedicine

Extent of Pelvic Lymph Node Dissection at Partial Cystectomy: Effect on Cancer-Specific Mortality.

Longoni M, Marmiroli A, Falkenbach F et al. · 2026 · International journal of urology : official journal of the Japanese Urological Association

Introduction We assessed the extent of pelvic lymph node dissection (PLND) at partial cystectomy (PC) according to PC eligibility (≤cT2 stage, tumor ≤ 3 cm and segmental resection possible) and tested its effect on cancer-specific…

View details →DOI: 10.1111/iju.70483
Negative / Null Result ReportMedicine

Evaluation of pharmacological thromboprophylaxis in critically Ill elderly patients: A multicenter cohort Study.

Alqahtani R, Sulaiman KA, Aljuhani O et al. · 2025 · Heart & lung : the journal of critical care

Background Older adults are at a higher risk of developing venous thromboembolism (VTE), particularly when admitted to the Intensive Care Units (ICUs). Parenteral anticoagulation is the primary method used for thromboprophylaxis in…

View details →DOI: 10.1016/j.hrtlng.2025.07.013
Negative / Null Result ReportOpen accessMedicine

Effects of high-definition transcranial direct current stimulation for the treatment of chronic insomnia: a randomized, double-blind, controlled trial.

Li J, Li A, Jiao J et al. · 2025 · Scientific reports

To evaluate effects of 10-day high-definition transcranial direct current stimulation (HD-tDCS) over the dorsal medial prefrontal cortex (DMPFC) in patients with chronic insomnia. Fifty-five chronic insomnia patients were randomized into…

View details →DOI: 10.1038/s41598-025-09304-4
Negative / Null Result ReportOpen accessMedicine

Men talk less than women during multitasking.

Szameitat AJ, Szameitat DP · 2026 · Psychological research

Contrary to the widespread stereotype that women are better at multitasking than men, no consistent sex differences in multitasking abilities between males and females have been found. We developed a novel multitasking paradigm consisting…

View details →DOI: 10.1007/s00426-026-02279-5
Negative / Null Result ReportMedicine

Plasmatic variability of direct oral anticoagulants in people with atrial fibrillation and previous gastric surgery: a pilot case series.

Romoli M, Vitiello M, Lotti EM et al. · 2025 · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Background Data on cardioembolic prevention with direct oral anticoagulants (DOAC) in atrial fibrillation (AF) patients with previous gastric surgery are lacking. We report inter- and intra-individual differences in DOAC concentration in…

View details →DOI: 10.1007/s10072-024-07937-3
Negative / Null Result Report

Exposure levels and target attainment of meropenem in adult patients admitted to the intensive care unit: a prospective observational study

El-Haffaf I, Marsot A, Paillault A et al. · 2024 · Preprint

Aim: Patients hospitalized in the intensive care units (ICU) with serious infections require rapid and optimal broad-spectrum antibiotic regimens to ensure favorable outcomes. The purpose of this study was to evaluate the exposure and…

View details →DOI: 10.22541/au.172813042.22321169/v1
Negative / Null Result ReportMedicine

Clinical risk factors associated with the need for tracheostomy in traumatic cervical and high thoracic spinal cord injury.

Konrad M, Shah B, Rady E et al. · 2025 · American journal of surgery

Background Our objective was to assess the association of completeness and level of spinal cord injury (SCI) with the need for tracheostomy and identify additional risk factors predictive of tracheostomy. Methods This was a retrospective…

View details →DOI: 10.1016/j.amjsurg.2024.116033
Negative / Null Result ReportOpen accessMedicine

Association between Vitamin D Receptor Polymorphisms, Tight Junction Proteins and Clinical Features of Adult Patients with Atopic Dermatitis.

Grieco T, Moliterni E, Paolino G et al. · 2024 · Dermatology practical & conceptual

Introduction Few studies have explored the intricate connections between vitamin D receptor (VDR) gene polymorphisms, VDR, tight junction (TJ) protein expression and clinical features of atopic dermatitis (AD). Methods From 43 adult AD…

View details →DOI: 10.5826/dpc.1403a214
Negative / Null Result ReportMedicine

A qualitative study on perceptions of adolescents' sexual and reproductive health education in Yogyakarta, Indonesia.

Sikoki B, Larastiti C, Suriastini NW et al. · 2024 · International journal of adolescent medicine and health

Introduction Sexual and reproductive health (SRH) education in Yogyakarta, Indonesia, is contentious due to societal and religious taboos in the Javanese Muslim community and being misunderstood as a potential catalyst for the premarital…

View details →DOI: 10.1515/ijamh-2023-0036
Negative / Null Result ReportMedicine

Comparison of WALANT versus locoregional nerve block in staged bilateral endoscopic carpal tunnel release.

Verrewaere D, Reyniers P, Vandevivere H et al. · 2024 · Hand surgery & rehabilitation

Background Carpal tunnel release can be performed as open or endoscopic surgery. In WALANT (wide awake local anesthesia no tourniquet) a tourniquet is not used, ensuring less discomfort for the patient. In locoregional distal nerve block,…

View details →DOI: 10.1016/j.hansur.2024.101974
Negative / Null Result ReportOpen accessMedicine

Real-world effectiveness of vonoprazan-based regimen versus rabeprazole-based dual therapy for <i>Helicobacter pylori</i> eradication in a high-resistance, multi-ethnic region: a multicenter study in Guizhou, China.

Huang Y, Zheng J, Yang Z et al. · 2026 · Frontiers in medicine

Introduction While vonoprazan-amoxicillin dual therapy has achieved > 90% eradication rates for Helicobacter pylori (H. pylori) in clinical trials, its effectiveness in "real-world" regions with high primary antibiotic resistance and…

View details →DOI: 10.3389/fmed.2026.1801129
Negative / Null Result ReportOpen accessMedicine

A consensus exercise to inform the future of National Health Service General Dental Services using a modified-Delphi technique.

Chestnutt IG, Pattinson R, Brocklehurst P et al. · 2026 · British dental journal

Background Problems relating to the commissioning and delivery of National Health Service (NHS) General Dental Services (GDS) have been well-documented.Objectives This study aimed to gain consensus on issues deemed of importance to the…

View details →DOI: 10.1038/s41415-025-9100-x
Negative / Null Result ReportMedicine

Amikacin therapeutic drug monitoring: Evaluation of therapy performance and analytical techniques in a developing country setting.

Steffens NA, Petreceli RR, Azevedo VC et al. · 2025 · Clinical biochemistry

Introduction Healthcare systems face several challenges, with microbial infections being one of the main concerns. Therapeutic drug monitoring (TDM) is a strategy that has been encouraged to optimize antimicrobial regimens, particularly…

View details →DOI: 10.1016/j.clinbiochem.2025.110874
Negative / Null Result ReportOpen accessMedicine

Outcomes Following Staged Bilateral Total Knee Replacements: The Influence of First-Side Surgery on Results of the Second Side.

Boktor J, Jayaraju U, Joseph V et al. · 2024 · Cureus

Background In the UK, the vast majority of bilateral total knee replacements (BTKRs) are performed as staged procedures. Historically, the second-operated knee, in patients undergoing staged BTKRs, has poorer outcomes compared with the…

View details →DOI: 10.7759/cureus.70374
Negative / Null Result ReportOpen accessMedicine

Empirical Anatomical Versus HAFE-Guided Cardioneuroablation for Vasovagal Syncope: Long-Term Efficacy and Safety Outcomes.

Zhang B, Du X, Luo C et al. · 2026 · Clinical cardiology

Background and aims Vasovagal syncope (VVS) poses challenges despite therapy, and optimal cardioneuroablation (CNA) targeting ganglionated plexi (GPs) remains debated. This study compared long-term efficacy and safety between empirical…

View details →DOI: 10.1002/clc.70348
Negative / Null Result ReportMedicine

Primary outcomes and anticipated effect sizes in randomised clinical trials assessing peripheral and truncal nerve blocks: a systematic scoping review.

Sorenson S, Flyger SSB, Pingel L et al. · 2025 · British journal of anaesthesia

Background Peripheral and truncal nerve blocks provide effective analgesia facilitating perioperative care. However, thresholds for clinically relevant effects remain undetermined and are left for clinicians to choose. These choices are…

View details →DOI: 10.1016/j.bja.2024.09.029
Negative / Null Result ReportOpen accessMedicine

Impact of cannabidiol on myocardial recovery in patients with acute myocarditis: primary results of the ARCHER study.

McNamara DM, Cooper LT, Friedrich MG et al. · 2026 · ESC heart failure

Introduction Cannabidiol has been shown to exert significant anti-inflammatory effects and has demonstrated efficacy in murine models of autoimmune myocarditis, pericarditis, and heart failure. The ARCHER Study assessed whether a…

View details →DOI: 10.1093/eschf/xvaf034
Negative / Null Result ReportOpen accessMedicine

Effects of Multimodal and Unimodal Physical Training Interventions on Visual Function in Glaucoma and Elderly Controls - A Pilot Study.

Moffack Djuloun C, Al-Nosairy KO, Beyer R et al. · 2026 · Clinical ophthalmology (Auckland, N.Z.)

Purpose This study aimed to investigate the effects of a 12-week multimodal motor-cognitive and resistance training (MMI) compared to a unimodal resistance training intervention (UMI) on static and dynamic visual function in glaucoma (GLA)…

View details →DOI: 10.2147/opth.s574933
Negative / Null Result ReportOpen accessMedicine

Use of 1 mm Cerclage Cables in Surgical Treatment of Periprosthetic Femur Fractures.

Brown HS, Wall B, Mears SC et al. · 2024 · Geriatric orthopaedic surgery & rehabilitation

Introduction 1 mm cerclage cables have been introduced that can be placed under plates and hold reduction of periprosthetic femur fractures (PPFFx) around total hip arthroplasty (THA). Their utilization remains controversial due to the…

View details →DOI: 10.1177/21514593241302655
Negative / Null Result ReportMedicine

Long-term prognosis of elderly patients undergoing atrial septal defect closure: Are we acting too late?

Lima MR, Paiva MS, Maltês S et al. · 2025 · Current problems in cardiology

Background Atrial septal defects (ASD) often go unrecognized until very late in life. The impact of ASD closure on life expectancy in elderly patients remains unclear. This study compares the survival of patients≥65-years who underwent ASD…

View details →DOI: 10.1016/j.cpcardiol.2024.102930