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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19871 results in Negative / Null Result Report · page 420 of 663

Negative / Null Result ReportMedicine

The effect of midwife-led education based on Pender's health promotion model (MidLed-PHPM) on the perinatal mental health of immigrant women.

Cevik A, Alan S · 2026 · Women and birth : journal of the Australian College of Midwives

Background Perinatal mental health issues are a global problem that constitutes a significant part of the burden on maternal and infant health. This situation could pose a risk, especially for immigrant women, who are a vulnerable group.…

View details →DOI: 10.1016/j.wombi.2026.102213
Negative / Null Result ReportOpen accessMedicine

Physical performance responses to match venue and outcome in elite soccer.

Nobari H, Kamis O, Atıcı AR et al. · 2026 · BMC sports science, medicine & rehabilitation

Background It is widely accepted that match venue influences technical, tactical, fitness, nutrition, the importance of the match, sleep, and psychological factors. This study investigates the impact of match venue (i.e., home vs. away)…

View details →DOI: 10.1186/s13102-026-01723-8
Negative / Null Result ReportOpen accessMedicine

Effects of MDMA treatment and cessation on sexual behaviour and testicular functions in male sprague-dawley rats.

Obembe OO, George ET, Mustapha RA et al. · 2026 · BMC pharmacology & toxicology

BACKGROUND: 3,4-Methylenedioxymethamphetamine (MDMA) is a psychostimulant known for its social and empathogenic effects. However, its long-term impact on sexual performance and reproductive functions remain controversial. OBJECTIVE: In…

View details →DOI: 10.1186/s40360-026-01131-1
Negative / Null Result Report

Analysis of the effect of vertebroplasty via kambin's triangular approach in the treatment of spinal deformity with vertebral compression fracture

Jiang Z, Tan X, Zhang M et al. · 2026 · Preprint

Abstract Objective : To explore the clinical efficacy of percutaneous vertebroplasty (PVP) via Kambin's triangle in the treatment of senile spinal deformity accompanied by vertebral compression fractures. Methods : A retrospective analysis…

View details →DOI: 10.21203/rs.3.rs-9403084/v1
Negative / Null Result ReportOpen accessMedicine

A Comparison of Monoaxial Pedicle Screws Versus Polyaxial Pedicle Screws in Posterior Fusion Surgery for Adolescent Idiopathic Scoliosis (Lenke Type 1).

Hammad A, Saleh ME, Shehab AA · 2026 · Cureus

Background Adolescent idiopathic scoliosis (AIS) is the most common form of spinal deformity in adolescents, characterized by a three-dimensional curvature of the spine with unknown etiology. Surgical intervention is indicated in…

View details →DOI: 10.7759/cureus.107673
Negative / Null Result ReportOpen accessMedicine

Effects of music during endoscopy on pain, anxiety and vital signs: a randomized controlled study.

Bozkurt SN, Kocasli S · 2026 · BMC complementary medicine and therapies

AIMS: The aim of this study was to the effects of music during the endoscopy procedure on anxiety, pain and vital signs. METHODS: This study was conducted as a randomized, controlled, double-blind trial. The study population consisted of…

View details →DOI: 10.1186/s12906-026-05381-8
Negative / Null Result ReportOpen accessMedicine

Quantifying glenoid bone loss in the setting of primary reverse shoulder arthroplasty.

MacFarlane AJ, Larson JH, Kucharik MP et al. · 2026 · Journal of shoulder and elbow arthroplasty

Background Presently, there is no quantifiable and objective criteria for defining severe glenoid bone loss (GBL) for primary reverse total shoulder arthroplasty (rTSA). In this study, we sought to establish quantifiable thresholds of…

View details →DOI: 10.1016/j.jsea.2026.100015
Negative / Null Result ReportOpen accessMedicine

Prognostic Value of Combined Neutrophil-to-Lymphocyte Ratio and Prognostic Nutritional Index in Advanced Ovarian Cancer Treated With Neoadjuvant Chemotherapy.

Ishida H, Egashira H, Asano N et al. · 2026 · Cureus

Background Inflammation- and nutrition-related biomarkers such as the neutrophil-to-lymphocyte ratio (NLR) and prognostic nutritional index (PNI) have been reported as prognostic factors for ovarian cancer. However, their clinical…

View details →DOI: 10.7759/cureus.108250
Negative / Null Result ReportMedicine

Effect of remazolam combined with hydromorphone postoperative analgesia on cognitive function in elderly patients undergoing hip replacement.

Zheng X, Fu X, Shao Y et al. · 2026 · American journal of translational research

Objective To investigate the effect of remazolam combined with hydromorphone on postoperative cognitive function in elderly patients undergoing hip replacement. Methods 184 elderly patients who underwent hip replacement in Sir Run Run Shaw…

View details →DOI: 10.62347/tfej7525
Negative / Null Result Report

Under-correction is not advisable in valgus knee and lateral approach is more feasible than medial approach to achieve this: A 5-year follow-up study

Li S, Chai H, Bao W et al. · 2026 · Preprint

Abstract Background: It is commonly recommended to restore the mechanical axis to within –0° ± 3° in valgus knee. However, the situation is quite different when the alignment is –3° or 3° in the presence of a compromised MCL in Ranawat…

View details →DOI: 10.21203/rs.3.rs-9715753/v1
Negative / Null Result ReportOpen accessMedicine

Effects of ultrasound-assisted tumbling on physicochemical properties, myofibrillar protein structure, and protein oxidation during beef curing.

Jin L, Zhang J, Zhang R et al. · 2026 · Ultrasonics sonochemistry

The aim of this study was to investigate the effects of ultrasound-assisted tumbling (100, 300, 500, and 700 W) with different treatment times (30, 60, 90, 120, 150, and 180 min) on the quality, myofibrillar protein structure, and protein…

View details →DOI: 10.1016/j.ultsonch.2026.107919
Negative / Null Result ReportOpen accessMedicine

Effectiveness of Acupressure on Anxiety, Fatigue, and Sleep Quality Among Operating Room Personnel: A Randomized Controlled Trial.

Abjar R, NasiriFormi E, Kazemi AH et al. · 2026 · Health science reports

Background and aims High-quality sleep, calmness, and lack of fatigue are vital for the health of critical hospital staff. Operating room personnel experience significant mental and physical stress, including anxiety and sleep…

View details →DOI: 10.1002/hsr2.72680
Negative / Null Result Report

Association of Primary Nocturnal Enuresis with Renal Parenchymal Thickness: Insights from a Study on Enuresis Prevalence and Related Factors

Merikhi A, Gheisari A, Kasiri P et al. · 2026 · Preprint

Abstract Background: Nocturnal Enuresis (NE), characterized by the inability to control nighttime voiding in children above five years, is one of the common problems faced by the young generation today and can result in some psychological…

View details →DOI: 10.21203/rs.3.rs-9818630/v1
Negative / Null Result ReportMedicine

<i>Invitro</i> Hepatic like Differentiation of Umbilical Cord-Derived Mesenchymal Stem Cells through FGF and IGF Factor Preconditioning.

Zahid Habib Q, Tahir M, Bakhtawar F et al. · 2026 · Journal of stem cells & regenerative medicine

Introduction Liver diseases remain a major global health burden, with limited treatment options for advanced hepatic dysfunction. Current treatment options are limited and mainly supportive, with liver transplantation being the only…

View details →DOI: 10.46582/jsrm.2201004
Negative / Null Result ReportOpen accessMedicine

Studying the expression levels of LncRNA-MEG3 and miR-147b in the serum of psoriasis patients with and without dyslipidemia.

Kamel M, Marzouk RE, Shaker OG et al. · 2026 · Scientific reports

Psoriasis is a chronic systemic inflammatory skin disorder that is strongly associated with metabolic disorders, including obesity, insulin resistance, hypertension, and dyslipidemia. Dyslipidemia causes abnormalities in lipid profiles,…

View details →DOI: 10.1038/s41598-026-52391-0
Negative / Null Result ReportMedicine

The effectiveness of virtual reality in reducing preoperative anxiety among oral surgery patients under general anesthesia: a salivary stress biomarker and questionnaire-based study.

Yuza AT, Nurwiadh A, Hadikhrisna I et al. · 2026 · BMC oral health

Background Preoperative anxiety is a common psychological response to surgical operations affecting the emotional, cognitive and physiological state of the patient. It can be measured by both objective and subjective methods. While the…

View details →DOI: 10.1186/s12903-026-08466-5
Negative / Null Result ReportMedicine

Craniofacial Growth and Hypodontia in Individuals Born with Van der Woude Syndrome.

Vesterbacka M, Parikakis K, Ganzer N et al. · 2026 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

ObjectiveTo study craniofacial growth and hypodontia in individuals born with Van der Woude syndrome (VWS) and compare with matched controls with and without a cleft.DesignA multicenter retrospective case-control study.SettingIndividuals…

View details →DOI: 10.1177/10556656261463128
Negative / Null Result ReportOpen accessMedicine

Optical coherence tomography angiography evaluation of retinal and choriocapillaris changes after pars plana vitrectomy for macula-off rhegmatogenous retinal detachment: perfluoropropane versus silicone oil tamponade.

Karatepe MS, Erol YÖ · 2026 · BMC ophthalmology

BACKGROUND: Rhegmatogenous retinal detachment (RRD) with macular involvement may lead to persistent visual impairment despite successful anatomical repair. Different intravitreal tamponade agents used during pars plana vitrectomy (PPV) may…

View details →DOI: 10.1186/s12886-026-04760-6
Negative / Null Result Report

Underrecognized Osteoporosis in Internal Medicine Outpatients: Sex-Specific Disparities in Prevalence, Risk Stratification, and Treatment in a Large Elderly Cohort

Okuno R, Homma Y, Matsuno K et al. · 2026 · Preprint

Abstract Background: As the population ages, osteoporosis is becoming a substantial health problem. Internal medicine outpatients often have multiple comorbidities and are considered at high risk for osteoporosis; however, osteoporosis…

View details →DOI: 10.21203/rs.3.rs-9878157/v1
Negative / Null Result ReportOpen accessMedicine

Allelopathic effects of four spontaneous plants from arid regions on the germination and growth of selected weeds and crops.

Harabi M, Elfalleh W, Mergby D et al. · 2026 · Frontiers in pharmacology

The study investigates the allelopathic potential of the aqueous extracts of four plants species; Cleome arabica L., Diplotaxis harra (Forssk.) Boiss., Nerium oleander L., and Retama raetam (Forssk.) Webb. Collected from Tunisian arid…

View details →DOI: 10.3389/fphar.2026.1746401
Negative / Null Result ReportOpen accessMedicine

Correlation of Scaphotrapezoid Contact Pressures With Degree of Trapezoid Resection: Does Eliminating Contact Matter?

Anz H, Roylance J, Ismaily S et al. · 2026 · Journal of hand surgery global online

Purpose Scaphotrapeziotrapezoid (STT) arthritis is the third most common hand arthritis in the United States. In the setting of thumb carpometacarpal arthroplasty, varying degrees of partial excision of the proximal trapezoid have been…

View details →DOI: 10.1016/j.jhsg.2026.101049
Negative / Null Result ReportOpen accessMedicine

Differential spatiotemporal dynamics of cell wall-degrading enzymes underlie pathogenicity variation in two <i>Alternaria</i> species causing kiwifruit soft rot.

Ling LZ, Tai SH, Teng H et al. · 2026 · PeerJ

Kiwifruit soft rot caused by fungal pathogens can result in substantial postharvest losses. While Alternaria alternata and A. tenuissima have been implicated in this disease, their pathogenic mechanisms remain poorly characterized. This…

View details →DOI: 10.7717/peerj.21223
Negative / Null Result Report

Digital Transformation, Governance Quality, and International Portfolio Optimisation: Evidence from the European Communication Services Sector

Nawlo M, Alkaraan F, Katalo H · 2026 · Preprint

Digital transformation is reshaping industries, business models, and investment opportunities, creating new challenges for international portfolio management. The European communication services sector has become a strategic component of…

View details →DOI: 10.20944/preprints202606.0844.v1
Negative / Null Result ReportOpen accessMedicine

Instability of Oculomotor Control in Parkinson's Disease Without Freezing of Gait: Evidence From Reflexive and Voluntary Saccade Variability.

Daeinejad FS, Foumani MS, Behzadipour S et al. · 2026 · The European journal of neuroscience

Parkinson's disease (PD) is associated with alterations in both voluntary and reflexive eye movements; however, the characteristics of oculomotor variability across task contexts remain incompletely understood. This study investigated…

View details →DOI: 10.1111/ejn.70443
Negative / Null Result ReportOpen accessMedicine

Osteogenic Differentiation Induced by Dental Pulp Stem Cells Secretome: A Dose-Dependent Comparative Study.

Kadkhodazadeh M, Amid R, Kheiri A et al. · 2026 · Clinical and experimental dental research

Objectives To investigate the effects of dental pulp stem cell-derived conditioned medium (DPSC-CM) on the proliferation, migration, and osteogenic differentiation of periodontal ligament stem cells (PDLSCs). Primary goals were to (i)…

View details →DOI: 10.1002/cre2.70395
Negative / Null Result ReportMedicine

Comparison of Myringoplasty Outcomes Among External Auditory Canal Packing, Blood on the Graft Surface, or No External Auditory Canal Packing for Chronic Tympanic Membrane Perforation: A Randomized Study.

Lou Z, Yang H · 2026 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

Objective The objective of this study was to compare graft outcomes and complications of myringoplasty among external auditory canal packing (EAC) with Nasopore, blood on the graft surface, and no EAC packing. Materials and methods…

View details →DOI: 10.1097/mao.0000000000004914