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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19871 results in Negative / Null Result Report · page 419 of 663

Negative / Null Result Report

Evaluation of the effect of photodynamic therapy using Rose Bengal Pigment in the Presence of Sodium Nitrite and carbon quantum dots Synthesized from Acyclovir Precursor on Growth inactivating of Herpes Simplex Virus

Farmany A, Razavi P, Parsania M et al. · 2025 · Preprint

Abstract Purpose To evaluate whether Rose Bengal (RB) with sodium nitrite (NaNO₂) and acyclovir derived carbon quantum dots (CQDs) can photodynamically inactivate herpes simplex virus type 1 (HSV 1) in vitro. Methods Acyclovir-derived CQDs…

View details →DOI: 10.21203/rs.3.rs-7694736/v1
Negative / Null Result ReportMedicine

Standard- versus high-dose tigecycline in pneumonia due to carbapenem-resistant Acinetobacter baumannii: A propensity score-matched retrospective study.

Özgen-Top Ö, Aysert-Yildiz P, Tekin-Taş Z et al. · 2026 · Infectious diseases now

Objectives This study aimed to compare the effectiveness and safety of standard-dose and high-dose tigecycline in pneumonia caused by carbapenem-resistant Acinetobacter baumannii (CRAB). Methods This retrospective, propensity score-matched…

View details →DOI: 10.1016/j.idnow.2025.105242
Negative / Null Result ReportMedicine

Whole-lesion histogram analysis of multi-model diffusion-weighted imaging for characterization and molecular classification of breast lesions.

Yuan Y, Huang M, Peng J et al. · 2026 · La Radiologia medica

Purpose To evaluate the value of whole-lesion histogram analysis derived from mono-exponential, bi-exponential, and stretched-exponential DWI models in differentiating benign from malignant breast lesions and exploring molecular subtypes.…

View details →DOI: 10.1007/s11547-025-02156-y
Negative / Null Result ReportMedicine

Neuroinflammation does not exacerbate post-traumatic stress-disorder (PTSD)-like brain measures or behaviour after a traumatic event in male rats.

Xavier S, Al-Saabary H, Foran D et al. · 2026 · Neuroscience

Post-traumatic stress disorder (PTSD) is strongly linked to neuroinflammation, with immune activation in brain regions such as the amygdala and hippocampus potentially contributing to its long-term persistence. Yet, whether…

View details →DOI: 10.1016/j.neuroscience.2025.12.014
Negative / Null Result Report

Agreements between 24-2 and 24-2C Test Grids for Chloroquine/Hydroxychloroquine Retinopathy Patients and High-Risk Patients

Ratanawongphaibul K, Wongwachira C, Suwajanakorn D et al. · 2025 · Preprint

Abstract Purpose To compare the SITA Standard 24-2 and SITA Faster 24-2C tests in patients with chloroquine/hydroxychloroquine (CQ/HCQ) retinopathy and those at high risk. Methods A prospective, cross-sectional study of 75 participants who…

View details →DOI: 10.21203/rs.3.rs-6769459/v1
Negative / Null Result ReportMedicine

Effect of copper and iron on the oxidation of vegetable oil during aging

Randhawa S, Mukherjee T · 2025 · Journal of Food Composition and Analysis.

The research paper investigates how elemental copper and iron, affect the aging process of canola, coconut, groundnut, rice bran, soybean, and sunflower oils. Samples analysed biannually over two years indicate that the addition of copper,…

Negative / Null Result ReportMedicine

Effect of Arginine Supplementation on Vasodilation and Muscular Performance in Young Men: A Randomized, Double-Blind, Crossover Study.

Borges CC, Alves da Silva W, de Sá Filho AS et al. · 2026 · International journal of sport nutrition and exercise metabolism

This study aimed to evaluate the effects of short-term oral L-arginine (ARG) supplementation on vascular parameters, nitric oxide (NO) concentration, and muscular performance during upper limb resistance exercise in healthy young men. A…

View details →DOI: 10.1123/ijsnem.2025-0125
Negative / Null Result Report

Metabolic interoceptive rewards shape affect, but not action

Fleming HA, Whines A, Whelehan P et al. · 2025 · Preprint

Central to survival is our ability to learn that the sensory properties of food are associated with metabolic interoceptive signals (e.g., changing blood glucose). These signals influence cognition and brain activity, shaping the hedonic…

View details →DOI: 10.31234/osf.io/px3ub_v1
Negative / Null Result ReportMedicine

Electrocardiographic LVH criteria: Poor diagnostic accuracy even with optimized cutoffs. Insights from MESA study.

de Alencar JN, Felicioni SP · 2025 · Journal of electrocardiology

Background Electrocardiographic (ECG) "left ventricular hypertrophy (LVH) criteria" are widely used as surrogates for increased LV mass but show limited sensitivity. We evaluated their diagnostic performance against cardiac magnetic…

View details →DOI: 10.1016/j.jelectrocard.2025.154138
Negative / Null Result ReportOpen accessMedicine

Biomechanical evaluation of patch augmentation in a rotator cuff repair model using a porcine flexor digitorum profundus tendon: influence of knot tying and time-zero stability.

Rhee SM, Cho CH, Kim M et al. · 2025 · Clinics in shoulder and elbow

Background This study evaluates the biomechanical effects of acellular dermal matrix (ADM) patch augmentation in a rotator cuff repair model and determines the effect of medial knot tying on time-zero stability. Methods A biomechanical…

View details →DOI: 10.5397/cise.2025.00164
Negative / Null Result ReportMedicine

A Simplified and Data-Driven Lung Ultrasound Approach for Predicting Surfactant Need in Preterm Infants: A Pilot Study Using Machine Learning and Rule-Based Models.

Meau-Petit V, Mottez C, Bhojnagarwala B et al. · 2026 · Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

Objectives Six-region lung ultrasound (LUS) scores show good predictive value for predicting surfactant need in preterm infants but rely on a fixed threshold, which may lead to misclassification near the cut-off and lack data-driven…

View details →DOI: 10.1002/jum.70092
Negative / Null Result ReportOpen accessMedicine

Correlation between systemic blood pressure and free flap perfusion: A photoplethysmography study.

Sahu SA, Mishra JK, De M et al. · 2026 · GMS Interdisciplinary plastic and reconstructive surgery DGPW

Background Microvascular tissue transfer is the method of choice for oncological and trauma reconstruction. Successful free tissue transfer requires technical expertise and management of patients and surgery related factors. However,…

View details →DOI: 10.3205/iprs000194
Negative / Null Result ReportMedicine

Does Hypnosis Aid Memory Retrieval?: A Review of Steven Jay Lynn's Research.

Krackow E, Rashed J, Thompson I · 2025 · The International journal of clinical and experimental hypnosis

Steven Jay Lynn was one of the most prolific clinical psychologists who made major contributions to the scientific literature in numerous areas, including in the area of hypnosis and memory. We review this work, limited to studies…

View details →DOI: 10.1080/00207144.2025.2508410
Negative / Null Result Report

MdLRR-RLK1-MdGRP1-LIKE module improved biotic resistance in apple

Chen W, Zhang C, Guo W et al. · 2025 · Preprint

Apple is an important economic species, and it always suffered by biotic stress during its growth and development. Fungi and pests are two types of biotic stress that have significant destructive effects on apples. Besides, the LRR-RLKs…

View details →DOI: 10.22541/au.175022852.28343178/v1
Negative / Null Result Report

Preliminary results of a randomized controlled trail: Effects of remotely supervised physical activity on health profile in frail older adults

Zhang X, Li F, Li J et al. · 2025 · Preprint

Introduction Supervised physical activity (PA) interventions have demonstrated efficacy and safety in improving health outcomes among frail populations. However, the growing disparity between limited healthcare resources and the rapidly…

View details →DOI: 10.1101/2025.06.26.25330386
Negative / Null Result ReportMedicine

Mitomycin C in Non-endoscopic Endonasal Dacryocystorhinostomy: A Randomized Clinical Trial Involving 442 Cases.

Mohapatra S, Rath S, Kapoor AG et al. · 2026 · American journal of ophthalmology

Purpose To evaluate whether 0.04% mitomycin C (MMC) application at the ostium enhances the outcome of non-endoscopic endonasal dacryocystorhinostomy (NEED) in individuals with primary acquired nasolacrimal duct obstruction (PANDO). Design…

View details →DOI: 10.1016/j.ajo.2025.10.005
Negative / Null Result ReportMedicine

Investigating the role of ketogenic diet and high-dose vitamin C in modulating doxorubicin toxicity in a murine breast cancer model

Al-Jada DN, Takruri HR, Talib WH et al. · 2025 · Biochemical and Biophysical Research Communications

In this study, we investigated the effectiveness of combining the ketogenic diet (KD) with high-dose vitamin C (VitC) as adjuvant nutritional therapy to mitigate doxorubicin (DOX) toxicity, with a focus on cardiotoxicity, while enhancing…

Negative / Null Result ReportMedicine

Enhanced recruitment methods for a dietary intervention trial aimed at reducing risk of colorectal cancer.

Harvin S, Guetterman TC, Hirko KA et al. · 2026 · Contemporary clinical trials

This study developed and evaluated strategies to optimize recruitment and retention to a mobile health-supported dietary intervention trial, the MyBestGI Study. This included instituting a Personal Technology Assistant and enhancing the…

View details →DOI: 10.1016/j.cct.2026.108322
Negative / Null Result Report

Respiratory Biofeedback Training as an Adjunct Intervention in Pulmonary Rehabilitation for Late-Stage COPD: A Pilot Trial

Lagravinese G, Castellana G, Genco M et al. · 2025 · Preprint

Abstract Background: Chronic obstructive pulmonary disease (COPD) is associated with persistent dyspnea, reduced functional capacity, and significant cognitive and affective impairments. Pulmonary rehabilitation improves the physical and…

View details →DOI: 10.21203/rs.3.rs-6974767/v1
Negative / Null Result ReportMedicine

Reevaluating diagnostic confidence: the impact of delayed excretory phase imaging in CT urography on detecting renal and urinary tract abnormalities.

Firoozeh N, Park SY, Basavalingu D et al. · 2026 · Abdominal radiology (New York)

Objective To assess the diagnostic value of the delayed excretory phase in computed tomography urography (CTU) for detecting renal and urinary tract abnormalities and its impact on readers' confidence in patients with hematuria, given…

View details →DOI: 10.1007/s00261-025-05145-x
Negative / Null Result ReportMedicine

Commercial cytokine assay on equine cerebrospinal fluid does not distinguish equine degenerative myeloencephalopathy from cervical vertebral stenotic myelopathy.

Payette F, Kulp JC, Graves A et al. · 2025 · American journal of veterinary research

Objective To measure and compare CSF cytokine concentrations among horses with equine neuroaxonal dystrophy (eNAD)/equine degenerative myeloencephalopathy (EDM), horses with cervical vertebral stenotic myelopathy (CVSM), and control horses…

View details →DOI: 10.2460/ajvr.25.06.0212
Negative / Null Result ReportMedicine

Moderate intermittent hypoxic conditioning to enhance cerebrovascular function in the elderly: a randomized controlled trial.

Randy H, Perrin TP, Ghaith A et al. · 2025 · American journal of physiology. Regulatory, integrative and comparative physiology

Aging is associated with cerebrovascular impairment, increasing the risk for neurovascular and degenerative diseases. Intermittent hypoxic conditioning (IHC) has been proposed as a valuable strategy to enhance vascular health. However, its…

View details →DOI: 10.1152/ajpregu.00160.2025
Negative / Null Result ReportMedicine

Comparative Analysis of Four Risk Stratification Models to Identify Patients with Acute Pulmonary Embolism at Risk of Short-term Mortality.

Bonsu KO, Young SW, Lee T et al. · 2025 · Seminars in thrombosis and hemostasis

Acute pulmonary embolism (PE) is potentially life-threatening, with up to 15% risk of death. We compared four risk stratification models to identify outpatients at risk of mortality up to 90 days post acute PE. A retrospective cohort study…

View details →DOI: 10.1055/a-2621-0465
Negative / Null Result ReportMedicine

Effects of passive information dissemination on human papillomavirus vaccination attitudes and knowledge among pharmacy visitors: A cluster randomized controlled trial.

Wakui N, Kawakubo S, Harayama M et al. · 2025 · Journal of the American Pharmacists Association : JAPhA

Background In Japan, human papillomavirus (HPV) vaccination rates remain low, partially owing to safety concerns from media reports. Pharmacies, as accessible health care facilities, often serve as sources of health information. However,…

View details →DOI: 10.1016/j.japh.2025.102901
Negative / Null Result ReportOpen accessMedicine

Subacromial bursa augmentation in arthroscopic rotator cuff repair: Clinical and doppler ultrasound assessment-A preliminary study.

Freislederer F, Dimitriu M, Endell D et al. · 2026 · Journal of experimental orthopaedics

Purpose To determine whether augmentation with the subacromial bursa influences postoperative tendon healing, particularly regarding morphology and vascularity, after arthroscopic rotator cuff repair. Methods In this prospective…

View details →DOI: 10.1002/jeo2.70714
Negative / Null Result ReportMedicine

Entomopathogenic Nematodes Induce Metabolic Reallocation in Maize Roots Without Altering the Performance of Two Root Herbivores, Diabrotica virgifera and Diabrotica balteata.

Verdecia-Mogena AM, Himmighofen PA, Mateo P et al. · 2025 · Plant, cell & environment

Entomopathogenic nematodes (EPNs) are key biological control agents in agriculture, but their direct effects on plant metabolism and resistance to herbivory remain underexplored. By combining transcriptomic, metabolomic, and herbivore…

View details →DOI: 10.1111/pce.70143
Negative / Null Result ReportOpen accessMedicine

The Impact on Audience Engagement of Coordinating a Public Health Campaign on Antimicrobial Resistance Through a Network of Health Content Creators: Longitudinal Observational Study.

Chen F, Cooper J, Acharya A et al. · 2026 · JMIR public health and surveillance

Background Antimicrobial resistance (AMR) is a significant global health threat. Several public health campaigns aimed to raise AMR awareness and inspire related behavioral changes have been delivered in a time-specific, coordinated…

View details →DOI: 10.2196/86587
Negative / Null Result Report

Entomopathogenic Nematodes Induce Metabolic Reallocation in Maize Roots without Altering Root Herbivore Performance

Verdecia-Mogena AM, Himmighofen P, Mateo P et al. · 2025 · Preprint

Entomopathogenic nematodes (EPNs) are key biological control agents in agriculture, but their direct effects on plant metabolism and resistance to herbivory remain underexplored. By combining transcriptomic, metabolomic, and herbivore…

View details →DOI: 10.22541/au.174918965.53456893/v1