A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19871 results in Negative / Null Result Report · page 418 of 663
Batool SM, Lee H, Muralidharan K et al. · 2026 · Cancers
Characterizing the m6A epigenetic landscape is essential for understanding glioma biology, yet transcriptome-wide mapping of these modifications at isoform resolution across specific tumor subtypes has remained limited. Conventional…
Chen Y, Gao L, Zheng Z et al. · 2026 · Scientific reports
Preoperative decision-making regarding extended pelvic lymph node dissection (ePLND) in prostate cancer remains challenging. Existing nodal-risk prediction tools are mainly based on clinicopathologic variables and may show suboptimal…
Alghonemy WY, Ahmed NM, Abou Samra AA et al. · 2026 · Journal of oral biology and craniofacial research
Objective To evaluate the regenerative effects of platelet-rich plasma (PRP) combined with 3% low-molecular-weight hyaluronic acid (HA) gel in treating ligature-induced periodontitis in rats. Methods •40 male albino rats divided into 5…
Selim AAMA · 2026 · Natural product research
Three hydrazone chromones 3a-c ( 3a, b in trans isomer while 3c was a mixture) and three hydrazone furanochromones 7a-c ( 7a in trans while 7b, c in cis ) carrying carboxylic acid or its bioisostere sulphonamide group were synthesised.…
Chen L, Liang W, Guo Y et al. · 2026 · Biomedical chromatography : BMC
Paeoniae Radix Alba (PRA, roots of Paeonia lactiflora Pall.) yields stir-baked (sbPRA), charred (cPRA), and carbonized (caPRA) specifications through increasing degrees of stir-baking. In this study, an ultrahigh-performance liquid…
Omran SA, Elnaggar MS, Youssef FS et al. · 2026 · Natural products and bioprospecting
Marine-derived Penicillium fungus gained significant attention in recent years due to their potential as a valuable source of unique natural compounds with a wide range of chemical structures and bioactive capabilities. The primary origins…
Feng K, Bao Y, Ren J et al. · 2026 · Life (Basel, Switzerland)
MicroRNA (miRNA) regulation plays a pivotal role in intracellular gene expression. Analysis of miRNA profiles can provide critical insights into disease states. As cancer-associated molecules reported in previous studies, miRNAs may serve…
Khan H, Collela Be M, Khan Z et al. · 2026 · BMC plant biology
Background Sowing period has a considerable effect on cotton productivity by regulating the use of thermal resources, but its effect on various soils depth layers has not been properly measured. The current study investigated the impacts…
Riehm A, Senicourt L, O'Shaughnessy E et al. · 2026 · Diagnostic and interventional imaging
Purpose The purpose of this study was to develop a machine learning-based algorithm based on a combination of magnetic resonance imaging (MRI) and color-Doppler ultrasound (CDUS) to characterize lacrimal gland lesions. Materials and…
Tran K · 2026 · Preprint
Abstract Objective: The aperiodic (1/f) component of the EEG power spectrum indexes the cortical excitation-to-inhibition (E:I) ratio and is predicted to be progressively altered by amyotrophic lateral sclerosis (ALS), a disease defined by…
Kawakami H, Yuasa H, Kuroda H et al. · 2026 · Preprint
Terrestrial environmental DNA (eDNA) approaches are rapidly expanding, yet robust, field-ready substrates for detecting insect DNA remain limited in forest ecosystems. Tree sap is a localized microhabitat that attracts diverse insects and…
Cao C, Ma S · 2026 · Preprint
Short-term environmental exposures have been linked to cognitive and behavioral outcomes, although many reported associations may reflect broader geographic and contextual differences. Using longitudinal data from the All of Us Research…
Itoh K, Otsuki N, Tsutani H et al. · 2026 · Preprint
Background: Recurrent pneumonia during antimicrobial therapy in patients receiving chemotherapy can be difficult to interpret. It may reflect persistence of the initial pathogen, inadequate antimicrobial exposure, noninfectious mimics,…
Yılmaz NA · 2026 · Clinical oral investigations
Objectives This study evaluated the effects of two universal adhesives, applied under three protocols, self-etch (SE), conventional total-etch (CTE), and modified total-etch (MTE) with 1% (w/v) gallic acid, on shear bond strength (SBS),…
Tatsuki O · 2026 · Preprint
Abstract Background Discrepancies between observational and randomized controlled trial (RCT) meta-analyses are typically attributed to confounding. An alternative explanation — that RCTs systematically exclude high-risk patients, causing…
Fyrand K, Xu C, Evensen Ø · 2026 · Fish & shellfish immunology
Streptococcus agalactiae serotype Ia is a major bacterial pathogen in Nile tilapia (Oreochromis niloticus), and vaccines for juvenile fish, especially immersion vaccines, remain unavailable. We evaluated live attenuated vaccine candidates…
Bao JR, Jones RS · 2026 · Journal of clinical microbiology
Three enzyme immunoassays (EIAs) were evaluated on two platforms each for detecting Cryptosporidium , Giardia , and Campylobacter in stool samples compared to reference methods. The Cryptosporidium EIAs run on stool specimens in three…
Burke ND, Anderson AL, Schjenken JE et al. · 2026 · Preprint
ABSTRACT Capacitation, the process whereby sperm gain the functional competence to fertilize an egg in the absence of de novo transcription and translation, is orchestrated by a hierarchy of kinases driving the phosphorylation of sperm…
Kang AJ, Tseng CH, Wei MY · 2026 · The journals of gerontology. Series A, Biological sciences and medical sciences
Background Accurate case ascertainment of chronic conditions is critical for research, clinical decision-making, and population health management, especially for older adults with high multimorbidity. However, validation of ICD-based case…
Joy N, Soslow JH, Crum K et al. · 2026 · Cardiology in the young
Background Pulmonary valve replacement may be required for patients with pulmonary valve disease. Exertional symptoms related to cardiovascular disease are an indication for pulmonary valve replacement; however, quantification of symptom…
Boscariol R, Tressoldi P · 2026 · Preprint
This preregistered study is a replication and extension of prior exploratory work comparing an Intuition Market (IM) with a traditional Prediction Market (PM) in forecasting binary financial outcomes. A previous exploratory study suggested…
Tang L, Sun C, Chen Z et al. · 2026 · Preprint
Abstract Background This study aimed to investigate the effects of curcumin supplementation and aerobic exercise on delaying age-related skeletal muscle atrophy and to further explore their potential synergistic effects. The findings are…
Aghdam EB, Romeralo C, Knapp DG et al. · 2026 · Preprint
Abstract Soilborne oomycetes of the genus Phytophthora are an increasing concern in European beech ( Fagus sylvatica ) forests, where they can damage root systems and contribute to tree decline. Because Phytophthora inoculum may persist in…
Parmar A, Saini N, Chhatre A et al. · 2026 · Preprint
Abstract Smartphone GNSS receivers are increasingly relied upon for location-dependent workflows in surveying, citizen science, agriculture, forestry, and field-based environmental data collection. The release of raw GNSS measurements…
Wadington M, Eklund K, Kilgus SP et al. · 2026 · School psychology (Washington, D.C.)
Research highlights the importance of the early identification of social, emotional, and behavioral concerns in young children; however, there are limitations regarding the usability and technical adequacy of available measures. The…
Tsuboi R, Murakami S, Miyata M et al. · 2026 · Preprint
Abstract BACKGROUND Dysphagia in Parkinson’s disease (PD) increases aspiration pneumonia risk and is associated with poor prognosis. Although subthalamic nucleus deep brain stimulation (STN-DBS) effectively treats motor symptoms, dysphagia…
Liao Y, Zhan L, Li H · 2026 · Basic & clinical pharmacology & toxicology
This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2018, enrolling a total of 4525 children and adolescents aged 6-15 years. Weighted logistic regression,…
Ashraf S, Ismail T, Akhtar S et al. · 2026 · Ultrasonics sonochemistry
Phyllanthus emblica L. (amla) is a medicinal fruit, rich in secondary metabolites with reported anti-inflammatory and antimicrobial effects. The current study aimed to assess the impact of drying and extraction techniques on phytochemical…
Krishna J, Khan Z, Chandra Y et al. · 2026 · Journal of nephrology
The epidemiology of kidney diseases is poorly known in several settings, including the Pacific Islands. To contribute to filling this gap, the current study aims to explore the incidence, distribution and patterns of biopsy-proven…
Hattori T, Hamaguchi M, Hashimoto Y et al. · 2026 · Diabetes, obesity & metabolism
Background In type 2 diabetes, impaired glucagon action in the liver (hepatic glucagon resistance) may disrupt the liver-α-cell axis. We examined the associations of fasting glucagon and a modified glucagon-alanine index (GAI) with…