A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19871 results in Negative / Null Result Report · page 413 of 663
Promer K, Brenner SB, Ostrer L et al. · 2026 · Current opinion in HIV and AIDS
Purpose of review This article reviews the evidence behind mpox antiviral therapies which are clinically available and/or or under clinical investigation. For much of the mpox epidemic, tecovirimat has been used compassionately but there…
Lehrer S · 2025 · Preprint
Abstract Background Monoclonal antibodies targeting pathological tau have repeatedly failed in Alzheimer’s disease (AD) clinical trials. Whether plasma phosphorylated tau (pTau) exhibits dynamic progression or cognitive relevance in…
Weirauch T, Yahav D, Zahavi I et al. · 2026 · Infection
The escalating global threat of antimicrobial resistance represents a critical challenge for contemporary medicine. Intestinal colonization by multidrug-resistant organisms (MDROs) is increasingly identified as a primary driver of…
Kirkiz Kayalı S, Deveci TS, Gülbahar Ö et al. · 2026 · Transplantation proceedings
Introduction Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for hematologic disorders. Acute graft-versus-host disease (aGVHD) remains a major cause of nonrelapse mortality. Distinguishing aGVHD from…
Ferreira AV, Dias M, Silva PA et al. · 2026 · Preprint
Abstract Background Brain tissue oxygen pressure (PbtO₂) monitoring is increasingly used in neurocritical care, but whether PbtO₂ provides complementary information beyond conventional parameters such as intracranial pressure (ICP) and…
Zhao Y, Zhao Q, Yu X et al. · 2026 · Preprint
Abstract Learning behavior is an important acquired behavior in fish, and the capacity for learning and memory plays a crucial role in foraging or anti-predator behavior. In this study, we selected the juveniles of S. schlegelii as the…
Sun Al, Liu ZH, Li L et al. · 2026 · Preprint
Abstract Background To measure the eyelid margin width and the distance between the eyelash gray lines in Han Chinese children, providing data for pediatric ocular anthropometry. Methods This prospective, single-center, observational study…
Patel J, Patil S · 2026 · Journal of bodywork and movement therapies
Background Stroke survivors exhibit gait inefficiencies with increased energy expenditure, potentially linked to kinematic deficits. This exploratory study examined whether peak sagittal joint angles predict Energy Expenditure Index (EEI)…
Keskin E · 2026 · Journal of health psychology
This cross-sectional descriptive study investigated the association between caffeine consumption and anxiety and depression among Turkish university students, a population experiencing high academic stress and widespread caffeine use. A…
Steiger, Almeida, Massini et al. · 2026 · Journal of functional morphology and kinesiology
Objectives: This study aimed to compare the acute effects of high-intensity resistance training (HIRT), low-intensity resistance training (LIRT), and low-intensity resistance training with blood flow restriction (LIRT-BFR) on heart rate…
Trovato, La Marca, Simonini et al. · 2026 · Journal of personalized medicine
Background/Objectives: The Systemic Immune-Inflammation Index (SII), derived from routine blood counts, has emerged as a potential marker of systemic inflammation in psoriasis. However, its longitudinal behavior across different systemic…
Biancari, Dell'Aquila, Mäkikallio et al. · 2026 · Journal of cardiovascular development and disease
Background: The nature and prognosis of type A intramural hematoma (TAIMH) are not well established. In this study, we evaluated the early and late outcome after surgery for this emergency condition. Methods: The ERTAAD registry included…
Aslan, Sural, Özçalışkan et al. · 2026 · Journal of cardiovascular development and disease
Total coronary revascularization via anterior thoracotomy (TCRAT) enables complete anatomical revascularization without sternotomy; however, data on its impact on left ventricular function remain limited. This study compared left…
Han, Yoo, Kang et al. · 2026 · Diseases (Basel, Switzerland)
Psoriasis is a chronic systemic inflammatory disease associated with increased cancer risk; however, its relationship with colorectal cancer (CRC) remains unclear. This question is particularly relevant in Asia, where CRC incidence has…
Rosso, Fico, Di Criscio et al. · 2026 · Frontiers in immunology
The diagnosis of Sjögren's Disease (SjD) remains challenging due to the non-specific nature of sicca symptoms and the need for invasive biopsies. This pilot study aimed to investigate the potential of salivary Substance P (SP), a…
Yokogawa, Yoon, Lee et al. · 2026 · Cureus
Background and objective It remains unclear whether atlas hypoplasia is causative of symptomatic cervical canal stenosis or represents an independent and unrelated finding. There have been few dedicated studies describing atlas hypoplasia,…
Mahajan, Akhtar, Sharma et al. · 2026 · Asian journal of transfusion science
Due to rapid technological advancements, several new methods such as telephone (TP), e-mail, social media, WhatsApp (WA), and Short Message Services are being used as effectively among blood centers worldwide for postdonation communication…
Chen, Spadaccini, Sahai et al. · 2026 · Endoscopy international open
Endoscopic ultrasound-guided choledochoduodenostomy using a lumen-apposing metal stent (EUS-CDSL) has been shown in randomized controlled trials (RCTs) to be effective compared with endoscopic retrograde cholangiopancreatography (ERCP) in…
Kim, Seo, Nam et al. · 2026 · Cancer research and treatment
Preclinical studies suggest that sodium-glucose cotransporter-2 inhibitors (SGLT-2is) may have cancer-preventive effects; however, clinical evidence remains inconclusive. Therefore, this study aimed to evaluate the association between the…
Huang, Xu, Qin et al. · 2026 · Lancet (London, England)
Successful reperfusion after endovascular thrombectomy does not consistently result in functional independence in acute ischaemic stroke. We aimed to assess the efficacy and safety of tirofiban, a glycoprotein IIb/IIIa receptor antagonist,…
Harris, Housman · 2026 · Applied neuropsychology. Adult
Neuropsychological performance is influenced by demographic/premorbid factors in addition to acquired cognitive impairment. This study examined relationships between educational attainment, reading ability, and executive functions in a…
Pan, Luan, Zhang et al. · 2026 · PloS one
Scale-Invariant Feature Transform (SIFT) features are widely used in target recognition and tracking. This study aimed to exploit the robust performance of the SIFT algorithm to accurately calculate tumor tissue displacement during…
Peretó Villaescusa, Coelho, Grillo et al. · 2026 · European journal of orthopaedic surgery & traumatology : orthopedie traumatologie
Postoperative knee stiffness following total knee arthroplasty (TKA) is a challenging complication that may require surgical intervention when conservative treatment fails. Although manipulation under anesthesia (MUA) and arthroscopic…
Heigl, Paganetti, Honaker et al. · 2026 · Langenbeck's archives of surgery
The feasibility and impact of Enhanced Recovery after Surgery (ERAS) protocols in emergency settings remain poorly understood due to patient instability, limited preoperative optimization, and inconsistent protocol adherence. Therefore,…
Fajriani, Djawad, Tabri et al. · 2026 · Dermatology reports
Xerosis is a prevalent skin disorder among patients with chronic kidney disease (CKD) undergoing hemodialysis (HD). While both Aloe vera cream 30% and urea cream 20% have been shown to improve skin hydration in cases of xerosis cutis,…
Fahmy, El-Geleel, Anwar et al. · 2026 · Journal of the American Dental Association (1939)
Caries is the most prevalent chronic disease in children, affecting more than 530 million people worldwide. Timely restoration of primary molars is critical for maintaining function and preventing premature tooth loss. The choice of…
Jesus, Alves, Resende · 2026 · CoDAS
To validate and standardize the online application of the Scale of Self-Perception of Central Auditory Processing Skills (EAPAC) - expanded for Brazilian adults. The EAPAC was expanded and answered by 1,274 Brazilian individuals aged 18 to…
Inoue, Ono, Okazaki et al. · 2026 · Cureus
Objectives Early prediction of neurological outcomes in patients with out-of-hospital cardiac arrest (OHCA) is critical for guiding treatment decisions. Machine learning (ML) model and grey-white matter ratio (GWR), both derived from brain…
Kataruka, Sannyashi, Bhattacharjee et al. · 2026 · Cureus
Neuropathic ulcers occur mainly at the plantar aspect and correspond to areas with peak plantar pressure, usually seen in a sensory-deficient foot. Trophic ulcers are seen in diabetic neuropathy, post-leprosy, and any other neurological…
Harvey, Morita, Huynh et al. · 2026 · JMIR medical informatics
Health care providers spend an excessive amount of time within electronic medical record (EMR) systems documenting patient encounters, often amounting to hours of work outside of regular office hours. This affects physician productivity…