A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20240 results in Negative / Null Result Report · page 405 of 675
El Ayat N, Boutalline M, Tannouche A · 2026 · BMC psychiatry
Background Autism Spectrum Disorder (ASD) affects 1 in 100 children globally, yet early detection remains challenging due to reliance on subjective behavioral assessments and limited specialist availability, particularly in…
Uwalaka CH, Akinboye D, Agoro IO et al. · 2026 · Preprint
Abstract Background Tuberculosis (TB) remains a major public health challenge in Nigeria, where poor treatment adherence and inadequate patient knowledge continue to contribute to adverse treatment outcomes and multidrug-resistant TB.…
Schneider BS, Pfaehler CD, Hao KA et al. · 2026 · The Journal of the American Academy of Orthopaedic Surgeons
Background Although os acromiale is often noted on preoperative imaging in patients undergoing reverse total shoulder arthroplasty (rTSA), its clinical significance is ill-defined. The purpose of this study was to compare the clinical…
Cacciatore S, Abbatecola G, Calvani R et al. · 2026 · Medical sciences (Basel, Switzerland)
Background/objectives Ozone therapy has been proposed across multiple clinical conditions based on hormetic, antioxidant, and immunomodulatory effects, but its efficacy and safety remain controversial. We conducted an umbrella review to…
Maseroli E, Alfaroli C, Cirillo M et al. · 2026 · Journal of endocrinological investigation
Purpose To assess whether the Ketogenic Diet (KD) is associated with improvements in biochemical markers of hyperandrogenism in women diagnosed with Polycystic Ovary Syndrome (PCOS) with obesity or overweight. Methods A systematic search…
Cooke T, Soderquist CR, Mansukhani MM et al. · 2026 · The journal of applied laboratory medicine
Background JAK2, CALR, and MPL mutations are defining features of myeloproliferative neoplasms (MPNs). Molecular testing for variants in these genes is standard of care in the diagnosis of MPNs. A high reimbursement denial rate led to…
Magee GA, Mussa FF · 2026 · Seminars in vascular surgery
Dissection morphology is important when considering landing zones for thoracic endovascular aortic repair. Landing proximally in a healthy aorta, free of dissection and intramural hematoma, is generally recommended. For the most common…
Hirai Y, Fujimoto A, Sasaki M et al. · 2026 · Endoscopy international open
Background and study aims It is desirable to develop a safe, cost-effective, and easy approach to prevent strictures after esophageal endoscopic submucosal dissection (ESD). We explored use of a novel rebamipide solution, an anti-ulcer…
Yamaguchi K, Watanabe O, Mitsuki T et al. · 2026 · Transplantation and cellular therapy
The clinical benefit of adding high-dose cytarabine (HDCA) to fludarabine (FLU), busulfan (BU), and melphalan (MEL)-based conditioning for cord blood transplantation (CBT) in acute myeloid leukemia (AML) remains unclear. We aimed to…
Ye L, Yue W, Lin K et al. · 2026 · Scientific reports
Triple therapy combining transarterial chemoembolisation (TACE), tyrosine kinase inhibitors (TKIs), and immune checkpoint inhibitors (ICIs) has shown efficacy in unresectable hepatocellular carcinoma (HCC), but evidence in elderly patients…
Zuo P, Jiang K, Zou W et al. · 2026 · Neurosurgery
Background and objectives Atypical choroid plexus papillomas (ACPPs) are exceedingly uncommon. The treatment strategies for managing this condition remain a topic of debate. The main aim of this study was to elucidate the clinical features…
Kakoudaki T, Poon SS, Kumar P · 2026 · Cardiovascular revascularization medicine : including molecular interventions
Background Surgical ventricular reconstruction (SVR) is not always feasible in patients with ischaemic cardiomyopathy and left ventricular (LV) aneurysm, due to high surgical risk. The Revivent-TC Transcatheter Ventricular Enhancement…
Kang KM, Lee HY, Ahn HM et al. · 2026 · Cancer research and treatment
Purpose The role of adjuvant chemotherapy (ACT) in pathologic T3N0 (pT3N0) rectal cancer, which has a favorable prognosis, remains controversial because high-risk groups for recurrence are not well defined. This study investigated…
Narayan P · 2026 · Indian journal of thoracic and cardiovascular surgery
There has been controversy over the ideal management strategy for asymptomatic carotid artery stenosis. Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trials (CREST-2) evaluated whether adding carotid…
Belgioia L, D'Onofrio I, Filauro M et al. · 2026 · Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale
Objective To evaluate the impact of postoperative radiotherapy (PORT) on survival outcomes in patients with laryngeal cancer treated with partial laryngectomy. Methods In this retrospective multicentre study, 312 patients with supraglottic…
Cui Y, Liu JL, Jiang CH et al. · 2026 · Diabetes, obesity & metabolism
Background Early dual antiplatelet therapy (DAPT) after intravenous thrombolysis is safe but ineffective in improving 90-day functional outcomes in minor stroke. Given the effect of diabetes mellitus (DM) with antiplatelet treatment, we…
Chi SY, Chou SE, Chou FF et al. · 2026 · World journal of surgery
Background Thyroidectomy for Graves' disease (GD) is associated with an increased risk of intraoperative bleeding, particularly in patients with enlarged and hypervascular thyroid glands. This retrospective cohort study evaluated factors…
Honda K, Furukawa S · 2026 · JASA express letters
This study addresses methodological issues in the modulation-masking paradigm for future clinical applications for assessing modulation filters. The aim of the paradigm is to determine a target-modulation threshold in a fixed-depth masker.…
Hayes MW, Porter WM, Snider JL et al. · 2026 · Field Crops Research.
The rising cost of crop inputs has driven farmers to reduce costs. One area they have focused on is the seeding rate in an effort to minimize seed cost. Numerous studies have been completed every few years to evaluate optimum seeding rates…
Goda S, Yamada T, Goto Y et al. · 2026 · BMC pulmonary medicine
Background The neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation, with prognostic value in interstitial lung disease (ILD). However, the association between baseline NLR and the therapeutic efficacy of nintedanib…
Esmeray A, Yazili HB, Gelmis M et al. · 2026 · The Canadian journal of urology
Objectives Supracostal access during percutaneous nephrolithotomy (PCNL) increases the risk of pulmonary complications. Although routine postoperative thoracic imaging is commonly performed to detect these events, its clinical necessity…
Alhammadi S, Chalk C · 2026 · The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Myasthenia gravis (MG) is an autoimmune neuromuscular disorder characterized by fatigable weakness and increased perioperative vulnerability. Postoperative myasthenic crisis, defined as respiratory failure requiring prolonged ventilation…
Tsukagoshi J, Penaloza N, Laico AJ et al. · 2026 · Annals of vascular surgery
Background While carotid endarterectomy (CEA) and carotid artery stenting (CAS) reduce the long-term risk of stroke, patients with a short life expectancy or multiple medical comorbidities, including end-stage renal disease (ESRD), may not…
Davies F, Butler MK · 2026 · Eye (London, England)
Introduction This real-world, retrospective review of SLT outcomes at Lancashire Teaching Hospitals NHS Foundation Trust aimed to establish whether there is any net benefit in using topical drop treatment prior to SLT compared with…
Clocchiatti-Tuozzo S, Qureshi AI, Rivier CA et al. · 2026 · Neurology
Background and objectives Intensive blood pressure (BP) reduction may reduce the risk of poor functional outcomes in patients with acute intracerebral hemorrhage (ICH). Whether these potential benefits apply similarly to lobar and deep…
Cataldo-Miranda P, Koh HJW, Stub D et al. · 2026 · Current problems in cardiology
Aims Beta-blocker therapy has traditionally been recommended following coronary events based on clinical trials involving patients with systolic dysfunction. Its survival benefit in patients with preserved left ventricular ejection…
Guillermo A, Domingo L, Fernando R · 2025 · Preprint
Background The DIGIT-HF trial reported that digitoxin reduced the composite risk of all-cause mortality or first heart failure hospitalization in patients with heart failure and reduced ejection fraction, summarized by a single hazard…
Tan W, Chen L, Li X et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology
Purpose Hydrosalpinx impairs embryo implantation and development, leading to infertility or miscarriage. Therefore, the effective treatment of hydrosalpinx is crucial for improving pregnancy outcomes. Here, we investigated the comparative…
Hosseinzadeh E, Arefnia M, Bayat M et al. · 2026 · Cancer biotherapy & radiopharmaceuticals
Background Intense hepatobiliary uptake of [ 99m Tc]Tc-sestamibi in myocardial perfusion scintigraphy (MPS) often degrades image quality by obscuring the inferior myocardial wall, leading to equivocal studies. While nonpharmacological…
Wen T, Ihlefeld A · 2025 · Preprint
It has been widely believed that a key factor in creating realistic spatial audio in virtual reality (VR) is the head-related transfer function (HRTF), which is unique to each individual, but costly to measure for widespread use. This…