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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19866 results in Negative / Null Result Report · page 404 of 663

Negative / Null Result ReportMedicine

The Drug-Coated Balloon and Primary Patency in Endovascular Therapy for Femoropopliteal Lesions With "Black Rock" Nodular Calcification.

Shikama T, Otaki Y, Kinoshita D et al. · 2026 · Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists

Objective Nodular calcifications occupying the lumen in the femoropopliteal artery, known as "Black Rock (BR)" lesions, are associated with poor patency. We focused on the drug-coated balloon (DCB) and examined whether the impact of final…

View details →DOI: 10.1177/15266028261434775
Negative / Null Result ReportOpen accessMedicine

No-touch versus conventional radiofrequency ablation for treating solitary recurrent hepatocellular carcinoma ≤ 3 cm: a retrospective cohort study.

Wu G, Ou X, Zou M et al. · 2026 · Journal of cancer research and clinical oncology

OBJECTIVE: This study aimed to compare the outcomes of no-touch radiofrequency ablation (NT-RFA) and conventional RFA (C-RFA) in the treatment of solitary recurrent hepatocellular carcinoma (rHCC) ≤ 3 cm. METHODS: 255 patients with rHCC…

View details →DOI: 10.1007/s00432-026-06453-5
Negative / Null Result ReportMedicine

The Shear Bond Strength Between Calcium Silicate-Based Biomaterials and Glass Ionomer Restorative Materials: An In Vitro Comparative Study.

Salık M, Bakır EP · 2026 · Journal of functional biomaterials

Aim: The aim of this study was to comparatively evaluate the shear bond strengths between different calcium silicate-based biomaterials and glass ionomer-based restorative materials. Materials and Methods: In this in vitro study, a total…

View details →DOI: 10.3390/jfb17060309
Negative / Null Result ReportMedicine

[Comparison of Imaging Efficacy and Patient Tolerability Between a Novel Cellulose-Based anda Conventional Starch-Based Oral Contrast Agent: A Prospective Randomized Controlled Trial].

Liang H, Gui Y, Lv K et al. · 2026 · Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

Objective To compare the imaging efficacy and patient tolerability of a novel cellulose-based oral contrast agent with a conventional starch-based agent in gastric contrast-enhanced ultrasound,thus providing evidence-based support for…

View details →DOI: 10.3881/j.issn.1000-503x.17161
Negative / Null Result Report

NATURAL RESOURCES or INSTITUTIONS? Revisiting the Determinants of FDI in Sub-Saharan Africa through a Panel Smooth Transition Model (PSTR)

SECK AB, DOGBE KA, AVOUBA F–GN · 2026 · Preprint

Abstract Institutions are widely recognized as key factors in attracting foreign direct investment (FDI) and fostering economic development in host countries. However, there is growing evidence that natural resources may also play a…

View details →DOI: 10.21203/rs.3.rs-9635942/v1
Negative / Null Result ReportOpen accessMedicine

Consequences of the 2022 Intravenous Contrast Shortage on Emergency Department Care: A Retrospective Study.

Bellew S, Tjiattas-Saleski L, Butz D et al. · 2026 · The western journal of emergency medicine

Introduction Computed tomography (CT) is an essential diagnostic tool for evaluating emergency department (ED) patients. Between 15-20% of patients who present to the ED in the United States (US) undergo CT imaging. CT imaging with the use…

View details →DOI: 10.5811/westjem.62947
Negative / Null Result ReportMedicine

Cross-sectional and prospective associations between multidimensional psychological distress and urogenital disorders: findings from the UK biobank.

Liu H, Liu L, Zhao Z et al. · 2026 · Scientific reports

Psychological distress is a major public health issue with multisystemic effects, yet its multidimensional nature and specific links to urogenital disorders remain inadequately characterized due to methodological limitations of prior…

View details →DOI: 10.1038/s41598-026-58389-y
Negative / Null Result ReportOpen accessMedicine

Urolithin A improves motility, antioxidant defense, and mitochondrial function of chilled canine spermatozoa during 72-h liquid storage.

Mirzaei R, Soleimanzadeh A, Asri-Rezaei S · 2026 · Scientific reports

Dog semen conservation at cold temperatures (5 °C) is a valuable reproductive management tool, but it is bedeviled by issues of oxidative stress and mitochondrial damage that reduce sperm quality and viability. Urolithin A (UA), a natural…

View details →DOI: 10.1038/s41598-026-49089-8
Negative / Null Result ReportMedicine

Optic Flow-Induced Postural and Neuromuscular Responses in Individuals with Type 2 Diabetes over 12 Months: Relationship with Physical Activity Behaviour.

Laffi A, Piras A, Meoni A et al. · 2026 · Biomedicines

Background: Exercise plays a crucial role in the prevention and management of type 2 diabetes. During self-motion, optic flow provides visual information about heading direction and influences postural control. This study investigated…

View details →DOI: 10.3390/biomedicines14061349
Negative / Null Result ReportOpen accessMedicine

Effects of pregnancy type, genotype, and parturition stage on ewe behavior.

Güngör ÖF, Ünal N, Paksoy Y · 2026 · Archives animal breeding

This study aimed to investigate the effects of pregnancy type, genotype, and parturition stage on sheep behavior. It also examined how pregnancy type and genotype influence labor characteristics. These evaluations were necessary because…

View details →DOI: 10.5194/aab-69-289-2026
Negative / Null Result Report

Enhancing Port Performance through Digital Transformation: The Role of Networking Capability and Organizational transformation in Indonesian Container Ports

Pramitra B, Al Musadieq M, Afrianty TW et al. · 2026 · Preprint

Although digital transformation in port management has been widely discussed, previous studies have not extensively examined how organizational capabilities translate into performance through digital adoption at ports. This study addresses…

View details →DOI: 10.12688/f1000research.176261.3
Negative / Null Result ReportMedicine

The effect of music on financial anxiety: an experimental analysis among Italian young adults.

Degli Antoni G, Gandolfi G, Soana MG · 2026 · Health policy (Amsterdam, Netherlands)

Background Financial anxiety has increased over the past decade, particularly among young people. While prior research has examined its determinants and consequences, coping strategies have been very poorly explored so far. Objective This…

View details →DOI: 10.1016/j.healthpol.2026.105669
Negative / Null Result ReportMedicine

[Effects of repeated controlled ovarian stimulation on the expression of aerobic glycolysis-related enzymes at various stages of early embryo development in mice].

Shen LL, Shi BB, Xiong WY et al. · 2026 · Sheng li xue bao : [Acta physiologica Sinica]

This study aims to investigate whether the reduction in early embryonic development due to repeated controlled ovarian stimulation (COS) is associated with the expression levels of enzymes related to aerobic glycolysis. A repeated COS…

View details →DOI: 10.13294/j.aps.2026.0026
Negative / Null Result ReportOpen accessMedicine

Animal-origin-free culture improves mitotic response for chromosome aberration analysis of human peripheral blood.

Fujishima Y, Anderson D, Kamakura S et al. · 2026 · PNAS nexus

The lymphocyte culture method for chromosomal aberration analysis was established in the 1960s, and culture media supplemented with fetal bovine serum (FBS) have been routinely used. However, issues such as lot-to-lot variability,…

View details →DOI: 10.1093/pnasnexus/pgag120
Negative / Null Result ReportOpen accessMedicine

A Standardized Onion Peel-Derived Bioactive Ingredient Attenuates Palmitate-Induced Steatosis and Oxidative Stress by Modulating Mitochondrial Dynamics and Autophagy in HepG2 Cells.

Di Gregorio I, Migliaccio V, D'Elia M et al. · 2026 · Antioxidants (Basel, Switzerland)

Onion peel represents a valuable food by-product rich in bioactive phenolic compounds. Building on previous phytochemical investigations, an onion peel extract from the Rossa di Tropea variety was developed as a standardized bioactive…

View details →DOI: 10.3390/antiox15040513
Negative / Null Result ReportMedicine

The effect of sesame, canola, and sesame-canola oils on oxidative stress markers in patients with type 2 diabetes: A three-way randomized crossover clinical trial.

Moghtaderi F, Zimorovat A, Raeisi-Dehkordi H et al. · 2026 · Nutrition and health

BackgroundOxidative stress plays a critical role in the pathogenesis of chronic diseases. Canola oil (CO) and sesame oil (SO), due to their antioxidant constituents, may differentially influence oxidative stress biomarkers.AimThis study…

View details →DOI: 10.1177/02601060261453506
Negative / Null Result Report

Do CEO Characteristics Matter? Evidence on Sustainability Reporting and Tax Avoidance from Indonesian Listed Companies in The SRI-KEHATI Index

Kasma J, Hidayat K, ZA Z et al. · 2026 · Preprint

Background: This study aims to analyze the effect of CEO characteristics on sustainability reports and tax avoidance, as well as to examine the effect of sustainability reports as a mediating variable. The focus of this study is on…

View details →DOI: 10.12688/f1000research.178848.1
Negative / Null Result ReportMedicine

Depression and cognition: is there a bidirectional relationship?

Glei DA, Weinstein M · 2026 · Aging & mental health

Objectives The association between depression and cognition is well-established, but there is uncertainty regarding the direction of causation. We evaluated the relationship between depression and poor cognition in both directions. Method…

View details →DOI: 10.1080/13607863.2026.2648698
Negative / Null Result ReportMedicine

Beyond Conventional Care: The use of Alternative Medicine by Head and Neck Cancer Patients in Pakistan - A Retrospective study.

Akhtar, Ghaloo, Pasha et al. · 2026 · JPMA. The Journal of the Pakistan Medical Association

To investigate the prevalence, utilisation and association of diagnostic delay, tumour stage and recurrence with alternative medicine among head and neck cancer patients having undergone surgical resection. The retrospective,…

View details →DOI: 10.47391/jpma.aku-10surg-02
Negative / Null Result ReportOpen accessTechnology

Effects of Allicin Supplementation on the Mechanical and Viscoelastic Properties of the Tibia in Bovans Brown Hens

Anna Skic, Zbigniew Stropek, Kamil Drabik et al. · 2026 · Applied Sciences

Bone tissue exhibits viscoelastic behavior, and stress relaxation analysis provides valuable insight into its time-dependent mechanical performance. This study aimed to evaluate the effects of allicin supplementation on the mechanical and viscoelastic properties of tibial bone in Bovans Brown laying hens. Tibiae of 68-week-old hens were subjected to three-point bending tests to determine quasi-static mechanical properties, as well as stress relaxation tests conducted at three deformation velocities (0.1, 1, and 10 mm/s). Stress relaxation behavior was described using a five-parameter generaliz

View details →DOI: 10.3390/app16115377
Negative / Null Result ReportOpen accessTherapeutics. Pharmacology

A Pilot Study on the Impact of Cranberry and Ascorbic Acid Supplementation on the Urinary Microbiome of Healthy Women: A Randomized Controlled Trial

Alina Nussbaumer-Pröll, Bela Hausmann, Maria Weber et al. · 2025 · Antibiotics

Background : The collection of microorganisms that colonize the human genital and urinary tract is referred to as the genitourinary microbiome. Urinary tract infections (UTIs), which predominantly affect women, are linked to alterations in the genitourinary microbiome. Cranberries ( Vaccinium oxycoccos ), rich in proanthocyanidins, and ascorbic acid (vitamin C), known for their urinary acidification properties, are commonly used for UTI prevention. However, their effects on the genitourinary microbiome remain inadequately characterized. This pilot study assesses the genitourinary microbiome co

View details →DOI: 10.3390/antibiotics14030278
Negative / Null Result ReportOpen accessAgriculture

Comparative study on quality parameters of dry-cured beaver (Castor fiber) and nutria (Myocastor coypus) sausages

Jan Slováček, Šárka Nedomová, Markéta Janík Piechowiczová et al. · 2024 · Czech Journal of Food Sciences

The aim of the study was to define and compare the quality properties of dry-cured heat-treated meat products from the meat of free-living semi-aquatic wildlife species. Eurasian beaver (Castor fiber) and nutria (Myocastor coypus) are wild animals whose presence in the countryside is regulated in the Czech Republic. Basic chemical, microbiological, sensory analyses, and instrumental measurements of the colour and texture of dry-cured sausages (pork, as a control group with 51% lean pork and experimental groups with 51% lean beaver and nutria meat in fresh state) were performed. There were no s

View details →DOI: 10.17221/112/2024-cjfs
Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens

Frequency of MYD88 L256P mutation and its correlation with clinico-hematological profile in mature B-cell neoplasm

Raja Shekhar, Shano Naseem, Jogeshwar Binota et al. · 2021 · Hematology/Oncology and Stem Cell Therapy

Objective/background: B-cell neoplasms are clonal tumors of B cells at various stages of maturation, including diffuse large B-cell lymphoma (DLBCL), chronic lymphocytic lymphoma (CLL), Burkitt lymphoma (BL), lymphoplasmacytic lymphoma (LPL)/Waldenström’s macroglob- ulinemia (WM), splenic marginal zone lymphoma (SMZL), nodal marginal zone lymphoma (NMZL), mantle cell lymphoma (MCL), follicular lymphoma (FL), and hairy cell leukemia (HCL). In this study, we analyzed the frequency of MYD88 L265P mutation and its correlation with clinico-hematological profile in mature B-cell neoplasms. Methods:

View details →DOI: 10.1016/j.hemonc.2020.10.003
Negative / Null Result ReportOpen accessDiseases of the blood and blood-forming organs

Validation of a pulmonary embolism risk assessment model in gynecological inpatients

Zhen-Yi Jin, Chun-Min Li, Hong Qu et al. · 2024 · Thrombosis Journal

Abstract Objective To compare the predictive efficacy of the PADUA and Caprini models for pulmonary embolism (PE) in gynecological inpatients, analyze the risk factors for PE, and validate whether both models can effectively predict mortality rates. Methods A total of 355 gynecological inpatients who underwent computed tomography pulmonary angiography (CTPA) were included in the retrospective analysis. The comparative assessment of the predictive capabilities for PE between the PADUA and Caprini was carried out using receiver operating characteristic (ROC) curves. Logistic regression analysis

View details →DOI: 10.1186/s12959-024-00616-5
Negative / Null Result ReportOpen accessAstrophysics

Systematics in the Cepheid and TRGB Distance Scales: Metallicity Sensitivity of the Wesenheit Leavitt Law

Barry F. Madore, Wendy L. Freedman · 2024 · The Astrophysical Journal

Using an updated and significantly augmented sample of Cepheid and tip of the red giant branch (TRGB) distances to 28 nearby spiral and irregular galaxies, covering a wide range of metallicities, we have searched for evidence of a correlation of the zero-point of the Cepheid period–luminosity relation with H ii region (gas-phase) metallicities. Our analysis, for the 21 galaxies closer than 12.5 Mpc, results in the following conclusions: (1) The zero-points of the Cepheid and TRGB distance scales are in remarkably good agreement, with the mean offset in the zero-points of the most nearby distan

View details →DOI: 10.3847/1538-4357/acfaea
Negative / Null Result ReportOpen accessOphthalmology

Comparison of 12-month therapeutic effect of conbercept and ranibizumab for diabetic macular edema: a real-life clinical practice study

Yule Xu, Ao Rong, Wei Xu et al. · 2017 · BMC Ophthalmology

Abstract Background To compare the efficacy of intravitreal conbercept and ranibizumab in the treatment of diabetic macular edema (DME) in a real-life clinical practice. Methods This was a retrospective study. Among 62 Chinese patients with DME, 32 patients (36 eyes) received intravitreal conbercept (IVC) injections and 30 patients (32 eyes) received intravitreal ranibizumab (IVR) injections, once a month for 3 months followed by as needed therapy. All participants had at least 12 months of follow-up. We compared the changes in best-corrected visual acuity (BCVA) letter score and central retin

View details →DOI: 10.1186/s12886-017-0554-8