A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
130 results in Methods Dead-End · page 4 of 5
Han P, Chen P, Zhang L et al. · 2026 · Preprint
Abstract Background Small-incision lenticule extraction (SMILE) removes an intrastromal lenticule whose stiffness differs between corneal meridians, producing measurable stromal mechanical anisotropy. Whether this meridional anisotropy…
Aaby D, Sullivan JE, Carmona C et al. · 2026 · Archives of rehabilitation research and clinical translation
Objectives To quantify the Minimum Detectable Change (MDC) and the Minimal Clinically Important Difference (MCID) of the Box and Blocks Test (BBT) and Upper Extremity Fugl-Meyer Assessment (FMA-UE), and to determine whether there is a BBT…
Varol U, Kobylarz MD, López-Redondo M et al. · 2026 · Journal of clinical medicine
Background/Objectives : Shear wave elastography (SWE) may provide an objective method for quantifying piriformis muscle stiffness, but its clinical and research use requires evidence that the measurement procedure is reliable. This study…
Binda AC, Padula RS, Vianna de Andrade FPP et al. · 2026 · Journal of bodywork and movement therapies
Objectives The Reaching Performance Scale for Stroke (RPSS) is a clinically relevant tool to assess movement quality and compensatory strategies during reach-to-grasp tasks to a Close and Far targets. This study aimed to investigate the…
Pedauyé-Rueda B, Maté-Muñoz JL, Hernández-Lougedo J et al. · 2026 · Frontiers in aging
Background The Sarcopenia Optoelectronic Chair-Rise Velocity Test (SARC-T) has been proposed as an instrumented chair-rise measure related to physical function in sarcopenia; however, its test-retest measurement properties have not been…
Yamasaki R, Inoue Y · 2026 · Archives of physical medicine and rehabilitation
Objective To determine the minimal detectable change (MDC) of the 10-meter walk test (10MWT) and Timed Up and Go test (TUG) across different stages of Parkinson's disease (PD) severity as classified by the Hoehn & Yahr scale (H&Y). Design…
Carroll M, Gao Z, He L · 2026 · Foods (Basel, Switzerland)
Trace quantifications of arsenic (As) in foods by energy-dispersive X-ray fluorescence (ED-XRF) spectrometry are hindered by spectral overlap from lead (Pb) at characteristic emission lines. This study employed artificial neural networks…
De Laender F, Gonzalez A, Bleeckx O et al. · 2026 · Preprint
We provide a general theoretical explanation for a longstanding result in spatial ecology: weak dispersal among habitat patches promotes local biodiversity. Using analytical approximations of spatial Lotka–Volterra competition models, we…
Zips N, Kulko E, Kath-Schorr S · 2026 · Chembiochem : a European journal of chemical biology
mRNA translation can be controlled through chemical modification of the 5'-Cap, yet systematic insights into structure-reactivity relationships of bioorthogonally activatable Cap analogues remain limited. Here, we report the synthesis of…
La Vignera S, Condorelli RA · 2026 · Diagnostics (Basel, Switzerland)
Normogonadotropic azoospermia (NOAN) represents a diagnostic and therapeutic challenge in male infertility, affecting men with normal gonadotropin levels but absent sperm in the ejaculate. Emerging evidence has identified…
Anam C, Amilia R, Naufal A et al. · 2026 · Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
Purpose This study aims to evaluate statistical low-contrast detectability (SLCD) at multiple confidence levels (CLs) in computed tomography (CT) images and to determine the smallest detectable object sizes compared with human observers…
Noey JD, Kearfott KJ · 2026 · Health physics
This study examines the range of methodologies used to determine the minimum detectable dose for LiF:Mg,Ti thermoluminescent dosimeters, emphasizing the importance of incorporating uncertainties when assessing variability in dosimeter…
Csonka LL, Tikkakoski A, Karjalainen J et al. · 2026 · Clinical physiology and functional imaging
Background Peak expiratory flow (PEF) obtained from dedicated PEF meters and various types of spirometers is often used interchangeably in research, despite differences in both devices and expiratory maneuver technique. The aim of this…
Hossain D, Abir FA, Zhang S et al. · 2026 · Preprint
ABSTRACT Despite major advances in computational antibody engineering, no systematic comparison of modern open-source LLM backbone families for antibody sequence generation exists, nor is it known whether architectural differences matter…
Upreti A, Shonkwiler K, Riddick SN et al. · 2026 · Preprint
Methane (CH4) is a major component of natural gas and a potent greenhouse gas. Increasing atmospheric methane concentrations are attributed to emissive anthropogenic activities by an average of 13 ppb per yr since 2020 and are linked to a…
Kadesch, Weiss, Hetjens et al. · 2026 · Obesity surgery
Preoperative multidisciplinary team assessment (MTA) for bariatric surgery is complex and associated with high attrition rates. Digital health applications may improve patient engagement and completion rates, but evidence remains limited.…
Ribeiro, Lima · 2026 · ACS omega
Protein interactions are dynamic processes that are influenced by chemical and physical variables. While variable temperatures play an important role in understanding biological processes, their use in protein crystallography has been…
Xiang, Wei, Guo et al. · 2026 · Biomedicines
Objectives : To investigate the effects of Roxadustat and recombinant human erythropoietin (rHuEPO) on glycemic control and glycated hemoglobin (HbA1c) in non-dialysis type 2 diabetic kidney disease (DKD) patients with anemia. Methods :…
Zhang, Song, Ji et al. · 2026 · Ecotoxicology and environmental safety
The rise in electronic waste from the electronics industry has increased environmental and health risks. Pollutants like tris(2-chloroethyl) phosphate (TCEP) and lead (Pb) are particularly concerning for their harmful effects on…
Vrinzen, Stadhouders, Bloemendal et al. · 2026 · BMJ open
Concentration of care and collaborations between hospitals increasingly reorganise oncological care into Comprehensive Cancer Networks (CCNs), aiming to improve care outcomes and reduce costs. This study aims to evaluate the effect of four…
Qing Zhang, Shao-zheng Liu, Qing Zhang et al. · 2016 · Cellular Physiology and Biochemistry
Background/Aims: The function of BRAF V600E as a prognostic biomarker continues controversial by reason of conflicting results in the published articles. Methods: A systematical literature search for relevant articles was performed in PubMed, Cochrane Library, Google Scholar, Medline and Embase updated to August 5, 2015. The Chi-square test and I2 were employed to examine statistical heterogeneity. Pooled ORs with their corresponding 95% confidence intervals (95%CIs) were calculated to assess the relationship between clinicopathological features and BRAFV600E mutation. Subgroup analyses by eth
Samiei A, Najafabadi ZH, Akbari N et al. · 2026 · Journal of applied genetics
INTRODUCTION: Optimized vectors are crucial in modern molecular biology because they greatly enhance the efficiency of the DNA cloning procedure. This study aimed to design a novel engineered vector containing an HphI cassette to enhance…
Safoora AK, Vadakkepurayil K, Santhakumar M · 2026 · International journal of clinical pediatric dentistry
Background and objectives Dental anxiety is frequently observed in children and often poses a significant challenge to providing effective and high-quality dental care. Managing a child's anxiety in the clinical setting is a critical…
Tucker, Todd · 2013
A major question in investment treaty arbitration is whether it is biased against developing countries. This paper replicates the results from a frequently cited paper on this question (Franck, 2009) that failed to find statistically…
Ling, Siew-Eng, Liew, Venus Khim-Sen, Lau, Sie-Hoe · 2005
This study shows that augmented Dickey-Fuller (ADF) test failed to detect covariance nonstationary series. Supportive of Ahamada (2004), this study finds that the cumulative sums of squares procedure in Inclán and Tiao (1994) is useful to…
Ling, Siew-Eng, Venus, Khim-Sen Liew, Lau, Sie-Hoe · 2005
This study shows that augmented Dickey-Fuller (ADF) test failed to detect covariance nonstationary series. Supportive of Ahamada (2004), this study finds that the cumulative sums of squares procedure in Inclán and Tiao (1994) is useful to…
Fadi Fadil, Claudia Samol, Raffaela S. Berger et al. · 2022 · Metabolites
Metabolic fingerprinting by mass spectrometry aims at the comprehensive, semiquantitative analysis of metabolites. Isotope dilution, if successfully implemented, may provide a more reliable, relative quantification. Therefore, the 13 C labeled yeast extract of the IROA TruQuant kit was added as an internal standard (IS) to human urine samples measured in full-scan mode on a high-performance liquid chromatography-time-of-flight mass spectrometer (HPLC–TOFMS) system. The isotope ratio approach enabled the analysis of 112 metabolites. The correlation with reference data did not improve significan
Leslie Bilello, Andrew Ketterer, Shaked Yarza et al. · 2021 · Clinical and Experimental Emergency Medicine
Objective Optimal training methods remain controversial for rarely performed emergency procedures. Previous research has failed to demonstrate the superiority or inferiority of live anesthetized animal models (LAA) as compared to other modalities. Most of the data on LAA use comes from military contexts; less information is available for civilian emergency medicine (EM) training. We sought to characterize the prevalence of LAA use among civilian EM residency programs and reasons for its use or discontinuation. Methods Survey study of program directors of EM residency programs accredited by the
Iatropoulos S, Dandrieux PE, Navarro L et al. · 2024 · Scandinavian journal of medicine & science in sports
Despite exercise-based injury prevention programs (EIPPs) being widely researched and used, several randomized controlled trials (RCTs) have failed to show their protective effect on injury risk. This is potentially due to…
Gogebakan KC, Kunst N, Ghodsi A et al. · 2026 · Journal of nuclear medicine : official publication, Society of Nuclear Medicine
The TheraP trial demonstrated that 177 Lu-PSMA-617 improved progression-free survival (PFS) compared with cabazitaxel, with no significant difference in overall survival (OS). However, 177 Lu-PSMA-617 was associated with fewer severe…