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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20240 results in Negative / Null Result Report · page 398 of 675

Negative / Null Result ReportOpen accessMedicine

Mechanosensitivity and Adipose Thickness as Determinants of Pressure to Reach Deep Fasciae in Cervical and Thoracolumbar Regions.

Pires S, Freitas M, Pinho F et al. · 2025 · Sensors (Basel, Switzerland)

Objective We aimed to quantify the mechanical pressure required to reach the deep cervical and thoracolumbar fasciae, to examine its association with pressure pain threshold (PPT) and adipose tissue thickness, and to determine whether PPT…

View details →DOI: 10.3390/s25165073
Negative / Null Result ReportOpen accessMedicine

Lack of association between breastfeeding duration and body mass index in children and adolescents - A Swedish cohort study.

Haahr Vad O, Önnestam L, Bengtsson Boström K et al. · 2025 · PloS one

Aims The aim of the study was to investigate the association between breastfeeding duration and body mass index (BMI), overweight and obesity in children during follow-up until 16 years of age. Methods Observational cohort study of mothers…

View details →DOI: 10.1371/journal.pone.0319502
Negative / Null Result ReportOpen accessMedicine

<i>IL4</i> Gene Variants rs2243250 and rs2243248 and Their Association with Clinical Phenotypes of Severe Asthma in the Mexican Population: In Silico Functional Analysis and Regulatory Implications.

Montoya-Delgado IB, Ochoa-García IV, Escobedo-Salcedo ZL et al. · 2026 · International journal of molecular sciences

Severe asthma (SA) is a chronic respiratory disease characterized by clinical heterogeneity and poor therapeutic response. Variants in the IL4 gene, including rs2243250 and rs2243248, have been associated with asthma susceptibility and…

View details →DOI: 10.3390/ijms27114711
Negative / Null Result ReportOpen accessMedicine

Lack of association between food insecurity, eating disorders, and orthorexia nervosa: findings from a cross-sectional study in Lebanon.

Sacre H, Haddad C, Rizk R et al. · 2025 · Frontiers in public health

Objectives To investigate the association between food insecurity (FI), eating disorders (EDs), and orthorexia nervosa (ON) among Lebanese university students. Methods This cross-sectional study, conducted between 2021 and 2022, enrolled…

View details →DOI: 10.3389/fpubh.2025.1572654
Negative / Null Result ReportOpen accessMedicine

Lack of Association Between Sodium Intake and Cytokine Levels.

Wistrand H, Kaartinen NE, Jousilahti P et al. · 2024 · Integrated blood pressure control

Purpose The complex pathogenesis of hypertension, potentially involving inflammatory pathways, remains elusive. This study aimed to evaluate the relationship between 24-hour urinary sodium excretion and inflammatory cytokines alongside…

View details →DOI: 10.2147/ibpc.s483495
Negative / Null Result ReportOpen accessMedicine

Accounting for Time-Varying Confounding in a Self-Controlled Case Series of Fluoroquinolone Treatment for Uncomplicated Urinary Tract Infections and Risk of Collagen-Related Events.

Schultze A, Ju S, Drysdale M et al. · 2025 · Pharmacology research & perspectives

We report findings from three SCCS conducted to quantify the association between fluoroquinolone (FQ) use for the treatment of uncomplicated urinary tract infection (uUTI) and tendon rupture, retinal detachment, and uveitis. Female…

View details →DOI: 10.1002/prp2.70124
Negative / Null Result ReportOpen accessMedicine

Lack of association of ABO and RhD blood groups with COVID-19 mortality: A 2-center cross-sectional study in Saudi Arabia.

Halawani AJ, Alhamoud AH, Kabrah SM et al. · 2024 · Medicine

Several diseases, including both noninfectious diseases and bacterial and viral diseases, are associated with the ABO and RH blood group systems. Previous studies have shown a link between blood type and the probability of coronavirus…

View details →DOI: 10.1097/md.0000000000039673
Negative / Null Result ReportOpen accessMedicine

Lack of association between prior or concurrent malignancies and overall survival in gastroesophageal cancer: evidence from a large European single-center cohort.

Puhr HC, Berchtold L, Zingerle L et al. · 2026 · Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

Background History of malignant disease is a common exclusion criterion in clinical cancer trials, yet data on the impact of cancer survivorship on outcome in gastroesophageal cancer patients are scarce. Methods Retrospective association…

View details →DOI: 10.1007/s12094-025-04036-3
Negative / Null Result ReportOpen accessMedicine

Impact of Prediabetes on In-Hospital Mortality and Clinical Outcomes in Acute Pancreatitis: Insights from a Nationwide Inpatient Sample.

Dakkak T, Silin N, Mahmood R et al. · 2025 · Journal of clinical medicine

Background/Objectives : Prediabetes is characterized by insulin resistance and systemic inflammation, which may increase susceptibility to acute pancreatitis (AP). However, limited data exist on how prediabetes influences in-hospital…

View details →DOI: 10.3390/jcm14124271
Negative / Null Result ReportOpen accessMedicine

Association of Gallstone and Polymorphisms of ABCB11 Gene among the Adult Patients in Iran: A Case Control Study : Gallstone and ABCB11 Gene.

Yektamoghaddam S, Forghanifard MM, Zrrinpour V et al. · 2025 · Galen medical journal

Background Background: Gallstone disease (GSD) is a prevalent gastrointestinal condition influenced by genetic, environmental, and dietary factors. The ATP-binding cassette subfamily B member 11 (ABCB11) gene, encoding the bile salt export…

View details →DOI: 10.31661/gmj.v14i.4066
Negative / Null Result Report

An Induction Failed on a Whim? Or, WHIM Syndrome Resulting in a Failed Induction of Labor? [25G]

William A. Zammarrelli, Scott M. Petersen, Kimberly Hickey et al. · 2019 · Obstetrics &amp; Gynecology

INTRODUCTION: The physiology of labor, specifically cervical dilation, likely depends on immunomodulation. Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) Syndrome, is a rare immunodeficiency syndrome with patients…

View details →DOI: 10.1097/01.aog.0000558724.90392.e2
Negative / Null Result Report

The over-representation of phonological features in basic vocabulary doesn’t replicate when controlling for spatial and phylogenetic effects

Frederic Blum · 2026 · Linguistic Typology

Abstract The statistical over-representation of certain phonological features in the basic vocabulary of languages is often interpreted as reflecting potentially universal sound symbolic patterns. However, most of these cases have not been…

View details →DOI: 10.1515/lingty-2025-0050
Negative / Null Result Report

Deleuze and New Materialism

A. Janae Sholtz · 2025 · Philosophy Today

Deleuze and Guattari provide a sophisticated account of ontological relationality, many facets of which have been annexed into new materialist theory. It is worth asking how this happens and with what degree of accuracy. Deleuze’s…

View details →DOI: 10.5840/philtoday2025626569
Negative / Null Result ReportMedicine

Vitamin B 12 Availability and Interaction with Bacterium Mesorhizobium loti Affect Growth and Biochemical Composition of Mixotrophic Alga Euglena Gracilis.

Ghimire, Sohrabi, Zhou et al. · 2026 · Microbial ecology

Over 90% of the mixotrophic algae surveyed require vitamin B 12 (B 12 ), a micronutrient synthesized exclusively by certain prokaryotes. Bacteria-mediated B 12 supply presents an important but poorly understood control on physiology and…

View details →DOI: 10.1007/s00248-026-02816-0
Negative / Null Result Report

Can Public Information Replicate Institutional Bond Price Vendors?

Erik Huesca Burela · 2026 · Revista Mexicana de Economía y Finanzas

This paper aims to determine whether a transparent, vendor-style bond pricing framework built exclusively from public information can match the pricing accuracy of institutional vendors. The methodology constructs Treasury-based yield…

View details →DOI: 10.21919/remef.v21i2.1430
Negative / Null Result Report

ФИЗИОЛОГИЧЕСКИ ЗНАЧИМЫЕ ПАРАМЕТРЫ ТРОМБОЦИТОВ У ПОРОСЯТ МОЛОЧНО-РАСТИТЕЛЬНОГО ПИТАНИЯ

Завалишина С.Ю., Ткачева Е.С. · 2019 · Зоотехния

Большой физиологической важностью в организме поросят обладают тромбоциты, являющиеся важным компонентом системы поддержания гомеостаза. Их функциональные свойства в значительной степени определяют процессы гемоциркуляции в просвете…

View details →DOI: 10.25708/zt.2019.55.41.005
Negative / Null Result ReportMedicine

Bile duct segmental resection versus pancreaticoduodenectomy for middle-third extrahepatic cholangiocarcinoma: A propensity-matched, single-center retrospective analysis.

Park, Kim, Kim et al. · 2026 · Annals of hepato-biliary-pancreatic surgery

The optimal surgical approach for middle-third extrahepatic cholangiocarcinoma (MCC)-bile duct segmental resection (BDSR) or pancreaticoduodenectomy (PD)-remains controversial. This study aimed to compare the short- and long-term outcomes…

View details →DOI: 10.14701/ahbps.26-068
Negative / Null Result Report

Comparison of insulin resistance and lipid profile in clinically significant macular oedema versus non-clinically significant macular oedema in patients with type 2 diabetes mellitus

· 2025 · International Journal of Medicine and Medical Research

Lifestyle-related disorders, particularly diabetes, pose a significant global health challenge. Diabetic macular oedema, a microvascular complication, highlights the importance of managing insulin resistance and hyperlipidaemia for optimal…

View details →DOI: 10.63341/ijmmr/1.2025.22
Negative / Null Result Report

ChatGPT: Significant Systemic Limitations and Opportunities for Improvement

Rosario Milelli · 2026 · Journal of Artificial Intelligence, Virtual Reality, and Human-Centered Computing

ChatGPT, developed by OpenAI, has become a central tool in my professional workflow, supporting scholarly research, editorial writing, and creative projects. Drawing on extensive practical use, this perspective highlights both its…

View details →DOI: 10.66311/3069-2318.02.01.02
Negative / Null Result ReportMedicine

[Study on the incidence of adverse reactions following single versus simultaneous administration of the domestic diphtheria, tetanus, and acellular pertussis combined vaccine after immunization schedule adjustment].

Shao, Feng, Yang et al. · 2026 · Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]

This study compared the incidence of adverse reactions following single versus simultaneous administration of the domestic diphtheria, tetanus and acellular pertussis combined vaccine (DTaP) after the immunization schedule adjustment in…

View details →DOI: 10.3760/cma.j.cn112150-20251126-01116
Negative / Null Result Report

Failure to replicate the Aubert-Fleischl effect

Björn Jörges, Laurence R. Harris · 2025 · PLOS One

For many years the accepted wisdom in vision science has been that humans tend to underestimate the speed of an object when they pursue it with their gaze in comparison to when they fixate a spot in the visual scene and the object moves…

View details →DOI: 10.1371/journal.pone.0324420
Negative / Null Result Report

СОЦИАЛЬНО ЗНАЧИМЫЕ КАЧЕСТВА ЛИЧНОСТИ УЧАСТНИКОВ ОБЪЕДИНЕНИЯ «ВОЛОНТЕРЫ ПОБЕДЫ»

Е.Н. Малова · 2019 · Бизнес. Образование. Право

Актуальность определена существенными изменениями социокультурной, экономической, образовательной ситуации в стране и потребностями общества в развитии социально активной молодежи. Волонтерство добровольная безвозмездная социально значимая…

View details →DOI: 10.25683/volbi.2019.49.471
Negative / Null Result Report

A Bayesian Hierarchical Approach to Quasi-Replicate Dataset Modelling

Hassan M. Aljohani, Robert G. Aykroyd · 2025 · Mathematics

It is very common for multiple experiments to be conducted under non-identical but similar conditions, perhaps because of implementation errors, natural variability in experimental material, or gradual drifting of experimental conditions.…

View details →DOI: 10.3390/math13111751
Negative / Null Result Report

Value Orientation and Significant Insights as well as Critical Review on Major Challenges and Significant Opportunities on Commerce and Management Education in India

Mahadevappa Hanchinamani · 2022 · International Journal of Research Publication and Reviews

It has been widely debated that while scholars like Nitin Nohria Dean Harvard Business School from Indian origin are leading the world’s top B-Schools; BSchools in India are struggling to find a place among the Top 100 Global Institutions.…

View details →DOI: 10.55248/gengpi.2022.3.9.31