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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19866 results in Negative / Null Result Report · page 398 of 663

Negative / Null Result ReportMedicine

A Novel Template for Intravesical Botulinum Toxin Injection in Patients With Idiopathic Overactive Bladder: A Cohort Study.

Salcedo GG, Galvis JSS, Medina SEM et al. · 2026 · Neurourology and urodynamics

Introduction The intravesical injection of onoabotulinum toxin A is a cornerstone in the management of overactive bladder. Traditionally, treatment involves 20 injection sites, avoiding the bladder trigone. Recent studies have shown that…

View details →DOI: 10.1002/nau.70340
Negative / Null Result ReportMedicine

Clinical real-world data evaluation: comparison of central macular thickness after anti-VEGF treatment in diabetic macular edema patients treated with or without topical anti-glaucoma agents.

Baybora H, Özal E, Özal SA · 2026 · BMC ophthalmology

Background There are research findings suggesting that antiglaucoma agents may reduce aqueous humor outflow and decrease the elimination of intravitreally administered anti-vascular endothelial growth factor agents, prolonging their…

View details →DOI: 10.1186/s12886-026-04925-3
Negative / Null Result Report

ASSOCIATIONS BETWEEN LEVEL OF STRESS AND DEPRESSION AMONG STUDENTS

Ahiati JM · 2026 · Preprint

This research study examined the level of stress and depression associated with students and how social support influences the stress and depression levels of students. There are several interactions between stress, depression, and social…

View details →DOI: 10.31234/osf.io/jhxp8_v1
Negative / Null Result ReportOpen accessMedicine

Mid-Term Oncological Outcomes of Vaginal Natural Orifice Transluminal Endoscopic Surgery Compared with Total Laparoscopic Hysterectomy for Early-Stage Endometrial Cancer: A Single-Center Retrospective Study.

Imai K, Abe J, Chikazawa K et al. · 2026 · Journal of clinical medicine

Background/Objectives : Vaginal natural orifice transluminal endoscopic surgery (vNOTES) is increasingly being used to avoid abdominal incisions; however, its mid-term oncological safety in endometrial cancer remains unclear. Methods :…

View details →DOI: 10.3390/jcm15093350
Negative / Null Result ReportMedicine

Comparing Refractive Outcomes of Secondary Lens Surgery between Ophthalmology Subspecialties in Patients with Good Final Vision.

Sharma K, Israilevich RN, Ross E et al. · 2026 · Retina (Philadelphia, Pa.)

Purpose The study compares refractive outcomes of secondary intraocular lens (SIOL) surgery performed by vitreoretinal, anterior segment, and both surgeons. Methods Eyes included in this study underwent SIOLfrom 2012-2024and had a final…

View details →DOI: 10.1097/iae.0000000000004879
Negative / Null Result Report

Effectiveness and Safety of Dimethyl Fumarate in a Sample of Iraqi Patients with Relapsing-Remitting Multiple Sclerosis

ALqaraghuli MiA, Sheadeed Nm, karim AK et al. · 2026 · Preprint

Abstract Background: As multiple sclerosis (MS) is a long-lasting and highly variable disease, treatment aims to focus on reducing relapses and preventing the buildup of disability over time. Choosing an effective first disease-modifying…

View details →DOI: 10.21203/rs.3.rs-9626999/v1
Negative / Null Result ReportOpen accessMedicine

The clinical observation of ciprofol versus propofol anesthesia in hysteroscopic electrosurgical resection of submucosal myomas.

Li H, Li T, Guo Y et al. · 2026 · Frontiers in medicine

Background To evaluate the clinical efficacy of ciprofol versus propofol combined with alfentanil for anesthesia in patients undergoing hysteroscopic transcervical resection of submucosal myomas. Methods A total of 208 patients scheduled…

View details →DOI: 10.3389/fmed.2026.1829147
Negative / Null Result ReportOpen accessMedicine

Efficacy and safety of Ashwagandha root extract sustained-release (AshwaSR) capsules in healthy adult, stressed subjects: A randomized, double-blind, placebo-controlled, parallel-group, 3-arm clinical trial.

Thanawala S, Shah R, Alluri KV et al. · 2026 · Medicine

Background The adaptogenic effects of Ashwagandha root extract are evident. An earlier study showed the therapeutic effects of a once-daily sustained-release (SR) formulation (300 mg) of Ashwagandha root extract over an extended period.…

View details →DOI: 10.1097/md.0000000000047990
Negative / Null Result ReportOpen accessMedicine

Assessing the effect of deficit irrigation and biochar application on soil water depletion, root distribution, and water productivity of cucumber in semi-arid West Texas.

Kafle A, Singh S, Singh M et al. · 2026 · Frontiers in plant science

Understanding crop root growth and distribution and soil water depletion under water deficit conditions is critical for developing sustainable production practices for cucumber ( Cucumis sativus L.) in semi-arid regions like West Texas.…

View details →DOI: 10.3389/fpls.2026.1796736
Negative / Null Result ReportMedicine

Post Operative Pain During and After Root Canal Treatment in a Government Hospital Setting in Nepal.

Tripathi R, Dahal S, Acharya N et al. · 2026 · Journal of Nepal Health Research Council

Background Postoperative pain is a most common symptom of endodontic patients after root canal treatments (RCTs). The aim of this study was to evaluate Postoperative pain during and after root canal treatment (RCT) among patients at a…

View details →DOI: 10.33314/jnhrc.v23i04.4626
Negative / Null Result ReportMedicine

CT-Based Blood Burden Scores for Predicting Shunt-Dependent Hydrocephalus After Aneurysmal Subarachnoid Hemorrhage: A Comparative Analysis of Quantitative and Qualitative Scoring Systems.

Sarkis H, Kerhani AA, Hedderich DM et al. · 2026 · World neurosurgery

Background/objective Shunt-dependent hydrocephalus represents a major complication of aneurysmal subarachnoid hemorrhage (aSAH), yet no universally adopted CT-based prediction tool exists. Fisher-based scales suffer from a ceiling effect…

View details →DOI: 10.1016/j.wneu.2026.125088
Negative / Null Result ReportMedicine

Surface roughness and surface microhardness of bulk-fill and conventional resin composites after erosive-abrasive cycles: A laboratory study.

Devletli Ozygit L, Eyuboglu GB · 2026 · American journal of dentistry

Purpose To investigate comparatively the changes in surface roughness and surface microhardness of resin composites applied with traditional incremental layering technique and bulk-fill resin composites after erosive/abrasive applications.…

Negative / Null Result ReportOpen accessMedicine

Effects of load carriage methods on fall risk and gait variability during stair ascent: a functional data analysis approach.

Zhang X, Li Y, Fang Y et al. · 2026 · Frontiers in bioengineering and biotechnology

Objective Based on the existing research that predominantly focuses on loaded level walking or employs discrete-point methods to analyze stair negotiation, this study utilizes functional data analysis to systematically investigate the…

View details →DOI: 10.3389/fbioe.2026.1740819
Negative / Null Result ReportMedicine

Comparison of decentration, tilt, and dynamic stability between retropupillary iris claw and scleral fixated intraocular lenses with flanged haptics.

Zeilinger J, Regitnig P, Kronschläger M et al. · 2026 · Journal of cataract and refractive surgery

Purpose To compare decentration, tilt, and dynamic stability ("wobble") between retropupillary fixated iris claw intraocular lenses (IOL) and double needle flanged scleral fixated technique. Setting Vienna Institute for Research in Ocular…

View details →DOI: 10.1097/j.jcrs.0000000000001975
Negative / Null Result ReportOpen accessMedicine

Alfentanil May Reduce Early Postoperative Nausea and Vomiting in Moderate-to-High Risk Patients Undergoing Gastrointestinal Endoscopy: A Prospective Double-Blind Randomized Study.

Gu XY, Cao JF, Zhang XY et al. · 2026 · Drug design, development and therapy

Objective This trial aimed to compare the effects of alfentanil and sufentanil on postoperative nausea and vomiting (PONV) in patients at moderate-to-high risk undergoing sedated gastrointestinal endoscopy. Methods Two hundred and eighteen…

View details →DOI: 10.2147/dddt.s598415
Negative / Null Result ReportMedicine

Visual outcomes following implantation of intracorneal rings with sharp and round triangular cross-section designs in keratoconus.

Soleimani S, Pirhadi S, Jadidi K et al. · 2026 · International ophthalmology

Purpose To compare the visual, refractive, corneal curvature, and aberrometry outcomes one year following implantation of two intra-stromal corneal rings (ICRS) with different cross-sectional designs. Methods This retrospective…

View details →DOI: 10.1007/s10792-026-04038-2
Negative / Null Result ReportOpen accessMedicine

Morphometrıc evaluatıon of patıents wıth mandıbular hypomobılıty due to coronoıd process hyperplasıa usıng cone beam computed tomography.

Kurt Akgül Ş, Boylu ÖF · 2026 · Surgical and radiologic anatomy : SRA

PURPOSE: Mandibular hypomobility is a condition in which the jaw joint is restricted due to various causes, including temporomandibular joint disorders (TMD), ankylosis, head and neck infections and tumors, coronoid processes hyperplasia…

View details →DOI: 10.1007/s00276-026-03830-0
Negative / Null Result ReportOpen accessMedicine

Evaluation of multiple freeze-thaw cycles on growth factor and cytokine stability in canine platelet lysate: PDGF, TGF-<i>β</i>, and TNF-<i>α</i> preservation across cycles.

Sumner SM, Naskou MC · 2026 · Frontiers in veterinary science

Introduction Platelet-rich plasma (PRP) and platelet lysate (PL) are biologically active products used in regenerative medicine because of their high concentrations of growth factors, cytokines, and other bioactive molecules that promote…

View details →DOI: 10.3389/fvets.2026.1817599
Negative / Null Result ReportMedicine

Observation on the clinical effects of four kinds of root canal filling materials in the treatment of chronic periapical periodontitis.

Wang K, Chen Y, Fu H et al. · 2026 · American journal of translational research

Objective To compare the clinical efficacy of four root canal filling materials for the treatment of chronic periapical periodontitis. Methods The clinical data of 200 patients with chronic periapical periodontitis from January 2023 to…

View details →DOI: 10.62347/lpao8126
Negative / Null Result ReportMedicine

Residual gastric content after holding of glucagon-like peptide-1 receptor agonists before elective surgery: a cross-sectional study - the RESIDUAL study.

Boudreau C, Couture M, Rousseau-Saine N et al. · 2026 · BMC anesthesiology

Introduction Glucagon-like peptide-1 receptor agonists (GLP-1 RA) are now increasingly used for glycemic control in type 2 diabetes mellitus as well as for weight loss. Their effect on gastric emptying may increase the risk of aspiration…

View details →DOI: 10.1186/s12871-026-03999-2
Negative / Null Result ReportMedicine

Desflurane versus sevoflurane and postoperative inflammatory biomarkers in older adults undergoing minor- to moderate-risk noncardiac surgery.

Adamowitsch N, Reiterer C, Fleischmann E et al. · 2026 · Scientific reports

Volatile anesthetics modulate inflammatory responses, but it remains unclear whether desflurane and sevoflurane differ in their effects on postoperative inflammation. We evaluated in this secondary analysis of a prospective randomized…

View details →DOI: 10.1038/s41598-026-55579-6
Negative / Null Result ReportOpen accessMedicine

Bacterial Diversity in Leaf-Cutter Ant Species: Host-Microbe Interactions and Environmental Effects.

Gianaris A, Ramalho MO, de Oliveira AA et al. · 2026 · Neotropical entomology

Historically, studies have sought to identify host-specific factors in host-microbe interactions as a means of understanding evolutionary success. The genus Atta, comprising leaf-cutter ants, is native to the southern Neotropics and…

View details →DOI: 10.1007/s13744-026-01386-7