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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21309 results · page 394 of 711

Negative / Null Result ReportOpen accessMedicine

Polymerizable inhibitor can reduce shrinkage stress of resin composite.

He J, Garoushi S, Lassila L et al. · 2026 · Clinical oral investigations

Objective The purpose of this study was to prepare dental resin composites (DRCs) with low shrinkage stress and limited leachable inhibitor content by incorporating a synthesized polymerizable inhibitor PBHT…

View details →DOI: 10.1007/s00784-026-06901-z
Negative / Null Result ReportOpen accessMedicine

Three-dimensional analysis of maxillary asymmetry in patients with mandibular prognathism.

Atarashi C, Osawa K, Saito D et al. · 2026 · Maxillofacial plastic and reconstructive surgery

Background Jaw deviation is a common feature of skeletal mandibular prognathism and often extends to the maxilla, complicating diagnosis and treatment planning in surgical orthodontic treatment. Since occlusion and maxillary morphology…

View details →DOI: 10.1186/s40902-026-00506-y
Negative / Null Result ReportOpen accessMedicine

Development of engineered magnetic liposome/exosome hybrid as a novel caffeine nanocarrier for restraining liver fibrosis induced in rats.

Elakkad YE, Refai H, Ahmed HH et al. · 2026 · Scientific reports

Liver fibrosis, a severe health issue linked to liver injury, inflammation, and cell death, often progresses to liver cancer without effective treatments. In this study, an exosome-nanoliposome hybrid loaded with caffeine (Caff) was…

View details →DOI: 10.1038/s41598-025-31169-w
Negative / Null Result ReportOpen accessMedicine

Determining the Optimal Volume of Ropivacaine Combined with Dexmedetomidine for Programmed Intermittent Epidural Bolus in Labor Analgesia: A Randomized Dose-Response Study.

Song C, Ni J, Liu C et al. · 2026 · Drug design, development and therapy

Background The programmed intermittent epidural bolus (PIEB) technique is effective for labor analgesia. Although ropivacaine combined with dexmedetomidine is used for epidural labor analgesia, the optimal PIEB volume for this regimen…

View details →DOI: 10.2147/dddt.s598405
Negative / Null Result ReportOpen accessMedicine

P2X7 receptor and neuroinflammation in neurodegenerative disorders: an autoradiography study with [ 18 F]JNJ-64413739.

Ashok AH, Field S, Ramakrishnan NK et al. · 2026 · Nuclear medicine communications

Background Neuroinflammation plays a crucial role in neurodegenerative disorders such as Alzheimer's disease. The P2X7 receptor (P2X7R), expressed on microglia, is involved in neuroinflammatory responses. Despite evidence of P2X7R…

View details →DOI: 10.1097/mnm.0000000000002153
Negative / Null Result ReportMedicine

Comparison of Outcomes after Minimally Invasive Transverse Distal Metatarsal Osteotomy (MITO) and Proximal Phalangeal Osteotomy for Hallux Valgus With and Without Rheumatoid Arthritis: A Matched Cohort Study.

Yoon YK, Shim DW, Kim JH et al. · 2026 · Foot & ankle international

Background There is an increasing role for joint-preserving surgery in hallux valgus (HV) management among patients with rheumatoid arthritis (RA). We compared radiologic and clinical outcomes after minimally invasive transverse distal…

View details →DOI: 10.1177/10711007261435610
Negative / Null Result ReportOpen accessMedicine

Comparative evaluation of <i>Calotropis gigantea</i> latex and sodium hypochlorite as tissue-dissolving agents - an <i>in vitro</i> study on concentration and time-dependent proficiency.

Ravi M, Annadurai P, Gupta R · 2026 · Biomaterial investigations in dentistry

Background Complete removal of organic tissue and microorganisms from the root canal system is essential for successful endodontic therapy. Sodium hypochlorite (NaOCl) remains the gold standard irrigant for its tissue-dissolving and…

View details →DOI: 10.2340/biid.v13.45992
Negative / Null Result ReportOpen accessMedicine

Radiological differentiation of succinate dehydrogenase-deficient renal cell carcinoma from renal oncocytoma and chromophobe renal cell carcinoma.

Wang G, Yu Y, Han Y et al. · 2026 · BMC cancer

Purpose To characterize the imaging features of succinate dehydrogenase-deficient renal cell carcinoma (SDH-RCC) and compare them with those of renal oncocytoma (RO) and chromophobe RCC (chRCC). Methods This retrospective two-center study…

View details →DOI: 10.1186/s12885-026-16112-0
Negative / Null Result ReportOpen accessMedicine

The effects of 8 weeks of repeated sprint training on aerobic endurance, anaerobic power, agility and explosive strength in college badminton players.

Wei C, An J, Lin Y et al. · 2026 · PeerJ

Background Badminton is a physically demanding sport requiring a combination of aerobic endurance, anaerobic power, agility, and explosive strength. Repeated sprint training (RST) has emerged as a time-efficient strategy for improving…

View details →DOI: 10.7717/peerj.21111
Negative / Null Result ReportMedicine

Laparoscopic vs. robotic cholecystectomy for patients with cirrhosis: A propensity score-matched, single center analysis.

McCabe M, Cheung Z, Mungara T et al. · 2026 · Journal of robotic surgery

Patients with cirrhosis have increased rates of gallstone formation. While laparoscopic cholecystectomy (LC) is known to be safe in cirrhosis, perioperative morbidity remains higher than the general population. Prior work has suggested…

View details →DOI: 10.1007/s11701-026-03583-3
Negative / Null Result ReportOpen accessMedicine

Some carcass and meat quality characteristics of Anatolian local and Mast geese in semi-intensive conditions.

Ürer H, Yıldırım İ, Asker G et al. · 2026 · Tropical animal health and production

In this study, meat quality characteristics of Anatolian local geese (Anser anser domesticus) and Mast geese (Anser anser) reared under semi-intensive conditions were compared. A total of 100 geese were used: 50 from each breed, 25 males…

View details →DOI: 10.1007/s11250-026-05076-9
Negative / Null Result ReportOpen accessMedicine

The Efficacy and Safety of Dehydrated Alcohol Versus Lauromacrogol for Sclerotherapy of Simple Renal Cysts: A Retrospective Comparison Study.

Dong C, Xu S · 2026 · Health science reports

Background and aims Dehydrated alcohol and lauromacrogol are the predominant sclerosing agents employed in cyst ablation. A clear determination of the therapeutic effects comparison between the two is still lacking. This study evaluates…

View details →DOI: 10.1002/hsr2.72475
Negative / Null Result ReportMedicine

Intermittent hemodialysis with regional citrate anticoagulation vs. priming heparin and pre-dilution HDF in patients at Risk Of Bleeding in Nephrology (the ROBIN randomized control trial).

Moranne O, Gerbal M, Chkair S et al. · 2026 · Blood purification

Introduction This single center randomized controlled trial (NCT03562754) compared pre-diluted IHDF (PIHDF) without systemic anticoagulation and the Prometheus system with regional citrate anticoagulation (IHD-RCA) in high-bleeding-risk…

View details →DOI: 10.1159/000552412
Negative / Null Result ReportOpen accessMedicine

The effect of spreader graft use on voice in rhinoplasty cases: a prospective randomized controlled study.

Ulkumen B, Mutlu S, Celik O · 2026 · Brazilian journal of otorhinolaryngology

Objective This study aimed to evaluate the impact of spreader graft placement during cosmetic rhinoplasty on both objective acoustic measures and subjective voice quality. Methods In this prospective, double-blind, controlled study,…

View details →DOI: 10.1016/j.bjorl.2026.101847
Negative / Null Result ReportMedicine

Association between short (≤ 30-day) dual antiplatelet therapy and 1-year major adverse cardiac events after drug-coated balloon-based non-stent percutaneous coronary intervention following optimal lesion preparation: a propensity score-based cohort study.

Kuroda S, Sawada T, Yui R et al. · 2026 · Cardiovascular intervention and therapeutics

Drug-coated balloon (DCB)-based non-stent percutaneous coronary intervention (PCI) may allow shorter dual antiplatelet therapy (DAPT), but whether a ≤ 30-day regimen is associated with worse outcomes remains unclear, particularly in…

View details →DOI: 10.1007/s12928-026-01312-z
Negative / Null Result ReportOpen accessMedicine

The influence of different skeletal patterns on TMJ anatomy: a comprehensive CBCT study across various sagittal and vertical skeletal patterns in adults.

Eslami S, Sayahpour B, Tashakor A et al. · 2026 · Clinical oral investigations

Objective This study aimed to evaluate the impact of sagittal and vertical skeletal patterns as well as gender on temporomandibular joint (TMJ) morphology using Cone Beam Computed Tomography (CBCT). Methods A cross-sectional analysis was…

View details →DOI: 10.1007/s00784-026-06916-6
Negative / Null Result ReportMedicine

Phacoemulsification Combined With 360° Gonioscopy-Assisted Transluminal Trabeculotomy: Prospective 12-Month Outcomes in Primary Open-Angle and Primary Angle-Closure Glaucoma.

Maheshwari D, Nagdev NG, Pillai MR et al. · 2026 · Journal of glaucoma

Precis This study concludes that combined gonioscopy assisted transluminal trabeculotomy-phacoemulsification have similar efficacy in terms of intraocular pressure and antiglaucoma medication reduction in primary open angle and primary…

View details →DOI: 10.1097/ijg.0000000000002753
Negative / Null Result Report

A Randomized, Controlled, Double Blind Clinical Study to Evaluate Use of Hydron Alkaline Ionised Water (HAIW) in Healthy Participants

Malhotra VK, Tamoli S, Kalbhor R et al. · 2026 · Preprint

Background and Objectives Alkaline Ionized Water (AIW) is considered among the highest quality healthy drinking water worldwide and is widely discussed for its various health benefits. Hydron Alkaline Ionized Water (HAIW) is produced…

View details →DOI: 10.64898/2026.06.17.26355908
Negative / Null Result ReportMedicine

The Effect of Smoking History on Inflammatory Biomarkers in Synovial Fluid of Patients Undergoing Arthroscopic Knee Surgery for Meniscal Injury.

Kurtz JL, Ehlers M, Montgomery SR Jr et al. · 2026 · The American journal of sports medicine

Background Smoking has been linked to alterations in cellular inflammatory pathways and adverse outcomes in orthopaedic procedures. It is unclear how patient smoking affects the intra-articular microenvironment in the setting of…

View details →DOI: 10.1177/03635465261459231
Negative / Null Result ReportMedicine

The Effect of a Web-Based Diabetes Education Program on Care Outcomes of Individuals With Type 2 Diabetes.

Elyeli K, Esmaeilzadeh S, Esmaeilzadeh S · 2026 · Computers, informatics, nursing : CIN

Diabetes is characterized as the "pandemic of the age" due to its increasing prevalence. Since it is a disease that affects all areas of life, it causes negative effects on the quality of life and self-care activities. This study aimed to…

View details →DOI: 10.1097/cin.0000000000001334
Negative / Null Result ReportOpen accessMedicine

Denture trueness and subjective retention analysis of digital monolithic dentures.

Ibrahim EA, Hanno KIH, Alrafah E et al. · 2026 · The journal of advanced prosthodontics

Purpose The aim is to evaluate the trueness and displacement of tooth position as well as subjective retention of the monolithic complete denture (CD). Materials and methods Twenty-two completely edentulous patients received (n = 22)…

View details →DOI: 10.4047/jap.2026.18.2.80
Negative / Null Result ReportOpen accessMedicine

Nano-magnolol enhances the modulatory effects of magnolol on cognitive performance and BACE1-related biochemical changes in an STZ-induced rat model of Alzheimer's disease.

Youssef B, Ibrahim EA, Moselhy SS et al. · 2026 · Discover nano

Background The Late-onset Alzheimer's disease (LOAD) is progressive cognitive deficits associated with different abnormalities as cholinergic dysfunction, amyloid accumulation, inflammation, and oxidative stress. Magnolol is a polyphenolic…

View details →DOI: 10.1186/s11671-026-04506-9