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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19866 results in Negative / Null Result Report · page 392 of 663

Negative / Null Result ReportOpen accessMedicine

Combined Prognostic Value of Nutritional and Inflammatory Indices for Predicting Functionally Significant Coronary Stenosis Verified by FFR: The PNI-SII-GINI Study.

Aydın MZ, Arin CB, Teber MK et al. · 2026 · Journal of inflammation research

Background Systemic inflammatory and nutritional indices have been associated with coronary artery disease burden and prognosis; however, their ability to predict lesion-level functional ischemia remains uncertain. This study evaluated…

View details →DOI: 10.2147/jir.s585010
Negative / Null Result ReportOpen accessMedicine

Immunosuppressive Medications and Nonserious Infections in People With Rheumatoid Arthritis: A Prospective Cohort Study.

George MD, Gavigan K, Venkatachalam S et al. · 2026 · ACR open rheumatology

Objective People with rheumatoid arthritis (RA) are at increased risk of serious infection, but less is known about nonserious infections. Our prospective cohort study evaluated associations between medications for RA and the risk of…

View details →DOI: 10.1002/acr2.90050
Negative / Null Result ReportOpen accessMedicine

Social norm intervention in real-world supermarkets in the Netherlands: A quasi-experimental evaluation of effects on perceived social norms and meat substitute purchases.

Wolfswinkel SMM, Raghoebar S, de Vet E et al. · 2026 · Applied psychology. Health and well-being

Social norm perceptions are implicit rules of conduct that describe what is normal and acceptable behavior. Changing social norm perceptions through textual and physical social norm communications can be a promising approach to changing…

View details →DOI: 10.1111/aphw.70159
Negative / Null Result ReportOpen accessMedicine

Circulating Omentin Levels in Heart Failure: A Case-Control Study.

Currò D, Vergani E, Nicolazzi MA et al. · 2026 · International journal of molecular sciences

Cardiovascular diseases remain the leading cause of global mortality, with heart failure (HF) representing a critical clinical endpoint. HF is traditionally classified into two distinct phenotypes based on left ventricular ejection…

View details →DOI: 10.3390/ijms27093998
Negative / Null Result ReportOpen accessMedicine

Association between optical coherence tomography biomarkers and systemic inflammatory indices in neovascular age-related macular degeneration.

Kocamış Ö · 2026 · BMC ophthalmology

BACKGROUND: Neovascular age-related macular degeneration (nAMD) is a leading cause of irreversible central vision loss in elderly individuals. Increasing evidence indicates that systemic inflammation contributes to nAMD pathogenesis.…

View details →DOI: 10.1186/s12886-026-04753-5
Negative / Null Result ReportOpen accessMedicine

The association of previous and current non-chronic low back pain with daily physical activity in middle- and older-aged adults.

Gonçalves TR, Cunha DB, Mediano MFF et al. · 2025 · BMC public health

Background Low back pain (LBP) is a leading cause of years lived with disability. However, the association of non-chronic LBP with levels of daily physical activity (PA) remains poorly explored. This study investigated the association…

View details →DOI: 10.1186/s12889-025-21453-9
Negative / Null Result ReportMedicine

Lack of association between rs1049353 polymorphism of the CNR1 gene and suicide attempt frequency in Polish population.

Wierzbiński P, Henzler M, Hubska J · 2022 · Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego

Suicidal behaviour is a major public health problem in Poland. There is compelling evidence that genetic factors contribute to the risk for suicidal behavior. Studies suggest a link between single nucleotide polymorphism (SNP) rs1049353…

Negative / Null Result ReportOpen accessMedicine

Retrospective Study of Serum Vitamin D Levels and Metabolic-Associated Fatty Liver Disease in 222 Children and Adolescents Aged 6-18 Years With Obesity.

Gümüş CY, Özer Y, Kaşko Arıcı Y · 2026 · Medical science monitor : international medical journal of experimental and clinical research

BACKGROUND Vitamin D deficiency is common in pediatric obesity and has been proposed to contribute to metabolic-associated fatty liver disease (MAFLD). This retrospective study aimed to evaluate serum 25-hydroxyvitamin D (25[OH]D) levels…

View details →DOI: 10.12659/msm.952489
Negative / Null Result ReportMedicine

Neighborhood Deprivation and Breast Cancer Mortality Among Black and White Women.

Barber LE, Maliniak ML, Moubadder L et al. · 2024 · JAMA network open

Importance Neighborhood deprivation has been associated with increased breast cancer mortality among White women, but findings are inconsistent among Black women, who experience different neighborhood contexts. Accounting for interactions…

View details →DOI: 10.1001/jamanetworkopen.2024.16499
Negative / Null Result ReportOpen accessMedicine

Association between systolic blood pressure trajectories and successful aging in middle-aged and elderly Chinese individuals: a longitudinal study.

Xin Y, Qian X, Yang Y · 2025 · BMC public health

Background This study aimed to prospectively assess the relationship between systolic blood pressure (SBP) trajectories and successful aging in middle-aged and elderly Chinese individuals. Methods A total of 1,960 participants from the…

View details →DOI: 10.1186/s12889-025-25709-2
Negative / Null Result ReportOpen accessMedicine

The lack of association between different LDL-C levels and oxidized LDL in patients with type 2 diabetes.

Rabizadeh S, Seyedi SA, Nabipoorashrafi SA et al. · 2023 · Chronic diseases and translational medicine

Background High concentrations of low-density lipoprotein cholesterol (LDL-C) have been a known risk factor for cardiovascular diseases. Also, the role of oxidized LDL (ox-LDL) in forming atherosclerosis plaque has been proven. However, it…

View details →DOI: 10.1002/cdt3.84
Negative / Null Result ReportMedicine

Goal Concordance in the Advancing Symptom Alleviation with Palliative Treatment Clinical Trial of a Nurse and Social Worker Palliative Telecare Team Intervention.

Lange AV, Hess E, Barón AE et al. · 2026 · Journal of palliative medicine

Background Providing and measuring goal-concordant care is a priority. Objective Determine the effect of a nurse and social worker palliative telecare team intervention on goal concordance and participants' understanding of care focus.…

View details →DOI: 10.1177/10966218261444977
Negative / Null Result ReportMedicine

Association of serum sodium levels with fractures and mortality in patients undergoing maintenance hemodialysis.

Soeda K, Komaba H, Nakagawa Y et al. · 2024 · Journal of nephrology

Background Hyponatremia is implicated in pathological bone resorption and has been identified as a risk factor for bone fracture in the general population. However, there are limited data on the association between serum sodium levels and…

View details →DOI: 10.1007/s40620-024-01904-z
Negative / Null Result ReportOpen accessMedicine

Red meat intake during pregnancy and childhood and risk of type 1 diabetes: findings from the ABIS birth cohort.

Lampousi AM, Zeng J, Löfvenborg JE et al. · 2026 · Diabetologia

Aims/hypothesis The role of red meat in type 1 diabetes risk remains unclear. We examined whether maternal and early-life red meat intake is associated with the development of type 1 diabetes and whether such associations are modified by…

View details →DOI: 10.1007/s00125-026-06671-z
Negative / Null Result ReportMedicine

Plasma anti-CD4 IgG levels are associated with poor immune recovery in people with HIV initiating antiretroviral therapy.

Bowler SA, Premeaux TA, Ratzan L et al. · 2025 · AIDS (London, England)

A segment of people with HIV on effective antiretroviral therapy (ART) continue to experience poor immune recovery, leaving them at heightened risk of non-AIDS-defining events (NAEs). The production of anti-CD4 IgG autoreactive antibodies…

View details →DOI: 10.1097/qad.0000000000004044
Negative / Null Result ReportMedicine

Challenges and lessons learned in attempts to develop in vitro models for ultrasound neuromodulation using local field potential measurements in hippocampal tissue.

Prieto ML, Madison DV, Maduke M · 2025 · Biophysical journal

Ultrasound neuromodulation is a rapidly developing tool for noninvasive control of brain activity. An in vitro model recapitulating the effects of ultrasound on neural tissue in vivo would be extremely valuable in guiding the development…

View details →DOI: 10.1016/j.bpj.2025.06.039
Negative / Null Result ReportMedicine

Pumping Behaviors of Breast Pump-Dependent Mothers of Preterm Infants in the Neonatal Intensive Care Unit (NICU): Importance of the First Five Postpartum Days.

Medina Poeliniz C, Hoban R, Janes J et al. · 2025 · Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine

Objective: To determine if cumulative measures of pumping behaviors over the first 5 days postpartum predicted lactation outcomes by postpartum days 7 (achievement of secretory activation [SA] and pumped milk volume) and 14 (achievement of…

View details →DOI: 10.1089/bfm.2024.0396
Negative / Null Result ReportMedicine

Targeting synaptic plasticity and acetylcholine dysregulation in the medial prefrontal cortex: Rosmarinic acid attenuates Autism-like phenotypes in Shank3B<sup>-/-</sup> mice via the CREB/BDNF pathway.

Shi J, Chen M, Zhang Y et al. · 2026 · Psychopharmacology

Rationale Autism spectrum disorder (ASD) is characterized by cognitive deficits, repetitive behaviors, and social impairments. The SH3 and multiple ankyrin repeat domains protein 3B-deficient (Shank3B -/- ) mouse model displays ASD-related…

View details →DOI: 10.1007/s00213-025-06877-w
Negative / Null Result ReportOpen accessMedicine

No light, no problem: provision of light during simulated transport does not alter broiler chick performance or welfare outcomes.

McGregor D, Shynkaruk T, Adler CAB et al. · 2026 · Poultry science

Commercial transport of newly hatched poultry species typically occurs under darkness. The impact of providing light during chick transportation has not been investigated and previous research suggests blue light may have a calming effect…

View details →DOI: 10.1016/j.psj.2026.107110
Negative / Null Result ReportMedicine

Role of beta-blocker therapy on the sympathetic effects in stroke heart syndrome.

Prandin G, Naccarato M, Furlanis G et al. · 2025 · Clinical autonomic research : official journal of the Clinical Autonomic Research Society

Background Sympathetic activation, inflammation, and neuro-endocrine response after an ischemic stroke contribute to the development of the stroke heart syndrome (SHS). One marker of SHS is a troponin "rise and fall pattern" > 30%. Among…

View details →DOI: 10.1007/s10286-025-01139-3
Negative / Null Result ReportMedicine

Recommendations on the health outcomes of infant formula supplemented with biotics by the ESPGHAN Special Interest Group on Gut Microbiota and Modifications.

Dinleyici EC, Indrio F, Szajewska H et al. · 2026 · Journal of pediatric gastroenterology and nutrition

For many years, biotics (including probiotics, prebiotics, human identical milk oligosaccharides, synbiotics, and postbiotics) have been added to infant formula to influence the gut microbiota of formula-fed infants, aiming to bring it…

View details →DOI: 10.1002/jpn3.70195
Negative / Null Result ReportOpen accessMedicine

Factors associated with efficacy of occipital nerve stimulation in medically intractable chronic cluster headache.

Brandt RB, Lansbergen CS, Kollenburg L et al. · 2025 · Headache

Background/objective Occipital nerve stimulation (ONS) has become an established therapy for medically intractable chronic cluster headache (MICCH), but unfortunately, one third of the patients do not respond satisfactorily. Reliable…

View details →DOI: 10.1111/head.14985
Negative / Null Result ReportMedicine

Action observation with motor simulation of reactive stepping: A randomized study in older adults with a history of falls.

Hagedoorn L, Ruiz-Rodríguez A, Leijen I et al. · 2025 · Experimental gerontology

Background Perturbation-based training improves reactive stepping responses to prevent falling following a loss-of-balance. As there is currently no safe and feasible method for home-based practice, this randomized study investigated…

View details →DOI: 10.1016/j.exger.2024.112645
Negative / Null Result ReportMedicine

Lack of Effect of Antioxidants on Biopharmaceutics Classification System (BCS) Class III Drug Permeability.

Chiang Yu Y, Lu D, Rege B et al. · 2024 · Journal of pharmaceutical sciences

The addition of antioxidants to pharmaceutical products is a potential approach to inhibit nitrosamine formation, particularly in solid oral dosage forms like tablets and capsules. The objective was to assess the effect of ten antioxidants…

View details →DOI: 10.1016/j.xphs.2024.03.005
Negative / Null Result ReportOpen accessMedicine

Limited efficacy of a therapeutic anti-CD40 monoclonal antibody to inhibit activated CD4 T cell autoimmunity in vitro.

Gootjes C, Zwaginga JJ, Nikolic T et al. · 2026 · PloS one

Iscalimab is a nondepleting anti-CD40 monoclonal antibody, expected to suppress immune responses by blocking the costimulation by antigen-presenting cells through CD40-CD40L ligation. This therapeutic antibody indeed inhibited…

View details →DOI: 10.1371/journal.pone.0351131