Negative / Null Result ReportMedicine
S Krishnan V, Hodgetts SI, Harvey AR et al. · 2025 · Biogerontology
This two part study on the afferent connectivity of lumbar spinal motor neurons in normal ageing mice investigates; Study 1: time course analysis of age-related changes in the synaptic coverage of lumbar spinal cords of male C57BL/BJ mice…
View details →DOI: 10.1007/s10522-025-10348-2 Negative / Null Result Report
Gonotkov MA, Safiulina VF · 2026 · Preprint
Whole-cell patch-clamp studies often fail to observe the expected effect of melatonin on the IK1 current in cardiomyocytes, which may be due to cytoplasmic dialysis and the loss of key components of the intracellular signaling system. The…
View details →DOI: 10.64898/2026.02.04.703771 Negative / Null Result ReportMedicine
Borghero G, Pierri V, Pili F et al. · 2024 · Amyotrophic lateral sclerosis & frontotemporal degeneration
Objective To analyze disease-modifying effects of percutaneous endoscopic gastrostomy (PEG) insertion for supporting nutrition, noninvasive ventilation (NIV), and tracheostomy-assisted ('invasive') ventilation (TIV) in amyotrophic lateral…
View details →DOI: 10.1080/21678421.2024.2351185 Negative / Null Result ReportMedicine
Maiden MJ, Torpy DJ, Ludbrook GL et al. · 2024 · Experimental and therapeutic medicine
Triiodothyronine (T3) concentrations in plasma decrease during acute illness and it is unclear if this contributes to disease. Clinical and laboratory studies of T3 supplementation in disease have revealed little or no effect. It is…
View details →DOI: 10.3892/etm.2024.12611 Negative / Null Result ReportOpen accessMedicine
Nygaard B, Jensen CZ, Jorsal M et al. · 2025 · European thyroid journal
Objective Patients are increasingly using and requesting LT4/LT3 combination treatment for persistent hypothyroid symptoms, but the efficacy and side effects of long-term therapy remain largely unexplored. This study aimed to describe the…
View details →DOI: 10.1530/etj-24-0275 Negative / Null Result ReportMedicine
Cioe PA, Stang GS, Azam D et al. · 2025 · Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Introduction Smoking cessation rates in people with HIV (PWH) are lower than in the general population, even when evidence-based treatments are used. This 16-week study examined the feasibility, acceptability, and preliminary efficacy of…
View details →DOI: 10.1093/ntr/ntaf123 Negative / Null Result ReportMedicine
Parales-Girón JE, Dos Santos Neto JM, Lock AL · 2026 · Journal of dairy science
We evaluated the effects of whole cottonseed (WCS) and fatty acid (FA) supplementation on the production responses of early-lactation cows. Fifty-two multiparous cows were used in a randomized complete block design with a 2 × 2 factorial…
View details →DOI: 10.3168/jds.2025-26931 Negative / Null Result ReportOpen accessMedicine
Martin EL, Adarve-Rengifo I, Siddons SR et al. · 2026 · Ecology and evolution
Terrestrial leaf litter can release chemical compounds into the water, creating a solution called "leachate" that can have direct and indirect impacts on freshwater organisms. In this study, we investigated the direct effects of leaf…
View details →DOI: 10.1002/ece3.73668 Negative / Null Result ReportMedicine
Forde G, Ifantides KB, Mayadev A et al. · 2026 · Toxicon : official journal of the International Society on Toxinology
OnabotulinumtoxinA (onabotA) is approved for the treatment of various therapeutic indications, which require retreatment. In clinical practice, many patients receive onabotA for multiple therapeutic indications concomitantly over extended…
View details →DOI: 10.1016/j.toxicon.2025.108666 Negative / Null Result ReportMedicine
Anderbrant O, Huynh H, Isaksson A et al. · 2025 · Journal of Applied Entomology
Currant, and in particular blackcurrant, Ribes nigrum, is widely grown in Europe. It is the host of a number of pest insects, but their occurrence and the damage they cause vary geographically. In northern Europe, three lepidopteran…
Negative / Null Result Report
Xicota L, Cheng R, Barral S et al. · 2025 · Preprint
ABSTRACT Introduction Polygenic risk scores (PRS) have been used to assess an individual’s risk for various diseases, including Alzheimer’s disease (AD). This study applied the PRS approach to a cohort of families ascertained for healthy…
View details →DOI: 10.1101/2025.07.21.25331660 Negative / Null Result ReportMedicine
Quévreux P, Zou K, Barot S et al. · 2025 · Freshwater Biology
The classical concepts of top‐down and bottom‐up cascading effects in ecosystems are challenged by the interactions between green and brown food webs. The green food web relies on photosynthesis and the brown food web relies on the…
Negative / Null Result ReportMedicine
Amindarolzarbi A, Satcowitz K, Khalil A et al. · 2025 · Nuclear medicine communications
Objective The appropriate clinical management of indeterminate small renal masses can be improved based on accurate risk stratification. This study aimed to investigate the impact of renal function on the uptake of technetium-99m ( 99m…
View details →DOI: 10.1097/mnm.0000000000001960 Negative / Null Result ReportOpen accessMedicine
Brizuela M, Bony AR, Garcia-Caraballo S et al. · 2026 · Experimental physiology
Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage-gated calcium and potassium channels by G protein-coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the…
View details →DOI: 10.1113/ep093318 Negative / Null Result ReportMedicine
Lemper M, Luetjens CM, Fuchs A et al. · 2025 · Reproductive toxicology (Elmsford, N.Y.)
To further understand the safety profile of zilucoplan, reproductive toxicology studies in non-human primates (NHPs) were performed, including a male fertility study and a combined embryo-foetal development (EFD) and enhanced pre- and…
View details →DOI: 10.1016/j.reprotox.2025.108877 Negative / Null Result ReportOpen accessMedicine
Alshuweishi Y, Binzomah Alghamdi F, Patrick K et al. · 2025 · Cells
AMP-activated protein kinase (AMPK) is activated by reduced cellular energy charge and mimics the action of insulin in muscle by stimulating increased trafficking of GLUT4 to the plasma membrane. In contrast, we have previously reported…
View details →DOI: 10.3390/cells14221811 Negative / Null Result Report
Kishinevsky M, Ferrer-Suay M, Ives AR · 2024 · Preprint
The enemy release hypothesis, that the success of invading species is due to release from natural enemies that occur in their home range but not in the new range, can be an important explanation for successful invasions. Testing this…
View details →DOI: 10.1101/2024.11.05.621954 Negative / Null Result ReportMedicine
Almutairi NM, Hayes J, Hampson KM et al. · 2025 · Vision research
Individuals with mild traumatic brain injury (mTBI) exhibit significant accommodative abnormalities. Accommodation microfluctuation (MFs) plays an important role in the accommodation steady-state control. This study was set to investigate…
View details →DOI: 10.1016/j.visres.2025.108545 Negative / Null Result ReportOpen accessMedicine
Kim AR, Jamka J, Jackson WF et al. · 2026 · Cells
Anticontractile factors secreted by perivascular adipose tissue (PVAT) play an important role in regulating vascular tone. This process is driven by the neurotransmitter norepinephrine (NE), but recent data show that adrenergic innervation…
View details →DOI: 10.3390/cells15100906 Negative / Null Result ReportMedicine
Mockett BG, Davies JWT, Mills ZB et al. · 2024 · Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Group I metabotropic glutamate receptors (Gp1-mGluRs) exert a host of effects on cellular functions, including enhancement of protein synthesis and the associated facilitation of long-term potentiation (LTP) and induction of long-term…
View details →DOI: 10.1098/rstb.2023.0481 Negative / Null Result ReportOpen accessMedicine
Fu SJ, Cheng KM, Hsiao CT et al. · 2024 · Cell communication and signaling : CCS
Loss-of-function mutations in the human gene encoding the neuron-specific Ca 2+ channel Ca V 2.1 are linked to the neurological disease episodic ataxia type 2 (EA2), as well as neurodevelopmental disorders such as developmental delay and…
View details →DOI: 10.1186/s12964-024-01960-9 Negative / Null Result ReportOpen accessMedicine
Videtta G, Sasia C, Quadrino S et al. · 2026 · Molecules (Basel, Switzerland)
Activation of microglia and resulting neuroinflammation are central processes that significantly contribute to neurodegenerative disease progression. Treatments capable of attenuating neuroinflammation are therefore an urgent medical need.…
View details →DOI: 10.3390/molecules31010196 Negative / Null Result ReportOpen accessMedicine
Nguyen AP, Hadi DL, Todd DA et al. · 2026 · Clinical pharmacology and therapeutics
Cinnamon (Cinnamomum spp.) is used as a culinary spice and dietary supplement. A major constituent, cinnamaldehyde, was previously shown to inactivate cytochrome P450 (CYP) 2A6 in vitro. A mechanistic static model predicted an ~5-fold…
View details →DOI: 10.1002/cpt.70218 Negative / Null Result ReportOpen accessMedicine
Burman MA, Zuke JT · 2026 · PloS one
Early life pain and stress have lasting consequences on nervous system development that can interact with later stress or trauma to create a susceptibility to fear, anxiety, depression and chronic pain among other psychological disorders.…
View details →DOI: 10.1371/journal.pone.0326300 Negative / Null Result ReportOpen accessMedicine
Kim TE, Bae JW, Hong S et al. · 2025 · The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology
Donepezil, an acetylcholinesterase inhibitor, is widely used for managing the symptoms of Alzheimer's disease (AD), yet its clinical response varies widely among individuals. This study aims to investigate the influence of CYP2D6 genetic…
View details →DOI: 10.4196/kjpp.24.239 Negative / Null Result ReportOpen accessMedicine
Hu Q, Zhong W, Hu R · 2026 · Inquiry : a journal of medical care organization, provision and financing
Research on income inequality and obesity shows inconsistent results. This study tests if this relationship depends on a country's existing inequality level. We analyzed individual-level data (N = 22 938) from the 2011 and 2021…
View details →DOI: 10.1177/00469580261444418 Negative / Null Result ReportOpen accessMedicine
Abkur T, Boogers A, Grippe T et al. · 2025 · Movement disorders clinical practice
Background The coexistence of tics with Parkinson's disease (PD) is rare, as they often emerge at different ages, follow different trajectories and involve contrasting pathophysiological mechanisms related to dopamine availability and…
View details →DOI: 10.1002/mdc3.70111 Negative / Null Result ReportMedicine
Leproult I, Lemaire B, Portrat S · 2024 · Memory & cognition
Elaboration has emerged as a potential maintenance mechanism involved in the substantial contribution of long-term memory (LTM) to working memory (WM) performance. The objective of the current study was to determine whether elaborative…
View details →DOI: 10.3758/s13421-024-01615-7 Negative / Null Result ReportOpen accessMedicine
Lee KE, Nishi M, Kim J et al. · 2024 · Frontiers in endocrinology
Rationale MG53's known function in facilitating tissue repair and anti-inflammation has broad applications to regenerative medicine. There is controversy regarding MG53's role in the development of type 2 diabetes mellitus. Objective This…
View details →DOI: 10.3389/fendo.2024.1425426 Negative / Null Result ReportOpen accessMedicine
Krakowian D, Lach M, Żemła P et al. · 2025 · Cytotechnology
The HeLa 9903 cell line is used in the in vitro endocrine disruption assay (OECD 455). After treatment with an estrogen receptor agonist, the luminescence of these cells increases. However, some autoactivation of this test system may…
View details →DOI: 10.1007/s10616-025-00817-4 