e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20240 results in Negative / Null Result Report · page 390 of 675

Negative / Null Result ReportOpen accessMining engineering. Metallurgy

Development and Validation of Virtual Reality Application in Mining Education

Yutaka ITO, Masato TAKEUCHI, Shuto MIKAMI et al. · 2020 · Journal of MMIJ

Productivity, safety and its improvement is also an integral part of a good mining operation. In recent times, due to constraints on time and cost, it has become increasingly harder to conduct training and safety inductions at mine sites. For the purpose of overcoming these limitations, the use of virtual reality (VR) is proposed for mining education and training. VR has already been introduced in the education and training of miners overseas, and quantitative studies on the effects of using VR for miner's education and training have been made. However, Japan has only one such application

View details →DOI: 10.2473/journalofmmij.136.33
Negative / Null Result ReportOpen accessMedicine

Effect of secukinumab dose escalation on MRI-detected inflammation and structural damage in axial spondyloarthritis: a clinical, investigator-initiated, treat-to-target study (TRACE)

Oliver Hendricks, Mikkel Østergaard, Susanne Juhl Pedersen et al. · 2026 · RMD Open

Introduction Evidence of treat-to-target strategies including secukinumab dose escalation in patients with axial spondyloarthritis (axSpA) remains limited. We investigated the effect of a treat-to-target approach aiming for Axial Spondyloarthritis Disease Activity Score (ASDAS) remission, assessed by clinical and MRI outcomes over 24 weeks.Methods TRACE was a multicentre study including biologic-naïve patients with active axSpA. Sixteen weeks after secukinumab 150 mg initiation, patients in ASDAS remission (<1.3)(week 16 remitters) continued the same dose, while non-remitters (week 16 non-remi

View details →DOI: 10.1136/rmdopen-2026-006774
Negative / Null Result Report

The Ki67 index of preoperative breast cancer puncture is correlated with lymph node metastasis, ER, PR and AR expression: A retrospective study of real world data

Zhang X, Liu X, Wang L et al. · 2026 · Preprint

Abstract Objective Breast cancer is a prevalent malignant disease among women. Currently, the primary clinical treatment strategies involve classifying breast cancer based on the expression of Ki67, estrogen receptor (ER), progesterone…

View details →DOI: 10.21203/rs.3.rs-9088621/v1
Negative / Null Result ReportOpen accessMedicine

Analysis of the correlation between thyroid hormones and thyroid volume by gender: A volumetric computed tomography study

Serkan Oner, Yusuf Secgin, Zulal Oner et al. · 2022 · Medicine Science

The aim of this study was to evaluate the correlation between triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) hormones and thyroid gland volume with volumetric analysis performed by using computed tomography (CT) images. In this retrospective study, IV contrasted thoracic CT images taken for different indications between 2019 January and 2020 January were scanned from the archive system of the hospital. 67 (31F, 36M) individuals chosen randomly among patients whose CT results were reported as normal and who had taken thyroid hormone tests within the past week were

View details →DOI: 10.5455/medscience.2022.02.037
Negative / Null Result ReportOpen accessSports

Associations between postural orientation errors in patients undergoing rehabilitation for ACL reconstruction and future patient-reported outcomes: An explorative study

Anna Cronström, Eva Ageberg, Erika Zeraidi et al. · 2023 · JSAMS Plus

Objective: To investigate associations between postural orientation errors (POEs) in patients undergoing rehabilitation for anterior cruciate ligament reconstruction (ACLR) and patient-reported outcomes (PROMs) at 2-year follow-up. Design: Prospective cohort study. Methods: Fifty-three participants (mean (SD) 27 (6.5) years, 24 women), (mean (range) 7 (4–10) months post ACLR) were included. At baseline, all participants were visually assessed for POEs using a validated test battery. The POE subscales Activities of Daily Living and Sport were used in the analysis. At 2-years, the following PROM

View details →DOI: 10.1016/j.jsampl.2023.100039
Negative / Null Result ReportOpen accessSurgery

Investigating the effect of serum level of uric acid on the immunogenicity of hepatitis B vaccination in dialysis patients

Nasibe Golestani, Najmeh Shamspour, Jalal Azmandian et al. · 2024 · Egyptian Liver Journal

Abstract Introduction HBV infection is a significant concern in dialysis patients, influenced by various factors. This study aims to investigate the impact of serum uric acid levels on the immunogenicity of hepatitis Bvaccination in dialysis patients. Method A cross-sectional study was conducted, involving 125 hemodialysis patients. Prior to dialysis, assessments were made for uric acid, vitamin D, HBsAg, andHBsAb. Patients were divided into two groups based on uric acid levels: high level (≥ 6.5 mg/dl) and low level ( 10). In patients with low uric acid, 1 (7.7%) had low HBsAb and 12 (92.3%)

View details →DOI: 10.1186/s43066-024-00328-5
Negative / Null Result ReportOpen accessMedicine

Left ventricular myocardial deformation assessment in asymptomatic patients with recently diagnosed sarcoidosis of the respiratory tract and/or extrapulmonary sarcoidosis

Roman Panovský, Martina Doubková, Mary Luz Mojica-Pisciotti et al. · 2021 · Orphanet Journal of Rare Diseases

Abstract Background Sarcoidosis is a systemic granulomatous disease affecting different organs including the heart. Myocardial strain analysis could potentially detect the early stages of cardiac dysfunction in sarcoidosis patients. The present study aims to assess the use of cardiac magnetic resonance (CMR) strain analysis using feature tracking (FT) in the detection of early cardiac involvement in asymptomatic patients with sarcoidosis. Methods One hundred and thirteen CMR studies of patients with sarcoidosis of the respiratory tract and/or extrapulmonary sarcoidosis without pre-existing kno

View details →DOI: 10.1186/s13023-021-02038-2
Negative / Null Result ReportOpen accessPublic aspects of medicine

Interaction of household air pollution and healthy lifestyle on the risk of sarcopenia: China Health and Retirement Longitudinal Study

Tao Zeng, Xinliang Liao, Jie Wu · 2025 · Environmental Health and Preventive Medicine

Background: Exposure to air pollution and adherence to a healthy lifestyle have been identified to be related to sarcopenia. However, the interactive effects between these two factors remain insufficiently elucidated. The present study was designed to investigate the potential interaction exposure to air pollution with healthy lifestyle on the risk of developing sarcopenia. Methods: In the retrospective cohort study, all data was extracted from China Health and Retirement Longitudinal Study. Household air pollution was assessed based on the utilization of solid fuels for cooking and heating. A

View details →DOI: 10.1265/ehpm.24-00280
Negative / Null Result ReportOpen accessMedicine (General)

Evaluating ovarian blood supply anatomy and variability via digital subtraction angiography in patients with cesarean scar pregnancy undergoing uterine artery embolization

Guo Zheng, Huiling Gao, Zhao Jin et al. · 2026 · Frontiers in Medicine

BackgroundPreservation of ovarian perfusion is a critical consideration during uterine artery embolization (UAE), as inadvertent disruption can reduce ovarian reserve. Given the complex and variable anatomy of ovarian blood supply, this study aimed to characterize its anatomical origins and variations using digital subtraction angiography (DSA) in patients undergoing UAE for cesarean scar pregnancy (CSP).MethodsThis retrospective study included patients with type II or III CSP who underwent first-time UAE at Heibei Maternity Hospital, China, between August 2020 and October 2024. Pre-embolizati

View details →DOI: 10.3389/fmed.2026.1730033
Negative / Null Result ReportOpen accessHuman anatomy

Odontoid process angulation range in a South African skeletal population sample: An osteological study

Ricardo Jonker, Glen J. Paton, Shahed Nalla · 2025 · Translational Research in Anatomy

Background: This study investigated the angulation of the odontoid process in a South African skeletal population to establish normative vertical angulation in the sagittal plane and assess variations across population affinity groups, biological sexes, and age categories. The study also investigated standardizing techniques for measuring the angle of the odontoid process. Methods: A cross-sectional study was conducted on 200 cervical axis vertebrae from the Raymond A. Dart Collection. Angulation measurements were taken using digital photographs, ImageJ software and statistical analyses (one-w

View details →DOI: 10.1016/j.tria.2025.100388
Negative / Null Result ReportOpen accessMedicine

Interventions that support women, girls, and people who menstruate to participate in physical activity: a rapid overview of reviews.

Csontos J, Brown N, Edwards A et al. · 2026 · BMC public health

BACKGROUND: Adults (age 18–64 years) are recommended 150–300 min of moderate-to-vigorous or 75–150 min of vigorous-intensity physical activity per week. Irrespective, the number of women not meeting recommended physical activity is 5%…

View details →DOI: 10.1186/s12889-026-27122-9
Negative / Null Result ReportOpen accessMedicine

Recovery and Return to Sport in Pediatric Osteochondral Defects of the Knee: Evaluating the Influence of Lesion Size.

Corcoran E, Samuel Z, Force A et al. · 2026 · Orthopaedic journal of sports medicine

Background Osteochondral defects (OCDe) of the knee in pediatric patients can significantly impact long-term joint function. This study aimed to evaluate the impact of lesion size on patient characteristics, treatment decisions, and…

View details →DOI: 10.1177/2325967126s00110
Negative / Null Result ReportOpen accessMedicine

Antibiotic-free short-term storage of canine sperm at 5 °C preserves functional and mitochondrial integrity.

Castro M, Carrasco-Zambrano N, Pezo F et al. · 2026 · Frontiers in veterinary science

The routine prophylactic use of antibiotics in sperm preservation for reproductive biotechnologies poses increasing concerns due to its potential role in promoting antimicrobial resistance. Therefore, developing storage systems that…

View details →DOI: 10.3389/fvets.2026.1774926
Negative / Null Result Report

Individual and Interaction Effects of Mechanization and Crop-Livestock Diversification on Household Dietary Diversity in Arsi Zone, Oromia Regional State, Ethiopia

Abebe GM, Demissie WM, Zewdie MC · 2026 · Preprint

Abstract Mechanization has immense potential to improve agricultural productivity and overall production, while crop–livestock diversification plays a crucial role in enhancing nutrition security; however, the combined effects of…

View details →DOI: 10.21203/rs.3.rs-10046750/v1
Negative / Null Result ReportOpen accessMedicine

Examining the Impact of Trial Length on Detecting Medication Effects for Alcohol Use Disorder: A Meta-Regression Study.

Belnap MA, Witkiewitz K, Schacht JP et al. · 2026 · Alcohol, clinical & experimental research

Background The U.S. Food and Drug Administration (FDA) recommends a minimum duration of 6 months for randomized controlled trials (RCTs) evaluating pharmacotherapies for alcohol use disorder (AUD). The relationship between trial length and…

View details →DOI: 10.1111/acer.70306
Negative / Null Result Report

Olfactory notes in the mind space

Caldana M, Rusconi E · 2026 · Preprint

Olfaction is one of our most archaic senses but its central mechanisms are lesser known than those of other senses. In this work, we address a possible link between olfactory stimuli and mental spatial representations. Although olfactory…

View details →DOI: 10.31234/osf.io/nk3ty_v4
Negative / Null Result ReportOpen accessMedicine

The ameliorative effects of <i>Myrmecodia</i> sp. as an antibiotic growth promoter in broiler chicken with avian pathogenic <i>Escherichia coli</i> infection.

Lisnanti EF, Lokapirnasari WP, Al-Arif MA et al. · 2025 · Open veterinary journal

Background Broiler livestock supports the fulfillment of animal protein in a country where the meat price is affordable for the wider population. However, its progress faces numerous challenges, with colibacillosis, induced by APEC, being…

View details →DOI: 10.5455/ovj.2025.v15.i11.41
Negative / Null Result ReportOpen accessMedicine

Acute Creatine Ingestion Before Resistance Training Enhances Strength Performance More than Ingestion During or After Training: A Randomized Crossover Pilot Trial.

Ben Maaoui K, Delleli S, Jebabli A et al. · 2026 · Nutrients

Background/Objectives : Although creatine (Cr) supplementation is well established for enhancing strength exercise adaptations, limited evidence exists regarding whether the timing of a single Cr dose relative to exercise acutely…

View details →DOI: 10.3390/nu18111789
Negative / Null Result Report

Effectiveness of Emotion Self-Regulation Training in Reducing Risk-Taking Behaviors Among Adolescent Girls Dependent on Social Media

Rahmani N, Bahramkhani M, Alizadeh A et al. · 2026 · Preprint

Abstract Background: Social media dependency and risk-taking behaviors are common among adolescents, especially girls. Excessive social media use can lead to negative consequences, including increased risky behaviors. This study evaluated…

View details →DOI: 10.21203/rs.3.rs-9854238/v1
Negative / Null Result ReportMedicine

Effect of Variation in Extended Depth-Of-Focus Design on Myopia Control and Visual Function in Japanese Children.

Ninomiya S, Koh S, Ueshima S et al. · 2026 · Eye & contact lens

Objectives To evaluate the efficacy of extended depth-of-focus (EDOF) soft contact lenses with different optical profiles in controlling myopia progression and their effect on visual function in Japanese children. Methods In this 12-month…

View details →DOI: 10.1097/icl.0000000000001294
Negative / Null Result ReportMedicine

Altermagnetic and Dipolar Splitting of Magnons in FeF_{2}.

Sears J, Garlea VO, Lederman D et al. · 2026 · Physical review letters

FeF_{2} is a prototypical rutile antiferromagnet recently proposed as an altermagnet, with a magnetic symmetry that permits spin-split electronic bands and chiral magnons. Using very-high-resolution inelastic neutron scattering on a single…

View details →DOI: 10.1103/g6dt-rf8c
Negative / Null Result ReportMedicine

The mediating role of job performance and satisfaction in the effect of digital leadership on heavy workload among healthcare workers.

Sağbaş M, Oktaysoy O, Topcuoglu E · 2026 · Journal of health organization and management

Purpose This study aims to investigate the mediating roles of job performance and job satisfaction in the effect of digital leadership on heavy workloads among healthcare workers. By focusing on the phenomenon of leadership in digital…

View details →DOI: 10.1108/jhom-06-2025-0301
Negative / Null Result ReportMedicine

Visual-Spatial Influences on Vocal Intensity: Effects of Speaker-to-Listener Distance and Room Size in Immersive Virtual Reality.

Daşdöğen Ü, Hitchcock J, Ahn S et al. · 2026 · Journal of speech, language, and hearing research : JSLHR

Objectives The aim of this study was to investigate the effects of speaker-to-listener distance versus room size on individuals' voice perception and production using immersive virtual reality (IVR). Method Fifteen vocally healthy…

View details →DOI: 10.1044/2026_jslhr-25-00798