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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

AllReplication FailureNegative / Null Result ReportFailed Experiment ReportAbandoned HypothesisMethods Dead-EndShort NoteNull DatasetProtocol

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

By fieldMedicine 12,264Computer Science 750Biochemistry, Genetics and Molecular Biology 431Social Sciences 305Psychology 304Physics 280Neuroscience 254Economics, Econometrics and Finance 199Environmental Science 177Mathematics 159Engineering 143Agricultural and Biological Sciences 142

19859 results in Negative / Null Result Report · page 388 of 662

Negative / Null Result ReportMedicine

Exploring an integrated group psychotherapy-exercise program for multiple sclerosis: a non-randomized pilot study.

Abelovska, Malinova, Sucha et al. · 2026 · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

This pilot study evaluated "Your Health Belongs to You," a six-week group intervention combining psychotherapy and exercise to improve quality of life, emotional health, and symptom management in individuals with Multiple Sclerosis (MS),…

View details →DOI: 10.1007/s10072-026-09130-0
Negative / Null Result ReportMedicine

MMP-9 Genotypes Serve as Oral Cancer Predictive Marker for Smokers.

Shih, Hsu, Yang et al. · 2026 · Anticancer research

Oral cancer represents a major health burden in Taiwan, with tobacco use, alcohol consumption, and betel quid chewing recognized as predominant environmental risk factors. Matrix metalloproteinase-9 (MMP-9) has been implicated in tumor…

View details →DOI: 10.21873/anticanres.18191
Negative / Null Result ReportMedicine

Effects, Acceptability, and Use of a Dynamically Tailored Mobile What Do You Drink Intervention to Reduce Excessive Drinking Among Adolescents and Young Adults in the Netherlands: Randomized Controlled Trial.

van Keulen, Voogt, Kleinjan et al. · 2026 · JMIR mHealth and uHealth

Excessive alcohol consumption among adolescents and young adults is a serious health problem. Dynamically tailored interventions could reduce their excessive drinking. We therefore developed "What Do You Drink" (WDYD), a 17-week…

View details →DOI: 10.2196/68468
Negative / Null Result ReportMedicine

Comparison of Submental Muscle Activation and Tongue Pressure of Tongue Hold, Effortful Swallow and Mendelsohn Maneuvers in Different Gravitational Positions.

Cengiz, Yıldırım, Yaşaroğlu et al. · 2026 · Dysphagia

This study aimed to investigate the effects of Tongue Hold Maneuver (THM), Mendelsohn Maneuver (MM), and Effortful Swallow Maneuver (ESM) performed under different gravitational positions (90° sitting, 45° sitting, supine, and…

View details →DOI: 10.1007/s00455-026-10961-4
Negative / Null Result ReportMedicine

Improving ricotta cheese shelf life using saffron petal extract double nanoemulsions stabilized by plant proteins and Lepidium sativum L. gum.

Bakhshalipoor, Bolandi, Nahidi et al. · 2026 · Scientific reports

This study evaluated the effects of double nanoemulsions of saffron petal extract (DN-SPE), stabilized with soybean (SPI) and pea protein isolates (PPI), alone or combined with Lepidium sativum L. seed gum (LSG) (SL or PL), on the quality…

View details →DOI: 10.1038/s41598-026-52693-3
Negative / Null Result ReportMedicine

Cholinesterase activity determines the action potential-dependent increase in glycine receptor-mediated inhibitory synaptic transmission in the substantia gelatinosa of the spinal trigeminal nucleus of the rat.

Kawamura, Masaki, Kato · 2026 · Journal of pharmacological sciences

Acetylcholine-mediated modulation of pain-associated behaviors has been progressively well described. The mechanisms of cholinergic antinociception have been reported to involve the activation of nAChRs or mAChRs modulating GABAergic…

View details →DOI: 10.1016/j.jphs.2026.05.002
Negative / Null Result ReportMedicine

Astrocyte inhibition impacts metaplasticity in the hippocampal CA 1 area following traumatic brain injury.

Rezagholizadeh, Tavassoli, Saeedi et al. · 2026 · Brain research bulletin

Traumatic Brain Injury (TBI) is an important contributing factor to cognitive impairment, frequently linked to disturbances in synaptic plasticity and metaplasticity. Astrocytes, as essential regulators of synaptic function, are crucial…

View details →DOI: 10.1016/j.brainresbull.2026.111954
Negative / Null Result ReportMedicine

The Relationship Between Frailty and Care Dependency in Patients with Diabetic Foot Ulcers: A Structural Equation Modeling Approach.

Gurcay, Bilgin, Sert et al. · 2026 · Advances in skin & wound care

Frailty, resulting from physical and psychological factors, may lead to the development of care dependency in people diagnosed with diabetic foot. This study was conducted to determine frailty and care dependency in patients diagnosed with…

View details →DOI: 10.1097/asw.0000000000000461
Negative / Null Result ReportMedicine

Smartphone-delivered cognitive behavioral therapy for subthreshold depression with physical comorbidities: Evidence from the RESiLIENT trial.

Cui, Luo, Tajika et al. · 2026 · Journal of affective disorders

This study aimed to examine the effectiveness of smartphone-delivered cognitive behavioral therapy (CBT) in participants with subthreshold depression, considering the potential influence of physical comorbidities. In this secondary…

View details →DOI: 10.1016/j.jad.2026.121954
Negative / Null Result ReportMedicine

The impact of universal credit on mental, physical, and financial well-being: longitudinal evidence from the UK household longitudinal survey.

Bai, Kim, Cao et al. · 2026 · Social psychiatry and psychiatric epidemiology

Universal Credit (UC) is a major UK welfare reform that consolidates six means-tested benefits into a single monthly payment, aiming to simplify benefits delivery and incentivize labor market participation. However, concerns have emerged…

View details →DOI: 10.1007/s00127-026-03108-1
Negative / Null Result ReportMedicine

Comparative bio-efficacy and molecular insights of North-Western Himalayan conifers, Cedrus deodara and Juniperus macropoda essential oils against two storage insect pests.

Guleria, Horijan, Kumar et al. · 2026 · Scientific reports

The study aimed to evaluate fumigation and repellent properties of essential oils (EOs) from Juniperus macropoda leaves and cedarwood, Cedrus deodara against storage pests viz., Tribolium castaneum and Callosobruchus maculatus. Further,…

View details →DOI: 10.1038/s41598-026-52009-5
Negative / Null Result ReportMedicine

Age-Related Hearing Loss and Cognition: The Role of Bilingualism.

Heidari, Amiri, Mobarakeh · 2026 · Journal of speech, language, and hearing research : JSLHR

Age-related hearing loss (ARHL) has been associated with cognitive decline. Although bilingualism may influence cognitive performance, its interaction with hearing loss remains unclear. This study aimed to investigate the effects of ARHL…

View details →DOI: 10.1044/2026_jslhr-25-00649
Negative / Null Result ReportMedicine

Retrospective Propensity-Matched Comparison of Noninvasive Positive Pressure Ventilation Versus High-Flow Nasal Cannula on Reintubation Rates in Neurosurgical Intensive Care Patients.

Wang, Lv, Zeng et al. · 2026 · Neurocritical care

This study compared the effectiveness of noninvasive positive pressure ventilation (NIPPV) and high-flow nasal cannula (HFNC) in preventing reintubation among neurosurgical intensive care patients following extubation. A retrospective…

View details →DOI: 10.1007/s12028-026-02495-2
Negative / Null Result ReportMedicine

Impact of various forms of vitamin D on endothelial dysfunction triggered by high glucose conditions in Wistar rats.

Le Jan, Gourmelon, Destrumelle et al. · 2026 · Microvascular research

Endothelial dysfunction (ED) is a hallmark of metabolic disturbances such as Metabolic Syndrome (MetS), where oxidative stress and reduced nitric oxide (NO) bioavailability play key roles. High glucose (HG), a major metabolic alteration in…

View details →DOI: 10.1016/j.mvr.2026.104960
Negative / Null Result ReportMedicine

Effect of Iron-Containing Micronutrient Powders on Growth and Malaria-Induced Anaemia Among Preschool Children in Ghana: A Cluster-Randomized, Double-Blind, Placebo-Controlled Trial.

Tchum, Koto, Kanyoke et al. · 2026 · medRxiv : the preprint server for health sciences

Affecting 40% of infants and young children worldwide, anaemia in sub-Saharan Africa hampers cognitive and physical development, often in ways that cannot be reversed. Iron-based micronutrient powders (MNPs) are recommended to combat…

View details →DOI: 10.64898/2026.04.24.26351649
Negative / Null Result ReportMedicine

Integrating UTAUT and TTF models with personal innovativeness to examine smart home appliance adoption for sustainable consumption.

Wang, Chao, Chen et al. · 2026 · Scientific reports

Smart home appliances are pivotal for advancing energy efficiency and environmental sustainability; however, their widespread adoption faces complex psychological and functional barriers. This study investigates the key determinants of…

View details →DOI: 10.1038/s41598-026-51248-w
Negative / Null Result ReportMedicine

Effect of crossword puzzle on nursing students' willingness to work with older adults and gerontological nursing competence: A waiting list randomized controlled trial.

Erdoğan, Ayaz-Alkaya · 2026 · Nurse education in practice

To evaluate the effect of crossword puzzle activities on nursing students' willingness to work with older adults and their competence in gerontological nursing. Although crossword puzzles are widely used learning tools, their effects in…

View details →DOI: 10.1016/j.nepr.2026.104844
Negative / Null Result ReportMedicine

Effects of Diet Composition and Yeast Cell Wall Supplementation on Ruminal Fermentation, Gas Kinetics, Methane Production and Digestibility Assessed In Vitro Using Gas Production and Daisy II Incubator Systems.

Ramay, Bundur, Riaz et al. · 2026 · Veterinary medicine and science

Optimizing ruminant diets and mitigating methane emissions using feed additives like yeast cell wall is of growing significance in animal nutrition. The present study aimed to evaluate the effects of varying roughage-to-concentrate (R:C)…

View details →DOI: 10.1002/vms3.70978
Negative / Null Result ReportMedicine

Plasma chaperone-mediated autophagy associated protein HSPA8 combined with white matter hyperintensities serves as the predictive marker of early-stage Alzheimer's disease.

Yan, Liang, Zhou et al. · 2026 · Frontiers in aging neuroscience

The relationship between plasma chaperone-related autophagy proteins and white matter hyperintensity (WMH) in Alzheimer's disease (AD) remains unclear. We employed 4D-DIA proteomics to identify plasma protein changes, and evaluated the…

View details →DOI: 10.3389/fnagi.2026.1753692
Negative / Null Result ReportMedicine

Tumor-derived complement C3 overexpression in STK11-mutant lung adenocarcinoma drives tumor growth and immune checkpoint inhibitor resistance.

Suzuki, Kandar, Ting et al. · 2026 · Cancer immunology research

Loss-of-function STK11 mutations occur in 15-20% of lung adenocarcinomas (LUAD) and correlate with immunotherapy failure and worse survival. By integrating analysis of human tumor samples, a human LUAD cell line panel, and CCLE and TCGA…

View details →DOI: 10.1158/2326-6066.cir-25-0534
Negative / Null Result ReportMedicine

Synergistic Effects of IMP-1700, Ciprofloxacin, and X-Ray Radiation in Bacteria and Mammalian Cell Lines: Implications for Use in Antimicrobial-Resistant Bacteria.

Andersen, Sloth, Bøgestad et al. · 2026 · MicrobiologyOpen

IMP-1700 was developed as a compound designed to target bacterial DNA repair-associated pathways, including homologous recombination mediated by the AddAB/RecBCD system. While its antibacterial properties are well established, the…

View details →DOI: 10.1002/mbo3.70270
Negative / Null Result ReportMedicine

Differential predictors of smoking quit attempts between single- and poly-tobacco-using adolescents: a Korean national survey analysis.

Kang, Lee, Choi et al. · 2026 · Frontiers in public health

Despite the rapid rise in adolescent poly-tobacco use, evidence on what drives quit attempts in this high-risk group remains limited compared to single-product users. This study identifies these differential predictors using a…

View details →DOI: 10.3389/fpubh.2026.1727685