A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19859 results in Negative / Null Result Report · page 387 of 662
Chantre-Justino M, Silvestre RT, Delmonico L et al. · 2026 · World journal of oncology
Background Bone sarcomas are rare and heterogeneous malignant neoplasms of mesenchymal origin, often associated with poor clinical outcomes. Being rare neoplasms, a comprehensive analysis of the molecular mechanisms involved in the tumor…
Akyuz C, Sunamak O, Selman A et al. · 2026 · Journal of clinical medicine
Background : Signet-ring cell colorectal cancer (SRCC) and colorectal cancer with a signet-ring cell component (SRC) are rare histological subtypes associated with poor prognosis. Although these entities are classified separately based on…
Fuchida H, Sawada D, Hirota T et al. · 2026 · Toxicology reports
Objective Lactobacillus gasseri CP2305 (L. gasseri CP2305) has been reported to exert intestinal regulatory, anti-stress, and sleep-improving effects in healthy adults. This study aimed to evaluate the safety of an excessive intake of L.…
Alheany ARA, Abdulkareem AZ, Abdullah ZA et al. · 2026 · Asian Pacific journal of cancer prevention : APJCP
Background Hodgkin lymphoma (HL) arises from germinal center B cells through complex viral, genetic, and environmental factors. This study examines HHV-6B infection and the IL-18 rs1946518 polymorphism as potential contributors to…
Balasekaran G, Boey P, Ng YC · 2026 · Preprint
Abstract Purpose To develop and validate the OMNI RPE Color-Face Scale (CFS) on adults. Methods A total of 28 healthy participants were recruited for the study which involved scale development and validation. Scale development –…
McCoy J, Gatt D, Shaw M et al. · 2026 · Pediatric pulmonology
Rationale Primary ciliary dyskinesia (PCD) is a phenotypically diverse disease; the impact of nutritional status on clinical trajectories in patients with PCD is not well defined. The aim of this study is to examine the impact of…
Liu J, Wu Y, Yang D et al. · 2026 · BMC medical imaging
BACKGROUND: Glomerulonephritis (GN) is a major contributor to chronic kidney disease, highlighting the need for reliable biomarker to monitor GN. This study aimed to evaluate the potential of diffusion kurtosis imaging (DKI) for dynamic…
Ojinnaka GC, Okoye OI, Ojinnaka NC et al. · 2026 · Journal of tropical pediatrics
To compare the academic performance of urban primary school children with strabismus and/or amblyopia seen at the Eye Clinic of University of Nigeria Teaching Hospital (UNTH), Ituku-Ozalla, Enugu, Nigeria, with that of their controls. In…
Ji RT, Xie XF, Jia ZY et al. · 2026 · Huan jing ke xue= Huanjing kexue
Cultivating salt-tolerant rice （STR） is an effective approach to ameliorating coastal saline soils （CSL）. In this study， the CSL without STR cultivation served as the control （CK）， while soils with different rice cultivation years （1-5…
Duke DJ, Wang H, Rao L et al. · 2026 · International journal of pharmaceutics
Design of the mouthpiece of a pressurised metered dose inhaler is generally informed by patient needs, followed by manufacturing and product differentiation considerations. However, relatively few studies have investigated whether the size…
Gonsalves V, Flake C, West D et al. · 2026 · Annals of dyslexia
Practitioner knowledge about dyslexia is related to improved educational practices, but few measures of dyslexia knowledge have been validated with rigorous processes. The current study developed the Dyslexia Assessment and Intervention…
Dantagnan CA, Salem C, Charavet C et al. · 2026 · American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics
Introduction This study aimed to compare the effect of artificial saliva (AS) aging on the trueness and precision of direct-printed aligners vs thermoformed aligners. Methods Four types of aligners were manufactured from the same reference…
Chen Z, He S, Li C et al. · 2026 · Preprint
Abstract Objectives To evaluate the diagnostic accuracy of anterior joint space widening on Cone Beam Computed Tomography (CBCT) for identifying anterior disc displacement (ADD) of the temporomandibular joint (TMJ), using Magnetic…
Bettiol NB, de Carvalho FA, Siessere S et al. · 2026 · Dentistry journal
Background: The relationship between facial aesthetic procedures and changes in the stomatognathic system has attracted increasing interest, motivating investigations into their functional and structural impacts. This longitudinal…
Lee D, Koo J, Jeon H et al. · 2026 · AAPS PharmSciTech
Tofacitinib (Tofa), a Biopharmaceutics Classification System Class III drug, exhibits pH-dependent solubility and a strong tendency to agglomerate, potentially affecting tablet uniformity, in vitro dissolution behavior, and in vivo…
Nguyen DV, Nguyen HTT · 2026 · JACC. Asia
Background Evidence regarding the effect of mineralocorticoid receptor antagonist therapy on the risk of new-onset diabetes remains inconsistent. Objectives This study aimed to examine the effect of spironolactone on the risk of incident…
Baldeon-Calisto M, Perez-Pérez N, Guevara C · 2026 · Physics in medicine and biology
Objective. Vision foundation models (FMs) have shown strong potential for adapting to diverse downstream tasks without specialized fine-tuning. However, their performance in head and neck cancer (HNC) tumor segmentation remains…
Ansorena X, Quiñones I, Hernandez M et al. · 2026 · Preprint
Purpose: We present the clinical case of AB, a right-handed individual who experienced a stroke affecting the right temporo-parietal cortex, resulting in phonological short-term memory (pSTM) impairment. Functional MRI revealed…
Güngör İlhan GM, Erdoğan Y, Özbey İpek H et al. · 2026 · Nigerian journal of clinical practice
Background This study aimed to evaluate the effect of different cement types on the fracture strength of zirconia crowns fabricated at varying occlusal cement gap widths for primary molars using a computer-aided design and manufacturing…
Luo G, He T, Yin D et al. · 2026 · Journal of environmental management
Foliar application technology has received considerable research attention due to its potential to mitigate the accumulation of heavy metals such as cadmium and lead in crops. However, to date, there are very few inorganic foliar sprays…
Hasan N, Harisudin M, Kusnandar K et al. · 2026 · Preprint
Abstract Moving from risk perception to concrete farm action remains a central challenge in sustainable agriculture. Farmers may be aware of environmental and health risks, but such awareness does not automatically translate into…
Park S, Kim J, Kwon Y et al. · 2026 · Preprint
The striatum, a critical hub for motor skill learning, is located deep within the subcortical region, making noninvasive stimulation particularly challenging. Nevertheless, recent studies suggest that transcranial magnetic stimulation…
Gu Z, Wang M, Liang Z et al. · 2026 · Preprint
Consistent behavioural differences among individuals have been documented across many animal taxa, yet their developmental consequences remain less clear in domestic production systems. This gap is especially relevant in managed…
Yagdiran B, Kirisci B, Cekmen N et al. · 2026 · BMC pulmonary medicine
Purpose Pulmonary hypertension (PH) is associated with systemic hemodynamic changes that may influence graft perfusion following liver transplantation (LT). In this study, we aimed to evaluate whether pre-transplant PH risk, as estimated…
Savariau L, Tasdemir N, Thale I et al. · 2026 · Preprint
Invasive lobular carcinoma (ILC) is the most frequently diagnosed special histological subtype of invasive breast cancer and accounts for 10 – 15% of all cases. The pathognomonic hallmark of ILC is the genetic loss of E-cadherin ( CDH1 )…
Abd Elhamed HB, Mohamed Ahmed EA, Youssif EF et al. · 2026 · Journal of clinical medicine
Background and Objectives : Chronic nonspecific neck pain (NSNP) is among the most common musculoskeletal disorders. Global postural re-education (GPR) might be effective in decreasing neck pain (NP) and dysfunction and improving forward…
Ashraf N, Hong Q, Guo Z et al. · 2026 · BMC cancer
Background Hepatocellular carcinoma (HCC) is a global health burden and hepatitis B virus (HBV) infection is a common cause. Antiviral therapy has the possibility to reduce the incidence of HCC, and recurrence of HCC after surgical…
Chahardoli A, Mostafaei A · 2026 · Scientific reports
Caffeic acid (CA) biomolecule was applied for the biofabrication of AuNPs (CA-AuNPs) as a reducing and stabilizing agent under optimal conditions. This study aimed to investigate the biological efficacy of CA-AuNPs by testing their…
Jones M, Motesharei A, Abdul W et al. · 2026 · The American journal of sports medicine
Background Combined anterior cruciate ligament (ACL) and medial collateral ligament (MCL) injuries are common in professional sport, but there is little evidence available regarding the long-term impact of them on players' sporting…
Shi L, Liu X, Qiu T et al. · 2026 · BMC public health
Background HIV and syphilis are sexually transmitted diseases (STDs) that share transmission routes and risks factors. Many countries face the dual challenge of HIV and syphilis epidemics. Co-infection can mutually accelerate disease…