A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20240 results in Negative / Null Result Report · page 387 of 675
Rocco C, Larrouy-Maumus G, Wissuwa M et al. · 2026 · Preprint
1 Summary Zinc (Zn) deficiency limits rice productivity and poses a risk to human health, particularly in populations reliant on rice-based diets. Although rice germplasm exhibits wide variation in Zn-deficiency tolerance, the underlying…
Kaba Ö, Tanatar A, Koç R et al. · 2026 · Jornal de pediatria
Objectives Colchicine is an essential component of familial Mediterranean fever (FMF) treatment. It is suggested that it may affect vitamin B 12 levels by affecting intestinal absorption. This research focused on examining the impact of…
Kim S, Kim JH, Shin JY et al. · 2026 · Age and ageing
Background Depression is common in older adults, who are also at elevated risk of bleeding due to age-related physiological changes and comorbidities. Concerns have been raised regarding potential bleeding risk from concomitant use of…
Wang R, Dai P, Deng X et al. · 2026 · Journal of thoracic disease
Background Thymoma is an uncommon cancer of the thymus and postoperative radiotherapy (PORT) is often considered for selected patients with high-risk or locally advanced thymoma after resection. The effect of PORT on overall survival (OS)…
Bolton A · 2026 · Preprint
Abstract While the ecological effects of internal combustion engines are well documented, especially in susceptible arctic areas like Svalbard, effects on specific genera of plants are largely neglected. The Saxifraga genus was selected…
Au YE, Baskaran R, Li JY et al. · 2026 · Preprint
Abstract Background The ability to appraise and apply research is fundamental to the practice of evidence-based medicine (EBM). Despite the General Medical Council’s (GMC) mandate for United Kingdom (UK) medical graduates to integrate…
Patel M, Schwartz K, Schenk M et al. · 2026 · Orthopaedic journal of sports medicine
Background Ulnar collateral ligament (UCL) reconstruction (UCLR) of the elbow is common in throwing athletes and reliably allows return to play. The literature supports stress imaging of the elbow to evaluate the integrity of the UCL. The…
Kumar P, Gordon A, Fisher E et al. · 2026 · The Australian & New Zealand journal of obstetrics & gynaecology
Background Routine third trimester ultrasound scans have been introduced in several maternity centres to increase detection of fetal growth disorders and improve perinatal outcomes. Aims To assess changes in obstetric and neonatal outcomes…
Kasowanjete P, Dhilip Kumar SS, Houreld N · 2026 · Lasers in medical science
The phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), mammalian target of rapamycin (mTOR) (PI3K/AKT/mTOR) pathway regulates cell survival, proliferation, and the synthesis of protein. Photobiomodulation (PBM) stimulates…
Shannon ES, Sparks SA, McNaughton LR et al. · 2026 · European journal of applied physiology
PURPOSE: Hydrogen cation (H+) accumulation is exacerbated in hypoxia. Sodium bicarbonate (NaHCO3) ingestion can reduce fatigue associated with high-intensity exercise performance by counteracting H+ ion accumulation. The present study…
Ayyildiz BG, Terzioglu B, Eken S · 2026 · Journal of applied oral science : revista FOB
Objective This study aimed to compare the effectiveness of injectable platelet-rich fibrin (I-PRF) using a submucosal injection technique for creeping attachment in thin and thick phenotypes with gingival recession. Methodology The study…
Mobarak A, Chatterjee U, Munoz J et al. · 2026 · Preprint
Abstract The Swachh Bharat Mission - Gramin (SBM-G) was launched by the Prime Minister of India in 2014 during his inaugural independence-day address, as a flagship program to eliminate open defecation in India by 2019. Touted as the…
Wang J, He B, Kuerban G et al. · 2026 · Pakistan journal of pharmaceutical sciences
Background Evidence from experimental and clinical studies suggests that anesthetic drugs may modulate tumor biology by influencing immune regulation, inflammation and intracellular calcium signaling. However, the extent to which…
Wang Y, Qu J, Wang T et al. · 2026 · Blood purification
The relationship between baseline serum creatinine (SCr) levels at the initiation of continuous renal replacement therapy (CRRT) and in-hospital mortality remains unclear. This study aimed to investigate this relationship in critically ill…
Sharma M, Kaur N · 2026 · Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes
The reproductive toxicity of nitrate in juvenile and adult female rats, and its amelioration with ascorbic acid, curcumin or their combination, was studied. Rats were classified into five groups: control, nitrate, nitrate + ascorbic acid,…
Egorova K, Maaniitty T, Kärpijoki H et al. · 2026 · Preprint
Peripheral physiological processes contribute to emotions; however, the extent of the influence of internal signals on subjective emotional experiences remains a subject of debate. Methods Here we investigated the bodily sensations induced…
Puga T, Haechten T, Cush C et al. · 2025 · Orthopaedic journal of sports medicine
Background Kickoffs in the National Football League (NFL) are historically one of the most dangerous plays during an NFL game, with high levels of injuries. In 2024, the NFL introduced new rules aimed at reducing injuries during kickoffs,…
Javaheri J, Asgari M, Mohaghegh P et al. · 2026 · Preprint
Abstract Background: Routine monitoring, identification, early diagnosis and screening of diseases caused by environmental and industrial pollutants by all physicians who will practice in large and polluted cities or areas affected, must…
Sliman H, Sliman RKA, Aker A et al. · 2026 · Preprint
Abstract Background: Emotional stress in conflict zones may impact cardiovascular health, particularly acute coronary syndrome incidence. This retrospective study assesses the Israel–Hamas conflict's impact on ST-elevation myocardial…
Zander C, Rau A, Lützen N et al. · 2026 · Fluids and barriers of the CNS
BACKGROUND: CSF loss in spontaneous intracranial hypotension (SIH) has been related to alterations in glymphatic flow, which is poorly understood in this disease. Advanced multi-shell diffusion-weighted MRI (dMRI) enables quantification of…
Aziz F, Waseem M, Asghar Z et al. · 2026 · Preprint
Abstract Air pollution is a major public health crisis in Pakistan, driven by rapid urbanization, industrial expansion, agricultural burning, and inadequate monitoring infrastructure. This study evaluates five major pollutants inlcuding…
SAKDAVONG J, SEBBAG A · 2026 · Preprint
Abstract Rapid advancements in Generative AI enable the synthesis of photorealistic pedagogical agents, yet their impact on human information processing remains debated. While Social Agency Theory predicts benefits from social priming,…
Alsaffar SF, Khaleel HM · 2025 · Preprint
Background Polycystic ovarian syndrome (PCOS) is a hormonal, metabolic disorder in women of reproductive age. It can be induced by genetic, immunological, and environmental determinants. The main pathophysiology of PCOS, is…
Shin E, Kim M, Soo TJ et al. · 2026 · Preprint
ABSTRACT To resolve discrepancies in the literature regarding the association between Alzheimer’s disease (AD) and Biondi body (BB) amyloid in choroid plexus epithelial cells (CPECs), we investigated postmortem hippocampal paraffin blocks…
Ni J, Yan Y, Zhang L · 2026 · Preprint
Abstract Background: Growing recognition has established rare diseases as a public health priority. With over 20 million rare disease patients in China, establishing a robust medical security system is crucial for advancing the Healthy…
Choo TH, Galfalvy HC, Keilp JG et al. · 2026 · Journal of affective disorders
Depression and its severe outcomes, suicidal ideation and behavior, are exacerbated by stress. A broad literature links dysregulation of the hypothalamic-pituitary-adrenocortical (HPA) stress response system to depression, suicidal…
Guedes Marques M, Maia P, Martins A et al. · 2026 · The journal of vascular access
Background The most common causes of early primary failures of a vascular access (VA) is related to small caliber vessels. Weight gain between dialyses expands both extracellular and blood volume, which may lead to rises in intravascular…
Medina-Valdebenito D, Espinoza-Palavicino T, Terán-Mendoza O et al. · 2026 · Journal of aging and health
ObjectivesThis study examined the influence of hearing status and loneliness on verbal fluency trajectories in adults aged 60 years and older, assessing their contributions to baseline performance and longitudinal change over…
Géczi R, Géczi G, Tóth L · 2026 · Sports (Basel, Switzerland)
The aim of this study was to examine the relative contribution of physical performance, executive functions, and competitive anxiety to competitive success in junior tennis players. A total of 39 national-level junior athletes (20 males,…
Bigdelu L, Ahmadi M, Shahri B et al. · 2026 · Scientific reports
Prediction of cardiovascular diseases (CVD) is a challenge that cardiologists have always faced all the times. Aortic propagation velocity (APV) is an echocardiography index that can be helpful with this regard; however, few studies have…