A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20240 results in Negative / Null Result Report · page 385 of 675
Amaravadi RK · 2022 · Autophagy
Macroautophagy/autophagy is a resistance mechanism to targeted therapy in BRAF mutant cancers. Preclinical evidence and clinical trial data demonstrate that hydroxychloroquine (HCQ) is an effective autophagy inhibitor at clinically…
Terentieva EI, Komleva PD, Antonova SM et al. · 2026 · International journal of molecular sciences
Pharmacological chaperones (PCs)-small molecules that normalize the 3D structure of mutant protein molecules-are promising substances for pharmacological treatment of grave hereditary pathologies. In this study, possible chaperone-like…
Ghazali M, Sele V, Sahuquillo A et al. · 2026 · Journal of hazardous materials
The increasing interest in seaweed as a potential feed and food source has prompted concerns regarding the presence of potentially toxic arsenic (As) species. Seaweed is known to contain the organic As species arsenosugars, but the…
Daniloski D, Ibáñez RA, McCarthy NA et al. · 2026 · Journal of dairy science
Bovine β-casein (β-CN) is a major milk protein that exists as multiple genetic variants, distinguished by differences in their amino acid sequences. Among these, the A1 and A2 variants are the most extensively studied. They differ at…
Noorman L, Bekebrede AF, de Vries S et al. · 2026 · Animal : an international journal of animal bioscience
In vitro and in situ experiments, primarily conducted using human cells, have demonstrated that metabolites produced during protein fermentation can negatively affect intestinal health. However, in vivo research on their impact on…
Nass N, Sprung S, Ignatov A et al. · 2026 · Cancer treatment and research communications
In cancer, aerobic glycolysis predominantly used to provide energy. This high glycolytic flow results in the formation of reactive aldehydes such as glyoxal and methylglyoxal forming advanced glycation end products (AGEs) by reacting with…
Willey CN, Bufi R, Takemon Y et al. · 2026 · American journal of physiology. Renal physiology
Increased concentrations of neuroblastoma suppressor of tumorigenicity 1 (NBL1) in the blood have been associated with disease progression in diabetic kidney disease (DKD) and IgA nephropathy. However, it is unclear whether NBL1 is a…
Claus L, Zhang X, Ocasio L et al. · 2026 · Clinical radiology
Aim Computed tomography angiography (CTA) is essential for preprocedural assessment in transcatheter aortic valve replacement (TAVR), particularly as TAVR becomes the preferred treatment for high-risk patients with severe aortic stenosis.…
Söröd M, Gyllencreutz E · 2026 · The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Introduction Cardiotocography (CTG) is used for fetal surveillance to prevent asphyxia related neonatal outcomes during pregnancy and delivery. In Sweden, all delivery wards have transitioned from CTG registered and printed on paper inside…
Dai R, Wells CD · 2025 · Preprint
Climate change is driving the poleward expansion of many species, including the Atlantic blue crab ( Callinectes sapidus ), whose northern range now extends into the Gulf of Maine. As a recently arrived predator, the blue crab may pose a…
Al-Othman S, Wu Y, Fontanaud P et al. · 2026 · Preprint
SUMMARY Resident cardiac macrophages are understood to facilitate atrioventricular (AV) node conduction because they purportedly couple to AV node myocytes via connexin43 (Cx43) containing gap junctions. We tested this mechanism using…
Vieira Y, Sobral M, Mateus V et al. · 2026 · International journal of psychophysiology : official journal of the International Organization of Psychophysiology
Transcranial direct current stimulation (tDCS) has emerged as a promising tool to investigate and modulate emotional and social processes, including compassion. By targeting cortical regions implicated in empathy and prosocial behaviour…
Jin Z, Li J, Thackray AE et al. · 2026 · Appetite
Oxyntomodulin (OXM) is a gut-derived peptide hormone with anorexigenic properties that reduce food intake and increase energy expenditure. This study investigated the effect of a single bout of moderate-intensity running on OXM…
Harris MB, Milsom WK · 2025 · Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology
During hibernation, golden-mantled ground squirrels (Spermophilus lateralis) breathe in distinct multi-breath episodes separated by prolonged periods of apnea. We hypothesized that vagal afferent feedback from pulmonary stretch receptors,…
Liu Y, Sun J, Hu Y et al. · 2026 · Clinical and experimental reproductive medicine
Objective Previous studies have reported a higher rate of small for gestational age (SGA) newborns from fresh embryo transfers compared with frozen-thawed embryo transfers (FET), potentially due to the supraphysiologic serum estradiol…
Flensted-Jensen M, Kleis-Olsen AS, Weinreich CM et al. · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)
Advanced glycation end-products (AGEs) accumulate with age and may contribute to skeletal muscle decline, yet their distribution within muscle compartments is unknown. Resistance training (RT) and high-intensity interval training (HIIT)…
Park JK, Lee JE, Kim JS et al. · 2026 · Journal of hazardous materials
Microplastics (MPs) are emerging contaminants that disrupt development, physiology, and redox homeostasis in aquatic organisms. However, their detailed impacts on amphibians and the potential for antioxidant-based mitigation remain poorly…
Bahabri M, Figueiredo JN, Kara Y et al. · 2026 · Nanotechnology
In this study, the growth of vertical graphene (VG) nanosheets on copper (Cu) substrates in a direct-current plasma-enhanced chemical vapor deposition (PECVD) system was studied. The plasma process during the VG growth was characterized…
Lake J, Mariniello M, Schiano G et al. · 2026 · Journal of the American Society of Nephrology : JASN
Key points Lipocalin-2 upregulation paralleled intracellular uromodulin aggregates in mouse and cellular models of autosomal dominant tubulointerstitial kidney disease because of pathogenic uromodulin. The induction of lipocalin-2 was…
Spry ER, Travis KB, Ragland KJ et al. · 2025 · Molecular and cellular endocrinology
Aims Semaglutide (SEMA) is a glucagon-like peptide-1 receptor agonist (GLP-1RA) that has recently emerged as a popular pharmacological treatment for type 2 diabetes and insulin resistance due to its weight loss properties. Previous studies…
Stub M, Ramhøj L, Axelstad M et al. · 2026 · Reproductive toxicology (Elmsford, N.Y.)
Perfluorooctane sulfonate (PFOS) and tetrabromobisphenol A (TBBPA) are environmental pollutants with known endocrine disrupting potential. Both substances display various thyroid hormone (TH) system disrupting effects, both in vitro and in…
Panzenböck LF, Abdel Nour G, Dürrschnabel DL et al. · 2026 · Global spine journal
Study DesignRandomized controlled trial.ObjectivesTo characterize postoperative C-reactive protein (CRP) trajectories as predictors of surgical site infection (SSI) following lumbar spine surgery, to determine optimal CRP thresholds, and…
Yardimci A, Ertugrul NU, Akkoc RF et al. · 2026 · Reproductive biology
Ozone (O₃) has been used to treat various diseases for many years, with most preclinical studies focusing on its effects in conditions such as testicular torsion and ischemia-reperfusion injury; however, its impact on male reproductive…
Wang CI, Cho YC, Lin YP · 2025 · Environmental Technology & Innovation
Harmful asbestos-containing waste is generated during old building demolition. This study aims to develop a thermal-chemical treatment method to detoxify asbestos-containing waste and explore the potential use of detoxified…
Kęska P, Zielińska D, Karbowiak M et al. · 2025 · Food Chemistry
The aim of this study was to evaluate the effectiveness of cell-free supernatants (CFS) produced by selected lactic acid bacteria (LAB) strains: Lacticaseibacillus paracasei B1 and Lactiplantibacillus plantarum O24 as antioxidant and…
Patoglu OR, Horne RSC, Mann DL et al. · 2026 · European journal of pediatrics
A hallmark of Prader-Willi syndrome (PWS) is hypothalamic-pituitary axis dysfunction, which can result in reduced growth hormone (GH) production. While GH replacement therapy is common in children with PWS, it has also been implicated in…
Eser M, Yazıcı C, Kandemir Ü et al. · 2026 · Research in veterinary science
Ivermectin (IVR) is a semi-synthetic macrocyclic lactone widely used against nematodes. Under physiological conditions, its central nervous system (CNS) penetration is limited by P-glycoprotein-mediated efflux at the blood-brain barrier…
Targhetta VP, Vieira RdS, Ranfley H et al. · 2025 · Preprint
Inflammasomes are multiprotein complexes that activate pro-caspase-1, leading to the maturation of the pro-inflammatory cytokines IL-1β and IL-18. Nlrp1 , the first receptor identified with inflammasome-forming capacity, is highly…
Wooliver R, Neupane A, DeBruyn JM et al. · 2026 · Journal of environmental quality
Microplastics derived from agricultural plastic films accumulate in soils, potentially impacting ecosystem functions such as soil organic carbon (SOC) storage. Microbial degradation of biodegradable plastics, which are intentionally tilled…
Inoue H · 2025 · Preprint
Abstract The novel coronavirus SARS-CoV-2, commonly referred to as COVID-19, triggered a global pandemic. Although understanding the nature of international infection spread is critically important, extracting diffusion networks from…