Negative / Null Result ReportMedicine
Han, Wang, Shang et al. · 2026 · Journal of hazardous materials
Cadmium (Cd) accumulation in river floodplains is threatening grain safety and agro-ecosystem sustainability. We conducted a 10-month field-mesocosm experiment to evaluate the effectiveness, side effects and underlying mechanisms of three…
View details →DOI: 10.1016/j.jhazmat.2026.141870 Negative / Null Result ReportMedicine
Zhao, Xie, Yu et al. · 2026 · BMC cancer
BACKGROUND: Vessels that encapsulate tumor clusters (VETC) is a powerful predictor of aggressive hepatocellular carcinoma (HCC) and associated with poor outcomes of HCC. Imaging surrogates of VETC potentially help predict postsurgical…
View details →DOI: 10.1186/s12885-026-15895-6 Negative / Null Result ReportMedicine
Li, Tong, Xue et al. · 2026 · Journal of hepatology
Hepatic stellate cells (HSCs) are activated during cholestasis. However, beyond liver fibrosis, whether HSCs influence bile acid (BA) synthesis and homeostasis remain largely unknown. This study investigates the role of activated HSCs…
View details →DOI: 10.1016/j.jhep.2026.03.023 Negative / Null Result ReportMedicine
Li, Zhou, Xu et al. · 2026 · Microorganisms
The present study investigates the effects of tannic acid (TA) on body composition, immune function, and gut microbiota in Brandt's voles ( Lasiopodomys brandtii ); analyzes the gut microbiota-immune parameter associations during their…
View details →DOI: 10.3390/microorganisms14030577 Negative / Null Result ReportMedicine
Almuraikhi, Alkhamees, Tareen et al. · 2026 · Current issues in molecular biology
Glycogen synthase kinase-3 (GSK3) inhibition is a commonly used approach to promote osteogenic differentiation through activation of Wnt signaling. However, 6-bromoindirubin-3'-oxime (BIO), which is commonly used for GSK3 inhibition, also…
View details →DOI: 10.3390/cimb48030316 Negative / Null Result ReportMedicine
Yıldırım Ş, İnci A, Karaduru Avcı A et al. · 2026 · Biomolecules & biomedicine
Primary membranous nephropathy (pMN) is a principal cause of nephrotic syndrome in adults. The identification of the M-type phospholipase A2 receptor (PLA2R) antigen has significantly advanced non-invasive management; however, the precise…
View details →DOI: 10.17305/bb.2026.14167 Negative / Null Result ReportMedicine
Aba O, Yalçın Sezen G, Ersoy Karka O · 2026 · BMC anesthesiology
Purpose This study aimed to evaluate perioperative changes in optic nerve sheath diameter (ONSD) and regional cerebral oxygen saturation (rSO₂) using noninvasive monitoring techniques during laparoscopic abdominal surgery, and to assess…
View details →DOI: 10.1186/s12871-026-03978-7 Negative / Null Result ReportMedicine
Çetinkaya F, Uslu E · 2026 · Journal of perioperative practice
Objective This study aimed to determine whether there is a relationship between patients' health literacy levels and their preoperative anxiety during the preoperative period. Design An analytical cross-sectional study. Methods The…
View details →DOI: 10.1177/17504589261441562 Negative / Null Result ReportOpen accessMedicine
Sugiarta AP, Anggani HS, Purbiati M · 2025 · Journal of orthodontic science
Objective This study aims to demonstrate the correlation between anterior tooth retraction and changes in the dimensions of the pharyngeal airway in cases of bimaxillary protrusion. Materials and methods Changes in dental parameters and…
View details →DOI: 10.4103/jos.jos_23_25 Negative / Null Result ReportMedicine
Storck, Schönefeld, Bellstedt et al. · 2026 · Journal of surgical education
Prior knowledge activation (PKA) has long been considered a cornerstone of surgical education, yet recent meta-analyses reveal conflicting evidence regarding its effectiveness. This study examined when PKA enhances surgical education by…
View details →DOI: 10.1016/j.jsurg.2026.103915 Negative / Null Result ReportMedicine
Manikanta, Kumar, Mani et al. · 2026 · Scientific reports
Distributed generators (DGs) are recent emerging technologies which are executed in distribution system (DS) to reduce power losses (PLs). However, optimal location and sizing of DG (OLSDG) remain a challenging combinatorial optimization…
View details →DOI: 10.1038/s41598-026-55639-x Negative / Null Result ReportMedicine
Wu, Zhang, Xi et al. · 2026 · Critical reviews in oncology/hematology
Ovarian cancer remains an immunologically "cold" tumor, with early all-comer immune checkpoint inhibitor (ICI) trials largely negative despite underlying immunogenicity. This review takes a clinician-centric, stage-specific view linking…
View details →DOI: 10.1016/j.critrevonc.2026.105459 Negative / Null Result ReportMedicine
Partlova, Comley, Haigh et al. · 2026 · Experimental neurology
Spinal muscular atrophy (SMA) is characterized by motor neuron loss and neuromuscular junction (NMJ) pathology. Although SMN-upregulating therapies such as Nusinersen markedly improve survival and motor function for many patients,…
View details →DOI: 10.1016/j.expneurol.2026.115898 Negative / Null Result ReportMedicine
Li, Nelson, Li et al. · 2026 · Cancer research
Synovial sarcoma (SyS) incorporates the SS18::SSX fusion oncoprotein into GLTSCR1-containing BRG1/BRM and associated factors (GBAF) complexes, which confers a dependency on the GBAF subunit BRD9. However, SyS clinical trials with multiple…
View details →DOI: 10.1158/0008-5472.can-25-5405 Negative / Null Result ReportMedicine
Khairil, Benny, Jerry et al. · 2026 · Pharmaceuticals (Basel, Switzerland)
The integration of artificial intelligence (AI) into the life sciences has accelerated significantly between 2022 and 2026, accompanied by global investment exceeding USD 100 billion and widespread expectations of a transformative impact…
View details →DOI: 10.3390/ph19060916 Negative / Null Result ReportMedicine
Lee · 2026 · Journal of clinical medicine
Hypoxic-ischemic brain injury remains the leading cause of death and neurological disability after cardiac arrest. Although targeted temperature management (TTM) and other neuroprotective strategies have demonstrated promising results in…
View details →DOI: 10.3390/jcm15124496 Negative / Null Result ReportMedicine
Wu, Li, Zhu et al. · 2026 · Microorganisms
The gut microbiome, often termed the human "second genome", profoundly influences host physiology through metabolic interactions, immune modulation, and gut-brain axis signaling. Dysbiosis is implicated in the pathogenesis of obesity,…
View details →DOI: 10.3390/microorganisms14061174 Negative / Null Result ReportMedicine
Mulita, Kouroupi, Verras et al. · 2026 · Diagnostics (Basel, Switzerland)
Background and Clinical Significance: Ganglioneuromas are rare benign tumors of neural crest origin, with gastrointestinal involvement being uncommon and ampullary localization exceptionally rare. Pancreatic neuroendocrine tumors (NETs)…
View details →DOI: 10.3390/diagnostics16121778 Negative / Null Result ReportMedicine
Gosavi, Sritharan, Bell et al. · 2026 · Annals of hepato-biliary-pancreatic surgery
Perioperative chemotherapy is frequently used for resectable colorectal liver metastases (CRLM), despite persistent uncertainty regarding the extent of its survival benefit. This perspective revisits the evidence supporting this practice…
View details →DOI: 10.14701/ahbps.26-103 Negative / Null Result ReportMedicine
Matsumiya, Ding, Ikegami et al. · 2026 · Journal of immunology (Baltimore, Md. : 1950)
Pathogen-derived RNAs function as pathogen-associated molecular patterns (PAMPs) that activate innate immune responses through pattern recognition receptors (PRRs). While viral RNA is well established as a trigger of antiviral immunity,…
View details →DOI: 10.1093/jimmun/vkag149 Negative / Null Result ReportMedicine
Zhang, Zhang, Kwan et al. · 2026 · Social science & medicine (1982)
Urban noise pollution has become a critical environmental issue affecting residents' quality of life. Existing research struggles to capture heterogeneity in noise sensitivity across different populations and cannot precisely quantify the…
View details →DOI: 10.1016/j.socscimed.2026.119516 Negative / Null Result ReportMedicine
Yang, Yang, Du et al. · 2026 · BMC cancer
Accurate prognostic assessment remains challenging in patients with hepatocellular carcinoma (HCC). Although the fibrosis-4 (FIB-4) index is widely used for non-invasive evaluation of liver fibrosis, its prognostic value in HCC remains…
View details →DOI: 10.1186/s12885-026-16360-0 Negative / Null Result ReportMedicine
Sun, Wang, Lai et al. · 2026 · Neural regeneration research
The regulatory network of the spleen, a densely innervated immune hub, undergoes pathological remodeling following spinal cord injury. Whether targeted electrical stimulation of the spleen at specific frequencies can reverse peripheral…
View details →DOI: 10.4103/nrr.nrr-d-26-00245 Negative / Null Result ReportMedicine
Chen, Hu, Peng et al. · 2026 · Journal of immunology research
This multicenter study aimed to analytically compare the performance of automated quantitative assays-chemiluminescence immunoassay (CLIA) and multiplexed bead immunoassay (MBI)-for detecting anti-Ro/La antibodies in Chinese patients with…
View details →DOI: 10.1155/jimr/9771858 Negative / Null Result ReportMedicine
Tishchenko, De Boeck, Van Waesberghe et al. · 2026 · Journal of virology
Gap junctional intercellular communication (GJIC) enables the direct transfer of signaling molecules between neighboring cells and plays an important role in innate antiviral immunity by facilitating bystander defense responses. We…
View details →DOI: 10.1128/jvi.00773-26 Negative / Null Result ReportMedicine
Li, Feng · 2026 · Infection and drug resistance
Tropheryma whipplei (TW) , a Gram-positive bacterium, is the etiologic agent of Whipple's disease, a chronic and systemic condition that primarily involves the gastrointestinal tract. Chlamydia psittaci (C. psittaci) is a zoonotic pathogen…
View details →DOI: 10.2147/idr.s609565 Negative / Null Result ReportMedicine
Lin, Lin, Chen · 2026 · Frontiers in medicine
Postoperative chylothorax is an uncommon but challenging complication after thoracic surgery. Low-dose external beam radiotherapy (RT) has been proposed as an adjunct treatment when conservative management or surgical intervention fails,…
View details →DOI: 10.3389/fmed.2026.1828683 Negative / Null Result ReportMedicine
Kashyap, Chang, Lu et al. · 2026 · Affective science
Social expectations are a ubiquitous part of human experience, yet little is known about the emotions associated with failing to fulfill others' social expectations. In two studies, we examined the effects of failing to fulfill others'…
View details →DOI: 10.1007/s42761-026-00365-w Negative / Null Result ReportMedicine
Chi, Zheng, Guo et al. · 2026 · Drug design, development and therapy
Ischemia-percussion (I/R) injury describes a paradoxical phenomenon in which blood flow restoration following ischemia not only fails to salvage the tissue but also exacerbates tissue injury. Due to the unique physiological functions, cell…
View details →DOI: 10.2147/dddt.s608894 Negative / Null Result ReportMedicine
He, Shen, Hu et al. · 2026 · The New phytologist
Interploidy hybridization in plants is constrained by a postzygotic barrier. Triploid production via 2x × 4x interploidy hybridization is an important strategy for obtaining seedless cultivar in some fruit tree crops…
View details →DOI: 10.1111/nph.71369 