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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20240 results in Negative / Null Result Report · page 379 of 675

Negative / Null Result ReportOpen accessMedicine

Investigating the effect of Ranolazine drug on the pathophysiology of asthma in a rat model.

Sadeghi M, Shahrooz S, Aghamohammadi M et al. · 2025 · BMC research notes

Objective Asthma is a common multifactorial inflammatory disease affecting both children and adults. Various cells and cytokines contribute to this inflammatory process. Smooth muscle contraction, vascular congestion, and airway edema lead…

View details →DOI: 10.1186/s13104-025-07455-1
Negative / Null Result ReportOpen accessMedicine

Education and Provision of a Pest Management Tool Kit to Residents in Low-Income Housing: Effect on Cockroach Reduction.

Pan X, Sarker S, Yu JJ et al. · 2026 · Insects

High rates of pest infestations are frequently reported in low-income homes in the U.S. However, even with access to effective insecticides, most residents are unaware of how to properly control indoor pests. We designed and evaluated the…

View details →DOI: 10.3390/insects17050483
Negative / Null Result ReportMedicine

De novo donor specific antibody (dnDSA) development with tacrolimus versus Belatacept based regimens in kidney transplant recipients.

Kass C, Katz-Greenberg G, Bodner J et al. · 2025 · Transplant immunology

Purpose Belatacept has been associated with less de novo specific antibody (dnDSA) development, but few publications have compared the incidence of dnDSA development between tacrolimus and belatacept-based immunosuppression regimens. The…

View details →DOI: 10.1016/j.trim.2025.102297
Negative / Null Result Report

“Inhaled Nitric Oxide in Neonates with Pulmonary Hypertension in Amazonas, Brazil: Physiological Improvement Versus Impact on Relevant Clinical Outcomes”

Ferreira RD, Faleiros Ferreira CH, Gonçalves-Ferri WA · 2025 · Preprint

Background Inhaled nitric oxide (iNO) is a standard treatment for neonatal pulmonary hypertension in high-resource settings. Yet, its efficacy and cost-effectiveness in low- and middle-income countries (LMICs) remain underexplored. This…

View details →DOI: 10.1101/2025.08.19.25333602
Negative / Null Result ReportOpen accessMedicine

Biallelic variants in DNAH11 cause male infertility with asthenozoospermia in a Chinese non-consanguineous family: A case report.

Zhang Y, Pan J, Hou J et al. · 2025 · Medicine

Rationale Asthenozoospermia (AZS), a leading cause of male infertility, frequently results from genetic defects that disrupt flagellar assembly. Mutations in the DNAH11 gene can cause abnormal dynein arm structures, leading to AZS and…

View details →DOI: 10.1097/md.0000000000046556
Negative / Null Result ReportMedicine

A Comparison of Intravenous and Oral Transmucosal Administration of Pentobarbital Sodium for Humane Euthanasia in White Leghorn Chickens (<i>Gallus gallus domesticus</i>).

Masri A, Tully TN, Como K et al. · 2025 · Journal of avian medicine and surgery

Euthanasia is a common veterinary medical procedure performed on terminally ill backyard chickens ( Gallus gallus domesticus ). To reduce stress for these animals, it is important to develop a euthanasia protocol that provides a rapid and…

View details →DOI: 10.1647/avianms-d-24-00022
Negative / Null Result ReportOpen accessMedicine

Effect of Human-Derived Collagen Injection on Clinical and Structural Outcomes after Arthroscopic Rotator Cuff Repair: A Prospective Randomized Controlled Trial.

Lee JH, Hwang K, Jeong WK · 2026 · Clinics in orthopedic surgery

Background Arthroscopic rotator cuff repair is widely performed; yet tendon healing failure still occurs in some cases and remains a challenge. To address this issue, several studies have investigated intraoperative injection or patch…

View details →DOI: 10.4055/cios25235
Negative / Null Result ReportMedicine

Antibody Responses Elicited by Vaccination with Recombinant LaSota Virus Expressing IBV Spike in Chickens with Maternal Antibodies.

Cuadrado C, Breedlove C, Toro H · 2025 · Avian diseases

Vaccination with a recombinant Newcastle disease virus (NDV) LaSota (LS) strain expressing Arkansas (Ark) -type infectious bronchitis virus (IBV) spike ectodomain (Se) protein and granulocyte-macrophage colony-stimulating factor (GMCSF)…

View details →DOI: 10.1637/aviandiseases-d-25-00035
Negative / Null Result ReportMedicine

Stem migration and bone density at ten years : a randomized radiostereometry and dual-energy X-ray absorptiometry study on a short uncemented hip stem with and without a collar.

Daudi S, Zampelis V, Belfrage O et al. · 2025 · The bone & joint journal

Aims Short, uncemented hip stems might provide a favourable alternative in total hip arthroplasty (THA) by preserving proximal bone mass through reduced strain-adaptive remodelling. We evaluated and compared the migration and…

View details →DOI: 10.1302/0301-620x.107b9.bjj-2024-1720.r1
Negative / Null Result ReportMedicine

Intramuscular Tacrolimus Pharmacokinetics in a Pediatric Porcine Model for Partial Heart Transplantation.

Steen L, Javed H, Contorno E et al. · 2025 · Transplantation proceedings

Objective The cornerstone of immunosuppression for transplantation is tacrolimus. One of the most reliable routes for administering tacrolimus in porcine models is intramuscular injection. However, the pharmacokinetics of intramuscular…

View details →DOI: 10.1016/j.transproceed.2025.07.030
Negative / Null Result ReportMedicine

Mapping the ABC transporter landscape in the human lung: A comprehensive characterisation of P-gp, MRP1 and BCRP expression and functional activity in human lung epithelial cells.

Simon S, Shanmugalingam T, Neu T et al. · 2025 · European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Active efflux transporters can play a substantial role in the drug disposition of their substrates in the human body. Efflux transporters like P-glycoprotein (P-gp), multidrug resistance associated protein 1 (MRP1) and breast cancer…

View details →DOI: 10.1016/j.ejps.2025.107333
Negative / Null Result ReportOpen accessMedicine

EFFICACY OF PROBIOTICS IN PREVENTING CHEMOTHERAPY-INDUCED DIARRHEA IN GASTROINTESTINAL CANCER PATIENTS.

DE Souza GC, Araujo Filho HB, DE Oliveira CZ et al. · 2025 · Arquivos de gastroenterologia

Background Chemotherapy-induced diarrhea is a common and distressing side effect experienced by patients undergoing cancer treatment, particularly those with gastrointestinal cancer. It can lead to significant health complications,…

View details →DOI: 10.1590/s0004-2803.24612025-020
Negative / Null Result Report

Kia Tīmata Pai (Best Start Study): Observed Te Reo Māori Usage Within Early Childhood Education in Aotearoa New Zealand Following Professional Development

Mitchell Y, Thomas B, Clifford AE et al. · 2025 · Preprint

There is growing recognition amongst non-Indigenous New Zealanders of the importance of te reo Māori, the Indigenous language of Aotearoa (New Zealand). Several initiatives in Aotearoa aim to revitalise te reo Māori. Recent research…

View details →DOI: 10.31234/osf.io/sjfrb_v2
Negative / Null Result Report

Kia Tīmata Pai (Best Start Study): Observed Te Reo Māori Usage Within Early Childhood Education in Aotearoa New Zealand Following Professional Development

Mitchell Y, Thomas B, Clifford AE et al. · 2025 · Preprint

There is growing recognition amongst non-Indigenous New Zealanders of the importance of te reo Māori, the Indigenous language of Aotearoa (New Zealand). Several initiatives in Aotearoa aim to revitalise te reo Māori. Recent research…

View details →DOI: 10.31234/osf.io/sjfrb_v1
Negative / Null Result ReportMedicine

A Comprehensive Toxicological Safety Evaluation of <i>Anaerostipes caccae</i>.

Modica V, Glávits R, Clewell A et al. · 2025 · International journal of toxicology

Anaerostipes caccae CLB101 (CLB101) is an obligate, anaerobic bacteria that was isolated from the stool of a healthy infant. Due to its ability to produce butyrate and its potential promotion of microbiome health through multiple…

View details →DOI: 10.1177/10915818251367353
Negative / Null Result ReportMedicine

Antidepressant efficacy and safety of scopolamine in individuals with bipolar disorder (SCOPE-BD): A randomized double-blind placebo-controlled trial.

Miravalles C, Kane R, Rossier AT et al. · 2026 · Journal of affective disorders

Background Current treatments for depressive episodes in bipolar disorder are often limited by partial efficacy or delayed therapeutic response. Intravenous scopolamine, a pan-muscarinic antagonist, has shown rapid antidepressant effects…

View details →DOI: 10.1016/j.jad.2025.120888
Negative / Null Result ReportMedicine

Plane of nutrition through 92 days of age in beef × dairy hybrid steers influences subsequent finishing performance, feed efficiency, and carcass characteristics

Grote A, Genther-Schroeder O, Wilson BK et al. · 2025 · Applied Animal Science

Our objective was to determine the effect of plane of nutrition through 92 d of age on subsequent finishing performance, feed efficiency, and carcass characteristics in beef × dairy crossbred steers. Beef × dairy crossbred steers (n = 109)…

Negative / Null Result Report

Mother-Centric Motivational Interviewing for Behavioral Change and Obesity Prevention in Preschool-Aged Children in Bangladesh: A Pilot Study

Hossain MS, Islam F, Ferdous S et al. · 2025 · Preprint

Introduction Childhood obesity is a rising public health concern, particularly in low- and middle-income countries (LMICs) like Bangladesh, where the rate of obesity in children has increased. South Asian countries, traditionally burdened…

View details →DOI: 10.1101/2025.06.23.25330164
Negative / Null Result ReportOpen accessMedicine

Improving Diagnostic Quality of Anogenital Photodocumentation in Emergency Department Evaluations for Acute Child Sexual Assault.

Miller ZE, Digirolamo SJ, Molnar J et al. · 2026 · Pediatric quality & safety

Introduction Emergency department evaluations for acute child sexual assault include anogenital photodocumentation as a standard of care, which has implications for accurate clinical care and forensic significance. If photodocumentation…

View details →DOI: 10.1097/pq9.0000000000000876
Negative / Null Result ReportMedicine

Alignment and early clinical outcomes following total knee arthroplasty using a handheld navigation system compared to conventional instruments.

Nishida C, Shimoda B, Weldon RH et al. · 2025 · Archives of orthopaedic and trauma surgery

Introduction Proper lower extremity alignment is important for success and longevity of total knee arthroplasty (TKA). Conventional instrumentation has demonstrated higher rates of mechanical axis (MA) malalignment compared to robotic or…

View details →DOI: 10.1007/s00402-025-05998-3
Negative / Null Result ReportOpen accessMedicine

The murine Irs1 knockout model, generated by the spontaneous Irs1<sup>S57X</sup> mutation in homozygosity, exhibits high embryonic lethality, limiting studies of adult hematopoiesis.

Fenerich BA, Fernandes JC, Silva CLA et al. · 2026 · Hematology, transfusion and cell therapy

Introduction Insulin Receptor Substrate 1 (IRS1) is differentially expressed in hematological neoplasms suggesting a role in hematopoiesis and neoplastic transformation. Irs1 knockout mice represent a tool to investigate IRS1 function.…

View details →DOI: 10.1016/j.htct.2026.106465
Negative / Null Result ReportMedicine

Common Divalent Cations Elicit Sublethal Effects of Negatively Charged Nanoplastics on <i>Shewanella oneidensis</i> by Compromising Membrane Protein Functionality.

Zhang S, Jia B, Huang W et al. · 2025 · ACS nano

The toxicity of negatively charged nanoplastics (NNP) to bacteria is generally subtler than that of positively charged counterparts, owing to limited NNP-cell interaction. This study hypothesized that common environmental cations (Na + ,…

View details →DOI: 10.1021/acsnano.5c04610
Negative / Null Result ReportMedicine

Combination of Exercise and Group Occupational Therapy for Behavioural and Psychological Symptoms of Dementia: A Pilot Randomised Controlled Trial.

Yoshiura K, Murata M, Hamasuna M et al. · 2025 · Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

Background The behavioural and psychological symptoms of dementia (BPSD) increase the burden for the caregiver, often leading to difficulties in maintaining home care and triggering psychiatric hospitalisation. Effective management of BPSD…

View details →DOI: 10.1111/psyg.70085
Negative / Null Result ReportMedicine

Oxidation of Platina(II)corrole to Platina(IV)corrole.

Kato S, Miwa K, Takano H et al. · 2025 · Inorganic chemistry

Recently, the aromaticity and antiaromaticity of organometallacycles have received much attention to understand the cyclic electronic delocalization through d orbitals on the metal center. Here, we prepared a Pd(II) platina(II)corrole…

View details →DOI: 10.1021/acs.inorgchem.5c00942
Negative / Null Result ReportMedicine

Retrospective analysis of early functional and radiological outcomes between robotic, navigated and conventional total knee arthroplasty: A single Surgeon's series.

Leong JWK, Lee BH, Haniball J et al. · 2025 · Journal of clinical orthopaedics and trauma

Background Achieving a neutral mechanical axis alignment (MAA) in Total Knee Arthroplasty (TKA) is associated with increased implant longevity and patient satisfaction, and robot-assisted (robotic) TKA is touted to improve implant…

View details →DOI: 10.1016/j.jcot.2025.103145
Negative / Null Result Report

A Comprehensive Null Search for Prompt Radio Bursts Associated with 218 Gravitational Wave Events: The Strongest Constraints on Pre-Merger Fast Radio Burst Emission

Prajapati S · 2026 · Preprint

Abstract Binary neutron star mergers are known to produce gravitational waves and panchromatic electromagnetic afterglow emission hours to days after coalescence. However, a fundamental question remains unanswered: do these mergers…

View details →DOI: 10.21203/rs.3.rs-9595477/v1