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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19859 results in Negative / Null Result Report · page 377 of 662

Negative / Null Result ReportOpen accessMedicine

Assessment of HIF-1α and c-MYC in Breast Carcinoma and Their Association With Clinicopathological Parameters: A Cross-Sectional Study.

Mohapatra A, Mohanty M, Parida S et al. · 2025 · Cureus

Introduction Breast cancer is one of the most common malignancies. Early diagnosis and prevention usually lead to a good prognosis and a better survival rate. Despite significant advancements in the prevention, there is still a lack of…

View details →DOI: 10.7759/cureus.100539
Negative / Null Result ReportOpen accessMedicine

Acoustic Radiation Force Impulse (ARFI) Elastography as a diagnostic and monitoring tool for Bell's palsy: A Prospective Study.

Toprak M, Toprak N, Oncu MR et al. · 2026 · Journal of musculoskeletal & neuronal interactions

Objective To evaluate ARFI elastography as a diagnostic and monitoring tool in Bell's palsy by comparing affected and unaffected facial muscles, pre- and post-treatment. Methods Thirty patients with Bell's palsy (17 females and 13 males,…

Negative / Null Result ReportMedicine

Femoral component internal rotation in functionally aligned robotic-assisted total knee arthroplasty does not impair functional outcomes.

Philpott A, Lambers A, Lee S et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Femoral component internal rotation tightens the medial flexion gap and medialises femoral trochlea position, thus influencing patellofemoral tracking and function. Therefore, one of the tenets of mechanically aligned total knee…

View details →DOI: 10.1002/ksa.70509
Negative / Null Result ReportMedicine

Metabolic and psychiatric changes after laparoscopic sleeve gastrectomy in patients with mood disorders and metabolic syndrome.

Li S, Tan F, Tan J et al. · 2026 · Journal of psychosomatic research

Mood disorders often coexist with obesity and metabolic syndrome (MetS), but postoperative trajectories after laparoscopic sleeve gastrectomy (LSG) in Chinese patients are unclear. This retrospective cohort study included 36 patients with…

View details →DOI: 10.1016/j.jpsychores.2026.112909
Negative / Null Result ReportMedicine

Evaluating the Respiratory Muscle Function in Patients with Cleft Lip and Palate: Maximal Inspiratory and Expiratory Pressure Analysis.

Venkatasamy NS, Ayub II, Kailasam V et al. · 2026 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

ObjectiveTo evaluate the respiratory muscle strength in patients with cleft lip and palate (CLP) and correlate with airway dimensions.DesignCross-sectional.SettingThe study was conducted at a Sri Ramachandra Dental College and hospital in…

View details →DOI: 10.1177/10556656261458878
Negative / Null Result ReportMedicine

[The impact of obesity on lung function and asthma control in adolescent asthma patients].

Wu ZX, Hua SR, Xie X et al. · 2026 · Zhonghua er ke za zhi = Chinese journal of pediatrics

Objective: To explore the relationship between obesity and lung function, fractional exhaled nitric oxide (FeNO) levels, and asthma control in children and adolescents with asthma. Methods: A retrospective cohort study. A retrospective…

View details →DOI: 10.3760/cma.j.cn112140-20251202-01064
Negative / Null Result ReportMedicine

Occupational noise exposure and thyroid health: The role of oxidative stress and PI3K/AKT/Foxo3 signaling.

Mohammed RS, Ramadan MA, Abdelgwad MM et al. · 2026 · Journal of occupational and environmental medicine

Objectives The study investigated thyroid function, oxidative stress and PI3K/AKT/FoxO3 pathway in employees occupationally exposed to a noise. Methods Environmental noise levels were measured along with assessment of Serum levels of T3,…

View details →DOI: 10.1097/jom.0000000000003771
Negative / Null Result Report

Evaluation and Subcategorization of Perineural Invasion (by location) in Oral Cavity Squamous Cell Carcinoma and Its Correlation with Other Prognostic factors and Overall Survival: A Retrospective study

Masri MA, Fang Z, Arian R et al. · 2026 · Preprint

Abstract Background: Perineural invasion (PNI) is a key prognostic factor in oral squamous cell carcinoma (OSCC). Recent studies have proposed the importance of subcategorizing PNI based on location in relation to the tumor. However,…

View details →DOI: 10.21203/rs.3.rs-10035872/v1
Negative / Null Result ReportMedicine

Assessment of Lobule Thickness and Nasal Skin Thickness in Rhinoplasty: Is Lobule Thickness a Good Indicator for Estimating Nasal Skin Thickness?

Konukçu-Kayar B, Karaalioğlu B, Demir B et al. · 2026 · The Journal of craniofacial surgery

Nasal skin thickness is a key determinant of surgical planning, postoperative healing, and aesthetic outcomes in rhinoplasty (RNP). However, objective assessment of nasal skin thickness is not always feasible in routine clinical practice.…

View details →DOI: 10.1097/scs.0000000000013020
Negative / Null Result Report

Optimizing Early Compressive Strength of Ultrafine POFA-Based Green HSC: An Experimental and RSM Approach with Silica Fume and Hybrid Fibers

Alani AH, Ahmed D, Al-obaidi QA et al. · 2026 · Preprint

Recently, studies have focused on producing green, sustainable concrete with improved environmental performance, utilizing recycled waste materials. The early compressive strength of Green High Strength Concrete (GHSC) containing up to 60%…

View details →DOI: 10.12688/f1000research.175237.4
Negative / Null Result ReportOpen accessMedicine

No Evidence of Association Between Human 24-Hour Urinary Dopamine and Weight, BMI or Glucose Homeostasis in a Retrospective Analysis.

Mattelaer N, David S, Steenackers N et al. · 2026 · International journal of endocrinology and metabolism

Background Dopamine is an essential neurotransmitter involved in motivation and reward. In obesity, altered dopaminergic responses to food may drive excess energy intake, implicating dopamine in the pathophysiology of obesity.…

View details →DOI: 10.5812/ijem-166881
Negative / Null Result ReportMedicine

Development and Validation of the Nurses' Performance for Enhancing Patient Participation Scale.

Zhu L, Thungjaroenkul P, Abhicharttibutra K et al. · 2026 · Journal of nursing measurement

Background and Purpose: Patient participation is fundamental to modern health care. No validated instrument exists to assess nurses' performance in enhancing patient participation within Chinese health care. This study developed and…

View details →DOI: 10.1891/jnm-2025-0169
Negative / Null Result ReportMedicine

Relationship between hamstring flexibility (askling H-test) and isokinetic strength ratios in elite soccer players with prior hamstring strain injury: A cross-sectional study.

Takla MKN, Rageh MRM, Aboalata MAM et al. · 2026 · Journal of back and musculoskeletal rehabilitation

BackgroundRecurrent hamstring strain injuries are associated with deficits in eccentric strength and altered muscle-tendon extensibility, which may persist and contribute to reinjury risk.ObjectiveTo examine the relationship between…

View details →DOI: 10.1177/10538127261462651
Negative / Null Result Report

Inter-Limb Asymmetry and Its Limited Role in Physical Performance and Match Demands in Football Players with Spastic Hemiparesis: A Team Study

Peña-González I, Roldán A, Barquero BL et al. · 2026 · Preprint

Background: Inter-limb asymmetry has been widely studied as a potential determinant of physical performance in able-bodied athletes; however, its functional relevance in athletes with neurological impairments such as spastic hemiparesis…

View details →DOI: 10.20944/preprints202606.1603.v1
Negative / Null Result Report

Knowledge of Primary Pediatric Care Providers Regarding Attention Deficit Hyperactivity Disorder (ADHD) in the Southern Region, Saudi Arabia: A Cross-Sectional Study

Alwahbi Z, Asiri A · 2026 · Preprint

Abstract Purpose To assess the level of knowledge regarding ADHD among primary pediatric care providers and to identify factors associated with higher or lower knowledge levels in the southern region of Saudi Arabia in 2026. Methods This…

View details →DOI: 10.21203/rs.3.rs-9912726/v1
Negative / Null Result ReportMedicine

Severe visual loss and ocular complications after intra-arterial chemotherapy for retinoblastoma.

Solera-de-Andrés C, Spang-Valencia P, Peralta-Calvo J · 2026 · The British journal of ophthalmology

Background Retinoblastoma (RB) treatment aims to ensure survival, globe preservation and visual function. Intra-arterial chemotherapy (IAC) has improved globe salvage, but there remains limited information on visual outcomes following this…

View details →DOI: 10.1136/bjo-2025-328113
Negative / Null Result ReportMedicine

Density is a precursor in the perception of visual numerosity: Evidence from adaptation.

Durgin FH, Love A, Taylor G et al. · 2026 · Journal of experimental psychology. Human perception and performance

To dissociate density-based and number-based explanations of the aftereffects affecting visually perceived numerosity, a preregistered psychophysical experiment was conducted with 60 participants. The experiment was designed to address a…

View details →DOI: 10.1037/xhp0001434
Negative / Null Result ReportOpen accessMedicine

Spatioseasonal Variability and Correlations of Particle-Bound Organophosphate Esters in Providence, Rhode Island.

Gathof A, Jahaj L, Patalano S et al. · 2025 · ACS omega

The concentrations of organophosphate esters (OPEs) in atmospheric particulate matter (PM) collected every 6 days at two sites across Providence, Rhode Island (Providence College, PC, and the Port of Providence, Port) are reported for the…

View details →DOI: 10.1021/acsomega.5c07462
Negative / Null Result ReportOpen accessMedicine

Correlation Between Baseline Serum Testosterone Levels and Cognitive Gain Following Combined Oral Contraceptive Treatment in Patients With Polycystic Ovary Syndrome.

Kumari S, Marwah S, Manna S et al. · 2026 · Cureus

Background Combined oral contraceptives (COCs) are the cornerstone therapy for polycystic ovary syndrome (PCOS). While COCs have been shown to improve cognitive performance, the relationship between these gains and hormonal profiles,…

View details →DOI: 10.7759/cureus.108574
Negative / Null Result Report

Long-term and monthly changes in population characteristics and spatial distribution of the swimming crab Portunus trituberculatus in the Bohai Sea

Wu Q, Han Q, Shan X et al. · 2026 · Preprint

Abstract With the global decline of fish stocks, crustaceans have gained increasing ecological and economic significance. Portunus trituberculatus is a key crab species in the Asia-Pacific, with its highest density in China's Bohai Sea.…

View details →DOI: 10.21203/rs.3.rs-9095878/v1
Negative / Null Result ReportMedicine

A Comparative Analysis of Differences in Salivary hBD-2 Levels and Their Correlation with Dental Caries and Unstimulated Saliva pH in Children with Primary and Permanent Dentition.

Stojković B, Igić M, Jevtović Stoimenov T et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives : This exploratory study aimed to investigate potential differences and associations between salivary hBD-2 levels and dental caries, as well as between unstimulated salivary pH and salivary hBD-2 levels, in children…

View details →DOI: 10.3390/diagnostics16040591
Negative / Null Result Report

The Correlation Between Cognitive Function and Motoric Function With Quality of Life in Chidren Suspected of Down Syndrome

Mauludin MR, Permana I, Pratamawati TM et al. · 2026 · Preprint

Abstract Down syndrome is a genetic disorder caused by the presence of an extra copy of chromosome 21, commonly referred to as trisomy 21. In 2020, its prevalence was estimated at approximately 1 in 10.000 live births. The presence of an…

View details →DOI: 10.21203/rs.3.rs-9119273/v1
Negative / Null Result ReportOpen accessMedicine

FeNO as a Non-Invasive Biomarker of Type 2 Inflammation in Chronic Rhinosinusitis with Nasal Polyps: Correlation with Serum IgE and Eosinophils.

Fereydouni S, Jabbari-Azad F, Bakhshaee M et al. · 2026 · Iranian journal of otorhinolaryngology

Introduction Chronic rhinosinusitis with nasal polyps is a heterogeneous inflammatory disorder often driven by type 2 inflammation. Identification of non-invasive biomarkers, such as fractional exhaled nitric oxide (FeNO), may support the…

View details →DOI: 10.22038/ijorl.2025.88968.3979