A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19859 results in Negative / Null Result Report · page 375 of 662
SAKDAVONG J, SEBBAG A · 2026 · Preprint
Abstract Rapid advancements in Generative AI enable the synthesis of photorealistic pedagogical agents, yet their impact on human information processing remains debated. While Social Agency Theory predicts benefits from social priming,…
Alsaffar SF, Khaleel HM · 2025 · Preprint
Background Polycystic ovarian syndrome (PCOS) is a hormonal, metabolic disorder in women of reproductive age. It can be induced by genetic, immunological, and environmental determinants. The main pathophysiology of PCOS, is…
Shin E, Kim M, Soo TJ et al. · 2026 · Preprint
ABSTRACT To resolve discrepancies in the literature regarding the association between Alzheimer’s disease (AD) and Biondi body (BB) amyloid in choroid plexus epithelial cells (CPECs), we investigated postmortem hippocampal paraffin blocks…
Ni J, Yan Y, Zhang L · 2026 · Preprint
Abstract Background: Growing recognition has established rare diseases as a public health priority. With over 20 million rare disease patients in China, establishing a robust medical security system is crucial for advancing the Healthy…
Choo TH, Galfalvy HC, Keilp JG et al. · 2026 · Journal of affective disorders
Depression and its severe outcomes, suicidal ideation and behavior, are exacerbated by stress. A broad literature links dysregulation of the hypothalamic-pituitary-adrenocortical (HPA) stress response system to depression, suicidal…
Guedes Marques M, Maia P, Martins A et al. · 2026 · The journal of vascular access
Background The most common causes of early primary failures of a vascular access (VA) is related to small caliber vessels. Weight gain between dialyses expands both extracellular and blood volume, which may lead to rises in intravascular…
Medina-Valdebenito D, Espinoza-Palavicino T, Terán-Mendoza O et al. · 2026 · Journal of aging and health
ObjectivesThis study examined the influence of hearing status and loneliness on verbal fluency trajectories in adults aged 60 years and older, assessing their contributions to baseline performance and longitudinal change over…
Géczi R, Géczi G, Tóth L · 2026 · Sports (Basel, Switzerland)
The aim of this study was to examine the relative contribution of physical performance, executive functions, and competitive anxiety to competitive success in junior tennis players. A total of 39 national-level junior athletes (20 males,…
Bigdelu L, Ahmadi M, Shahri B et al. · 2026 · Scientific reports
Prediction of cardiovascular diseases (CVD) is a challenge that cardiologists have always faced all the times. Aortic propagation velocity (APV) is an echocardiography index that can be helpful with this regard; however, few studies have…
Karahan Yılmaz S, Güldüren S · 2026 · Nutricion hospitalaria
Introduction Introduction: a growing world population, constraints on natural resources and changing nutritional preferences all point to the need to find an alternative to traditional animal protein sources however food neophobia can come…
Berube M, Bortman JM, Law AC et al. · 2026 · Hip international : the journal of clinical and experimental research on hip pathology and therapy
Background The optimal threshold to blood transfusion in patients after hip fracture surgery is unclear. This study leveraged regression discontinuity to quantify blood transfusion practices across haemoglobin thresholds of 7.0, 8.0, and…
Li Y, Wang D, Liu B et al. · 2026 · Preprint
Abstract Background Pulsed field ablation (PFA) is a novel non-thermal technology for atrial fibrillation (AF) ablation, but its immediate systemic effects on electrolytes remain poorly characterized. Methods We prospectively enrolled 161…
Darch W, Soliman J, Higgins NC et al. · 2026 · Scientific reports
Vascular endothelial cells (VECs) play a critical role in tissue and organ homeostasis, wound healing, and immune function. VECs are commonly utilized for in vitro cell culture and in vivo tissue engineering applications which experience…
Almekaty K, Alhefnawy M, Ismael A et al. · 2026 · Urology
Objective To prospectively assess the clinical outcomes and safety of microsurgical denervation of the penis (MSDP) for treatment of lifelong premature ejaculation (LPE); and to examine the impact of transitioning from partial to more…
Salem AS, Albelasy NF, El-Bialy AA · 2026 · The Angle orthodontist
Objectives To compare the effectiveness of clear aligner (CA) vs removable inclined plane (RP) in improving the dentofacial changes and oral health-related quality of life (OHRQoL) in children with anterior crossbite in the mixed…
Erdem Altınyürek E, Öztürk VÖ · 2026 · BMC oral health
Background Gastritis is characterized by alterations in the gastric microbiota. This dysbiosis in the stomach may affect immune system regulation as well as influence the oral microbiota. Periodontal disease results from dysbiosis of…
Mamun AA · 2026 · 3 Biotech
Drought significantly alters soil microbial activity and carbon cycling, yet its effects across contrasting land-use systems remain insufficiently understood. This study investigated drought-induced changes in microbial communities and…
Tuncsoy M, Tuncsoy B · 2026 · Bulletin of environmental contamination and toxicology
Aluminum (Al) is a widely occurring element in nature and is the most abundant element in the earth's crust after oxygen and silicon. In this study, metal accumulation levels in the gills, liver and muscle tissues and liver SOD, CAT and…
Nersesyan A, Kundi M, Muradyan R et al. · 2026 · Mutagenesis
We investigated the impact of cigarette smoking, daily exposure to tar and nicotine, and the duration of smoking on genetic instability (chromosomal damage-micronuclei, MN, nuclear buds-gene amplification) as well as on disturbances in…
Bakir M, Sağmak S · 2026 · BMC oral health
Background This study aimed to evaluate the effects of different modeling resins on the surface roughness, surface gloss, and color stability of a nanohybrid resin composite. Methods Forty disk-shaped specimens (10 mm diameter × 2 mm…
Kaplan S, de Nascimento J, Contini A · 2026 · Drug safety
Background and objectives Concerns about modafinil and armodafinil use in pregnancy emerged from animal reproductive toxicity and limited human data, including a US registry suggesting increased risk of major congenital malformations…
McDonough W, Gevorkian J, Wong D et al. · 2026 · Surgical laparoscopy, endoscopy & percutaneous techniques
Background As part of the accreditation process for bariatric surgery, patients must go through a preoperative pathway. There will inevitably be patients who are seen in the clinic but never undergo surgery. This rate of attrition is…
Wakui N, Ogino Y, Nagumo H et al. · 2026 · BMC gastroenterology
Background Zinc deficiency is common in chronic liver disease and is closely associated with the progression of hepatic fibrosis and metabolic dysfunction. Although pemafibrate, a selective peroxisome proliferator-activated receptor alpha…
Biedermann M, Sifakakis I, Zinelis S et al. · 2026 · European journal of oral sciences
Rubbing phosphoric acid during etching has been shown to improve surface roughness in prepared enamel. This study aimed to compare intact enamel's surface roughness and resin tag lengths after etching with and without rubbing. Extracted…
Hamid R, Bayramoğlu MN, Şirolu S et al. · 2026 · Journal of clinical medicine
Background: In this study, we radiologically assessed potential increases in microvascularity, extracellular matrix-related changes, and tissue viscoelasticity following carboxytherapy for periorbital hyperpigmentation (POH). We also…
Akbulut NK, Yıldız I, Yılmaz MT · 2026 · Polish journal of veterinary sciences
Melatonin not only regulates circadian rhythms in animals but also supports reproductive health through its potent antioxidant properties and immunomodulatory effects. In this study, the effects of exogenous melatonin administration on…
Firoozjaei IT, Sabzi Z, Rajabloo M et al. · 2026 · Nursing research and practice
Background During pregnancy, extensive hormonal and metabolic changes can occur. Gestational diabetes can cause maternal and neonatal complications. Follow-ups have shown that women who first develop metabolic diseases during pregnancy…
Şenel SSD, Çetin A · 2026 · BMC psychology
Peer bullying poses a serious risk to adolescents' psychosocial development and school adjustment. However, culturally adapted and evidence-based intervention programs remain limited in non-Western societies. Restorative justice approaches…
Ebrahimi S, Tehrani H, Ghavami V et al. · 2025 · Journal of education and health promotion
Background Brucellosis is a major bacterial infectious disease common to human beings and animals. It is considered a prevalent infection in developing countries. The present research was carried out to explore the effect of an educational…
Bilgin O, Koç M · 2026 · Behavioral sciences (Basel, Switzerland)
Solution-focused brief group counseling is a systematic approach that centers on solutions rather than the problem itself. In this approach, which focuses on the strengths of the clients, the solutions are generated by the clients…