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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19859 results in Negative / Null Result Report · page 373 of 662

Negative / Null Result ReportOpen accessMedicine

Effects of MDMA treatment and cessation on sexual behaviour and testicular functions in male sprague-dawley rats.

Obembe OO, George ET, Mustapha RA et al. · 2026 · BMC pharmacology & toxicology

BACKGROUND: 3,4-Methylenedioxymethamphetamine (MDMA) is a psychostimulant known for its social and empathogenic effects. However, its long-term impact on sexual performance and reproductive functions remain controversial. OBJECTIVE: In…

View details →DOI: 10.1186/s40360-026-01131-1
Negative / Null Result Report

Analysis of the effect of vertebroplasty via kambin's triangular approach in the treatment of spinal deformity with vertebral compression fracture

Jiang Z, Tan X, Zhang M et al. · 2026 · Preprint

Abstract Objective : To explore the clinical efficacy of percutaneous vertebroplasty (PVP) via Kambin's triangle in the treatment of senile spinal deformity accompanied by vertebral compression fractures. Methods : A retrospective analysis…

View details →DOI: 10.21203/rs.3.rs-9403084/v1
Negative / Null Result ReportOpen accessMedicine

A Comparison of Monoaxial Pedicle Screws Versus Polyaxial Pedicle Screws in Posterior Fusion Surgery for Adolescent Idiopathic Scoliosis (Lenke Type 1).

Hammad A, Saleh ME, Shehab AA · 2026 · Cureus

Background Adolescent idiopathic scoliosis (AIS) is the most common form of spinal deformity in adolescents, characterized by a three-dimensional curvature of the spine with unknown etiology. Surgical intervention is indicated in…

View details →DOI: 10.7759/cureus.107673
Negative / Null Result ReportOpen accessMedicine

Effects of music during endoscopy on pain, anxiety and vital signs: a randomized controlled study.

Bozkurt SN, Kocasli S · 2026 · BMC complementary medicine and therapies

AIMS: The aim of this study was to the effects of music during the endoscopy procedure on anxiety, pain and vital signs. METHODS: This study was conducted as a randomized, controlled, double-blind trial. The study population consisted of…

View details →DOI: 10.1186/s12906-026-05381-8
Negative / Null Result ReportOpen accessMedicine

Quantifying glenoid bone loss in the setting of primary reverse shoulder arthroplasty.

MacFarlane AJ, Larson JH, Kucharik MP et al. · 2026 · Journal of shoulder and elbow arthroplasty

Background Presently, there is no quantifiable and objective criteria for defining severe glenoid bone loss (GBL) for primary reverse total shoulder arthroplasty (rTSA). In this study, we sought to establish quantifiable thresholds of…

View details →DOI: 10.1016/j.jsea.2026.100015
Negative / Null Result ReportOpen accessMedicine

Prognostic Value of Combined Neutrophil-to-Lymphocyte Ratio and Prognostic Nutritional Index in Advanced Ovarian Cancer Treated With Neoadjuvant Chemotherapy.

Ishida H, Egashira H, Asano N et al. · 2026 · Cureus

Background Inflammation- and nutrition-related biomarkers such as the neutrophil-to-lymphocyte ratio (NLR) and prognostic nutritional index (PNI) have been reported as prognostic factors for ovarian cancer. However, their clinical…

View details →DOI: 10.7759/cureus.108250
Negative / Null Result ReportMedicine

Effect of remazolam combined with hydromorphone postoperative analgesia on cognitive function in elderly patients undergoing hip replacement.

Zheng X, Fu X, Shao Y et al. · 2026 · American journal of translational research

Objective To investigate the effect of remazolam combined with hydromorphone on postoperative cognitive function in elderly patients undergoing hip replacement. Methods 184 elderly patients who underwent hip replacement in Sir Run Run Shaw…

View details →DOI: 10.62347/tfej7525
Negative / Null Result Report

Under-correction is not advisable in valgus knee and lateral approach is more feasible than medial approach to achieve this: A 5-year follow-up study

Li S, Chai H, Bao W et al. · 2026 · Preprint

Abstract Background: It is commonly recommended to restore the mechanical axis to within –0° ± 3° in valgus knee. However, the situation is quite different when the alignment is –3° or 3° in the presence of a compromised MCL in Ranawat…

View details →DOI: 10.21203/rs.3.rs-9715753/v1
Negative / Null Result ReportOpen accessMedicine

Effects of ultrasound-assisted tumbling on physicochemical properties, myofibrillar protein structure, and protein oxidation during beef curing.

Jin L, Zhang J, Zhang R et al. · 2026 · Ultrasonics sonochemistry

The aim of this study was to investigate the effects of ultrasound-assisted tumbling (100, 300, 500, and 700 W) with different treatment times (30, 60, 90, 120, 150, and 180 min) on the quality, myofibrillar protein structure, and protein…

View details →DOI: 10.1016/j.ultsonch.2026.107919
Negative / Null Result ReportOpen accessMedicine

Effectiveness of Acupressure on Anxiety, Fatigue, and Sleep Quality Among Operating Room Personnel: A Randomized Controlled Trial.

Abjar R, NasiriFormi E, Kazemi AH et al. · 2026 · Health science reports

Background and aims High-quality sleep, calmness, and lack of fatigue are vital for the health of critical hospital staff. Operating room personnel experience significant mental and physical stress, including anxiety and sleep…

View details →DOI: 10.1002/hsr2.72680
Negative / Null Result Report

Association of Primary Nocturnal Enuresis with Renal Parenchymal Thickness: Insights from a Study on Enuresis Prevalence and Related Factors

Merikhi A, Gheisari A, Kasiri P et al. · 2026 · Preprint

Abstract Background: Nocturnal Enuresis (NE), characterized by the inability to control nighttime voiding in children above five years, is one of the common problems faced by the young generation today and can result in some psychological…

View details →DOI: 10.21203/rs.3.rs-9818630/v1
Negative / Null Result ReportMedicine

<i>Invitro</i> Hepatic like Differentiation of Umbilical Cord-Derived Mesenchymal Stem Cells through FGF and IGF Factor Preconditioning.

Zahid Habib Q, Tahir M, Bakhtawar F et al. · 2026 · Journal of stem cells & regenerative medicine

Introduction Liver diseases remain a major global health burden, with limited treatment options for advanced hepatic dysfunction. Current treatment options are limited and mainly supportive, with liver transplantation being the only…

View details →DOI: 10.46582/jsrm.2201004
Negative / Null Result ReportMedicine

Helicobacter pylori infection carrying the CagA gene may be associated with the diagnosis and disease progression of tuberculosis.

Huang F, Zhan H, Yang Y et al. · 2026 · BMC infectious diseases

Background and objective Helicobacter pylori (H. pylori) infection is associated with infectious diseases caused by pathogens such as Orientia tsutsugamushi (the causative agent of scrub typhus) and Brucella. However, the impact of H.…

View details →DOI: 10.1186/s12879-026-13491-4
Negative / Null Result ReportOpen accessMedicine

Evaluation of the Advantages of Silicone Stent in Revision Endoscopic Dacryocystorhinostomy in a Tertiary Care Hospital.

Sonawane C, Raval RR, Bajaj A et al. · 2026 · International archives of otorhinolaryngology

Introduction Silicone stents are often employed in dacryocystorhinostomy (DCR) procedures to maintain the patency of the newly created tear drainage passage during the healing stage. These stents are flexible, biocompatible, and generally…

View details →DOI: 10.1055/s-0046-1818565
Negative / Null Result ReportOpen accessMedicine

The effect of timing on rehabilitation results in tumor-related spinal cord injuries.

Yorulmaz E, Geler-Kulcu D, Ramazanoglu AF et al. · 2026 · Turkish journal of physical medicine and rehabilitation

Objectives This study aims to investigate the impact of early initiated rehabilitation on outcomes in patients with spinal cord injuries related to tumors. Patients and methods In this retrospective cohort study conducted between January…

View details →DOI: 10.5606/tftrd.2026.17637
Negative / Null Result ReportOpen accessMedicine

Acute Effect of Percussive Massage on Cross-Section Area, Muscle Strength, and Late Muscle Pain of the Quadriceps Muscle Following a Fatigue Protocol in Physically Active Men: Randomized Clinical Trial.

da Rosa Castilho A, Aguiar AF, Ribeiro AS et al. · 2026 · Physiotherapy research international : the journal for researchers and clinicians in physical therapy

Background and purpose The massage gun is widely used to alleviate delayed-onset muscle soreness (DOMS); however, empirical evidence regarding its physiological effects remains limited. Objectives This study aimed to evaluate the acute…

View details →DOI: 10.1002/pri.70246
Negative / Null Result ReportOpen accessMedicine

Central European Sample Analysis of Traumatic Vertebral Fractures: A One-Year Retrospective Cohort Study.

Colella E, Pape HC, Mica L · 2026 · Healthcare (Basel, Switzerland)

Background/objectives The purpose of this study was to examine the sex-specific distribution of traumatic spinal fractures and potential predictive clinical factors for a more well-founded treatment evaluation. Methods This study is a…

View details →DOI: 10.3390/healthcare14081114
Negative / Null Result ReportMedicine

Less Is More! An Analysis of Postoperative Outcomes Comparing Low-Dose E. Coli-Derived rhBMP-2 and Mammalian rhBMP-2 in Lateral Lumbar Spinal Fusion Surgery.

Chiu ST, Seah SJ, Zeng GJ et al. · 2026 · Clinical spine surgery

Study design Retrospective clinical study. Objective Investigating the fusion effect and side effect profile between low-dose E.BMP-2 and mammalian rhBMP-2. Summary of background data Recombinant human bone morphogenetic protein-2…

View details →DOI: 10.1097/bsd.0000000000002115
Negative / Null Result ReportOpen accessMedicine

Novel factors associated with surgical conversion for duodenal perforation: case control study.

IShii K, Nishimura E, Tajima Y et al. · 2026 · Annals of medicine and surgery (2012)

Background Based on initial evaluation using indication criteria, conservative treatment or surgery is selected for duodenal ulcer perforation. However, some patients fail conservative management and require surgical intervention. This…

View details →DOI: 10.1097/ms9.0000000000004860
Negative / Null Result ReportOpen accessMedicine

Clinical outcomes of implants in atrophic ridges augmented with collagenated xenogeneic or autogenous bone: 4-year follow-up of a randomized clinical trial.

Romito GA, Soares HH, Nishyama R et al. · 2026 · Brazilian oral research

This study aimed to evaluate the long-term outcomes of dental implants placed in alveolar ridges augmented with collagenated xenogeneic bone blocks (CXBB) or autogenous bone blocks (ABB). In this non-interventional study, 20 patients…

View details →DOI: 10.1590/1807-3107bor-2026.vol40.030
Negative / Null Result ReportOpen accessMedicine

Taurine supplementation in fish meal-free diet improved growth, alleviated hypoxic-induced gill injury associating with Ca<sup>2+</sup> homeostasis and endoplasmic reticulum stress in sub-adult grass carp (<i>Ctenopharyngodon idella</i>).

Yan J, Feng L, Wu P et al. · 2026 · Animal nutrition (Zhongguo xu mu shou yi xue hui)

Taurine is a multifunctional feed additive that is abundant in fish meal but scarce in plant protein sources. The aim of this study was to investigate the effects of taurine supplementation in fish meal-free diet on sub-adult grass carp (…

View details →DOI: 10.1016/j.aninu.2025.10.016
Negative / Null Result ReportOpen accessMedicine

Impact of Continuous Nursing Intervention Delivered via Internet+ Platform on Inflammatory Responses in Ulcerative Colitis Patients.

Zhu J, Ren X, Wang Q et al. · 2026 · Patient preference and adherence

Objective To explore the application effect of continuity nursing intervention based on the "Internet +" platform in patients with ulcerative colitis (UC) and analyze its impact on patients' inflammatory responses. Methods A retrospective…

View details →DOI: 10.2147/ppa.s571511
Negative / Null Result ReportOpen accessMedicine

Studying the expression levels of LncRNA-MEG3 and miR-147b in the serum of psoriasis patients with and without dyslipidemia.

Kamel M, Marzouk RE, Shaker OG et al. · 2026 · Scientific reports

Psoriasis is a chronic systemic inflammatory skin disorder that is strongly associated with metabolic disorders, including obesity, insulin resistance, hypertension, and dyslipidemia. Dyslipidemia causes abnormalities in lipid profiles,…

View details →DOI: 10.1038/s41598-026-52391-0
Negative / Null Result ReportMedicine

The effectiveness of virtual reality in reducing preoperative anxiety among oral surgery patients under general anesthesia: a salivary stress biomarker and questionnaire-based study.

Yuza AT, Nurwiadh A, Hadikhrisna I et al. · 2026 · BMC oral health

Background Preoperative anxiety is a common psychological response to surgical operations affecting the emotional, cognitive and physiological state of the patient. It can be measured by both objective and subjective methods. While the…

View details →DOI: 10.1186/s12903-026-08466-5
Negative / Null Result ReportMedicine

Craniofacial Growth and Hypodontia in Individuals Born with Van der Woude Syndrome.

Vesterbacka M, Parikakis K, Ganzer N et al. · 2026 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

ObjectiveTo study craniofacial growth and hypodontia in individuals born with Van der Woude syndrome (VWS) and compare with matched controls with and without a cleft.DesignA multicenter retrospective case-control study.SettingIndividuals…

View details →DOI: 10.1177/10556656261463128
Negative / Null Result ReportOpen accessMedicine

Optical coherence tomography angiography evaluation of retinal and choriocapillaris changes after pars plana vitrectomy for macula-off rhegmatogenous retinal detachment: perfluoropropane versus silicone oil tamponade.

Karatepe MS, Erol YÖ · 2026 · BMC ophthalmology

BACKGROUND: Rhegmatogenous retinal detachment (RRD) with macular involvement may lead to persistent visual impairment despite successful anatomical repair. Different intravitreal tamponade agents used during pars plana vitrectomy (PPV) may…

View details →DOI: 10.1186/s12886-026-04760-6
Negative / Null Result Report

Underrecognized Osteoporosis in Internal Medicine Outpatients: Sex-Specific Disparities in Prevalence, Risk Stratification, and Treatment in a Large Elderly Cohort

Okuno R, Homma Y, Matsuno K et al. · 2026 · Preprint

Abstract Background: As the population ages, osteoporosis is becoming a substantial health problem. Internal medicine outpatients often have multiple comorbidities and are considered at high risk for osteoporosis; however, osteoporosis…

View details →DOI: 10.21203/rs.3.rs-9878157/v1
Negative / Null Result ReportOpen accessMedicine

Allelopathic effects of four spontaneous plants from arid regions on the germination and growth of selected weeds and crops.

Harabi M, Elfalleh W, Mergby D et al. · 2026 · Frontiers in pharmacology

The study investigates the allelopathic potential of the aqueous extracts of four plants species; Cleome arabica L., Diplotaxis harra (Forssk.) Boiss., Nerium oleander L., and Retama raetam (Forssk.) Webb. Collected from Tunisian arid…

View details →DOI: 10.3389/fphar.2026.1746401