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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19859 results in Negative / Null Result Report · page 372 of 662

Negative / Null Result ReportMedicine

The impact of delivery models on psychomotor performance of manual procedures: a pilot study.

Borgehammar J, McClenahan B, Miller E et al. · 2026 · The Journal of manual & manipulative therapy

Objective Developing psychomotor competence in orthopedic manual physical therapy (OMPT) techniques is fundamental to post-professional physical therapy education. Concerns persist about whether online instructional models and the rise of…

View details →DOI: 10.1080/10669817.2026.2680217
Negative / Null Result ReportMedicine

Effect of Concurrent Anti-Seizure Medications on the Efficacy of the Ketogenic Diet in Children with Epilepsy.

Sharma S, Aschner A, Kabir N et al. · 2026 · The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

Rationale The ketogenic diet (KD) is a well-established therapeutic option for children with non-surgical drug-resistant epilepsy (DRE). The purpose of this study was to determine whether specific anti-seizure medications (ASM) are…

View details →DOI: 10.1017/cjn.2026.10620
Negative / Null Result ReportMedicine

Clinical Outcomes in Japanese Patients with Chronic Limb Threatening Ischaemia Undergoing Tibial and Pedal Bypass with a Single Segment Great Saphenous Vein Graft.

Kobayashi T, Takahara M, Kikuchi S et al. · 2026 · European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

Objective A single segment great saphenous vein (GSV) with a diameter ≥ 3.0 mm is widely accepted as the standard conduit for tibial and pedal bypass in chronic limb threatening ischaemia (CLTI) based on studies in European and American…

View details →DOI: 10.1016/j.ejvs.2026.06.037
Negative / Null Result ReportMedicine

+Gz Exposure and Cervical Spine Degeneration on MRI Among Fighter Pilots: A 10-Year Follow-Up Study.

Keskimölö T, Kiviaho A, Karppinen J et al. · 2026 · Aerospace medicine and human performance

Introduction Fighter pilots are exposed to high +Gz forces, helmet-mounted equipment, and extreme head positions that potentially cause cervical spine degeneration and pain. This study aimed to investigate whether individual +Gz exposure,…

View details →DOI: 10.3357/amhp.6828.2026
Negative / Null Result ReportMedicine

Association Between Selenium, Ferritin, and Haemoglobin Levels and the Development of Preeclampsia.

Taymur BD, Toklucu G, Gunkaya OS et al. · 2026 · Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

Objective To evaluate the association between Selenium (Se) and other micronutrients (iron, ferritin, copper, zinc, and vitamin B12) and the development of preeclampsia (PE), and to assess their predictive performance. Study design An…

View details →DOI: 10.29271/jcpsp.2026.06.732
Negative / Null Result ReportMedicine

Episodic migraine is associated with a more atherogenic lipid profile rather than independent insulin resistance: a case-control study.

Szabóová S, Duraníková O, Örzsik B et al. · 2026 · Lipids in health and disease

Background Cardiometabolic factors may influence migraine biology through metabolic, inflammatory, and vascular mechanisms, but studies examining insulin resistance and dyslipidaemia in migraine have yielded inconsistent results, partly…

View details →DOI: 10.1186/s12944-026-02997-0
Negative / Null Result ReportMedicine

Physical Activity Patterns and Kidney Function Changes Among Hispanic/Latino Adults: The Hispanic Community Health Study/Study of Latinos.

Rivas-Nieto AC, Alver SK, Mooney SJ et al. · 2026 · Journal of physical activity & health

Background Physical activity (PA) may be a modifiable factor for chronic kidney disease (CKD) prevention, but evidence specific to Hispanic/Latino populations is limited. Our objective was to examine associations between PA type/volume…

View details →DOI: 10.1123/jpah.2025-0918
Negative / Null Result ReportMedicine

Retrospectively reported childhood ADHD symptoms and addiction severity in emerging adults with substance use disorders: cross-sectional indirect associations through time perspective.

Demirci SC, Aşik UB, Menkü BE et al. · 2026 · BMC psychiatry

Background Symptoms of attention-deficit/hyperactivity disorder (ADHD) are commonly observed in individuals with substance use disorders (SUD) and may be associated with increased addiction severity. Time perspective is a potential…

View details →DOI: 10.1186/s12888-026-08286-5
Negative / Null Result ReportMedicine

Post-discharge VTE prophylaxis after bariatric surgery: balancing bleeding risk and thrombosis prevention in 275,843 patients.

Gillikin AP, Rabinovich EP, Barajas-Gamboa JS et al. · 2026 · Surgical endoscopy

Background Post-discharge venous thromboembolism (VTE) chemoprophylaxis after metabolic and bariatric surgery is variably implemented in clinical practice, although the optimal pharmacologic agent and dosing regimen remain unclear. This…

View details →DOI: 10.1007/s00464-026-12954-8
Negative / Null Result ReportMedicine

Relationship Between Standing Long Jump Performance and Health-Related Indicators and Lifestyle Factors in Chilean Adolescents: A Cross-Sectional Study.

Montalva-Valenzuela F, Guzmán-Muñoz E, Castillo-Paredes A et al. · 2026 · Healthcare (Basel, Switzerland)

Background: The standing long jump (SLJ) is a field-based test of lower-limb muscular fitness in youth and a proposed indicator of health-related physical fitness. However, evidence on its relationship with psychological, sleep, dietary,…

View details →DOI: 10.3390/healthcare14121744
Negative / Null Result ReportMedicine

Perinatal and Lifestyle Factors Associated with Childhood Alanine Aminotransferase Levels as an Early Indicator of Metabolic Dysfunction-Associated Steatotic Liver Disease: A Population-Based Study.

de Ruyter H, Aitokari L, Iqbal A et al. · 2026 · The Journal of pediatrics

Objective To investigate associations of perinatal and lifestyle factors with alanine aminotransferase (ALT) levels as an early indicator of metabolic dysfunction-associated steatotic liver disease (MASLD). Study design Data from the…

View details →DOI: 10.1016/j.jpeds.2026.115146
Negative / Null Result Report

Early Neuroinflammatory Signatures and Glucagon-Like Peptide 1 Levels in Neuropathic Symptoms: Evidence from Newly Diagnosed Type 2 Diabetes Mellitus

Başcı ÖK, Sarı ÜS, Uysal S et al. · 2026 · Preprint

Abstract Aim Neuropathic symptoms are among the earliest neurological manifestations of type 2 diabetes mellitus (T2DM) and may precede electrophysiologically confirmed diabetic sensorimotor polyneuropathy (DSPN). The underlying mechanisms…

View details →DOI: 10.21203/rs.3.rs-9149051/v1
Negative / Null Result ReportMedicine

Systemic inflammatory indices as predictors of adverse outcomes in pregnancies with vascular events: A retrospective cohort study.

Toptas GR, Firatligil FB, Ozdal BB et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Objective To investigate the association between systemic inflammatory indices, including the systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI), and…

View details →DOI: 10.1002/ijgo.71056
Negative / Null Result ReportMedicine

Associations between testosterone and pre-androgens and sexual function; findings from the Australian Women's Midlife Years Study.

Wang Y, Islam RM, Hodge A et al. · 2026 · Fertility and sterility

Objective To determine the associations between the sex steroids and sexual function and difficulties in a national, community-based sample of women aged 40 to 69 years according to menopausal status. Design This was a prespecified…

View details →DOI: 10.1016/j.fertnstert.2026.05.156
Negative / Null Result ReportMedicine

Assessing the essential parameters of race, ethnicity and geography in endometrial cancer and the impact on presentation, treatment and outcomes.

Jamieson A, Kwon J, Gao T et al. · 2026 · Gynecologic oncology

Background Race, ethnicity, and geography can impact cancer management, genomics and outcomes. We aimed to determine the ethnic and geographic diversity of endometrial carcinoma (EC) patients in our province and their impact on molecular…

View details →DOI: 10.1016/j.ygyno.2026.05.011
Negative / Null Result ReportMedicine

Identification of chrono-nutrition behavior patterns and their associations with sociodemographic characteristics, diet quality, and obesity.

Murakami K, Shinozaki N, Livingstone MBE et al. · 2026 · The British journal of nutrition

While chrono-nutrition behaviors are inter-related, few studies examined patterns of chrono-nutrition behaviors using a comprehensive set of these behaviors. This study aimed to identify chrono-nutrition behavior patterns and examine their…

View details →DOI: 10.1017/s0007114526107090
Negative / Null Result ReportMedicine

Relationships between rest-activity rhythms, cancer-related fatigue, and quality of life: Results from a time-restricted eating randomized controlled trial.

Kleckner AS, Zhou Y, Diaz-Mercado Y et al. · 2026 · Chronobiology international

Circadian rest-activity rhythms, or a person's consistency in their daily activity and rest patterns, can be quantified using various parametric and non-parametric methods. However, these methods are seldom applied to understand symptoms…

View details →DOI: 10.1080/07420528.2026.2669594
Negative / Null Result ReportMedicine

IL-6 and TNFα are associated with depressive symptoms among men in a community-based cohort, with a tentative trend for IL-17A: Findings from the Shika Study in Japan.

Tsuboi H, Sakakibara H, Minamida-Urata Y et al. · 2026 · Neuro endocrinology letters

Objective Emerging evidence suggests that low-grade systemic inflammation contributes to depressive symptoms; however, population-based longitudinal evidence, particularly from community samples, remains limited. This study examined the…

Negative / Null Result ReportMedicine

Outcomes of extremely preterm infants with neonatal hyperglycemia and hypernatremia: a retrospective cohort study.

Fursule A, Athalye-Jape G, Deepak D et al. · 2026 · Journal of perinatology : official journal of the California Perinatal Association

Objective To assess whether early hypernatremia (HN) and/or hyperglycemia (HG) in the first postnatal week are associated with adverse neurodevelopmental outcomes in extremely preterm (EP; Study design This was a single-center…

View details →DOI: 10.1038/s41372-026-02683-0
Negative / Null Result ReportMedicine

Association between platelet indices and next-day bleeding and clotting in children and adults on extracorporeal membrane oxygenation: A retrospective study.

Chegondi M, Jawahar A, Badheka A et al. · 2026 · Perfusion

IntroductionBleeding and clotting phenotypes are common in patients supported with Extracorporeal Membrane Oxygenation (ECMO) and are associated with increased mortality. However, tools to distinguish bleeding from clotting phenotypes…

View details →DOI: 10.1177/02676591261445354
Negative / Null Result ReportMedicine

Subclinical malaria in sickle cell disease in Northern Uganda: prevalence, predictors, and hematologic impact.

Matejak NJ, Ngolobe H, O'Connell CT et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Objectives Sickle Cell Disease (SCD), characterized by persistently low hemoglobin (Hb) and hematocrit levels, is among the leading causes of under-five mortality in high prevalence countries. Sub-Saharan Africa bears the highest burden of…

View details →DOI: 10.1016/j.ijid.2026.108823
Negative / Null Result ReportMedicine

The relationships between proprioceptive awareness, balance, and spasticity in patients post-stroke with varying levels of trunk impairment.

Ada G, Duray M · 2026 · Physiotherapy theory and practice

Background Cervical and trunk proprioceptive deficits resulting from impaired sensorimotor integration post-stroke may contribute to deficiencies in balance reactions and tone regulation. Purpose: To examine relationships between cervical…

View details →DOI: 10.1080/09593985.2026.2656807
Negative / Null Result ReportMedicine

Associations between attitudes and beliefs about the role of nutrition and diet quality with pain interference and physical function.

Fredhoff B, Bernstetter A, Fotiou H et al. · 2026 · Complementary therapies in clinical practice

Background and purpose Nutrition likely influences pain, but the role of patient beliefs remains understudied in musculoskeletal conditions. This study examined whether beliefs about the role of nutrition in pain, diet quality, and eating…

View details →DOI: 10.1016/j.ctcp.2026.102057
Negative / Null Result ReportMedicine

Other-Oriented Perfectionism and Romantic Relationship Stress: The Role of Social Media Use Among Italians.

Amodeo AL, Giaquinto V, Reginelli F et al. · 2026 · Psychological reports

The present study examines the associations between other-oriented perfectionism and individual stress within romantic relationships, focusing on the intervening role of social media use as a relational context. Data were collected through…

View details →DOI: 10.1177/00332941261423478